Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation

Biotechnology and Bioengineering

Volumn 108, Issue 2, 2011, Pages 424-434

  Hoesli, Corinne A ^a   Raghuram, Kamini ^a   Kiang, Roger L J ^a   Mocinecová, Dušana ^b   Hu, Xiaoke ^c   Johnson, James D ^c   Lacík, Igor ^b   Kieffer, Timothy J ^c   Piret, James M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b POLYMER INSTITUTE   (Slovakia)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alginate; Diabetes; Emulsion; Encapsulation; Immobilization; Internal gelation

Indexed keywords

ALGINATE BEADS; BIOLOGICAL MOLECULE; CELL SURVIVAL; CELLULAR THERAPEUTICS; DIABETES; DROPLET FORMATION; EXTRUSION PROCESS; IMMOBILIZATION; IMMOBILIZED CULTURE; IMMUNE REJECTION; INTERNAL GELATION; MAMMALIAN CELLS; MATRIX; MICROBIAL CELLS; MIN6 CELLS; PANCREATIC ISLET; PROGENITOR CELL; SCALEABLE; STIMULATION INDICES;

ALGINATE; ANIMAL CELL CULTURE; CELL CULTURE; CELLS; COAGULATION; DROP FORMATION; EMULSIFICATION; EXTRUSION; GELATION; GLUCOSE; INSULIN; MAMMALS; SPRAY NOZZLES;

CELL IMMOBILIZATION;

ALGINIC ACID; GLUCOSE; INSULIN;

ADAPTATION; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMULSION; EXOCRINE CELL; GELATION; GRAFT REJECTION; IMMOBILIZED CELL; MAMMAL CELL; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET TRANSPLANTATION; STEM CELL; SUSPENSION;

ALGINATES; ANIMALS; BIOTECHNOLOGY; CELL LINE; CELL PROLIFERATION; CELLS, IMMOBILIZED; EMULSIONS; GLUCURONIC ACID; HEXURONIC ACIDS; INSULIN; ISLETS OF LANGERHANS; MICE; MICROSPHERES;

MAMMALIA;

EID: 78650187855     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22959     Document Type: Article

References (66)

1. Alexakis T, Boadi DK, Quong D, Groboillot A, O'Neill I, Poncelet D, Neufeld RJ. 1995. Microencapsulation of DNA within alginate microspheres and crosslinked chitosan membranes for in vivo application. Appl Biochem Biotechnol 50(1): 93-106.
2. Alper J. 2009. Geron gets green light for human trial of ES cell-derived product. Nat Biotechnol 27(3): 213-214.
3. Augst AD, Kong HJ, Mooney DJ. 2006. Alginate hydrogels as biomaterials. Macromol Biosci 6(8): 623-633.
4. Bavamian S, Klee P, Britan A, Populaire C, Caille D, Cancela J, Charollais A, Meda P. 2007. Islet-cell-to-cell communication as basis for normal insulin secretion. Diabetes Obes Metab 9: 118-132.
5. Boretti MI, Gooch KJ. 2006. Induced cell clustering enhances islet beta cell formation from human cultures enriched for pancreatic ductal epithelial cells. Tissue Eng 12(4): 939-948.
6. Buchwald P. 2009. FEM-based oxygen consumption and cell viability models for avascular pancreatic islets. Theor Biol Med Model 6: 5.
7. Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. 2006. CellProfiler: Image analysis software for identifying and quantifying cell phenotypes. Genome Biol 7(10): R100.
8. Chayosumrit M, Tuch B, Sidhu K. 2010. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm. Biomaterials 31(3): 505-514.
9. Choi CH, Jung JH, Rhee YW, Kim DP, Shim SE, Lee CS. 2007. Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed Microdevices 9(6): 855-862.
10. Constantinidis I, Rask I, Long RC, Jr., Sambanis A. 1999. Effects of alginate composition on the metabolic, secretory, and growth characteristics of entrapped beta TC3 mouse insulinoma cells. Biomaterials 20(21): 2019-2027.
11. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE. 2006. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24(11): 1392-1401.
12. de Vos P, Faas MM, Strand B, Calafiore R. 2006. Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials 27(32): 5603-5617.
13. Dufrane D, Gianello P. 2008. Pig islet xenotransplantation into non-human primate model. Transplantation 86(6): 753-760.
14. Efrat S. 2008. Ex-vivo expansion of adult human pancreatic beta-cells. Rev Diabet Stud 5(2): 116-122.
15. Engler AJ, Sen S, Sweeney HL, Discher DE. 2006. Matrix elasticity directs stem cell lineage specification. Cell 126(4): 677-689.
16. Gerecht-Nir S, Cohen S, Ziskind A, Itskovitz-Eldor J. 2004. Three-dimensional porous alginate scaffolds provide a conducive environment for generation of well-vascularized embryoid bodies from human embryonic stem cells. Biotechnol Bioeng 88(3): 313-320.
17. Godoy-Silva R, Chalmers JJ, Casnocha SA, Bass LA, Ma NN. 2009. Physiological responses of CHO cells to repetitive hydrodynamic stress. Biotechnol Bioeng 103(6): 1103-1117.
18. Hardikar AA, Risbud MV, Bhonde RR. 2000. Improved post-cryopreservation recovery following encapsulation of islets in chitosan-alginate microcapsules. Transplant Proc 32(4): 824-825.
19. Hauge-Evans AC, Squires PE, Persaud SJ, Jones PM. 1999. Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli-Enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48(7): 1402-1408.
20. Hirshberg B. 2007. Lessons learned from the international trial of the Edmonton protocol for islet transplantation. Curr Diab Rep 7(4): 301-303.
21. Hoesli CA, Luu M, Piret JM. 2009. A novel alginate hollow fiber bioreactor process for cellular therapy applications. Biotechnol Prog 25(6): 1740-1751.
22. Huang KS, Lai TH, Lin YC. 2007. Using a microfluidic chip and internal gelation reaction for monodisperse calcium alginate microparticles generation. Front Biosci 12: 3061-3067.
23. Jain R, Lammert E. 2009. Cell-cell interactions in the endocrine pancreas. Diabetes Obes Metabol 11: 159-167.
24. Kaddis JS, Danobeitia JS, Niland JC, Stiller T, Fernandez LA. 2010. Multicenter analysis of novel and established variables associated with successful human islet isolation outcomes. Am J Transplant 10(3): 646-656.
25. Koch S, Schwinger C, Kressler J, Heinzen C, Rainov NG. 2003. Alginate encapsulation of genetically engineered mammalian cells: Comparison of production devices, methods and microcapsule characteristics. J Microencapsul 20(3): 303-316.
26. Lacík I. 2006. Polymer chemistry in diabetes treatment by encapsulated islets of Langerhans: Review to 2006. Austr J Chem 59(8): 508-524.
27. Larisch BC, Poncelet D, Champagne CP, Neufeld RJ. 1994. Microencapsulation of Lactococcus lactis Subsp cremoris. J Microencapsul 11(2): 189-195.
28. Lee JS, Kim EJ, Chung D, Lee HG. 2009. Characteristics and antioxidant activity of catechin-loaded calcium pectinate gel beads prepared by internal gelation. Colloids Surf B Biointerfaces 74(1): 17-22.
29. Lim F, Sun AM. 1980. Microencapsulated islets as bioartificial endocrine pancreas. Science 210(4472): 908-910.
30. Liu Q, Rauth AM, Wu XY. 2007. Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsification-internal gelation-adsorption-polyelectrolyte coating method. Int J Pharm 339(1-2): 148-156.
31. Living Cell Technologies. 2010. Open-label investigation of the safety and effectiveness of DIABECELL(R) in patients with type I diabetes mellitus. ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: NLM Identifier: NCT00940173.
32. Luther MJ, Hauge-Evans A, Souza KLA, Jorns A, Lenzen S, Persaud SJ, Jones PM. 2006. MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Commun 343(1): 99-104.
33. Ma HL, Hung SC, Lin SY, Chen YL, Lo WH. 2003. Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. J Biomed Mater Res A 64(2): 273-281.
34. Maguire T, Novik E, Schloss R, Yarmush M. 2006. Alginate-PLL microencapsulation: Effect on the differentiation of embryonic stem cells into hepatocytes. Biotechnol Bioeng 93(3): 581-591.
35. Magyar JP, Nemir M, Ehler E, Suter N, Perriard JC, Eppenberger HM. 2001. Mass production of embryoid bodies in microbeads. Bioartif Organs III 944: 135-143.
36. Mahler S, Desille M, Fremond B, Chesne C, Guillouzo A, Campion JP, Clement B. 2003. Hypothermic storage and cryopreservation of hepatocytes: The protective effect of alginate gel against cell damages. Cell Transplant 12(6): 579-592.
37. Malpique R, Osorio LM, Ferreira DS, Ehrhart F, Brito C, Zimmermann H, Alves PM. 2009. Alginate encapsulation as a novel strategy for the cryopreservation of neurospheres. Tissue Eng Part C Methods 16(5): 965-977.
38. Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S. 2005. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 102(42): 15116-15121.
39. Morris ER, Rees DA, Thom D, Boyd J. 1978. Chiroptical and stoichiometric evidence of a specific, primary dimerization process in alginate gelation. Carbohydr Res 66: 145-154.
40. Murua A, Orive G, Hernandez RM, Pedraz JL. 2009. Cryopreservation based on freezing protocols for the long-term storage of microencapsulated myoblasts. Biomaterials 30(20): 3495-3501.
41. Pacek AW, Chamsart S, Nienow AW, Bakker A. 1999. The influence of impeller type on mean drop size and drop size distribution in an agitated vessel. Chem Eng Sci 54(19): 4211-4222.
42. Poncelet D, Lencki R, Beaulieu C, Halle JP, Neufeld RJ, Fournier A. 1992. Production of alginate beads by emulsification/internal gelation. I. Methodology. Appl Microbiol Biotechnol 38(1): 39-45.
43. Quong D, Neufeld RJ, Skjak-Braek G, Poncelet D. 1998. External versus internal source of calcium during the gelation of alginate beads for DNA encapsulation. Biotechnol Bioeng 57(4): 438-446.
44. Reis CP, Ribeiro AJ, Neufeld RJ, Veiga F. 2007. Alginate microparticles as novel carrier for oral insulin delivery. Biotechnol Bioeng 96(5): 977-989.
45. Rialland L, Guyomard C, Scotte M, Chesne C, Guillouzo A. 2000. Viability and drug metabolism capacity of alginate-entrapped hepatocytes after cryopreservation. Cell Biol Toxicol 16(2): 105-116.
46. Ricordi C. 2003. Islet transplantation: A brave new world. Diabetes 52(7): 1595-1603.
47. Schwinger C, Koch S, Jahnz U, Wittlich P, Rainov NG, Kressler J. 2002. High throughput encapsulation of murine fibroblasts in alginate using the JetCutter technology. J Microencapsul 19(3): 273-280.
48. Seeberger KL, Dufour JM, Shapiro AM, Lakey JR, Rajotte RV, Korbutt GS. 2006. Expansion of mesenchymal stem cells from human pancreatic ductal epithelium. Lab Invest 86(2): 141-153.
49. Serp D, Cantana E, Heinzen C, von Stockar U, Marison IW. 2000. Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization. Biotechnol Bioeng 70(1): 41-53.
50. Shenkman RM, Godoy-Silva R, Papas KK, Chalmers JJ. 2009. Effects of energy dissipation rate on islets of Langerhans: Implications for isolation and transplantation. Biotechnol Bioeng 103(2): 413-423.
51. Silva CM, Ribeiro AJ, Figueiredo IV, Goncalves AR, Veiga F. 2006. Alginate microspheres prepared by internal gelation: Development and effect on insulin stability. Int J Pharm 311(1-2): 1-10.
52. 2-guluronic acid interaction on alginate encapsulated betaTC3 cells. Biomaterials 25(13): 2603-2610.
53. Stabler C, Wilks K, Sambanis A, Constantinidis I. 2001. The effects of alginate composition on encapsulated betaTC3 cells. Biomaterials 22(11): 1301-1310.
54. Sugiura S, Oda T, Izumida Y, Aoyagi Y, Satake M, Ochiai A, Ohkohchi N, Nakajima M. 2005. Size control of calcium alginate beads containing living cells using micro-nozzle array. Biomaterials 26(16): 3327-3331.
55. Tatarkiewicz K, Garcia M, Lopez-Avalos M, Bonner-Weir S, Weir GC. 2001. Porcine neonatal pancreatic cell clusters in tissue culture: Benefits of serum and immobilization in alginate hydrogel. Transplantation 71(11): 1518-1526.
56. Thanos CG, Calafiore R, Basta G, Bintz BE, Bell WJ, Hudak J, Vasconcellos A, Schneider P, Skinner SJ, Geaney M, et al. 2007. Formulating the alginate-polyornithine biocapsule for prolonged stability: Evaluation of composition and manufacturing technique. J Biomed Mater Res A 83(1): 216-224.
57. Thu B, SkjakBraek G, Micali F, Vittur F, Rizzo R. 1997. The spatial distribution of calcium in alginate gel beads analysed by synchrotron-radiation induced X-ray emission (SRIXE). Carbohydr Res 297(2): 101-105.
58. Todorov I, Omori K, Pascual M, Rawson J, Nair I, Valiente L, Vuong T, Matsuda T, Orr C, Ferreri K, et al. 2006. Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 32(2): 130-138.
59. Tsang WG, Zheng T, Wang Y, Tang J, Rind HB, Francki A, Bufius N. 2007. Generation of functional islet-like clusters after monolayer culture and intracapsular aggregation of adult human pancreatic islet tissue. Transplantation 83(6): 685-693.
60. Tuch BE, Keogh GW, Williams LJ, Wu W, Foster JL, Vaithilingam V, Philips R. 2009. Safety and viability of microencapsulated human islets transplanted into diabetic humans. Diabetes Care 32(10): 1887-1889.
61. Tziampazis E, Sambanis A. 1995. Tissue engineering of a bioartificial pancreas-Modeling the cell environment and device function. Biotechnol Progr 11(2): 115-126.
62. Venkat RV, Stock LR, Chalmers JJ. 1996. Study of hydrodynamics in microcarrier culture spinner vessels: A particle tracking velocimetry approach. Biotechnol Bioeng 49(4): 456-466.
63. Wang N, Adams G, Buttery L, Falcone FH, Stolnik S. 2009. Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells. J Biotechnol 144(4): 304-312.
64. Wernersson ES, Tragardh C. 1999. Scale-up of Rushton turbine-agitated tanks. Chem Eng Sci 54(19): 4245-4256.
65. Xu XB, D'Hoker J, Stange G, Bonne S, De Leu N, Xiao XW, De Casteele MV, Mellitzer G, Ling ZD, Pipeleers D, et al. 2008. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132(2): 197-207.
66. Yang J, Goto M, Ise H, Cho CS, Akaike T. 2002. Galactosylated alginate as a scaffold for hepatocytes entrapment. Biomaterials 23(2): 471-479.