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Volumn 9, Issue SUPPL. 2, 2007, Pages 118-132

Islet-cell-to-cell communication as basis for normal insulin secretion

Author keywords

Beta cell; Cell coupling; Connnexins; Cx36; Gap junctions; Insulin secretion; Oscillations

Indexed keywords

CONNEXIN 36; GAP JUNCTION PROTEIN; INSULIN; ION CHANNEL; SULFONYLUREA;

EID: 35148845161     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2007.00780.x     Document Type: Conference Paper
Times cited : (97)

References (71)
  • 1
    • 12244307289 scopus 로고    scopus 로고
    • Communication of islet cells: Molecules, mechanisms, functions
    • In: Habener JF, Hussein M eds. Norwell: Kluwer Academic Publishers
    • Meda P, Bosco D. Communication of islet cells: Molecules, mechanisms, functions. In: Habener JF, Hussein M eds. Molecular Basis of Endocrine Pancreas Development and Functions. Norwell: Kluwer Academic Publishers, 2001; 138-159.
    • (2001) Molecular Basis of Endocrine Pancreas Development and Functions , pp. 138-159
    • Meda, P.1    Bosco, D.2
  • 2
    • 0036174965 scopus 로고    scopus 로고
    • Cellular function in multicellular system for hormone-secretion: Electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet
    • Kanno T, Gopel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: Electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet. Neurosci Res 2002; 42: 79-90.
    • (2002) Neurosci Res , vol.42 , pp. 79-90
    • Kanno, T.1    Gopel, S.O.2    Rorsman, P.3    Wakui, M.4
  • 3
    • 28944433950 scopus 로고    scopus 로고
    • Involvement of gap junctional communication in secretion
    • Michon L, Nlend Nlend R, Bavamian S et al. Involvement of gap junctional communication in secretion. Biochim Biophys Acta 2005; 1719: 82-101.
    • (2005) Biochim Biophys Acta , vol.1719 , pp. 82-101
    • Michon, L.1    Nlend Nlend, R.2    Bavamian, S.3
  • 4
    • 35148896626 scopus 로고    scopus 로고
    • The connexins, part I
    • Hervé JC, ed
    • Hervé JC, ed. The connexins, part I. Biochim Biophys Acta 2004; 1662: 1-172.
    • (2004) Biochim Biophys Acta , vol.1662 , pp. 1-172
  • 5
    • 33748635472 scopus 로고    scopus 로고
    • The connexins, part II
    • HervéJC, ed
    • HervéJC, ed. The connexins, part II. Biochim Biophys Acta 2005; 1711: 97-246.
    • (2005) Biochim Biophys Acta , vol.1711 , pp. 97-246
  • 7
    • 33750300467 scopus 로고    scopus 로고
    • Functional connexin "hemichannels": A critical appraisal
    • Spray DC, Ye ZC, Ransom BR. Functional connexin "hemichannels": A critical appraisal. Glia 2006; 54: 758-773.
    • (2006) Glia , vol.54 , pp. 758-773
    • Spray, D.C.1    Ye, Z.C.2    Ransom, B.R.3
  • 8
    • 33845195427 scopus 로고    scopus 로고
    • Connexin43 and the brain transcriptome of newborn mice
    • Iacobas DA, Iacobas S, Spray DC. Connexin43 and the brain transcriptome of newborn mice. Genomics 2007; 89: 113-123.
    • (2007) Genomics , vol.89 , pp. 113-123
    • Iacobas, D.A.1    Iacobas, S.2    Spray, D.C.3
  • 9
    • 12944263962 scopus 로고    scopus 로고
    • Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland
    • Li X, Olson C, Lu S, Nagy J. Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland. Histochem Cell Biol 2004; 122: 485-498.
    • (2004) Histochem Cell Biol , vol.122 , pp. 485-498
    • Li, X.1    Olson, C.2    Lu, S.3    Nagy, J.4
  • 10
    • 0034115365 scopus 로고    scopus 로고
    • Cx36 preferentially connects beta-cells within pancreatic islets
    • Serre-Beinier V, Le Gurun S, Belluardo N et al. Cx36 preferentially connects beta-cells within pancreatic islets. Diabetes 2000; 49: 727-734.
    • (2000) Diabetes , vol.49 , pp. 727-734
    • Serre-Beinier, V.1    Le Gurun, S.2    Belluardo, N.3
  • 11
    • 10744227426 scopus 로고    scopus 로고
    • Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets
    • Theis M, Mas C, Doring B et al. Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets. Exp Cell Res 2004; 294: 18-29.
    • (2004) Exp Cell Res , vol.294 , pp. 18-29
    • Theis, M.1    Mas, C.2    Doring, B.3
  • 13
    • 34047149839 scopus 로고    scopus 로고
    • Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics
    • Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M. Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes 2007; 56: 1078-1086.
    • (2007) Diabetes , vol.56 , pp. 1078-1086
    • Speier, S.1    Gjinovci, A.2    Charollais, A.3    Meda, P.4    Rupnik, M.5
  • 14
    • 0019445129 scopus 로고
    • Metabolic coupling between cultured pancreatic β-cells
    • Meda P, Amherdt M, Perrelet A, Orci L. Metabolic coupling between cultured pancreatic β-cells. Exp Cell Res 1981; 133: 421-430.
    • (1981) Exp Cell Res , vol.133 , pp. 421-430
    • Meda, P.1    Amherdt, M.2    Perrelet, A.3    Orci, L.4
  • 15
    • 0020513139 scopus 로고
    • In vivo modulation of gap junctions and dye coupling between B-cells of the intact pancreatic islet
    • Meda P, Michaels RL, Halban PA, Orci L, Sheridan JD. In vivo modulation of gap junctions and dye coupling between B-cells of the intact pancreatic islet. Diabetes 1983; 32: 858-868.
    • (1983) Diabetes , vol.32 , pp. 858-868
    • Meda, P.1    Michaels, R.L.2    Halban, P.A.3    Orci, L.4    Sheridan, J.D.5
  • 16
    • 34848866666 scopus 로고    scopus 로고
    • β-cells preferentially exchange cations via Cx36 gap junction channels
    • Charpantier E, Cancela J, Meda P. β-cells preferentially exchange cations via Cx36 gap junction channels, Diabetologia 2007; 50:
    • (2007) Diabetologia , vol.50
    • Charpantier, E.1    Cancela, J.2    Meda, P.3
  • 18
    • 0016746044 scopus 로고
    • A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas
    • Orci L, Malaisse-Lagae F, Ravazzola M et al. A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas. J Clin Invest 1975; 56: 1066-1070.
    • (1975) J Clin Invest , vol.56 , pp. 1066-1070
    • Orci, L.1    Malaisse-Lagae, F.2    Ravazzola, M.3
  • 19
    • 0036311276 scopus 로고    scopus 로고
    • Pulsatile insulin secretion: Detection, regulation, and role in diabetes
    • Porksen N, Hollingdal M, Juhl C, Butler P, Veldhuis JD, Schmitz O. Pulsatile insulin secretion: Detection, regulation, and role in diabetes. Diabetes 2002; 51 (Suppl. 1): S245-S254.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Porksen, N.1    Hollingdal, M.2    Juhl, C.3    Butler, P.4    Veldhuis, J.D.5    Schmitz, O.6
  • 20
    • 0017123493 scopus 로고
    • Electrophysiological evidence for coupling between beta cells of pancreatic islets
    • Meissner HP. Electrophysiological evidence for coupling between beta cells of pancreatic islets. Nature 1976; 262: 502-504.
    • (1976) Nature , vol.262 , pp. 502-504
    • Meissner, H.P.1
  • 21
    • 0036314998 scopus 로고    scopus 로고
    • Control mechanisms of the oscillations of insulin secretion in vitro and in vivo
    • Gilon P, Ravier MA, Jonas JC, Henquin JC. Control mechanisms of the oscillations of insulin secretion in vitro and in vivo. Diabetes 2002; 51 (Suppl. 1): S144-S151.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Gilon, P.1    Ravier, M.A.2    Jonas, J.C.3    Henquin, J.C.4
  • 23
    • 0036578921 scopus 로고    scopus 로고
    • Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
    • Kulkarni RN, Holzenberger M, Shih DQ et al. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 2002; 31: 111-115.
    • (2002) Nat Genet , vol.31 , pp. 111-115
    • Kulkarni, R.N.1    Holzenberger, M.2    Shih, D.Q.3
  • 24
    • 34147163066 scopus 로고    scopus 로고
    • EphA-ephrin-A mediated beta cell communication regulates insulin secretion from pancreatic islets
    • Konstantinova I, Nikolova G, Ohara-Imaizumi M et al. EphA-ephrin-A mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 2007; 129: 359-370.
    • (2007) Cell , vol.129 , pp. 359-370
    • Konstantinova, I.1    Nikolova, G.2    Ohara-Imaizumi, M.3
  • 25
    • 33847250987 scopus 로고    scopus 로고
    • The Fas pathway is involved in pancreatic beta cell secretory function
    • Schumann DM, Maedler K, Franklin I et al. The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A 2007; 104: 2861-2866.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2861-2866
    • Schumann, D.M.1    Maedler, K.2    Franklin, I.3
  • 26
    • 0022572975 scopus 로고
    • Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells
    • Salomon D, Meda P. Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp Cell Res 1986; 162: 507-520.
    • (1986) Exp Cell Res , vol.162 , pp. 507-520
    • Salomon, D.1    Meda, P.2
  • 27
    • 0024430064 scopus 로고
    • Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells
    • Bosco D, Orci L, Meda P. Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells. Exp Cell Res 1989; 184: 72-80.
    • (1989) Exp Cell Res , vol.184 , pp. 72-80
    • Bosco, D.1    Orci, L.2    Meda, P.3
  • 28
    • 0036091921 scopus 로고    scopus 로고
    • Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes
    • Yamagata K, Nammo T, Moriwaki M et al. Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes. Diabetes 2002; 51: 114-123.
    • (2002) Diabetes , vol.51 , pp. 114-123
    • Yamagata, K.1    Nammo, T.2    Moriwaki, M.3
  • 29
    • 1542269065 scopus 로고    scopus 로고
    • Differentiating the effects of Cx36 and E-cadherin for proper insulin secretion of MIN6 cells
    • Calabrese A, Caton D, Meda P. Differentiating the effects of Cx36 and E-cadherin for proper insulin secretion of MIN6 cells. Exp Cell Res 2004; 294: 379-391.
    • (2004) Exp Cell Res , vol.294 , pp. 379-391
    • Calabrese, A.1    Caton, D.2    Meda, P.3
  • 31
    • 0038010435 scopus 로고    scopus 로고
    • Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells
    • Caton D, Calabrese A, Mas C et al. Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells. J Cell Sci 2003; 116: 2285-2294.
    • (2003) J Cell Sci , vol.116 , pp. 2285-2294
    • Caton, D.1    Calabrese, A.2    Mas, C.3
  • 32
    • 0141844506 scopus 로고    scopus 로고
    • Connexin-36 contributes to control function of insulin-producing cells
    • Le Gurun S, Martin D, Formenton A et al. Connexin-36 contributes to control function of insulin-producing cells. J Biol Chem 2003; 278: 37690-37697.
    • (2003) J Biol Chem , vol.278 , pp. 37690-37697
    • Le Gurun, S.1    Martin, D.2    Formenton, A.3
  • 33
    • 0035704411 scopus 로고    scopus 로고
    • Emerging issues of connexin channels: Biophysics fills the gap
    • Harris AL. Emerging issues of connexin channels: Biophysics fills the gap. Q Rev Biophys 2001; 34: 325-472.
    • (2001) Q Rev Biophys , vol.34 , pp. 325-472
    • Harris, A.L.1
  • 34
    • 0037715161 scopus 로고    scopus 로고
    • Connexin gene pathology
    • Richard G. Connexin gene pathology. Clin Exp Dermatol 2003; 28: 397-409.
    • (2003) Clin Exp Dermatol , vol.28 , pp. 397-409
    • Richard, G.1
  • 35
    • 0015805119 scopus 로고
    • Structural coupling between pancreatic islet cells
    • Orci L, Unger RH, Renold AE. Structural coupling between pancreatic islet cells. Experientia 1973; 29: 1015-1018.
    • (1973) Experientia , vol.29 , pp. 1015-1018
    • Orci, L.1    Unger, R.H.2    Renold, A.E.3
  • 36
    • 0019308988 scopus 로고
    • Gap junction development is correlated with insulin content in the pancreatic B cell
    • Meda P, Halban P, Perrelet A, Renold AE, Orci L. Gap junction development is correlated with insulin content in the pancreatic B cell. Science 1980; 209: 1026-1028.
    • (1980) Science , vol.209 , pp. 1026-1028
    • Meda, P.1    Halban, P.2    Perrelet, A.3    Renold, A.E.4    Orci, L.5
  • 37
    • 0031926704 scopus 로고    scopus 로고
    • Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons
    • Condorelli DF, Parenti R, Spinella F et al. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci 1998; 10: 1202-1208.
    • (1998) Eur J Neurosci , vol.10 , pp. 1202-1208
    • Condorelli, D.F.1    Parenti, R.2    Spinella, F.3
  • 38
    • 33845961237 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between AII amacrine cells
    • Urschel S, Hoher T, Schubert T et al. Protein kinase A-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between AII amacrine cells. J Biol Chem 2006; 281: 33163-33171.
    • (2006) J Biol Chem , vol.281 , pp. 33163-33171
    • Urschel, S.1    Hoher, T.2    Schubert, T.3
  • 39
    • 0035882492 scopus 로고    scopus 로고
    • Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36
    • Guldenagel M, Ammermuller J, Feigenspan A et al. Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36. J Neurosci 2001; 21: 6036-6044.
    • (2001) J Neurosci , vol.21 , pp. 6036-6044
    • Guldenagel, M.1    Ammermuller, J.2    Feigenspan, A.3
  • 40
    • 0018770495 scopus 로고
    • Intercellular communication in pancreatic islet monolayer cultures: A microfluorometric study
    • Kohen E, Kohen C, Thorell B, Mintz DH, Rabinovitch A. Intercellular communication in pancreatic islet monolayer cultures: A microfluorometric study. Science 1979; 204: 862-865.
    • (1979) Science , vol.204 , pp. 862-865
    • Kohen, E.1    Kohen, C.2    Thorell, B.3    Mintz, D.H.4    Rabinovitch, A.5
  • 41
    • 18844480439 scopus 로고    scopus 로고
    • Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance
    • Charollais A, Gjinovci A, Huarte J et al. Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest 2000; 106: 235-243.
    • (2000) J Clin Invest , vol.106 , pp. 235-243
    • Charollais, A.1    Gjinovci, A.2    Huarte, J.3
  • 42
    • 0029101240 scopus 로고
    • Magnitude and modulation of pancreatic beta-cell gap junction electrical conductance in situ
    • Mears D, Sheppard NF, Atwater I, Rojas E. Magnitude and modulation of pancreatic beta-cell gap junction electrical conductance in situ. J Membr Biol 1995; 146: 163-176.
    • (1995) J Membr Biol , vol.146 , pp. 163-176
    • Mears, D.1    Sheppard, N.F.2    Atwater, I.3    Rojas, E.4
  • 43
    • 0347362782 scopus 로고    scopus 로고
    • Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
    • Martin D, Tawadros T, Meylan L et al. Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. J Biol Chem 2003; 278: 53082-53089.
    • (2003) J Biol Chem , vol.278 , pp. 53082-53089
    • Martin, D.1    Tawadros, T.2    Meylan, L.3
  • 44
    • 0037403708 scopus 로고    scopus 로고
    • On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells
    • Quesada I, Fuentes E, Andreu E, Meda P, Nadal A, Soria B. On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells. Am J Physiol Endocrinol Metab 2003; 284: E980-E987.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Quesada, I.1    Fuentes, E.2    Andreu, E.3    Meda, P.4    Nadal, A.5    Soria, B.6
  • 45
    • 0027055095 scopus 로고
    • Cyclic adenosine monophosphate prevents the glucocorticoid-mediated inhibition of insulin gene expression in rodent islet cells
    • Philippe J, Giordano E, Gjinovci A, Meda P. Cyclic adenosine monophosphate prevents the glucocorticoid-mediated inhibition of insulin gene expression in rodent islet cells. J Clin Invest 1992; 90: 2228-2233.
    • (1992) J Clin Invest , vol.90 , pp. 2228-2233
    • Philippe, J.1    Giordano, E.2    Gjinovci, A.3    Meda, P.4
  • 46
    • 0025149615 scopus 로고
    • Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells
    • Meda P, Bosco D, Chanson M et al. Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells. J Clin Invest 1990; 86: 759-768.
    • (1990) J Clin Invest , vol.86 , pp. 759-768
    • Meda, P.1    Bosco, D.2    Chanson, M.3
  • 47
    • 0025718832 scopus 로고
    • Actively synthesizing beta-cells secrete preferentially after glucose stimulation
    • Bosco D, Meda P. Actively synthesizing beta-cells secrete preferentially after glucose stimulation. Endocrinology 1991; 129: 3157-3166.
    • (1991) Endocrinology , vol.129 , pp. 3157-3166
    • Bosco, D.1    Meda, P.2
  • 48
    • 0001245306 scopus 로고    scopus 로고
    • Reconstructing islet function in vitro
    • Bosco D, Meda P. Reconstructing islet function in vitro. Adv Exp Med Biol 1998; 426: 285-298.
    • (1998) Adv Exp Med Biol , vol.426 , pp. 285-298
    • Bosco, D.1    Meda, P.2
  • 49
    • 0034745951 scopus 로고    scopus 로고
    • Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response
    • Jonkers FC, Henquin JC. Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response. Diabetes 2001; 50: 540-550.
    • (2001) Diabetes , vol.50 , pp. 540-550
    • Jonkers, F.C.1    Henquin, J.C.2
  • 50
    • 3042736858 scopus 로고    scopus 로고
    • Three roads to islet bursting: Emergent oscillations in coupled phantom bursters
    • Zimliki CL, Mears D, Sherman A. Three roads to islet bursting: Emergent oscillations in coupled phantom bursters. Biophys J 2004; 87: 193-206.
    • (2004) Biophys J , vol.87 , pp. 193-206
    • Zimliki, C.L.1    Mears, D.2    Sherman, A.3
  • 51
    • 0023680541 scopus 로고    scopus 로고
    • The gap junction: A channel for multiple functions?
    • Bruzzone R, Meda P. The gap junction: A channel for multiple functions? Eur J Clin Invest 1998; 18: 444-453.
    • (1998) Eur J Clin Invest , vol.18 , pp. 444-453
    • Bruzzone, R.1    Meda, P.2
  • 52
    • 0029588550 scopus 로고
    • Adequate connexin-mediated coupling is required for proper insulin production
    • Vozzi C, Ullrich S, Charollais A, Philippe J, Orci L, Meda P. Adequate connexin-mediated coupling is required for proper insulin production. J Cell Biol 1995; 131: 1561-1572.
    • (1995) J Cell Biol , vol.131 , pp. 1561-1572
    • Vozzi, C.1    Ullrich, S.2    Charollais, A.3    Philippe, J.4    Orci, L.5    Meda, P.6
  • 53
    • 0023227779 scopus 로고
    • Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo
    • Stefan Y, Meda P, Neufeld M, Orci L. Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo. J Clin Invest 1987; 80: 175-183.
    • (1987) J Clin Invest , vol.80 , pp. 175-183
    • Stefan, Y.1    Meda, P.2    Neufeld, M.3    Orci, L.4
  • 54
    • 0025941903 scopus 로고
    • Repeated glucose stimulation reveals distinct and lasting secretion patterns of individual rat pancreatic B cells
    • Giordano E, Bosco D, Cirulli V, Meda P. Repeated glucose stimulation reveals distinct and lasting secretion patterns of individual rat pancreatic B cells. J Clin Invest 1991; 87: 2178-2185.
    • (1991) J Clin Invest , vol.87 , pp. 2178-2185
    • Giordano, E.1    Bosco, D.2    Cirulli, V.3    Meda, P.4
  • 55
    • 0025764452 scopus 로고
    • Ion channels of glucose-responsive and -unresponsive beta-cells
    • Soria B, Chanson M, Giordano E, Bosco D, Meda P. Ion channels of glucose-responsive and -unresponsive beta-cells. Diabetes 1991; 40: 1069-1078.
    • (1991) Diabetes , vol.40 , pp. 1069-1078
    • Soria, B.1    Chanson, M.2    Giordano, E.3    Bosco, D.4    Meda, P.5
  • 56
    • 33244458017 scopus 로고    scopus 로고
    • Critical role of gap junction coupled k(atp) channel activity for regulated insulin secretion
    • Rocheleau JV, Remedi MS, Granada B et al. critical role of gap junction coupled k(atp) channel activity for regulated insulin secretion. PLoS Biol 2006; 4: E26.
    • (2006) PLoS Biol , vol.4
    • Rocheleau, J.V.1    Remedi, M.S.2    Granada, B.3
  • 57
    • 0023951171 scopus 로고
    • Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
    • O'Rahilly S, Turner RC, Matthews DR. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 1988; 318: 1225-1230.
    • (1988) N Engl J Med , vol.318 , pp. 1225-1230
    • O'Rahilly, S.1    Turner, R.C.2    Matthews, D.R.3
  • 58
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006; 116: 1802-1812.
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 59
    • 0024216145 scopus 로고
    • Islet dysfunction in non-insulin-dependent diabetes mellitus
    • Kahn SE, Porte D. Islet dysfunction in non-insulin-dependent diabetes mellitus. Am J Med 1988; 85: 4-8.
    • (1988) Am J Med , vol.85 , pp. 4-8
    • Kahn, S.E.1    Porte, D.2
  • 61
    • 0032928542 scopus 로고    scopus 로고
    • Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
    • Cox NJ, Frigge M, Nicolae DL et al. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet 1999; 21: 213-215.
    • (1999) Nat Genet , vol.21 , pp. 213-215
    • Cox, N.J.1    Frigge, M.2    Nicolae, D.L.3
  • 62
    • 0036230486 scopus 로고    scopus 로고
    • Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p
    • Mori Y, Otabe S, Dina C et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. Diabetes 2002; 51: 1247-1255.
    • (2002) Diabetes , vol.51 , pp. 1247-1255
    • Mori, Y.1    Otabe, S.2    Dina, C.3
  • 63
    • 14844307755 scopus 로고    scopus 로고
    • Association of the connexin36 gene (cx36) with juvenile myoclonic epilepsy
    • Mas C, Taske N, Deutsch S et al. Association of the connexin36 gene (cx36) with juvenile myoclonic epilepsy. J Med Genet 2004; 41: E93-e98.
    • (2004) J Med Genet , vol.41
    • Mas, C.1    Taske, N.2    Deutsch, S.3
  • 65
    • 0018643341 scopus 로고
    • Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion
    • Meda P, Perrelet A, Orci L. Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion. J Cell Biol 1979; 82: 441-448.
    • (1979) J Cell Biol , vol.82 , pp. 441-448
    • Meda, P.1    Perrelet, A.2    Orci, L.3
  • 66
    • 0035856952 scopus 로고    scopus 로고
    • Beta-cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C. Beta-cell death during progression to diabetes. Nature 2001; 414: 792-798.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 67
    • 32444447355 scopus 로고    scopus 로고
    • Connexin43-dependent mechanism modulates renin secretion and hypertension
    • Haefliger JA, Krattinger N, Martin D et al. Connexin43-dependent mechanism modulates renin secretion and hypertension. J Clin Invest 2006; 116: 405-413.
    • (2006) J Clin Invest , vol.116 , pp. 405-413
    • Haefliger, J.A.1    Krattinger, N.2    Martin, D.3
  • 68
    • 84878650095 scopus 로고    scopus 로고
    • Loss of Connexin40 alters renin production, causing hypertension
    • Krattinger N, Capponi A, Mazzolai L et al. Loss of Connexin40 alters renin production, causing hypertension. Kidney Int 2007; 2007:
    • (2007) Kidney Int , vol.2007
    • Krattinger, N.1    Capponi, A.2    Mazzolai, L.3
  • 69
    • 34547547315 scopus 로고    scopus 로고
    • Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis
    • Cohen-Salmon M, Regnault B, Cayet N et al. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A 2007; 104: 6229-6234.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6229-6234
    • Cohen-Salmon, M.1    Regnault, B.2    Cayet, N.3
  • 70
    • 7044221820 scopus 로고    scopus 로고
    • Microvascular development: Learning from pancreatic islets
    • Konstantinova I, Lammert E. Microvascular development: Learning from pancreatic islets. Bioessays 2004; 26: 1069-1075.
    • (2004) Bioessays , vol.26 , pp. 1069-1075
    • Konstantinova, I.1    Lammert, E.2
  • 71
    • 0030589479 scopus 로고    scopus 로고
    • Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro
    • Oyamada Y, Komatsu K, Kimura H, Mori M, Oyamada M. Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp Cell Res 1996; 229: 318-326.
    • (1996) Exp Cell Res , vol.229 , pp. 318-326
    • Oyamada, Y.1    Komatsu, K.2    Kimura, H.3    Mori, M.4    Oyamada, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.