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Volumn 116, Issue 1, 2011, Pages 82-92

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine

Author keywords

aging; Alzheimer's; amyloid; cholesterol; homocysteine; methionine

Indexed keywords

ABC TRANSPORTER A1; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; CHOLESTEROL; FOLIC ACID; HOMOCYSTEINE; METHIONINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; TAU PROTEIN; VITAMIN B GROUP;

EID: 78650168134     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07087.x     Document Type: Article
Times cited : (21)

References (49)
  • 2
    • 34249291912 scopus 로고    scopus 로고
    • Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet
    • Bernardo A., McCord M., Troen A. M., Allison J. D., and, McDonald M. P., (2007) Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet. Neurobiol. Aging 28, 1195-1205.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1195-1205
    • Bernardo, A.1    McCord, M.2    Troen, A.M.3    Allison, J.D.4    McDonald, M.P.5
  • 3
    • 40049100343 scopus 로고    scopus 로고
    • Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: Alleviation by S-adenosyl methionine
    • Chan A. Y., Alsaraby A., and, Shea T. B., (2008) Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: alleviation by S-adenosyl methionine. Brain Res. 1199, 133-137.
    • (2008) Brain Res. , vol.1199 , pp. 133-137
    • Chan, A.Y.1    Alsaraby, A.2    Shea, T.B.3
  • 4
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • Clarke R., Smith A. D., Jobst K. A., Refsum H., Sutton L., and, Ueland P. M., (1998) Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55, 1449-1455.
    • (1998) Arch. Neurol. , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 5
    • 3543104951 scopus 로고    scopus 로고
    • Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • Dietschy J. M., and, Turley S. D., (2004) Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397.
    • (2004) J. Lipid Res. , vol.45 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 6
    • 33846211794 scopus 로고    scopus 로고
    • Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial
    • Durga J., Van Boxtel M. P., Schouten E. G., Kok F. J., Jolles J., Katan M. B., and, Verhoef P., (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 369, 208-216.
    • (2007) Lancet , vol.369 , pp. 208-216
    • Durga, J.1    Van Boxtel, M.P.2    Schouten, E.G.3    Kok, F.J.4    Jolles, J.5    Katan, M.B.6    Verhoef, P.7
  • 7
    • 0026611283 scopus 로고
    • Incorporation of 3H-label from folic acid is tissue-dependent in folate-deficient rats
    • Eisenga B. H., Collins T. D., and, McMartin K. E., (1992) Incorporation of 3H-label from folic acid is tissue-dependent in folate-deficient rats. J. Nutr. 122, 977-985.
    • (1992) J. Nutr. , vol.122 , pp. 977-985
    • Eisenga, B.H.1    Collins, T.D.2    McMartin, K.E.3
  • 8
    • 0017285334 scopus 로고
    • Reduction of folate levels in the rat: Difference in depletion between the central and the peripheral nervous system
    • Fehling C., Jagerstad M., Lindstrand K., and, Elmquist D., (1976) Reduction of folate levels in the rat: difference in depletion between the central and the peripheral nervous system. Z. Ernahrungswiss. 15, 1-8.
    • (1976) Z. Ernahrungswiss. , vol.15 , pp. 1-8
    • Fehling, C.1    Jagerstad, M.2    Lindstrand, K.3    Elmquist, D.4
  • 9
    • 0031748093 scopus 로고    scopus 로고
    • The metabolism of homocysteine: Pathways and regulation
    • Finkelstein J. D., (1998) The metabolism of homocysteine: pathways and regulation. Eur. J. Pediatr. 157, S40-44.
    • (1998) Eur. J. Pediatr. , vol.157
    • Finkelstein, J.D.1
  • 10
    • 41249098662 scopus 로고    scopus 로고
    • B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    • Fuso A., Nicolia V., Cavallaro R. A., Ricceri L., D'Anselmi F., Coluccia P., Calamandrei G., and, Scarpa S., (2008) B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol. Cell. Neurosci. 37, 731-746.
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 731-746
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3    Ricceri, L.4    D'Anselmi, F.5    Coluccia, P.6    Calamandrei, G.7    Scarpa, S.8
  • 11
    • 33746299216 scopus 로고    scopus 로고
    • High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus
    • Ghribi O., Larsen B., Schrag M., and, Herman M. M., (2006) High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp. Neurol. 200, 460-467.
    • (2006) Exp. Neurol. , vol.200 , pp. 460-467
    • Ghribi, O.1    Larsen, B.2    Schrag, M.3    Herman, M.M.4
  • 12
    • 0041833480 scopus 로고    scopus 로고
    • Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine
    • Ho P. I., Ashline D., Dhitavat S., Ortiz D., Collins S. C., Shea T. B., and, Rogers E., (2003) Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol. Dis. 14, 32-42.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 32-42
    • Ho, P.I.1    Ashline, D.2    Dhitavat, S.3    Ortiz, D.4    Collins, S.C.5    Shea, T.B.6    Rogers, E.7
  • 13
    • 0035107609 scopus 로고    scopus 로고
    • Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
    • Hofmann M. A., Lalla E., Lu Y., et al. (2001) Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J. Clin. Invest. 107, 675-683.
    • (2001) J. Clin. Invest. , vol.107 , pp. 675-683
    • Hofmann, M.A.1    Lalla, E.2    Lu, Y.3
  • 16
    • 70350495437 scopus 로고    scopus 로고
    • Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
    • Jansen P. J., Lutjohann D., Thelen K. M., Von Bergmann K., Van Leuven F., Ramaekers F. C., and, Mulder M., (2009) Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. J. Alzheimers Dis. 18, 319-329.
    • (2009) J. Alzheimers Dis. , vol.18 , pp. 319-329
    • Jansen, P.J.1    Lutjohann, D.2    Thelen, K.M.3    Von Bergmann, K.4    Van Leuven, F.5    Ramaekers, F.C.6    Mulder, M.7
  • 18
    • 0036523032 scopus 로고    scopus 로고
    • Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease
    • Kruman I. I., Kumaravel T. S., Lohani A., Pedersen W. A., Cutler R. G., Kruman Y., Haughey N., Lee J., Evans M., and, Mattson M. P., (2002) Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22, 1752-1762.
    • (2002) J. Neurosci. , vol.22 , pp. 1752-1762
    • Kruman, I.I.1    Kumaravel, T.S.2    Lohani, A.3    Pedersen, W.A.4    Cutler, R.G.5    Kruman, Y.6    Haughey, N.7    Lee, J.8    Evans, M.9    Mattson, M.P.10
  • 19
    • 37349066157 scopus 로고    scopus 로고
    • Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice
    • Lalonde R., Barraud H., Ravey J., Gueant J. L., Bronowicki J. P., and, Strazielle C., (2008) Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res. 1188, 122-131.
    • (2008) Brain Res. , vol.1188 , pp. 122-131
    • Lalonde, R.1    Barraud, H.2    Ravey, J.3    Gueant, J.L.4    Bronowicki, J.P.5    Strazielle, C.6
  • 20
    • 20544445241 scopus 로고    scopus 로고
    • Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: A placebo-controlled randomized study
    • Lewerin C., Matousek M., Steen G., Johansson B., Steen B., and, Nilsson-Ehle H., (2005) Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am. J. Clin. Nutr. 81, 1155-1162.
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 1155-1162
    • Lewerin, C.1    Matousek, M.2    Steen, G.3    Johansson, B.4    Steen, B.5    Nilsson-Ehle, H.6
  • 21
    • 33748756864 scopus 로고    scopus 로고
    • Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance
    • Liao D., Tan H., Hui R., et al. (2006) Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ. Res. 99, 598-606.
    • (2006) Circ. Res. , vol.99 , pp. 598-606
    • Liao, D.1    Tan, H.2    Hui, R.3
  • 22
    • 33846119171 scopus 로고    scopus 로고
    • Relation of higher folate intake to lower risk of Alzheimer disease in the elderly
    • Luchsinger J. A., Tang M. X., Miller J., Green R., and, Mayeux R., (2007) Relation of higher folate intake to lower risk of Alzheimer disease in the elderly. Arch. Neurol. 64, 86-92.
    • (2007) Arch. Neurol. , vol.64 , pp. 86-92
    • Luchsinger, J.A.1    Tang, M.X.2    Miller, J.3    Green, R.4    Mayeux, R.5
  • 23
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund E. G., Xie C., Kotti T., Turley S. D., Dietschy J. M., and, Russell D. W., (2003) Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278, 22980-22988.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 24
    • 36248964572 scopus 로고    scopus 로고
    • Homocysteine induces tau hyperphosphorylation in rats
    • Luo Y., Zhou X., Yang X., and, Wang J., (2007) Homocysteine induces tau hyperphosphorylation in rats. Neuroreport 18, 2005-2008.
    • (2007) Neuroreport , vol.18 , pp. 2005-2008
    • Luo, Y.1    Zhou, X.2    Yang, X.3    Wang, J.4
  • 30
    • 0344011516 scopus 로고    scopus 로고
    • Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse
    • Quan G., Xie C., Dietschy J. M., and, Turley S. D., (2003) Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse. Brain Res. Dev. Brain Res. 146, 87-98.
    • (2003) Brain Res. Dev. Brain Res. , vol.146 , pp. 87-98
    • Quan, G.1    Xie, C.2    Dietschy, J.M.3    Turley, S.D.4
  • 31
    • 59149083352 scopus 로고    scopus 로고
    • First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates
    • Sankaranarayanan S., Holahan M. A., Colussi D., et al. (2009) First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. J. Pharmacol. Exp. Ther. 328, 131-140.
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 131-140
    • Sankaranarayanan, S.1    Holahan, M.A.2    Colussi, D.3
  • 32
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J., (1999) Homocysteine metabolism. Annu. Rev. Nutr. 19, 217-246.
    • (1999) Annu. Rev. Nutr. , vol.19 , pp. 217-246
    • Selhub, J.1
  • 34
    • 2342539069 scopus 로고    scopus 로고
    • The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin e deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration
    • Shea T. B., Ashline D., Ortiz D., Milhalik S., and, Rogers E., (2004) The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration. Neuromolecular Med. 5, 171-180.
    • (2004) Neuromolecular Med. , vol.5 , pp. 171-180
    • Shea, T.B.1    Ashline, D.2    Ortiz, D.3    Milhalik, S.4    Rogers, E.5
  • 35
    • 20944431925 scopus 로고    scopus 로고
    • Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells
    • discussion 173-180
    • Shi X. P., Tugusheva K., Bruce J. E., et al. (2005) Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells. J. Alzheimers Dis. 7, 139-148; discussion 173-180.
    • (2005) J. Alzheimers Dis. , vol.7 , pp. 139-148
    • Shi, X.P.1    Tugusheva, K.2    Bruce, J.E.3
  • 38
    • 24644472507 scopus 로고    scopus 로고
    • Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: Relevance to age-related neurodegeneration
    • Tchantchou F., Graves M., Ortiz D., Rogers E., and, Shea T. B., (2004) Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration. Neuromolecular Med 6, 93-103.
    • (2004) Neuromolecular Med , vol.6 , pp. 93-103
    • Tchantchou, F.1    Graves, M.2    Ortiz, D.3    Rogers, E.4    Shea, T.B.5
  • 41
    • 57349148222 scopus 로고    scopus 로고
    • Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine
    • Troen A. M., Chao W. H., Crivello N. A., D'Anci K. E., Shukitt-Hale B., Smith D. E., Selhub J., and, Rosenberg I. H., (2008b) Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J. Nutr. 138, 2502-2509.
    • (2008) J. Nutr. , vol.138 , pp. 2502-2509
    • Troen, A.M.1    Chao, W.H.2    Crivello, N.A.3    D'Anci, K.E.4    Shukitt-Hale, B.5    Smith, D.E.6    Selhub, J.7    Rosenberg, I.H.8
  • 42
    • 62949129136 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and Alzheimer's disease: A systematic review
    • Van Dam F., and, Van Gool W. A., (2009) Hyperhomocysteinemia and Alzheimer's disease: a systematic review. Arch Gerontol Geriatr 48, 425-430.
    • (2009) Arch Gerontol Geriatr , vol.48 , pp. 425-430
    • Van Dam, F.1    Van Gool, W.A.2
  • 43
    • 0026597164 scopus 로고
    • Long-term folate deficiency alters folate content and distribution differentially in rat tissues
    • Varela-Moreiras G., and, Selhub J., (1992) Long-term folate deficiency alters folate content and distribution differentially in rat tissues. J. Nutr. 122, 986-991.
    • (1992) J. Nutr. , vol.122 , pp. 986-991
    • Varela-Moreiras, G.1    Selhub, J.2
  • 44
    • 43249103554 scopus 로고    scopus 로고
    • Dietary methionine effects on plasma homocysteine and HDL metabolism in mice
    • Velez-Carrasco W., Merkel M., Twiss C. O., and, Smith J. D., (2008) Dietary methionine effects on plasma homocysteine and HDL metabolism in mice. J. Nutr. Biochem. 19, 362-370.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 362-370
    • Velez-Carrasco, W.1    Merkel, M.2    Twiss, C.O.3    Smith, J.D.4
  • 45
    • 38849086036 scopus 로고    scopus 로고
    • Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
    • Wahrle S. E., Jiang H., Parsadanian M., et al. (2008) Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J. Clin. Invest. 118, 671-682.
    • (2008) J. Clin. Invest. , vol.118 , pp. 671-682
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3
  • 46
    • 65349162724 scopus 로고    scopus 로고
    • Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
    • Zhang C. E., Wei W., Liu Y. H., Peng J. H., Tian Q., Liu G. P., Zhang Y., and, Wang J. Z., (2009) Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am. J. Pathol. 174, 1481-1491.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1481-1491
    • Zhang, C.E.1    Wei, W.2    Liu, Y.H.3    Peng, J.H.4    Tian, Q.5    Liu, G.P.6    Zhang, Y.7    Wang, J.Z.8
  • 47
    • 0035573652 scopus 로고    scopus 로고
    • Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice
    • Zhou J., Moller J., Danielsen C. C., Bentzon J., Ravn H. B., Austin R. C., and, Falk E., (2001) Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 21, 1470-1476.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1470-1476
    • Zhou, J.1    Moller, J.2    Danielsen, C.C.3    Bentzon, J.4    Ravn, H.B.5    Austin, R.C.6    Falk, E.7
  • 48
    • 76749128435 scopus 로고    scopus 로고
    • Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet
    • Zhuo J. M., and, Pratico D., (2010) Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. Exp. Gerontol. 45, 195-201.
    • (2010) Exp. Gerontol. , vol.45 , pp. 195-201
    • Zhuo, J.M.1    Pratico, D.2
  • 49
    • 77949675424 scopus 로고    scopus 로고
    • Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease
    • Zhuo J. M., Portugal G. S., Kruger W. D., Wang H., Gould T. J., and, Pratico D., (2010) Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Curr. Alzheimer Res. 7, 140-149.
    • (2010) Curr. Alzheimer Res. , vol.7 , pp. 140-149
    • Zhuo, J.M.1    Portugal, G.S.2    Kruger, W.D.3    Wang, H.4    Gould, T.J.5    Pratico, D.6


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