Immunomodulatory strategies prevent the development of autoimmune emphysema

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Hanaoka, Masayuki ^a   Nicolls, Mark R ^b   Fontenot, Andrew P ^a   Kraskauskas, Donatas ^c   Mack, Douglas G ^a   Kratzer, Adelheid ^a   Salys, Jonas ^a   Kraskauskiene, Vita ^c   Burns, Nana ^a   Voelkel, Norbert F ^c   Taraseviciene Stewart, Laimute ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; ENDOTHELIAL CELL ANTIBODY; INTERLEUKIN 1ALPHA; PRISTANE; T LYMPHOCYTE RECEPTOR BETA CHAIN; VASCULOTROPIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ FOXP3+ T LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; EMPHYSEMA; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INNATE IMMUNITY; LUNG ALVEOLUS; MALE; NICK END LABELING; NONHUMAN; RAT; T LYMPHOCYTE; UMBILICAL VEIN; WESTERN BLOTTING; ANIMAL; AUTOIMMUNITY; IMMUNOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CYTOKINES; EMPHYSEMA; IMMUNOMODULATION; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650160965     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-179     Document Type: Article

References (63)

1. Agusti AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 2003, 21:347-360. 10.1183/09031936.03.00405703, 12608452.
2. Wouters EF. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005, 2:26-33. 10.1513/pats.200408-039MS, 16113466.
3. de Jong JW, Belt-Gritter B, Koeter GH, Postma DS. Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. Respir Med 1997, 91:67-76. 10.1016/S0954-6111(97)90070-6, 9122514.
4. Noguera A, Busquets X, Sauleda J, Villaverde JM, MacNee W, Agusti AG. Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 158:1664-1668.
5. Schols AM, Buurman WA, Staal van den Brekel AJ, Dentener MA, Wouters EF. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996, 51:819-824. 10.1136/thx.51.8.819, 472555, 8795671.
6. Cosio MG, Guerassimov A. Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma. Am J Respir Crit Care Med 1999, 160:S21-S25.
7. Saetta M, Turato G, Maestrelli P, Mapp CE, Fabbri LM. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001, 163:1304-1309.
8. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004, 350:2645-2653. 10.1056/NEJMoa032158, 15215480.
9. Cosio MG, Majo J, Cosio MG. Inflammation of the airways and lung parenchyma in COPD: role of T cells. Chest 2002, 121:160S-165S. 10.1378/chest.121.5_suppl.160S, 12010846.
10. Hodge S, Hodge G, Holmes M, Reynolds PN. Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J 2005, 25:447-454. 10.1183/09031936.05.00077604, 15738287.
11. Agusti A, MacNee W, Donaldson K, Cosio M. Hypothesis: does COPD have an autoimmune component?. Thorax 2003, 58:832-834. 10.1136/thorax.58.10.832, 1746486, 14514931.
12. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 2009, 360:2445-2454. 10.1056/NEJMra0804752, 19494220.
13. Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 2007, 13:567-569. 10.1038/nm1583, 17450149.
14. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, et al. An animal model of autoimmune emphysema. Am J Respir Crit Care Med 2005, 171:734-742. 10.1164/rccm.200409-1275OC, 15563631.
15. Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 1994, 91:123-127. 10.1073/pnas.91.1.123, 42898, 8278351.
16. Pasquali L, Giannoukakis N, Trucco M. Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes. Advanced Drug Delivery Reviews 2008, 60:106-113. 10.1016/j.addr.2007.08.032, 18053613.
17. Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz MS, Guida J, et al. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. J Clin Invest 1996, 98:2640-2647. 10.1172/JCI119085, 507724, 8958229.
18. Freund YR, Blair PB. Depression of natural killer activity and mitogen responsiveness in mice treated with pristane. J Immunol 1982, 129:2826-2830.
19. Sprent J, Kishimoto H. The thymus and central tolerance. Transplantation 2001, 72:S25-S28.
20. Naji A. Induction of tolerance by intrathymic inoculation of alloantigen. Curr Opin Immunol 1996, 8:704-709. 10.1016/S0952-7915(96)80089-6, 8902397.
21. Fukada J, Kurimoto Y, Ruiz P, Aitouche A, Zeevi A, Li S, et al. Long-term survival of rat cardiac allografts by intrathymic plus portal venous injections of donor bone marrow cells and short-term tacrolimus immunosuppression. Transpl Int 2001, 14:311-319. 10.1111/j.1432-2277.2001.tb00065.x, 11692215.
22. Cober SR, Randolph MA, Lee WP. Skin allograft survival following intrathymic injection of donor bone marrow. J Surg Res 1999, 85:204-208. 10.1006/jsre.1999.5688, 10423320.
23. Li S, Louis LB, Kawaharada N, Yousem SA, Pham SM. Intrathymic inoculation of donor bone marrow induces long-term acceptance of lung allografts. Ann Thorac Surg 2003, 75:257-263. 10.1016/S0003-4975(02)04287-X, 12537225.
24. Bruneel A, Labas V, Mailloux A, Sharma S, Vinh J, Vaubourdolle M, et al. Proteomic study of human umbilical vein endothelial cells in culture. Proteomics 2003, 3:714-723. 10.1002/pmic.200300409, 12748950.
25. Chu Q, Moreland RJ, Gao L, Taylor KM, Meyers E, Cheng SH, Scheule RK. Induction of Immune Tolerance to a Therapeutic Protein by Intrathymic Gene Delivery. Mol Ther 2010, 18:2146-2154. 10.1038/mt.2010.164, 20664526.
26. Marodon G, Klatzmann D. In situ transduction of stromal cells and thymocytes upon intrathymic injection of lentiviral vectors. BMC Immunol 2004, 5:18. 10.1186/1471-2172-5-18, 516029, 15318949.
27. Marodon G, Fisson S, Levacher B, Fabre M, Salomon BL, Klatzmann D. Induction of antigen-specific tolerance by intrathymic injection of lentiviral vectors. Blood 2006, 108:2972-2978. 10.1182/blood-2006-03-010900, 16809618.
28. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000, 106:1311-1319. 10.1172/JCI10259, 387249, 11104784.
29. Imai K, Mercer BA, Schulman LL, Sonett JR, D'Armiento JM. Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur Respir J 2005, 25:250-258. 10.1183/09031936.05.00023704, 15684288.
30. Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol 2007, 19:685-693. 10.1093/intimm/dxm037, 17496315.
31. Mack DG, Lanham AK, Palmer BE, Maier LA, Watts TH, Fontenot AP. 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J Immunol 2008, 181:4381-4388.
32. Zozulya AL, Wiendl H. The role of regulatory T cells in multiple sclerosis. Nat Clin Pract Neurol 2008, 4:384-398. 10.1038/ncpneuro0832, 18578001.
33. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001, 163:737-744.
34. Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 2004, 125:626-632. 10.1378/chest.125.2.626, 14769747.
35. Aoshiba K, Yokohori N, Nagai A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol 2003, 28:555-562. 10.1165/rcmb.2002-0090OC, 12707011.
36. MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 2001, 429:195-207. 10.1016/S0014-2999(01)01320-6, 11698041.
37. Shapiro SD. Proteinases in chronic obstructive pulmonary disease. Biochem Soc Trans 2002, 30:98-102. 10.1042/BST0300098, 12023833.
38. Chan C, Lechler RI, George AJ. Tolerance mechanisms and recent progress. Transplant Proc 2004, 36:561S-569S. 10.1016/j.transproceed.2004.01.019, 15041406.
39. Goldschneider I, Cone RE. A central role for peripheral dendritic cells in the induction of acquired thymic tolerance. Trends Immunol 2003, 24:77-81. 10.1016/S1471-4906(02)00038-8, 12547504.
40. Kappler JW, Roehm N, Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987, 49:273-280. 10.1016/0092-8674(87)90568-X, 3494522.
41. Posselt AM, Barker CF, Friedman AL, Naji A. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 1992, 256:1321-1324. 10.1126/science.1598576, 1598576.
42. Chen W, Sayegh MH, Khoury SJ. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. J Immunol 1998, 160:1504-1508.
43. Chen W, Issazadeh S, Sayegh MH, Khoury SJ. In vivo mechanisms of acquired thymic tolerance. Cell Immunol 1997, 179:165-173. 10.1006/cimm.1997.1165, 9268500.
44. Khoury SJ, Gallon L, Chen W, Betres K, Russell ME, Hancock WW, et al. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 1995, 182:357-366. 10.1084/jem.182.2.357, 2192120, 7543136.
45. Pacholczyk R, Kern J. The T-cell receptor repertoire of regulatory T cells. Immunology 2008, 125:450-458. 10.1111/j.1365-2567.2008.02992.x, 2612558, 19128356.
46. Reeves WH, Lee PY, Weinstein JS, Satoh M, Lu L. Induction of autoimmunity by pristane and other naturally occurring hydrocarbons. Trends Immunol 2009, 30:455-464. 10.1016/j.it.2009.06.003, 2746238, 19699150.
47. Savarese E, Steinberg C, Pawar RD, Reindl W, Akira S, Anders HJ, et al. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 2008, 58:1107-1115. 10.1002/art.23407, 18383384.
48. Sullivan AK, Simonian PL, Falta MT, Mitchell JD, Cosgrove GP, Brown KK, et al. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med 2005, 172:590-596. 10.1164/rccm.200410-1332OC, 2718531, 15937291.
49. Aspinall R, Kampinga J. A novel lymphocyte surface antigen recognized by the monoclonal antibody HIS45. Thymus 1989, 13:245-252.
50. Voelkel NF, Vandivier RW, Tuder RM. Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 2006, 290:L209-L221. 10.1152/ajplung.00185.2005, 16403941.
51. Beyer K, Hausler T, Kircher M, Nickel R, Wahn U, Renz H. Specific V beta T cell subsets are associated with cat and birch pollen allergy in humans. J Immunol 1999, 162:1186-1191.
52. Ohta K, Hara H, Hayashi K, Itoh N, Ohi T, Ohta M. Tissue expression of rat ciliary neurotrophic factor (CNTF) mRNA and production of the recombinant CNTF. Biochem Mol Biol Int 1995, 35:283-290.
53. Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol 1998, 16:457-499. 10.3109/08830189809043005, 9646173.
54. Infante J, Llorca J, Mateo I, Rodriguez-Rodriguez E, Sanchez-Quintana C, Sanchez-Juan P, et al. Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk. Dement Geriatr Cogn Disord 2007, 23:215-218. 10.1159/000099471, 17290104.
55. Havemose-Poulsen A, Sorensen LK, Bendtzen K, Holmstrup P. Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol 2007, 78:475-492. 10.1902/jop.2007.060135, 17335371.
56. Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 2000, 165:6635-6643.
57. Taraseviciene-Stewart L, Voelkel NF. Molecular pathogenesis of emphysema. J Clin Invest 2008, 118:394-402. 10.1172/JCI31811, 2214683, 18246188.
58. Gebel S, Gerstmayer B, Kuhl P, Borlak J, Meurrens K, Muller T. The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression. Toxicol Sci 2006, 93:422-431. 10.1093/toxsci/kfl071, 16870687.
59. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 2006, 129:1673-1682. 10.1378/chest.129.6.1673, 16778289.
60. Mahoney JA, Rosen A. Apoptosis and autoimmunity. Curr Opin Immunol 2005, 17:583-588. 10.1016/j.coi.2005.09.018, 16214321.
61. Koethe SM, Kuhnmuench JR, Becker CG. Neutrophil priming by cigarette smoke condensate and a tobacco anti-idiotypic antibody. Am J Pathol 2000, 157:1735-1743. 1885717, 11073832.
62. Cooke A, Phillips JM, Parish NM. Tolerogenic strategies to halt or prevent type I diabetes. Nature Immunology 2001, 2:810-815. 10.1038/ni0901-810, 11526391.
63. Rosmalen JGM, van Ewijk V, Leenen PJM. T-cell education in autoimmune diabetes: teachers and students. Trends in Immunology 2002, 23:40-46. 10.1016/S1471-4906(01)02088-9, 11801453.