Induction of immune tolerance to a therapeutic protein by intrathymic gene delivery

Molecular Therapy

Volumn 18, Issue 12, 2010, Pages 2146-2154

  Chu, Qiuming ^a   Moreland, Rodney J ^a   Gao, Lan ^a   Taylor, Kristin M ^a   Meyers, Elizabeth ^a   Cheng, Seng H ^a   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; GLUCAN 1,4 ALPHA GLUCOSIDASE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PARVOVIRUS VECTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG MEGADOSE; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; LIVER PARENCHYMA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN; T LYMPHOCYTE ACTIVATION; THYMUS; VIRAL GENE DELIVERY SYSTEM;

EID: 78650866025     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.164     Document Type: Article

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