Induction of tolerance by intrathymic inoculation of alloantigen

Current Opinion in Immunology

Volumn 8, Issue 5, 1996, Pages 704-709

  Naji, Ali ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN;

ALLOGRAFT; ANIMAL TISSUE; AUTOIMMUNITY; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; RAT; SHORT SURVEY; SKIN ALLOGRAFT; T LYMPHOCYTE; THYMOCYTE; THYMUS; XENOGRAFT;

EID: 0030271845     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80089-6     Document Type: Article

References (60)

1. Krensky AM, Weiss A, Crabtree G, Davis M, Parham P. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med. 322:1990;510-517.
2. Fowlkes BJ, Ramsdell F. T-cell tolerance. Curr Opin Immunol. 5:1993;873-879.
3. Sprent J, Webb SR. Intrathymic and extrathymic clonal deletion of T cells. Curr Opin Immunol. 7:1995;196-205.
4. Von Boehmer H. Positive selection of lymphocytes. Cell. 76:1994;219-228.
5. Nossal GJV. Negative selection of lymphocytes. Cell. 76:1994;229-240.
6. Hogquist KA, Jameson SC, Heath WR, Howard JLK, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell. 76:1994;17-23.
7. Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher H-P, Zinkernagel RM, Tonegawa S. Evidence for an avidity model of T cell activation in the thymus. Cell. 73:1994;1041-1049.
8. Sebzda E, Wallace VA, Mayer J, Yaung RSM, Mak TW, Ohashi PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science. 263:1994;1615-1618.
9. Surh CD, Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature. 372:1994;100-103.
10. of outstanding interest Alam SM, Travers PJ, Wung JL, Nasholds W, Redpath S, Jameson SC, Gascoigne NRJ. T-cell-receptor affinity and thymocyte positive selection. Nature. 381:1996;616-620 An important study utilizing soluble, purified preparations of the main components of the TCR-MHC/peptide interaction to explore the kinetics and affinity of binding of a well characterized TCR to MHC/peptide complexes. The authors provide the strongest evidence which directly correlates the affinity of the interaction between the TCRs and MHC/peptide ligands with the outcome of thymic selection.
11. Burkly L, Lo D, Kanagawa R, Brinster R, Flavell R. T cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature. 342:1989;564-566.
12. Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med. 165:1987;302-319.
13. + suppressor cell and its mechanisms of action. J Exp Med. 171:1990;141-157.
14. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 172:1953;603-606.
15. Ruiz P, Nassiri M, Gregorian S, Viviana A, Streilein JW. Neonatal transplantation tolerance is associated with a systemic reduction in memory cells, altered chimeric cell phenotype, and modified eicosainoid and cytokine production. Transplantation. 61:1996;1198-1205.
16. Mayumi H, Good RA. Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigens by a tolerance-inducing method using cylophosphamide. J Exp Med. 169:1989;213-238.
17. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med. 169:1989;493-502.
18. Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science. 249:1990;1293-1295.
19. Lakey JRT, Warnock GL, Rajotte RV. Intrathymic transplantation of fresh and cryopreserved islets for the induction of the state of unresponsiveness in rats. Transplantation. 61:1996;506-508.
20. Ketchum RJ, Moyer C, Pan F, Donaldson DL, Forster J, Moore WV. Intrathymic transplantation of allogeneic perinatal islets does not induce donor-specific tolerance. Transplantation. 59:1995;784-793.
21. Mayo GL, Posselt AM, Campos L, Noorchashm N, Barker CF, Naji A. Intrathymic transplantation promotes survival of islet xenografts (rat→mouse). Transplant Proc. 26:1994;758.
22. Zeng Y, Bluestone JA, Ildstad ST, Torres MA, Montag AG, Thistlethwaite RJ Jr. Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat→B6 mouse). Transplant Proc. 25:1993;438-439.
23. Posselt AM, Odorico JS, Barker CF, Naji A. Promotion of prancreatic islet allograft suvival by intrathymic transplantation of bone marrow. Diabetes. 41:1992;771-775.
24. James T, Jin MX, Chowdhury NC, Oluwole SF. Tolerance induction to rat islet allografts by intrathymic inculation of donor spleen cells. Transplantation. 56:1993;1148-1152.
25. Oluwole SF, Jin MX, Chowdhury NC, James T, Fawwaz FA. Induction of specific unresponsiveness to rat islet allografts by intrathymic UVB donor spleen cells. Transplantation. 56:1993;1142-1147.
26. Campos L, Alfrey EJ, Posselt AM, Odorico JS, Barker CF, Naji A. Prolonged survival of rat orthotopic liver allografts after intrathymic inoculation of donor-strain cells. Transplantation. 55:1993;866-870.
27. Odorico JS, Barker CF, Posselt AM, Naji A. Induction of donor-specific tolerance to rat cardiac allografts by intrathymic inoculation of bone marrow. Surgery. 112:1992;370-376.
28. Odorico JS, Baker CF, Markmann JF, Posselt AM, Naji A. Prolonged survival of rat cardiac allografts after intrathymic inoculation of donor thymocytes. Transplant Proc. 25:1993;295-296.
29. Goss J, Nakafusa Y, Flye W. Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression. Ann Surg. 216:1992;409-416.
30. Odorico JS, Posselt AM, Naji A, Markmann JF, Barker CF. Promotion of rat cardiac allograft survival by intrathymic inoculation of donor splenocytes. Transplantation. 55:1993;1104-1107.
31. Krokos NV, Brons IGM, Sriwatanawongsa V, Makisalo H, Katami M, Davies HS, Calne RY. Intrathymic injection of donor antigen-presenting cells prolong heart graft survival. Transplant Proc. 25:1993;303-304.
32. Oluwole SF, Chowdhury NC, Fawwaz RA. Induction of donor-specific unresponsiveness to rat cardiac allografts by intrathymic injection of UV-B-irradiated donor spleen cells. Transplantation. 55:1993;1389-1395.
33. Remuzzi G, Rossini M, Imberti O, Perico N. Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation. Lancet. 337:1991;750-752.
34. Ohzato H, Monaco AP. Induction of specific unresponsiveness (tolerance) to skin allografts by intrathymic donor-specific splenocyte injection in antilymphocyte serum-treated mice. Transplantation. 54:1992;1090-1095.
35. of special interest Dono K, Wood ML, Ohzato H, Otsu I, Gottschalk R, Maki T, Monaco AP. Marked prolongation of rat skin xenografts induced by intrathymic injection of xenogeneic splenocytes and a short course of rapamycin in antilymphocyte serum-treated mice. Transplantation. 59:1995;929-932 Marked prolongation of skin xenograft (rat→mouse) survival was achieved in ALS- and rapamycin-treated mice inoculated with intrathymic donor spleen cells.
36. Sayegh MH, Perico N, Imberti O, Hancock WW, Carperter CB, Remuzzi G. Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts. Transplantation. 56:1993;461-465.
37. Sayegh MH, Perico N, Gallon L, Imberti O, Hancock WW, Remuzzi G, Carpenter CB. Mechanism of acquired thymic unresponsiveness to renal allografts. Transplantation. 58:1994;125-132.
38. Qian T, Schachner R, Brendel M, Kong SS, Alejandro R. Induction of donor-specific tolerance to rat islet allografts by intrathymic inoculation of solubilized spleen cell membrane antigens. Diabetes. 42:1993;1544-1546.
39. Oluwole SF, Jin MX, Chowdhury NC, Ohajekwe OA. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression. Transplantation. 58:1994;1077-1081.
40. Hamashima T, Stepkowski SM, Smith S, Kahan BD. Induction of transplantation tolerance by a single intrathymic injection of 3M KCI-extracted donor histocompatibility antigens combined with two doses of anti-rat α/β-T cell receptor nomoclonal antibodies. Transplantation. 58:1994;105-123.
41. Knechtle SJ, Wang J, Jiao S, Geissler EK, Sumimoto R, Wolff J. Induction of specific tolerance by intrathymic injection of recipient muscle cells tranfected with donor class I major histocompatibility complex. Transplantation. 57:1994;990-996.
42. Raviola E, Karnovsky MJ. Evidence for a blood-thymus barrier using electron-opaque tracers. J Exp Med. 136:1972;466-498.
43. Weiss L. Thymus. Weiss L. The Cells and Tissues of the Immune System: Structure, Functions, Interactions. 1972;79-99 Prentice-Hall Inc, Englewood Cliffs, New York.
44. Michie SA, Kirkpatrick EA, Rouse RV. Rare peripheral T cells migrate to the persist in normal mouse thymus. J Exp Med. 168:1988;1929-1934.
45. Agus DA, Surh CD, Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med. 173:1991;1039-1046.
46. Barker CF, Billingham RE. Immunologically privileged sites. Adv Immunol. 25:1977;1-54.
47. Mornssey PJ, Sharrow SO, Kohno Y, J.A Brozofsky, Singer A. Correlation of intrathymic tolerance with intrathymic chimerism in neonatally tolerized mice. Transplantation. 40:1985;68-72.
48. Matsuzaki G, Yoshikai Y, Ogimoto M, Kishihara K, Nomoto K. Clonal deletion of self-reactive T cells at the early stage of T cell development in thymus of radiation bone marrow chimeras. J Immunol. 145:1990;46-51.
49. Nakafusa Y, Goss JA, Flye MW. Prevention by thymectomy of tolerance induced by intrahymic injection of donor splenocytes. Surgery. 114:1993;183-190.
50. Odorico JS, O'Connor T, Campos L, Barker CF, Posselt AM, Naji A. Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow. Ann Surg. 218:1993;525-531.
51. Staples PJ, Gery I, Waksman BH. Role of the thymus in tolerance. 3. Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats. J Exp Med. 124:1966;127-139.
52. Kyewski BA, Fathman GC, Kaplan HS. Intrathymic presentation of circulating non-major histocompatibility complex antigens. Nature. 308:1984;196-199.
53. Shimonkevitz RP, Bevan MJ. Split tolerance induced by the intrathymic adoptive transfer of thymocyte stem cells. J Exp Med. 168:1988;143-156.
54. Campos L, Posselt AM, Deli BC, Mayo GL, Pete K, Barker CF, Naji A. The failure of intrathymic transplantation of nonimmunogenic islet allografts to promote induction of donor-specific unresponsiveness. Transplantation. 57:1994;950-953.
55. Goss JA, Nakafusa Y, Flye MW. MHC class II presenting cells are necessary for the induction of intrathymic tolerance. Ann Surg. 217:1993;492-501.
56. in vitro with an encephalitogenic peptide and injected intravenously were capalbe of preventing the development of EAE but this protection was lost in thymectomized recipients. Furthermore, the intravenous injection of thymic dendritic cells, isolated from animals previously injected intrathymically with the peptide, also prevented the development of EAE. These findings suggest that an interaction of thymic dendritic cells with a specific TCR of activated peripheral T cells can lead to the inactivation of the antigen-specific cells.
57. 2 receptor blocking abrogated donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides. J Exp Med. 180:1994;1967-1972.
58. 2 receptor is highly expressed in mouse immature thymocytes and mediated DNA fragmentation and apoptosis. J Exp Med. 178:1993;1825-1830.
59. Markmann JF, Odorico JS, Bassiri IT, Desai N, Kim JI, Barker CF. Deletion of donor reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cells. Transplantation. 55:1993;871-877.
60. + cells may function as suppressor cells.