γ-secretase inhibitor-I enhances radiosensitivity of glioblastoma cell lines by depleting CD133+ tumor cells

Archives of Medical Research

Volumn 41, Issue 7, 2010, Pages 519-529

  Lin, Jun ^a   Zhang, Xing Mei ^a   Yang, Jin Cheng ^b   Ye, Yong Bin ^a   Luo, Shen Qiu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Guangzhou Liuhuaqiao Hospital   (China)

Author keywords

Secretase Inhibitor; Glioblastoma; Radiosensitivity

Indexed keywords

CD133 ANTIGEN; GAMMA SECRETASE INHIBITOR; NOTCH RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CELL FRACTIONATION; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GLIOBLASTOMA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIVITY; RADIOSENSITIZATION; T CELL DEPLETION; TUMOR CELL;

ADULT; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, CD; CELL LINE, TUMOR; FEMALE; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; MICE; MICE, NUDE; OLIGOPEPTIDES; PEPTIDES; TRANSPLANTATION, HETEROLOGOUS;

EID: 78650129220     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2010.10.006     Document Type: Article

References (37)

1. Maher E.A., Furnari F.B., Bachoo R.M., et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001, 15:1311-1333.
2. Garden A.S., Maor M.H., Yung W.K., et al. Outcome and patterns of failure following limited-volume irradiation for malignant astrocytomas. Radiother Oncol 1991, 20:99-110.
3. Mukherjee B., McEllin B., Camacho C.V., et al. EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res 2009, 69:4252-4259.
4. Golding S.E., Morgan R.N., Adams B.R., et al. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biol Ther 2009, 8:730-738.
5. Noda S.E., El-Jawahri A., Patel D., et al. Molecular advances of brain tumors in radiation oncology. Semin Radiat Oncol 2009, 19:171-178.
6. Shih I.M., Wang T.L. Notch signaling, γ-secretase inhibitors, and cancer therapy. Cancer Res 2007, 67:1879-1882.
7. Hitoshi S., Alexson T., Tropepe V., et al. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev 2002, 16:846-858.
8. Hitoshi S., Seaberg R.M., Koscik C., et al. Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev 2004, 18:1806-1811.
9. Nakamura Y., Sakakibara S., Miyata T., et al. The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells. J Neurosci 2000, 20:283-293.
10. Weng A.P., Ferrando A.A., Lee W., et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004, 306:269-271.
11. Pece S., Serresi M., Santolini E., et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004, 167:215-221.
12. Politi K., Feirt N., Kitajewski J., et al. Notch in mammary gland development and breast cancer. Semin Cancer Biol 2004, 14:341-347.
13. Kanamori M., Kawaguchi T., Nigro J.M., et al. Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg 2007, 106:417-427.
14. Purow B.W., Haque R.M., Noel M.W., et al. Expression of Notch-1 and its ligands, Delta-Like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005, 65:2353-2363.
15. Weng A.P., Nam Y., Wolfe M.S., et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003, 23:655-664.
16. Nefedova Y., Sullivan D.M., Bolick S.C., et al. Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. BLOOD 2008, 111:2220-2229.
17. Curry C.L., Reed L.L., Golde T.E., et al. γ-secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 2005, 24:6333-6344.
18. Meng R.D., Shelton C.C., Li Y.M., et al. Gamma-secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res 2009, 69:573-582.
19. Liu G., Yuan X., Zeng Z., et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006, 5:67-78.
20. Furnari F.B., Fenton T., Bachoo R.M., et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007, 21:2683-2710.
21. Grossman S.A., Batara J.F. Current management of glioblastoma multiforme. Semin Oncol 2004, 31:635-644.
22. Bao S., Wu Q., McLendon R.E., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756-760.
23. Bao S., Wu Q., Sathornsumetee S., et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006, 66:7843-7848.
24. Singh S.K., Hawkins C., Clarke I.D., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
25. Galli R., Binda E., Orfanelli U., et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004, 64:7011-7021.
26. Singh S.K., Clarke I.D., Terasaki M., et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003, 63:5821-5828.
27. Hemmati H.D., Nakano I., Lazareff J.A., et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003, 100:15178-15183.
28. Qiang L., Yang Y., Ma Y.J., et al. Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. Cancer Lett 2009, 279:13-21.
29. Yu S.C., Ping Y.F., Yi L., et al. Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett 2008, 265:124-134.
30. Kondo T., Setoguchi T., Taga T., et al. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 2004, 101:781-786.
31. Shih A.H., Holland E.C. Notch signaling enhances nestin expression in gliomas. Neoplasia 2006, 8:1072-1082.
32. Zhang X.P., Zheng G., Zou L., et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol Cell Biochem 2008, 307:101-108.
33. Fan X., Khaki L., Zhu T.S., et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010, 28:5-16.
34. Liu S., Dontu G., Wicha M.S. Mammary stem cells, selfrenewal pathways, and carcinogenesis. Breast Cancer Res 2005, 7:86-95.
35. Patrawala L., Calhoun T., Schneider-Broussard R., et al. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic. Cancer Res 2005, 65:6207-6219.
36. Sriuranpong V., Borges M.W., Ravi R.K., et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001, 61:3200-3205.
37. Shou J., Ross S., Koeppen H., et al. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res 2001, 61:7291-7297.