Hepatoprotective Influence of Vitamin C on Thioacetamide-induced Liver Cirrhosis in Wistar Male Rats

Journal of Pharmacology and Toxicology

Volumn 6, Issue 3, 2011, Pages 218-233

  Al Attar, Atef M ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Histopathology; Liver cirrhosis; Physiology; Rats; Thioacetamide; Vitamin c

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CREATINE KINASE; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN; LACTATE DEHYDROGENASE; PROTEIN; THIOACETAMIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ERYTHROCYTE COUNT; HEMATOCRIT; HISTOPATHOLOGY; LEUKOCYTE COUNT; LIVER CIRRHOSIS; LIVER NECROSIS; LIVER PROTECTION; MALE; NONHUMAN; RAT;

EID: 78650116549     PISSN: 1816496X     EISSN: 2152100X     Source Type: Journal    
DOI: 10.3923/jpt.2011.218.233     Document Type: Article

References (96)

1. Agarwal, S.S., 2001. Development of Hep atoprotective Formula-tions from Plant Sources. In: Pharmacology and Therapeutics in the New Millennium, Gupta, S.K. (Ed.). Narosa Publishing House, New Delhi, India, ISBN: 0792370597, pp: 357-358.
2. Ahmed, O.M., H.A. Hamid, M. Bastway and N.A. Hasona, 2006. Antihyperglycemic effects of Plantago Ispaghula seeds aqueous extract in diabetic and hypercholesterolemic rats. J. Egypt. Ger. Soc. Zool, 51:371-393.
3. Al-Attar, A.M., 2007. Chemopreventive effect of cinnamon extract on carbon tetrachloride-induced physiological changes in the frog, Rana ridibunda. J. Applied Sci., 7: 79-90.
4. Al-Attar, A.M. and W.A. Al-Taisan, 2010. Preventive effects of black seed (Nigella sativa) extract on Sprague Dawly rats exposed to diazinon. Aust. J. Basic Applied Sci., 4: 957-968.
5. Alcolado, R., M.P. Arthur and J.P. Iredale, 1997. Pathogenesis of liver fibrosis. Clin. Sci., 92: 103-112.
6. An, J.H., J. Seong, H. Oh, W. Kim, K.H. Han and Y.H. Paik, 2006. Protein expression profiles in a rat cirrhotic model induced by thioacetamide. Korean J. Hepatol., 12: 93-102.
7. Andersen, M.W., N.R. Ballal, I.L. Goldknopf and H. Busch, 1981. Protein A24 lyase activity in nucleoli of thioacetamide- treated rat liver releases histone 2A and ubiquitin from conjugated protein A24. Biochem., 20: 1100-1104.
8. Arthur, M.J., D.A. Mann and J.P. Iredale, 1998. Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis. J. Gastrotroenterol. Hepatol., 13: S33-S38.
9. Aydin, A.F., Z. Kusku-Kiraz, S. Dogru-Abbasoglu, M. Gulluoglu, M. Uysal and N. Kocak-Toker, 2010. Effect of carnosine against thioacetamide-induced liver cirrhosis in rat. Peptides, 31:67-71.
10. Bedossa, P. and V. Paradis, 2003. Liver extracellular matrix in health and disease. J. Pathol., 200: 504-515.
11. Bianchi, G., E. Bugianesi, M. Ronchi, A. Fabbri, M. Zoli and G. Marchesini, 1997. Glutathione kinetics in normal man and in patients with liver cirrhosis. J. Hepatol., 26: 606-613.
12. Bruck, R., R. Schey, H. Aeed, A. Hochman, O. Genina and M. Pines, 2004. A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis. Liver Int., 24: 169-176.
13. CDC, 2005. National center for health statistics, http://www.cdc.gov/nchs/.
14. Campbell, J.S., S.D. Hughes, D.G Gilbertson, T.E. Palmer and M.S. Holdren et al, 2005. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA, 102: 3389-3394.
15. Chatterjea, M.N. and R. Shinde, 2002. Serum Enzymes in Heart Diseases. In: Textbook of Medical Biochemistry, Chatterjea, M.N. and R. Shinde (Eds.), 5th Edn, Jayppe Brothers Med. Publ. Ltd, New Delhi, ISBN: 8180613658, pp: 555-557.
16. Constantinou, M.A, S.E. Theocharis and E. Mikros, 2007. Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats. Toxicol. Applied Pharmcol, 218: 11-19.
17. Cruz, A, F.J. Padillo, E. Torres, CM. Navarrete and J.R. Munoz-Castaneda et al., 2005. Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats. J. Pineal Res, 39: 143-150.
18. Dai, K, J.Y. Qi and D.Y. Tian, 2005. Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice. World J. Gastroenterol, 11: 4822-4826.
19. Dodge, A.G, J.E. Richman, G. Johnson and L.P. Wackett, 2006. Metabolism of thioamides by Ralstoniapicketii TA. Applied Environ. Microbiol, 72: 7468-7476.
20. Dufour, J.F, R. De Lellis and M.M. Kaplan, 1998. Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment. Dig. Dis. Sci, 43: 2573-2576.
21. Dunn, W.L, 1974. Handbook of Histopathological and Histochemical Techniques. 3rd Edn, Redwood, Burn, Ltd, Trowbridge and Esher, ISBN: 0407729011.
22. Eroglu, A, S. Demirci, H. Akbulut, N. Sever, S. Demirer and A.E. Unal, 2002. Effect of granulocyte-macrophage colony-stimulating factor on hepatic regeneration after 70% hepatectomy in normal and cirrhotic rats. HPB (Oxford), 4: 67-73.
23. Farawati, R.A. and C.M.G. van den Berg, 2001. Thiols in coastal waters of the western North Sea and English channel. Environ. Sci. Technol, 35: 1902-1911.
24. Friedman, S.L, 2000. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem, 275: 2247-2250.
25. Friedman, S.L, 2003. Liver fibrosis-from bench to bedside. J. Hepatol, 38: S38-S53.
26. Fujimoto, J, 2000. Gene therapy for liver fibrosis. J. Gastroenterol Hepatol, 15: D33-D36.
27. Gahsteo, M, A. Suarez, M.P. Montilla, M.I. Torres, A. Gil and M.C. Navarro, 2006. Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats. Phytomedicine, 13: 101-108.
28. George, J, 2003. Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats. Clin. Chim. Acta, 335: 39-47.
29. Gieling, R.G, A.D. Burt and D.A. Mann, 2008. Fibrosis and cirrhosis reversibility - molecular mechanisms. Clin. Liver Dis, 12: 915-937.
30. Gnainsky, Y, Z. Kushnirsky, G. Bilu, Y. Hagai and O. Genina et al., 2007. Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling. Cell Tissue Res, 328: 153-166.
31. Guerra, R.R, M.R. Trotta, O.M. Parra, J.L. Avanzo and A. Bateman et al., 2009. Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat. Braz. J. Med. Biol. Res, 42: 1027-1034.
32. Gupta, A.K. and N. Misra, 2006. Hepatoprotective activity of aqueous ethanolic extract of Chamomile capitula in paracetamol intoxicated albino rats. Am. J. Pharmacol. Toxicol, 1: 17-20.
33. Halim, A.B, O. El-Ahmady, S. Hassab-Allab, F. Abdel Gahl, Y. Hafez and A. Darwish, 1997. Biochemical effect of antioxidants on lipids and liver function in experiment ally-induced liver damage. Ann. Clin. Biochem., 34: 656-663.
34. Hautekeete, M.L. and A. Geerts, 1997. The hepatic stellate (Ito) cell: Its role in human liver disease. Virchows-Arch., 430: 195-207.
35. Henderson, N.C. and J.P. Iredale, 2007. Liver fibrosis: Cellular mechanisms of progression and resolution. Clin. Sci, 112: 265-280.
36. Houskova, V., V. Stengl, S. Bakaradjieva, N. Murafa, A. Kalendova and F. Oplustil, 2007. Nanostructure materials of warfare agents and eco-toxins prepared by homogeneous hydrolysis with thioacetamide: Part 1-zinc oxide. J. Phys. Chem. Solids, 68: 716-720.
37. Huang, H.C, S.S. Wang, C.Y. Chan, Y.C. Chen, F.Y. Lee and F.Y. Chang et al, 2007. Role of hepatic nitric oxide synthases in rats with thioacetamide induced acute liver failure and encephalopathy. J. Chin. Med. Assoc, 760: 16-23.
38. Hui, AY. and S.L. Friedman, 2003. Molecular basis of hepatic fibrosis. Expert. Rev. Mol. Med, 5: 1-23.
39. Inoue, M, 2001. Protective Mechanisms Against Reactive Oxygen Species. In: The Liver: Biology and Pathobiology, Arias, I.M, J.L. Boyer, F.V. Chisari, N. Fausto, D. Schachter and D.A. Shafntz (Eds.), 4th Edn, Lippmcott Williams and Wilkms, Philadelphia, ISBN: 0-7817-2390-6, pp: 282-290.
40. Iqbal, K, A. Khan and M.M.A.K. Khattak, 2004. Biological significance of ascorbic acid (vitamin C) in human health-A review. Pak. J. Nutr, 3: 5-13.
41. Iredale, J.P, 2007. Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest, 117: 539-548.
42. Jam, S.K, P.W. Pemberton, A. Smith, R.F. McMahon, P.C. Burrows, A. Aboutwerat and T.W. Warnes, 2002. Oxidative stress in chronic hepatitis C: Not just a feature of late stage disease. J. Hepatol, 36: 805-811.
43. Kawada, N, 2004. Molecular mechanism of stellate cell activation and therapeutic strategy for liver fibrosis. Comp. Hepatol, 3: S3-S3.
44. Krishna, H. and A.V. Ramachandran, 2009. Biochemical alterations induced by the acute exposure to combination of chlorpyrifos and lead in Wistar rats. Biol. Med, 1: 1-6.
45. Kruszynska, Y.T. and N. Mclntyre, 1991. Carbohydrate Metabolism. In: The Oxford Textbook of Clinical Hepatology, Mclntyre, N, J-P Benhamou, J. Bircher, M. Rizzetto and J. Rodes (Eds.). Oxford University Press, New York, ISBN: 0-19-261968-3 pp: 129-143.
46. Kumar, G, G.S. Banu, P.V. Pappa, M. Sundararajan and M.R. Pandian, 2004. Hepatoprotective activity of Trianthemaportulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J. Ethnopharmacol, 92: 37-40.
47. Kuriakose, G.C. and M.G. Kurup, 2010. Hepatoprotective effect of Spirulina lonar on paracetamol induced liver damage in rats. Asian J. Exp. Biol. Sci, 1: 614-623.
48. Lai, C.L, V. Ratziu, M.F. Yuen and T. Poynard, 2003. Viral hepatitis B. Lancet, 362: 2089-2094.
49. Larralde, M, A. Santos Munoz, P. Boggio, V. Di Gruccio, I. Weis and A. Schygiel, 2007. Scurvy in a 10-month-old boy. Int. J. Dermatol, 46: 194-198.
50. Li, D. and S.L. Friedman, 1999. Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy. J. Gastroenterol. Hepatol, 14: 618-633.
51. Li, J.T, Z.X. Liao, J. Ping, D. Xu and H. Warng, 2008. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J. Gastroenterol, 43: 419-428.
52. Li, X., I.S. Benjamin and B. Alexander, 2002. Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality. J. Hepatol., 36: 488-493.
53. Lin, K.W. and J.T. Kirchner, 2004. Hepatitis B. Am. Fam. Physician, 69: 75-82.
54. Lin, S., N.K. Saxena, X. Ding, L.L. Stein and F.A. Anania, 2006. Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism. Mol. Endocrinol., 20: 3367-3388.
55. Luo, Y.J., J.P. Yu, Z.H. Shi and L. Wang, 2004. Ginkgo biloba extract reverses CC14-induced liver fibrosis in rats. World J. Gastroenterol., 10: 1037-1042.
56. Lv, X.H., L.P. Zhou, D.P. Liu, Y. Wang and B.Y. Wang et al., 2007. Traditional Chinese medicine Kang Xian Fu Fang I is effective for prophylaxis and treatment of alcoholic liver disease in rats. Hepatobiliary Pancreat. Dis. Int., 6: 182-187.
57. Madani, H., M. Talebolhosseini, S. Asgary and G.H. Naderi, 2008. Hepatoprotective activity of Silybum marianum and Cichorium intybus against thioacetamide in rat. Pak. J. Nutr., 7: 172-176.
58. Mandl, J., A. Szarka and G. Banhegyi, 2009. Vitamin C: Update on physiology and pharmacology. Br. J. Pharmacol, 157: 1097-1110.
59. Mane, R.S, B.R. Sankapal and CD. Lokhande, 2000. Thickness dependent properties of chemically deposited As2Sg thin films from thioacetamide bath. Mat. Chem. Phys, 64: 215-221.
60. Manea, F, C Radovan and J. Schoonman, 2006. Amperometric determination of thiourea in alkaline media on a copper oxide-copper electrode. J. Applied Electrochem, 36: 1075-1081.
61. McClain, C.J, Z. Song, S.S. Barve, D.B. Hill and I. Deaciuc, 2004. Recent advances in alcoholic liver disease IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am. J. Physiol. Gastromtest. Liver Physiol, 287: 497-502.
62. McHutchison, J.G, 2004. Understanding hepatitis C Am. J. Manage. Care, 10: S21-S29.
63. Meyer, S.A. and A.P. Kulkarni, 2001. Hepatotoxicity. In: Introduction to Biochemical Toxicology, Hodgson, E. and R.C. Smart (Eds.), 3rd Edn, John Wiley and Sons, New York, ISBN: 0471333344, pp: 487.
64. Mocroft, A, V. Soriano, J. Rockstroh, P. Reiss and O. Kirk et al., 2005. Is there evidence for an increase in the death rate from liver-related disease in patients with HIV. AIDS, 19: 2117-2125.
65. Nigam, P.K, 2007. Biochemical markers of myocardial injury. Indian J. Clin. Biochem, 22: 10-17.
66. Novosyadlyy, R, R. Dargel and J.G. Scharf, 2005. Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. Growth Horm. IGF Res, 15: 313-323.
67. Padmanabhan, M, M. Rajadurai and P.S.M. Prince, 2005. Effect of aegle marmelos leaf extract and-tocopherol on lipid peroxidation and antioxidants in isoproterenol induced myocardial infarction in rats. Cardiology, 1: 40-45.
68. Perez, M.J, A. Suarez, J.A. Gomez-Cap ill a, F. Sanchez-Medina and A. Gil, 2002. Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats. J. Nutr, 132: 652-657.
69. Pimentel, L, 2003. Scurvy: Historical review and current diagnostic approach. Am. J. Emerg. Med, 21: 328-332.
70. Pinzani, M. and F. Vizzutti, 2008. Fibrosis and cirrhosis reversibility: Clinical features and implications. Clin. Liver Dis, 12: 901-913.
71. Pinzani, M, 2000. Liver fibrosis. Springer Semin. Immunopathol, 21: 475-490.
72. Poynard, T., M.F. Yuen, V. Ratzm and C.L. Lai, 2003. Viral hepatitis C. Lancet, 362: 2095-2100.
73. Rafatullah, S., J.S. Mossa, A.M. Ageel, M.A. Al-Yahya and M. Tariq, 1991. Hepatoprotective and safety evaluation studies on Sarsaparilla. Int. J. Pharmacol., 29: 296-300.
74. Rahman, T.M. and H.J. Hodgson, 2003. The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. J. Hepatol., 38: 583-590.
75. Ramachandran, P. and J.P. Iredale, 2009. Reversibility of liver fibrosis. Ann. Hepatol., 8: 283-291.
76. Rao, M.G., C.V. Rao, P. Pushpangadan and A. Shirwaikar, 2006. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J. Ethnopharmacol., 103: 484-490.
77. Saile, B., N. Matthes, K. Neubauer, C. Eisenbach, H. El-Armouche, J. Dudas and G. Ramadori, 2002. Rat liver myofibroblasts and hepatic stellate cells differ in CD95-mediated apoptosis and response to TNF-alpha. Am. J. Physiol. Gastromtest. Liver Physiol., 283: G435-G444.
78. Salah, S.H., H.S. Abdou and E.A.A. Rahim, 2009. Modulatory effect of vitamins A, C and E mixtures against tefluthrin pesticide genotoxicity in rats. Res. J. Agric. Biol. Sci., 5: 1070-1078.
79. Saleem, M.T.S, CM. Chetty, S. Ramkanth, V.S.T. Rajan, K.M. Kumar and K. Gauthaman, 2010. Hepatoprotective herbs: A review. Int. J. Res. Pharm. Sci., 1: 1-5.
80. Seghrouchni, I., J. Drai, E. Bannier, J. Riviere and P. Calmard et al., 2002. Oxidative stress parameters in type 1, type 2 and insulin-retreated type 2 diabetes mellitus: Insulin treatment efficiency. Clin. Chim. Acta, 321: 89-96.
81. Sehrawat, A., T.H. Khan, L. Prasad, S. Sultana, 2006. Butea monosperma and chemomodulation: Protective role against thioacetamide-mediated hepatic alterations in Wistar rats. Phytomed., 13: 157-163.
82. Sharma, V.K., R.A. Rendom, F.J. Millero and F.G. Vasquez, 2000. Oxidation of thioacetamide by ferrate (VI). Mar. Chem, 70: 235-242.
83. Smirnoff, N. and G.L. Wheeler, 2000. Ascorbic acid in plants: Biosynthesis and function. Crit. Rev. Biochem. Mol. Biol., 19: 267-290.
84. Spataru, N., Spataru T. and A. Fujishima, 2005. Voltammetric determination of thiourea at conductive diamond electrodes. Electro analysis, 17: 800-805.
85. Spira, G., N. Mawasi, M. Paizi, N. Anbmder, O. Genma, R. Alexiev and M. Pines, 2002. Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats. J. Hepatol., 37: 331-339.
86. Stengel, V., S. Bakardjieva, N. Murafa, V. Houskova and K. Lang, 2008. Visible-light photo catalytic activity of Ti02/ZnS nanocomposites prepared by homogeneous hydrolysis. Micropor. Mesopor. Mat., 110: 370-378.
87. Takahara, Y., M. Takahashi, H. Wagatsuma, F. Yokoya and Q.W. Zhang et al., 2006. Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. World J. Gastroenterol., 12: 6473-6499.
88. Trennery, P.N. and R.H. Waring, 1983. Early changes in thioacetamide-induced liver damage. Toxicol. Lett., 19: 299-307.
89. Tripathi, B.K., S. Srivastava, R. Rastogi, D. Rania, V.J. Ram and A.K. Srivastava, 2003. Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats. Acta Pharm., 53: 91-100.
90. Tunez, I., M.C. Munoz, M.A. ViUavivicencio, F.J. Medina and E.P. Prado et a/., 2005. Hepato- and neurotoxicity induced by thioacetamide: Protective effects of melatonin and dimethylsulfoxide. Pharmacol. Res., 52: 223-228.
91. Von Szent-Gyorgyi, A., 2005. Biography: The nobel prize in physiology or medicine 1937. The Nobel Foundation, http://nobelprize.org/medicine/laureates/1937/szent-gyorgyi-bio.html.
92. Wang, T., K. Shankar, M.J.J. Ronis and H.M. Mehendale, 2000. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J. Pharmacol. Exp. Ther., 294: 473-479.
93. Weber, R., CA. Sabin, N. Frns-Moller, P. Reiss and W.M. El-Sadr et al, 2006. Liver-related deaths in persons infected with the human immunodeficiency virus: The D:A:D study. Arch. Intern. Med., 166: 1632-1641.
94. Yeh, C.N., A. Maitra, K.F. Lee, Y.Y. Jan and M.F. Chen, 2004. Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: An animal model recapitulating the multi-stage progression of human cholangiocarcinoma. Carcinogenesis, 25: 631-636.
95. Yoon, Y.H., H.Y. Yi and M.E. Hilton, 2005. Liver Cirrhosis Mortality in the United States, 1970-2002. NIAAA, USA.
96. Zaleska, A., P. Gorska, J.W. Sobczak and J. Hupka, 2007. Thioacetamide and thiourea impact on visible light activity of Ti02. Applied Catal. B: Environ., 76: 1-8.