Role of hepatic nitric oxide synthases in rats with thioacetamide-induced acute liver failure and encephalopathy

Journal of the Chinese Medical Association

Volumn 70, Issue 1, 2007, Pages 16-23

  Huang, Hui Chun ^a,c   Wang, Sun Sang ^b,c   Chan, Cho Yu ^a,c   Chen, Yi Chou ^a   Lee, Fa Yauh ^a,c   Chang, Full Young ^a,c   Chu, Chi Jen ^a,c   Lin, Han Chieh ^a,c   Lu, Rei Hwa ^a   Lee, Shou Dong ^a,c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b Taipei Municipal Gan Dau Hospital   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Fulminant hepatic failure; Hepatic encephalopathy; Nitric oxide; Nitric oxide synthase; Thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; RNA; SODIUM CHLORIDE; THIOACETAMIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; HEPATIC ENCEPHALOPATHY; LIVER FAILURE; MALE; MEDICAL ASSESSMENT; MOTOR ACTIVITY; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

EID: 33846870537     PISSN: 17264901     EISSN: 17287731     Source Type: Journal    
DOI: 10.1016/S1726-4901(09)70295-3     Document Type: Article

References (37)

1. Mousseau DD, Butterworth RF. Current theories on the pathogenesis of hepatic encephalopathy. Proc Soc Exp Biol Med 1994;206:329-44.
2. Hortelano S, Genaro AM, Bosca L. Phorbol esters induce nitric oxide synthase activity in rat hepatocytes. J Biol Chem 1992;267:24937-40.
3. Janigro D, West GA, Nguyen TS, Winn HR. Regulation of blood-brain barrier endothelial cells by nitric oxide. Circ Res 1994;75:528-38.
4. Master S, Gottstein J, Blei AT. Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology 1999;30:876-80.
5. Pannen BH, Al-Adili F, Bauer M, Clemens MG, Geiger KK. Role of endothelins and nitric oxide in hepatic reperfusion injury in the rat. Hepatology 1998;27:755-64.
6. Mannick JB, Asano K, Izumi K, Kieff E, Stamler JS. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 1994;79:1137-46.
7. Ferraresso M, Burra P, Cadrobbi R, Calabrese F, Pettenazzo E, Sarzo G, Parnigotto A, et al. Protective effect of L-arginine on liver ischemia-reperfusion injury. Transplant Proc 1997;29:393-4.
8. Minnard EA, Shou J, Naama H, Cech A, Gallagher H, Daly JM. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch Surg 1994;129:142-8.
9. Milosevic N, Schawalder H, Maier P. Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. Eur J Pharmacol 1999;368:75-87.
10. Wahl SM, McCartney-Francis N, Chan J, Dionne R, Ta L, Orenstein JM. Nitric oxide in experimental joint inflammation. Benefit or detriment? Cells Tissues Organs 2003;174:26-33.
11. Gardner CR, Heck DE, Yang CS, Thomas PE, Zhang XJ, DeGeorge GL, Laskin JD, et al. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 1998;27:748-54.
12. Chu CJ, Wang SS, Lee FY, Chang FY, Lin HC, Hou MC, Chan CC. Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. Eur J Clin Invest 2001;31:156-63.
13. Gammal SH, Basile AS, Geller D, Skolnick P, Jones EA. Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. Hepatology 1990;11:371-8.
14. Ribeiro J, Nordlinger B, Ballet F, Cynober L, Coudray-Lucas C, Baudrimont M, Legendre C, et al. Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacavalshunted rats. Hepatology 1992;15:12-8.
15. Tanoue K, Ohta M, Tarnawski AS, Wahlstrom KJ, Sugimachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996;110:549-57.
16. Ohta M, Tarnawski AS, Itani R, Pai R, Tomikawa M, Sugimachi K, Sarfeh IJ. Tumor necrosis factor a regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats. Hepatology 1998;27:906-13.
17. Morales-Ruiz M, Jimenez W, Perez-Sala D, Ros J, Leivas A, Lamas S, Rivera F, et al. Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. Hepatology 1996;24:1481-6.
18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
19. ω-nitro-L-arginine administration corrects peripheral vasodilatation and systemic capillary hypotension and ameliorates plasma volume expansion and sodium retention in portal hypertensive rats. Hepatology 1993;17:84-90.
20. Groszmann RJ. Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 1994;20:1359-63.
21. Lockwood AH, Yap EW, Wong WH. Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J Cerebr Blood F Met 1991;11: 337-41.
22. Larsen FS, Knudsen GM, Paulson OB, Vilstrup H. Cerebral blood flow autoregulation is absent in rats with fulminant hepatic failure. J Hepatol 1994;21:491-5.
23. Agarwal S, Kramer D, Yonas H, Obrist W, Kang Y, Martin M, Policare R. Cerebral hemodynamic changes in fulminant hepatic failure: a retrospective study. Hepatology 1994;19:80-7.
24. Lukivskaya O, Lis R, Zwierz K, Buko V. Effect of the nitric oxide donor and the nitric oxide synthase inhibitor on the liver of rats with chronic hepatitis induced by dimethylnitrosamine. Pol J Pharmacol 2004;56:599-604.
25. Cottart CH, Do L, Blanc MC, Vaubourdolle M, Descamps G, Durand D, Galen FX, et al. Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat. Hepatology 1999;29:809-13.
26. Nishida J, McCuskey RS, McDonnell D, Fox ES. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 1994;267:1135- 41.
27. Wang GS, Liu GT. Role of nitric oxide in immunological liver damage in mice. Biochem Pharmacol 1995;49:1277-81.
28. Vos TA, Gouw AS, Klok PA, Havinga R, van Goor H, Huitema S, Roelofsen H. Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology 1997;113:1323-33.
29. Kawachi S, Hines IN, Laroux FS, Hoffman J, Bharwani S, Gray L, Leffer D, et al. Nitric oxide synthase and post-ischemic liver injury. Biochem Biophy Res Co 2000;276:851-4.
30. Hines IN, Harada H, Bharwani S, Pavlick KP, Hoffman JM, Grisham MB. Enhanced post-ischemic liver injury in iNOS-deficient mice: a cautionary note. Biochem Biophy Res Co 2001; 284:972-6.
31. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995;81:641-50.
32. Isobe M, Katsuramaki T, Hirata K, Kimura H, Nagayama M, Matsuno T. Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver. Transplantation 1999;68:803-13.
33. Akahori M, Yamada S, Takeyama N, Tanaka T. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice. J Surg Res 1999;85:286-93.
34. Diez-Fernandez C, Sanz N, Alvarez AM, Zaragoza A, Cascales M. Influence of aminoguanidine on parameters of liver injury and regeneration induced in rats by a necrogenic dose of thioacetamide. Br J Pharmacol 1998;125:102-8.
35. Rahman TM, Hodgson HJ. The effects of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. J Hepatol 2003;38:583-90.
36. Szabo C, Ferrer-Sueta G, Zingarelli B, Southan G, Salzman AL, Radi R. Mercaptoethylguanine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 1997; 272:9030-6.
37. Rahman TM, Hodgson HJ. L-NAME and aminoguanidine (AMG)-selectivity and temporal differences in iNOS inhibition in a rat model of acute hepatic failure (AHF). J Hepatol 2000; 32:395.