Hepatoprotective activity of Silybum marianum and Cichorium intybus against thioacetamide in rat

Pakistan Journal of Nutrition

Volumn 7, Issue 1, 2008, Pages 172-176

  Madani, H ^a   Talebolhosseini, M ^a   Asgary, S ^a   Naderi, G H ^a  

^a UNIVERSITY OF ISFAHAN   (Iran)

Author keywords

Antioxidants; Cichorium intybus; Hepatoprotective; Polyphenolic compounds; Silybum marianum; Thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHICORY EXTRACT; FLAVONOID; PLANT EXTRACT; POLYPHENOL DERIVATIVE; POTASSIUM ION; SILYBUM MARIANUM EXTRACT; SODIUM ION; THIOACETAMIDE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CHICORY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; POTASSIUM BLOOD LEVEL; RAT; SILYBUM MARIANUM; SODIUM BLOOD LEVEL; STATISTICAL SIGNIFICANCE;

CICHORIUM INTYBUS; RATTUS; SILYBUM MARIANUM;

EID: 38049127161     PISSN: 16805194     EISSN: None     Source Type: Journal    
DOI: 10.3923/pjn.2008.172.176     Document Type: Article

References (27)

1. Amad, A., K.K. Pillai, A.K. Najmi and S.N. Pal, 2002. Evaluation of hepatoprotective potential of jigrine post-treatment against thioacetamide induced hepatic damage. J. Ethnopharmacol., 79: 35-41.
2. Baer-Dubowska, W., H. Szaefer and V. Krajka-Kuzniak, 1998. Inhibition of murin hepatic cytochrom P450 activities by natural and synthetic phenolic compounds. Xenobiotica, 28: 735-743.
3. Bruck, R., R. Hershkoviz, O. Lider, H. Aeed, L. Zaidel, Z. Matas, J. Barg and Z. Halpern, 1996. Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated Arg-Gly-Asp epitope. J. Hepatol., 24: 731-738.
4. Chattopadhyay, R.R., 2003. Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract:part II. J. Ethnopharmacol., 89: 217-219.
5. Diez-Fernandez, C., N. Sanz and M. Cascales, 1996. Intracellularcalcium concentration in hepatocytes from thioacetamide-treated rats. J. Hepatol., 24: 460-467.
6. Gazzani, G., M. Daglia, A. Papetti and C. Gregotti, 1999. In vitro and ex vitro anti- and prooxidant compoents of Cichorium intybus. J. Pharmaceutical and Biochemical analysis, 23: 127-133.
7. 4-induced hepatotoxicity in rodents. Fitoterapia, 73: 557-564.
8. Jeong, T.C., H.K. Gu, J. Park, H. Yun, H.C. Kim, C. Su Ha and J.K. Roh, 1999. Pretreatment of male BALB/c mice -ionone potentiates thioacetamide-induced hepatotoxicity. Toxicol. Letters, 105: 39-46.
9. Jeong, H.G., H.J. You, S.J. Park, A. Moon, Y.C. Chung, S.K. Kang and H.K. Chun, 2002. Hepatoprotective effects of 18 -glycerrheinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome P450 2E1 expression. Pharmacological Res., 46: 221-227.
10. Kim, K.H., J.H. Bae, S.W. Cha and S.S. Han, 2000. Role of metabolic activation by cytochorome P450 in thioacetamide-induced suppression of antibody response in male BALB/C mice. Toxicol. Letters, 114: 225-235.
11. Marja, P.K., I.H. Anu, J.V. Heikki, R. Jussi-Pekka, P. Kalevi, S.K. Tytti and H. Marina, 1999. Antioxidant activity of plant extracts containing phenolic compounds. J. Agri. Food Chem., 47: 3945-3962.
12. Mitra, S.K., M.V. Venkataranganna, R. Sundaram and S. Gopumadhavan, 1998. Protective effect of HD-03, a herbal formulatin, against various hepatotoxic agents in rats. J. Ethnopharmacol., 63: 181-186.
13. 4 liver damage. J. Appl. Toxicol., 10: 275-279.
14. Muriel, P., T. Garciapina, V. Perez-Alvarez and M. Mourelle, 1992. Silymarine protects against paracetamol-induced lipid peroxidation and liver damage. J. Appl. Toxicol., 73: 439-442.
15. Papetti, A., M. Daglia and G. Gazzani, 2002. Anti-and prooxidant activity of water soluble compounds in Cichorium intybus var. Silvestre. J. Pharmaceutical and Biomedical Analysis, 30: 939-945.
16. Pyo, Y.H., T.C. Lee, L., Logendra and R.T. Rosen, 2004. Antioxidant activity and phenolic compounds of Swiss chard (Beta vulgaris subspecies cycla) extracts. Food Chem., 85: 19-26.
17. Quaglia, M.G., E. Bossu, E. Donati, G. Mazzanti and A. Brandt, 1999. Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatograghy and capillary electrophoresis. J. Pharmaceutical and Biomedical Analysis, 19: 435-442.
18. Sakihama, Y., M.F. Cohen, S.C. Grace and H. Yamasaki, 2002. Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicol., 177: 67-80.
19. Sallie, R., J.M. Tredger and R. William, 1991. Drug and the liver. Biopharmaeutical Drug Disposition, 12: 251-259.
20. Sanz, N., C.D. Fernandez, L.F. Simon, A. Alvarez and M. Cascales, 1998. Necrogenic and regenerative responses of liver newly weaned rats against a sublethal dose of thioacetamide. Biochemica et Biophysica Acta, 1384: 66-78.
21. Schuppan, D., J. Jia, B. Brikhaus and E.G. Hahn, 1999. Herbal products for liver disease: A therapeutic challenge for the new millennium. Heatol., 30: 1099-1104.
22. Sun, F., 2000. Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver. Biochimica et Biophysica Acta, 1500: 181-185.
23. Vogel, G., B. Tuchweber, W. Trost and U. Mengs, 1984. Protection by silybinin against Amanita phalloides intoxication in beagles. Toxicol. Appl. Pharmacol., 73: 355-363.
24. Wagner, H., P. Diesel and M. Seitz, 1974. The chemistry and analysis of silymarin from Silybum marianum Gaertn. Arzneimittelforsch, 24: 466-474.
25. Zafar, R. and S. Mujahid Ali, 1998. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J. Ethnopharmacol., 63: 227-231.
26. Zaragoza, A., D. Andres, D. Sarrion and M. Cascales, 2000. Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats, inducibility of FAD monooxygenase system and age effect. Chemico-Biological Interactions. 124: 87-101.
27. Zix, M.H. and R. Agarwal, 1997. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin. Biochm. Biophys. Res. Commun., 239: 334-339.