ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Hong, Chen Jee ^a,b   Tsai, Pei Jane ^c   Cheng, Chih Ya ^a   Chou, Chuan Kai ^d   Jheng, Huei Fen ^c   Chuang, You Chung ^e   Yang, Chia Ning ^e   Lin, Ya Tzu ^a   Hsu, Chih Wei ^a   Cheng, Irene H ^a   Chen, Shiow Yi ^f   Tsai, Shih Jen ^a,b   Liou, Ying Jay ^a,b   Tsai, Yau Sheng ^c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL APPLIED RESEARCH LABORATORIES   (Taiwan)

^e NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

^f NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA; LEPTIN; LEPTIN RECEPTOR; NUCLEAR FACTOR Y; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MUTAGENESIS; CHROMOSOME 6; CHROMOSOME MAP; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSLIPIDEMIA; ENERGY BALANCE; EXON; FATTY LIVER; FEMALE; GENE MUTATION; GENETIC LINKAGE; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPERPHAGIA; HYPOTHALAMUS; INSULIN RESISTANCE; MALE; MORBID OBESITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; WEIGHT GAIN; WILD TYPE; ANIMAL; BODY WEIGHT; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; HUMAN; HYPERINSULINISM; METABOLISM; MOLECULAR EVOLUTION; MUTAGENESIS; MUTATION;

MAMMALIA; MUS;

ANIMALS; BODY WEIGHT; ETHYLNITROSOUREA; EVOLUTION, MOLECULAR; EXONS; GENETIC PREDISPOSITION TO DISEASE; HOMOZYGOTE; HUMANS; HYPERINSULINISM; LEPTIN; MICE; MUTAGENESIS; MUTATION; OBESITY, MORBID; RECEPTORS, LEPTIN;

EID: 78650114598     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015333     Document Type: Article

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