Different radiosensitivity of CD4+CD25+ regulatory T cells and effector T cells to low dose gamma irradiation in vitro

International Journal of Radiation Biology

Volumn 87, Issue 1, 2011, Pages 71-80

  Cao, Mengde ^a   Cabrera, Roniel ^a   Xu, Yiling ^a   Liu, Chen ^b   Nelson, David ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

apoptosis; gamma irradiation; hepatocellular carcinoma; radiosensitivity; regulatory T cells

Indexed keywords

CASPASE 3; CELL PROTEIN; CYTOKINE; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN BAX; THYMIDINE; TRITIUM;

ADVANCED CANCER; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; EFFECTOR CELL; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; GAMMA IRRADIATION; GAMMA RADIATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; T LYMPHOCYTE ACTIVATION; UPREGULATION;

AGED; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; LIVER NEOPLASMS; MALE; MIDDLE AGED; RADIATION TOLERANCE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 78650080854     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2010.518208     Document Type: Article

References (49)

1. Belka C, Ottinger H, Kreuzfelder E, Weinmann M, Lindemann M, Lepple-Wienhues A, et al. 1999. Impact of localized radiotherapy on blood immune cells counts and function in humans. Radiotherapy & Oncology 50:199-204. (Pubitemid 29155546)
2. Cao MD, Chen ZD, Xing Y. 2004. Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reaction. Cell Biology International 28:223-228. (Pubitemid 38230233)
3. + regulatory T cells. Laboratory Investigation 87:582-590. (Pubitemid 46788787)
4. + regulatory T cells. Cell Biology International 33:565-571.
5. Cole S. 1986. Long-term effects of local ionizing radiation treatment on Langerhans cells in mouse footpad epidermis. Journal of Investigative Dermatology 87:608-612. (Pubitemid 17178891)
6. Dobbs HJ, Barrett A, Rostom AY, Peckham MJ. 1981. Total-body irradiation in advanced non-Hodgkin's lymphoma. British Journal of Radiology 54:878-881. (Pubitemid 11020409)
7. Dunn PL, North RJ. 1991. Selective radiation resistance of immunologically induced T cells as the basis for irradiationinduced T-cell-mediated regression of immunogenic tumor. Journal of Leukocyte Biology 49:388-396.
8. Earnshaw WC, Martins LM, Kaufmann SH. 1999. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annunal Review of Biochemistry 68:383-324.
9. Finkel T. 1998. Oxygen radicals and signaling. Current Opinion in Cell Biology 10:248-253. (Pubitemid 28174767)
10. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR. 1999. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. Journal of Biological Chemistry 274:2225-2233.
11. Gross A, McDonnell JM, Korsmeyer SJ. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes & Development 13:1899-1911. (Pubitemid 29407357)
12. Harris MH, Thompson CB. 2000. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death and Differentiation 7:1182-1191. (Pubitemid 32042225)
13. Hashimoto S, Shirato H, Hosokawa M, Nishioka T, Kuramitsu Y, Matushita K, et al. 1999. The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats. Radiation Research 151:717-724. (Pubitemid 29252560)
14. James RF, Lake SP, Chamberlain J, Thirdborough S, Bassett PD, Mistry N, et al. 1989. Gamma irradiation of isolated rat islets pretransplantation produces indefinite allograft survival in cyclosporine-treated recipients. Transplantation 47:929-933. (Pubitemid 19161821)
15. Jin SZ, Pan XN, Wu N, Jin GH, Liu SZ. 2007. Whole-body low dose irradiation promotes the efficacy of conventional radiotherapy for cancer and possible mechanisms. Dose Response 5:349-358.
16. Jonathan EC, Bernhard EJ, McKenna WG. 1999. How does radiation kill cells? Current Opinion in Chemical Biology 3:77-83. (Pubitemid 29118984)
17. + regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immunity 2:1.
18. Jung MY, Kang HJ, Moon A. 2001. Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Letters 165:139-145. (Pubitemid 32244170)
19. Kasid U, Suy S, Dent P, Ray S, Whiteside TL, Sturgill TW. 1996. Activation of Raf by ionizing radiation. Nature 382:813-816. (Pubitemid 26299565)
20. Kipnis J, Avidan H, Markovich Y, Mizrahi T, Hauben E, Prigozhina TB, et al. 2004. Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells. European Journal of Neuroscience 19:1191-1198. (Pubitemid 38387196)
21. Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. 1997. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. Journal of Biological Chemistry 272:17810-17814. (Pubitemid 27311222)
22. + T-cell depletion. Cancer Research 63:8384-8392. (Pubitemid 37549493)
23. Lin CC, Wang TE, Liu CY, Lin CP, Liu TP, Chen MJ, et al. 2008. Potentiation of the immunotherapeutic effect of autologous dendritic cells by pretreating hepatocellular carcinoma with low-dose radiation. Clinical and Investigative Medicine 31:E150-159.
24. Liu R, Xiong S, Zhang L, Chu Y. 2010. Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells. Cellular & Molecular Immunology 7:157-162.
25. Liu SZ. 2007. Cancer control related to stimulation of immunity by low-dose radiation. Dose Response 5:39-47.
26. Liu SZ, Jin SZ, Liu XD, Sun YM. 2001. Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiationinduced immune changes. BMC Immunology 2:8.
27. McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, et al. 2004. A sense of danger from radiation. Radiation Research 162:1-19. (Pubitemid 39044714)
28. Merrick A, Errington F, Milward K, O'Donnell D, Harrington K, Bateman A, et al. 2005. Immunosuppressive effects of radiation on human dendritic cells: Reduced IL-12 production on activation and impairment of naive T-cell priming. British Journal of Cancer 92:1450-1458. (Pubitemid 40705012)
29. Miller GM, Kim DW, Andres ML, Green LM, Gridley DS. 2003. Changes in the activation and reconstitution of lymphocytes resulting from total-body irradiation correlate with slowed tumor growth. Oncology 65:229-241. (Pubitemid 37505831)
30. North RJ. 1984. Gamma-irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells. Cancer Immunology, Immunotherapy 16:175-181. (Pubitemid 14136526)
31. North RJ. 1986. Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells. Journal of Experimental Medicine 164:1652-1666. (Pubitemid 17184195)
32. Porter AG, Jänicke RU. 1999. Emerging roles of caspase-3 in apoptosis. Cell Death & Differentiation 6:99-104. (Pubitemid 29082297)
33. +Foxp3+ T cells in mice. Radiation Research 173:148-157.
34. Reuben JM, Korbling M, Gao H, Lee BN. 2004. The effect of low dose gamma irradiation on the differentiation and maturation of monocyte derived dendritic cells. Journal of Gravitational Physiology 11:P49-52.
35. Rho HS, Park SS, Lee CE. 2004. Gamma irradiation up-regulates expression of B cell differentiation molecule CD23 by NFkappaB activation. Journal of Biochemistry and Molecular Biology 37:507-514.
36. Richaud PM, Soubeyran P, Eghbali H, Chacon B, Marit G, Broustet A, et al. 1998. Place of low-dose total body irradiation in the treatment of localized follicular non-Hodgkin's lymphoma: Results of a pilot study. International Journal of Radiation Oncology, Biology, Physics 40:387-390. (Pubitemid 28114384)
37. Roses RE, Xu M, Koski GK, Czerniecki BJ. 2008. Radiation therapy and Toll-like receptor signaling: Implications for the treatment of cancer. Oncogene 27:200-207.
38. Safwat A. 2000a. The immunobiology of low-dose total-body irradiation: More questions than answers. Radiation Research 153(5 Pt 1):599-604. (Pubitemid 30252609)
39. Safwat A. 2000b. The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: A new look at an old method. Radiotherapy & Oncology 56:1-8. (Pubitemid 30408379)
40. Safwat A, Schmidt H, Bastholt L, Fode K, Larsen S, Aggerholm N, et al. 2005. A phase II trial of low-dose total body irradiation and subcutaneous Interleukin-2 in metastatic melanoma. Radiotherapy & Oncology 77:143-147. (Pubitemid 41682379)
41. Schü tze S, Tchikov V, Schneider-Brachert W. 2008. Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nature Reviews. Molecular Cell Biology 9:655-662. (Pubitemid 352032925)
42. Scott BR. 2008. Low-dose-radiation stimulated natural chemical and biological protection against lung cancer. Dose Response 6:299-318.
43. Shan YX, Jin SZ, Liu XD, Liu Y, Liu SZ. 2007. Ionizing radiation stimulates secretion of pro-inflammatory cytokines: Doseresponse relationship, mechanisms and implications. Radiation and Environmental Biophysics 46:21-29. (Pubitemid 46354798)
44. Shankar B, Premachandran S, Bharambe SD, Sundaresan P, Sainis KB. 1999. Modification of immune response by low dose ionizing radiation: Role of apoptosis. Immunology Letters 68:237-245. (Pubitemid 29301882)
45. +CD4+ T cells: A common basis between tumor immunity and autoimmunity. Journal of Immunology 163:5211-5218.
46. + regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes. Journal of Immunotherapy 25:207-217. (Pubitemid 34533310)
47. Wasserman J, Blomgren H, Rotstein S, Petrini B, Hammarström S. 1989. Immunosuppression in irradiated breast cancer patients: In vitro effect of cyclooxygenase inhibitors. Bulletin of the New York Academy of Medicine 65:36-44. (Pubitemid 19065026)
48. Wing K, Fehervari Z, Sakaguchi S. 2006. Emerging possibilities in the development and function of regulatory T cells. International Immunology 18:991-1000. (Pubitemid 43923419)
49. Zou W. 2006. Regulatory T cells, tumour immunity and immunotherapy. Nature Reviews. Immunology 6:295-307.