Immunosuppressive effects of radiation on human dendritic cells: Reduced IL-12 production on activation and impairment of naïve T-cell priming

British Journal of Cancer

Volumn 92, Issue 8, 2005, Pages 1450-1458

  Merrick, A ^a   Errington, F ^a   Milward, K ^a   O'Donnell, D ^a   Harrington, K ^b   Bateman, A ^c   Pandha, H ^d   Vile, R ^e   Morrison, E ^a   Selby, P ^a   Melcher, A ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e MAYO CLINIC   (United States)

Author keywords

Cytokines; Cytotoxic T cells; Immunotherapy; Interleukin 12

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DENDRITIC CELL; EFFECTOR CELL; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IONIZING RADIATION; MIXED LYMPHOCYTE REACTION; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; RADIATION RESPONSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOSUPPRESSION; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; PHENOTYPE; T-LYMPHOCYTES;

EID: 21044443288     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602518     Document Type: Article

References (40)

1. Anton D, Dabadghao S, Palucka K, Holm G, Yi Q (1998) Generation of dendritic cells from peripheral blood adherent cells in medium with human serum. Scand J Immunol 47: 116-121
2. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252
3. Cao MD, Chen ZD, Xing Y (2004) Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reaction. Cell Biol Int 28: 223-228
4. Celluzzi CM, Falo LD (1998) Physical interaction between dendritic cells and tumour cells results in an immunogen that induces protective and therapeutic tumour rejection. J Immunol 160: 3081-3085
5. Chakravarty PK, Alfieri A, Thomas EK, Beri V, Tanaka KE, Vikram B, Guha C (1999) Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer. Cancer Res 59: 6028-6032
6. Clerici M, Shearer GM, Clerici E (1998) Cytokine dysregulation in invasive cervical carcinoma and other human neoplasias: time to consider the TH1/TH2 paradigm. J Natl Cancer Inst 90: 261-263
7. Cohen-Jonathan E, Bernhard EJ, McKenna WG (1999) How does radiation kill cells? Curr Opin Chem Biol 3: 77-S3
8. De Vries IJ, Krooshoop DJ, Scharenborg NM, Lesterhuis WJ, Diepstra JH, Van Muijen GN, Strijk SP, Ruers TJ, Boerman OC, Oyen WJ, Adema GJ, Punt CJ, Figdor CG (2003) Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res 63: 12-17
9. Denfeld RW, Hara H, Tesmann JP, Martin S, Simon JC (2001) UVB-irradiated dendritic cells are impaired in their APC function and tolerize primed Th1 cells but not naive CD4+ T cells. J Leukoc Biol 69: 548-554
10. Fields RC, Shimizu K, Mule JJ (1998) Murine dendritic cells pulsed with whole tumour lysates mediate potent antitumour immune responses in vitro and in vivo. Proc Natl Acad Sci USA 95: 9482-9487
11. Gattoni-Celli S, Cole DJ (1996) Melanoma-associated tumour antigens and their clinical relevance to immunotherapy. Semin Oncol 23: 754-758
12. Gong J, Chen D, Kashiwaba M, Kufe D (1997) Induction of antitumour activity by immunization with fusions of dendritic and carcinoma cells. Nat Med 3: 558-561
13. Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S (2002) Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20: 621-667
14. Ho WY, Blattman JN, Dossett ML, Yee C, Greenberg PD (2003) Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction. Cancer Cell 3: 431-437
15. Illidge TM (1998) Radiation-induced apoptosis. Clin Oncol (R Coll Radiol) 10: 3-13
16. Jonuleit H, Giesecke A, Kandemir A, Paragnik L, Knop J, Enk AH (2000) Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells. Arch Dermatol Res 292: 325-332
17. Jung M, Dritschilo A (2001) NF-kappa B signaling pathway as a target for human tumor radiosensitization. Semin Radiat Oncol 11: 346-351
18. Lappin MB, Campbell JD (2000) The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy. Blood Rev 14: 228-239
19. Liao YP, Wang CC, Butterfield LH, Economou JS, Ribas A, Meng WS, Iwamoto KS, McBride WH (2004) Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells. J Immunol 173: 2462-2469
20. McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP (2004) A sense of danger from radiation. Radiat Res 162: 1-19
21. Melcher A, Bateman A, Harrington K, Ahmed A, Gough M, Vile R (2002) Dendritic cells for the immunotherapy of cancer. Clin Oncol (R Coll Radiol) 14: 185-192
22. Milas L, Mason KA, Ariga H, Hunter N, Neal R, Valdecanas D, Krieg AM, Whisnant JK (2004) CpG oligodeoxynucleotide enhances tumor response to radiation. Cancer Res 64: 5074-5077
23. Nakahara S, Tsunoda T, Baba T, Asabe S, Tahara H (2003) Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide. Cancer Res 63: 4112-4118
24. Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, Gabrilovich DI (1998) Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kB activation in haemopoietic progenitor cells. J Immunol 160: 1224-1232
25. Pettit AR, Quinn C, MacDonald KPA, Cavanagh LL, Thomas G, Townsend W, Handel M, Thomas R (1997) Nuclear localization of RelB is associated with effective antigen-presenting cell function. J Immunol 159: 3681-3691
26. Pickl WF, Majdic O, Kohl P, Stockl J, Riedl E, Scheinecker C, Bello-Fernandez C, Knapp W (1996) Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes. J Immunol 157: 3850-3859
27. Qi H, Denning TL, Soong L (2003) Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun 71: 3337-3342
28. Rescigno M, Granucci F, Citterio S, Foti M, Ricciardi-Castagnoli P (1999) Coordinated events during bacteria-induced DC maturation. Immunol Today 20: 200-203
29. Rescigno M, Winzler C, Delia D, Mutini C, Lutz M, Ricciardi-Castagnoli P (1997) Dendritic cell maturation is required for initiation of the immune response. J Leukoc Biol 61: 415-421
30. Romani N, Reider D, Heuer M, Ebner S, Kampgen E, Eibl B, Niederwieser D, Schuler G (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 196: 137-151
31. Schmitt DA, Ullrich SE (2000) Exposure to ultraviolet radiation causes dendritic cells/macrophages to secrete immune-suppressive IL-12p40 homodimers. J Immunol 165: 3162-3167
32. Schreiber E, Matthias P, Muller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17: 6419
33. Seite S, Zucchi H, Moyal D, Tison S, Compan D, Christiaens F, Gueniche A, Fourtanier A (2003) Alterations in human epidermal Langerhans cells by ultraviolet radiation: quantitative and morphological study. Br J Dermatol 148: 291-299
34. Simon JC, Hara H, Denfeld RW, Martin S (2002) UVB-irradiated dendritic cells induce nonproliferating, regulatory type T cells. Skin Pharmacol Appl Skin Physiol 15: 330-334
35. Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21: 685-711
36. Szmania S, Galloway A, Bruorton M, Musk P, Aubert G, Arthur A, Pyle H, Hensel N, Ta N, Lamb Jr L, Dodi T, Madrigal A, Barrett J, Henslee-Downey J, van Rhee F (2001) Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers. Blood 98: 505-512
37. Teitz-Tennenbaum S, Li Q, Rynkiewicz S, Ito F, Davis MA, McGinn CJ, Chang AE (2003) Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res 63: 8466-8475
38. Timmerman JM, Levy R (1999) Dendritic cell vaccines for cancer immunotherapy. Annu Rev Med 50: 507-529
39. Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3: 133-146
40. Yee C, Thompson JA, Roche P, Byrd DR, Lee PP, Piepkorn M, Kenyon K, Davis MM, Riddell SR, Greenberg PD (2000) Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo. J Exp Med 192: 1637-1644