-
1
-
-
17644364387
-
Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions
-
Roux F, Couraud PO. Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions. Cell Mol Neurobiol. 2005; 25: 41-58.
-
(2005)
Cell Mol Neurobiol
, vol.25
, pp. 41-58
-
-
Roux, F.1
Couraud, P.O.2
-
2
-
-
0042899083
-
Blood-brain barrier drug targeting: the future of brain drug development
-
; -, 51.
-
Pardridge WM. Blood-brain barrier drug targeting: the future of brain drug development. Mol Interv. 2003; 3: 90-105, 51.
-
(2003)
Mol Interv
, vol.3
, pp. 90-105
-
-
Pardridge, W.M.1
-
3
-
-
12344273726
-
The blood-brain barrier: bottleneck in brain drug development
-
Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005; 2: 3-14.
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
4
-
-
34547645047
-
Modelling of the blood-brain barrier in drug discovery and development
-
Cecchelli R, Berezowski V, Lundquist S, et al. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov. 2007; 6: 650-61.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 650-661
-
-
Cecchelli, R.1
Berezowski, V.2
Lundquist, S.3
-
5
-
-
34547637590
-
Drug targeting to the brain
-
Pardridge WM. Drug targeting to the brain. Pharm Res. 2007; 24: 1733-44.
-
(2007)
Pharm Res
, vol.24
, pp. 1733-1744
-
-
Pardridge, W.M.1
-
6
-
-
55749084894
-
Breaching the barrier
-
Dove A. Breaching the barrier. Nat Biotechnol. 2008; 26: 1213-5.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1213-1215
-
-
Dove, A.1
-
7
-
-
40849085422
-
Identification and design of peptides as a new drug delivery system for the brain
-
Demeule M, Regina A, Che C, et al. Identification and design of peptides as a new drug delivery system for the brain. J Pharmacol Exp Ther. 2008; 324: 1064-72.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 1064-1072
-
-
Demeule, M.1
Regina, A.2
Che, C.3
-
8
-
-
48749095941
-
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
-
Demeule M, Currie JC, Bertrand Y, et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J Neurochem. 2008; 106: 1534-44.
-
(2008)
J Neurochem
, vol.106
, pp. 1534-1544
-
-
Demeule, M.1
Currie, J.C.2
Bertrand, Y.3
-
10
-
-
33846007667
-
Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing
-
Mahley RW, Huang Y. Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing. J Clin Invest. 2007; 117: 94-8.
-
(2007)
J Clin Invest
, vol.117
, pp. 94-98
-
-
Mahley, R.W.1
Huang, Y.2
-
11
-
-
59649103200
-
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
-
Zhang C, An J, Strickland DK, et al. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol. 2009; 174: 586-94.
-
(2009)
Am J Pathol
, vol.174
, pp. 586-594
-
-
Zhang, C.1
An, J.2
Strickland, D.K.3
-
12
-
-
38349026548
-
Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
-
Wilhelmus MM, Otte-Holler I, Van Triel JJ, et al. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. Am J Pathol. 2007; 171: 1989-99.
-
(2007)
Am J Pathol
, vol.171
, pp. 1989-1999
-
-
Wilhelmus, M.M.1
Otte-Holler, I.2
Van Triel, J.J.3
-
13
-
-
0034836428
-
LRP: a multifunctional scavenger and signaling receptor
-
Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest. 2001; 108: 779-84.
-
(2001)
J Clin Invest
, vol.108
, pp. 779-784
-
-
Herz, J.1
Strickland, D.K.2
-
14
-
-
0024449363
-
The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein
-
Beisiegel U, Weber W, Ihrke G, et al. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature. 1989; 341: 162-4.
-
(1989)
Nature.
, vol.341
, pp. 162-164
-
-
Beisiegel, U.1
Weber, W.2
Ihrke, G.3
-
15
-
-
0025080835
-
Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor
-
Strickland DK, Ashcom JD, Williams S, et al. Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 1990; 265: 17401-4.
-
(1990)
J Biol Chem
, vol.265
, pp. 17401-17404
-
-
Strickland, D.K.1
Ashcom, J.D.2
Williams, S.3
-
16
-
-
51349102460
-
Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
-
Regina A, Demeule M, Che C, et al. Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. Br J Pharmacol. 2008; 155: 185-97.
-
(2008)
Br J Pharmacol.
, vol.155
, pp. 185-197
-
-
Regina, A.1
Demeule, M.2
Che, C.3
-
17
-
-
35548939476
-
In vivo time domain optical imaging of renal ischemia-reperfusion injury: discrimination based on fluorescence lifetime
-
Abulrob A, Brunette E, Slinn J, et al. In vivo time domain optical imaging of renal ischemia-reperfusion injury: discrimination based on fluorescence lifetime. Mol Imaging. 2007; 6: 304-14.
-
(2007)
Mol Imaging
, vol.6
, pp. 304-314
-
-
Abulrob, A.1
Brunette, E.2
Slinn, J.3
-
18
-
-
65249143425
-
Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging
-
Abulrob A, Brunette E, Slinn J, et al. Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging. Mol Imaging. 2008; 7: 248-62.
-
(2008)
Mol Imaging
, vol.7
, pp. 248-262
-
-
Abulrob, A.1
Brunette, E.2
Slinn, J.3
-
19
-
-
0034960962
-
Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice
-
Cisternino S, Rousselle C, Dagenais C, et al. Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice. Pharm Res. 2001; 18: 183-90.
-
(2001)
Pharm Res
, vol.18
, pp. 183-190
-
-
Cisternino, S.1
Rousselle, C.2
Dagenais, C.3
-
20
-
-
0033975029
-
Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice
-
Dagenais C, Rousselle C, Pollack GM, et al. Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice. J Cereb Blood Flow Metab. 2000; 20: 381-6.
-
(2000)
J Cereb Blood Flow Metab
, vol.20
, pp. 381-386
-
-
Dagenais, C.1
Rousselle, C.2
Pollack, G.M.3
-
21
-
-
54049120586
-
Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunocytochemical labeling
-
Pickering M, Pickering BW, Murphy KJ, et al. Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunocytochemical labeling. J Neurosci Methods. 2008; 173: 27-33.
-
(2008)
J Neurosci Methods
, vol.173
, pp. 27-33
-
-
Pickering, M.1
Pickering, B.W.2
Murphy, K.J.3
-
22
-
-
0032148360
-
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
-
Moestrup SK, Schousboe I, Jacobsen C, et al. beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin. J Clin Invest. 1998; 102: 902-9.
-
(1998)
J Clin Invest
, vol.102
, pp. 902-909
-
-
Moestrup, S.K.1
Schousboe, I.2
Jacobsen, C.3
-
23
-
-
51349102460
-
Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
-
Regina A, Demeule M, Che C, et al. Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2. Br J Pharmacol. 2008; 155: 185-97.
-
(2008)
Br J Pharmacol.
, vol.155
, pp. 185-197
-
-
Regina, A.1
Demeule, M.2
Che, C.3
-
24
-
-
0036721070
-
Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse
-
Banks WA, Goulet M, Rusche JR, et al. Differential transport of a secretin analog across the blood-brain and blood-cerebrospinal fluid barriers of the mouse. J Pharmacol Exp Ther. 2002; 302: 1062-9.
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 1062-1069
-
-
Banks, W.A.1
Goulet, M.2
Rusche, J.R.3
-
25
-
-
0021041669
-
The vascularization of the human cerebellar cortex
-
Duvernoy H, Delon S, Vannson JL. The vascularization of the human cerebellar cortex. Brain Res Bull. 1983; 11: 419-80.
-
(1983)
Brain Res Bull
, vol.11
, pp. 419-480
-
-
Duvernoy, H.1
Delon, S.2
Vannson, J.L.3
-
26
-
-
33750017850
-
Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier
-
Ito S, Ohtsuki S, Terasaki T. Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier. Neurosci Res. 2006; 56: 246-52.
-
(2006)
Neurosci Res
, vol.56
, pp. 246-252
-
-
Ito, S.1
Ohtsuki, S.2
Terasaki, T.3
-
27
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata M, Yamada S, Kumar SR, et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000; 106: 1489-99.
-
(2000)
J Clin Invest
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
-
28
-
-
0028298886
-
Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
-
Bu G, Maksymovitch EA, Nerbonne JM, et al. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J Biol Chem. 1994; 269: 18521-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 18521-18528
-
-
Bu, G.1
Maksymovitch, E.A.2
Nerbonne, J.M.3
-
29
-
-
34147143557
-
Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit
-
Polavarapu R, Gongora MC, Yi H, et al. Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood. 2007; 109: 3270-8.
-
(2007)
Blood
, vol.109
, pp. 3270-3278
-
-
Polavarapu, R.1
Gongora, M.C.2
Yi, H.3
-
30
-
-
0027374047
-
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions
-
Rebeck GW, Reiter JS, Strickland DK, et al. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. 1993; 11: 575-80.
-
(1993)
Neuron
, vol.11
, pp. 575-580
-
-
Rebeck, G.W.1
Reiter, J.S.2
Strickland, D.K.3
-
31
-
-
0029094357
-
Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain
-
Tooyama I, Kawamata T, Akiyama H, et al. Subcellular localization of the low density lipoprotein receptor-related protein (alpha 2-macroglobulin receptor) in human brain. Brain Res. 1995; 691: 235-8.
-
(1995)
Brain Res
, vol.691
, pp. 235-238
-
-
Tooyama, I.1
Kawamata, T.2
Akiyama, H.3
-
32
-
-
0026693345
-
Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain
-
Wolf BB, Lopes MB, VandenBerg SR, et al. Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am J Pathol. 1992; 141: 37-42.
-
(1992)
Am J Pathol
, vol.141
, pp. 37-42
-
-
Wolf, B.B.1
Lopes, M.B.2
VandenBerg, S.R.3
-
33
-
-
34547663157
-
GM1 ganglioside induces vasodilation and increases catalase content in the brain
-
Furian AF, Oliveira MS, Royes LF, et al. GM1 ganglioside induces vasodilation and increases catalase content in the brain. Free Radic Biol Med. 2007; 43: 924-32.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 924-932
-
-
Furian, A.F.1
Oliveira, M.S.2
Royes, L.F.3
-
34
-
-
12344273724
-
Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
-
Tsuji A. Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx. 2005; 2: 54-62.
-
(2005)
NeuroRx
, vol.2
, pp. 54-62
-
-
Tsuji, A.1
-
35
-
-
34948888151
-
Clearance of amyloid-beta by circulating lipoprotein receptors
-
Sagare A, Deane R, Bell RD, et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007; 13: 1029-31.
-
(2007)
Nat Med
, vol.13
, pp. 1029-1031
-
-
Sagare, A.1
Deane, R.2
Bell, R.D.3
-
37
-
-
60349087926
-
Taurine uptake across the human intestinal brush-border membrane is via two transporters: H(+)-coupled PAT1 (SLC36A1) and Na(+)- and Cl(-)-dependent TauT (SLC6A6)
-
Anderson CM, Howard A, Walters JR, et al. Taurine uptake across the human intestinal brush-border membrane is via two transporters: H(+)-coupled PAT1 (SLC36A1) and Na(+)- and Cl(-)-dependent TauT (SLC6A6). J Physiol. 2009; 587: 731-44.
-
(2009)
J Physiol
, vol.587
, pp. 731-744
-
-
Anderson, C.M.1
Howard, A.2
Walters, J.R.3
-
38
-
-
0035839647
-
Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes
-
Drain J, Bishop JR, Hajduk SL. Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes. J Biol Chem. 2001; 276: 30254-60.
-
(2001)
J Biol Chem
, vol.276
, pp. 30254-30260
-
-
Drain, J.1
Bishop, J.R.2
Hajduk, S.L.3
-
39
-
-
58049199498
-
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid {beta} peptides in an in vitro model of the blood-brain barrier cells
-
Yamada K, Hashimoto T, Yabuki C, et al. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid {beta} peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem. 2008; 283: 34554-62.
-
(2008)
J Biol Chem
, vol.283
, pp. 34554-34562
-
-
Yamada, K.1
Hashimoto, T.2
Yabuki, C.3
-
40
-
-
48749095941
-
Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
-
Demeule M, Currie JC, Bertrand Y, et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J Neurochem. 2008; 106: 1534-44.
-
(2008)
J Neurochem
, vol.106
, pp. 1534-1544
-
-
Demeule, M.1
Currie, J.C.2
Bertrand, Y.3
-
41
-
-
33845931332
-
Three complement-like repeats compose the complete alpha2-macroglobulin binding site in the second ligand binding cluster of the low density lipoprotein receptor-related protein
-
Dolmer K, Gettins PG. Three complement-like repeats compose the complete alpha2-macroglobulin binding site in the second ligand binding cluster of the low density lipoprotein receptor-related protein. J Biol Chem. 2006; 281: 34189-96.
-
(2006)
J Biol Chem
, vol.281
, pp. 34189-34196
-
-
Dolmer, K.1
Gettins, P.G.2
-
42
-
-
0030860903
-
The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation
-
Wu SM, Boyer CM, Pizzo SV. The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation. J Biol Chem. 1997; 272: 20627-35.
-
(1997)
J Biol Chem
, vol.272
, pp. 20627-20635
-
-
Wu, S.M.1
Boyer, C.M.2
Pizzo, S.V.3
-
43
-
-
34247582332
-
siRNA delivery into human T cells and primary cells with carbon-nanotube transporters
-
Liu Z, Winters M, Holodniy M, et al. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew Chem Int Ed Engl. 2007; 46: 2023-7.
-
(2007)
Angew Chem Int Ed Engl
, vol.46
, pp. 2023-2027
-
-
Liu, Z.1
Winters, M.2
Holodniy, M.3
-
44
-
-
0029860084
-
The low density lipoprotein receptor-related protein can function independently from heparan sulfate proteoglycans in tissue factor pathway inhibitor endocytosis
-
Warshawsky I, Herz J, Broze GJ Jr, et al. The low density lipoprotein receptor-related protein can function independently from heparan sulfate proteoglycans in tissue factor pathway inhibitor endocytosis. J Biol Chem. 1996; 271: 25873-9.
-
(1996)
J Biol Chem
, vol.271
, pp. 25873-25879
-
-
Warshawsky, I.1
Herz, J.2
Broze Jr, G.J.3
-
45
-
-
0141907727
-
Cellular uptake [correction of utake] of the Tat peptide: an endocytosis mechanism following ionic interactions
-
Vives E. Cellular uptake [correction of utake] of the Tat peptide: an endocytosis mechanism following ionic interactions. J Mol Recognit. 2003; 16: 265-71.
-
(2003)
J Mol Recognit
, vol.16
, pp. 265-271
-
-
Vives, E.1
-
46
-
-
0035933826
-
Pentosan polysulfate as an inhibitor of extracellular HIV-1 Tat
-
Rusnati M, Urbinati C, Caputo A, et al. Pentosan polysulfate as an inhibitor of extracellular HIV-1 Tat. J Biol Chem. 2001; 276: 22420-5.
-
(2001)
J Biol Chem
, vol.276
, pp. 22420-22425
-
-
Rusnati, M.1
Urbinati, C.2
Caputo, A.3
-
47
-
-
58149131290
-
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model
-
Gosselet F, Candela P, Sevin E, et al. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res. 2009; 1249: 34-42.
-
(2009)
Brain Res
, vol.1249
, pp. 34-42
-
-
Gosselet, F.1
Candela, P.2
Sevin, E.3
-
48
-
-
0037131885
-
Pharmacogenomics of organic anion-transporting polypeptides (OATP)
-
Tirona RG, Kim RB. Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv Drug Deliv Rev. 2002; 54: 1343-52.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 1343-1352
-
-
Tirona, R.G.1
Kim, R.B.2
-
49
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R, Du Yan S, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003; 9: 907-13.
-
(2003)
Nat Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
-
50
-
-
57149110011
-
CNS delivery via adsorptive transcytosis
-
Herve F, Ghinea N, Scherrmann JM. CNS delivery via adsorptive transcytosis. AAPS J. 2008; 10: 455-72.
-
(2008)
AAPS J
, vol.10
, pp. 455-472
-
-
Herve, F.1
Ghinea, N.2
Scherrmann, J.M.3
-
51
-
-
0034700141
-
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters
-
Wender PA, Mitchell DJ, Pattabiraman K, et al. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc Natl Acad Sci USA. 2000; 97: 13003-8.
-
(2000)
Proc Natl Acad Sci USA.
, vol.97
, pp. 13003-13008
-
-
Wender, P.A.1
Mitchell, D.J.2
Pattabiraman, K.3
-
52
-
-
0037169486
-
Possible existence of common internalization mechanisms among arginine-rich peptides
-
Suzuki T, Futaki S, Niwa M, et al. Possible existence of common internalization mechanisms among arginine-rich peptides. J Biol Chem. 2002; 277: 2437-43.
-
(2002)
J Biol Chem
, vol.277
, pp. 2437-2443
-
-
Suzuki, T.1
Futaki, S.2
Niwa, M.3
-
54
-
-
12344273726
-
The blood-brain barrier: bottleneck in brain drug development
-
Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx. 2005; 2: 3-14.
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
56
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods. 2000; 44: 235-49.
-
(2000)
J Pharmacol Toxicol Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
|