Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans

Microbiology

Volumn 156, Issue 12, 2010, Pages 3522-3531

  Palmer, Jonathan M ^a   Mallaredy, Sandeep ^b   Perry, Dustin W ^b   Sanchez, James F ^c   Theisen, Jeffrey M ^a   Szewczyk, Edyta ^d,f   Oakley, Berl R ^d,e   Wang, Clay C C ^c   Keller, Nancy P ^a   Mirabito, Peter M ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e UNIVERSITY OF KANSAS   (United States)

^f UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; KU ANTIGEN; NUCLEAR PROTEIN; PROTEIN CLRD; PROTEIN HDAA; PROTEIN HEPA; PROTEIN NKUA; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIDULANS; CHROMOSOME 3; CHROMOSOME 6; COMPUTER MODEL; CONTROLLED STUDY; GENE CLUSTER; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REPRESSION; GENE SILENCING; HETEROCHROMATIN; NONHUMAN; OPEN READING FRAME; PLEIOTROPY; PRIORITY JOURNAL; SEXUAL SPORE; TELOMERE; TELOMERE POSITION EFFECT; TRANSGENE;

ANTIGENS, NUCLEAR; ASPERGILLUS NIDULANS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; HETEROCHROMATIN; TELOMERE;

EMERICELLA NIDULANS; EUKARYOTA;

EID: 78650050833     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.039255-0     Document Type: Article

References (47)

1. Adhvaryu, K. K., Morris, S. A., Strahl, B. D. & Selker, E. U. (2005). Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Eukaryot Cell 4, 1455-1464.
2. Arnaud, M. B., Chibucos, M. C., Costanzo, M. C., Crabtree, J., Inglis, D. O., Lotia, A., Orvis, J., Shah, P., Skrzypek, M. S. & other authors (2010). The Aspergillus Genome Database, a curated comparative genomics resource for gene, protein and sequence information for the Aspergillus research community. Nucleic Acids Res 38, D420-D427.
3. Barrales, R. R., Jimenez, J. & Ibeas, J. I. (2008). Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae. Genetics 178, 145-156.
4. Bok, J. W. & Keller, N. P. (2004). LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3, 527-535.
5. Bok, J. W., Chiang, Y.-M., Szewczyk, E., Reyes-Dominguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H. C., Watanabe, K., Strauss, J. & other authors (2009). Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol 5, 462-464.
6. Boulton, S. J. & Jackson, S. P. (1998). Components of the Kudependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 17, 1819-1828.
7. Braus, G. H., Krappmann, S. & Eckert, S. E. (2002). Sexual development in ascomycetes fruit body formation of Aspergillus nidulans. In Molecular Biology of Fungal Development, pp. 215-244. Edited by H. Osiewacz. New York: Marcel Dekker, Inc.
8. Bruggeman, J., Debets, A. J. M. & Hoekstra, R. F. (2004). Selection arena in Aspergillus nidulans. Fungal Genet Biol 41, 181-188.
9. Bühler, M. & Moazed, D. (2007). Transcription and RNAi in heterochromatic gene silencing. Nat Struct Mol Biol 14, 1041-1048.
10. Castaño, I., Pan, S.-J., Zupancic, M., Hennequin, C., Dujon, B. & Cormack, B. P. (2005). Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol 55, 1246-1258.
11. Clutterbuck, A. J. & Farman, M. L. (2008). Aspergillus nidulans linkage map and genome sequence: closing gaps and adding telomeres. In The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, pp. 57-73. Edited by G. H. Goldman & S. A. Osmani. Boca Raton, FL: CRC Press.
12. Dubrana, K., Perrod, S. & Gasser, S. M. (2001). Turning telomeres off and on. Curr Opin Cell Biol 13, 281-289.
13. Eckert, S. E., Hoffmann, B., Wanke, C. & Braus, G. H. (1999). Sexual development of Aspergillus nidulans in tryptophan auxotrophic strains. Arch Microbiol 172, 157-166.
14. Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D. & Selker, E. U. (2004). HP1 is essential for DNA methylation in Neurospora. Mol Cell 13, 427-434.
15. Gottschling, D. E., Aparicio, O. M., Billington, B. L. & Zakian, V. A. (1990). Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63, 751-762.
16. Greenstein, S., Shadkchan, Y., Jadoun, J., Sharon, C., Markovich, S. & Osherov, N. (2006). Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence for transcriptional repression of pyr4 expression in the cetA-disrupted strain. Fungal Genet Biol 43, 42-53.
17. Grewal, S. I. & Jia, S. (2007). Heterochromatin revisited. Nat Rev Genet 8, 35-46.
18. Gwynne, D. I., Miller, B. L., Miller, K. Y. & Timberlake, W. E. (1984). Structure and regulated expression of the SpoC1 gene cluster from Aspergillus nidulans. J Mol Biol 180, 91-109.
19. Hoffmann, B., Wanke, C., Lapaglia, S. K. & Braus, G. H. (2000). c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans. Mol Microbiol 37, 28-41.
20. Hoffmeister, D. & Keller, N. P. (2007). Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24, 393-416.
21. Jenuwein, T. & Allis, C. D. (2001). Translating the histone code. Science 293, 1074-1080.
22. Laurenson, P. & Rine, J. (1992). Silencers, silencing, and heritable transcriptional states. Microbiol Rev 56, 543-560.
23. Lies, C. M., Cheng, J., James, S. W., Morris, N. R., O'Connell, M. J. & Mirabito, P. M. (1998). BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function. J Cell Sci 111, 1453-1465.
24. Louw, C., Young, P. R., van Rensburg, P. & Divol, B. (2010). Epigenetic regulation of PGU1 transcription in Saccharomyces cerevisiae. FEMS Yeast Res 10, 158-167.
25. Miller, B. L., Miller, K. Y. & Timberlake, W. E. (1985). Direct and indirect gene replacements in Aspergillus nidulans. Mol Cell Biol 5, 1714-1721.
26. Mishra, K. & Shore, D. (1999). Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins. Curr Biol 9, 1123-1126.
27. Mondoux, M. A. & Zakian, V. A. (2007). Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres. Genetics 177, 2541-2546.
28. Nayak, T., Szewczyk, E., Oakley, C. E., Osmani, A., Ukil, L., Murray, S. L., Hynes, M. J., Osmani, S. A. & Oakley, B. R. (2006). A versatile and efficient gene-targeting system for Aspergillus nidulans. Genetics 172, 1557-1566.
29. Ottaviani, A., Gilson, E. & Magdinier, F. (2008). Telomeric position effect: from the yeast paradigm to human pathologies? Biochimie 90, 93-107.
30. Palmer, J. M. & Keller, N. P. (2010). Secondary metabolism in fungi: does chromosomal location matter? Curr Opin Microbiol 13, 431-436.
31. Palmer, J. M., Perrin, R. M., Dagenais, T. R. & Keller, N. P. (2008). H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryot Cell 7, 2052-2060.
32. Rehmeyer, C., Li, W., Kusaba, M., Kim, Y.-S., Brown, D., Staben, C., Dean, R. & Farman, M. (2006). Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae. Nucleic Acids Res 34, 4685-4701.
33. Rehmeyer, C. J., Li, W., Kusaba, M. & Farman, M. L. (2009). The telomere-linked helicase (TLH) gene family in Magnaporthe oryzae: revised gene structure reveals a novel TLH-specific protein motif. Curr Genet 55, 253-262.
34. Reyes-Dominguez, Y., Bok, J. W., Berger, H., Shwab, E. K., Basheer, A., Gallmetzer, A., Scazzocchio, C., Keller, N. & Strauss, J. (2010). Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol Microbiol 76, 1376-1386.
35. Robellet, X., Oestreicher, N., Guitton, A. & Vélot, C. (2010). Gene silencing of transgenes inserted in the Aspergillus nidulans alcM and/ or alcS loci. Curr Genet 56, 341-348.
36. Rosas-Hernández, L. L., Juárez-Reyes, A., Arroyo-Helguera, O. E., De Las Peñas, A., Pan, S.-J., Cormack, B. P. & Castaño, I. (2008). yKu70/yKu80 and Rif1 regulate silencing differentially at telomeres in Candida glabrata. Eukaryot Cell 7, 2168-2178.
37. Schoeftner, S. & Blasco, M. A. (2009). A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs. EMBO J 28, 2323-2336.
38. Shaaban, M., Palmer, J., El-Naggar, W. A., El-Sokkary, M. A., Habib, E.-S. E. & Keller, N. P. (2010). Involvement of transposon-like elements in penicillin gene cluster regulation. Fungal Genet Biol 47, 423-432.
39. Shimizu, K. & Keller, N. P. (2001). Genetic involvement of a cAMPdependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157, 591-600.
40. Shwab, E. K., Bok, J. W., Tribus, M., Galehr, J., Graessle, S. & Keller, N. P. (2007). Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot Cell 6, 1656-1664.
41. Smith, K. M., Kothe, G. O., Matsen, C. B., Khlafallah, T. K., Adhvaryu, K. K., Hemphill, M., Freitag, M., Motamedi, M. R. & Selker, E. U. (2008). The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9. Epigenetics Chromatin 1, 5.
42. Szewczyk, E., Nayak, T., Oakley, C. E., Edgerton, H., Xiong, Y., Taheri-Talesh, N., Osmani, S. A. & Oakley, B. R. (2006). Fusion PCR and gene targeting in Aspergillus nidulans. Nat Protoc 1, 3111-3120.
43. Tamaru, H. & Selker, E. U. (2001). A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277-283.
44. Tamaru, H., Zhang, X., McMillen, D., Singh, P. B., Nakayama, J., Grewal, S. I., Allis, C. D., Cheng, X. & Selker, E. U. (2003). Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet 34, 75-79.
45. Timberlake, W. E. (1980). Developmental gene regulation in Aspergillus nidulans. Dev Biol 78, 497-510.
46. Tsitsigiannis, D. I., Zarnowski, R. & Keller, N. P. (2004). The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans. J Biol Chem 279, 11344-11353.
47. Yang, L., Ukil, L., Osmani, A., Nahm, F., Davies, J., De Souza, C. P., Dou, X., Perez-Balaguer, A. & Osmani, S. A. (2004). Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in Aspergillus nidulans. Eukaryot Cell 3, 1359-1362.