-
1
-
-
27144517504
-
-
Chronic myelogenous leukemia V.I. Available from: [Last accessed 19 September 2008]
-
Chronic myelogenous leukemia V.I.2008. NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network, 2008. Available from: www.nccn.org/professionals/ physician-gls/PDF/cml.pdf. [Last accessed 19 September 2008]
-
(2008)
NCCN Clinical Practice Guidelines in Oncology
-
-
-
2
-
-
73349122639
-
Chronic Myeloid Leukemia: An update of concepts and management recommendations of European LeukemiaNet
-
Baccarani M, Cortes J, Pane F, et al. Chronic Myeloid Leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009;27:6041-6051
-
(2009)
J Clin Oncol
, vol.27
, pp. 6041-6051
-
-
Baccarani, M.1
Cortes, J.2
Pane, F.3
-
3
-
-
34249676964
-
Chronic myeloid leukaemia as a model of disease evolution in human cancer
-
Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 2007;7:441-453
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 441-453
-
-
Melo, J.V.1
Barnes, D.J.2
-
4
-
-
47949103199
-
Induction of chronic myelogenous leukemia in mice by 210 bcr-abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by 210 bcr-abl gene of the Philadelphia chromosome. Science 1990;87:6649-6653
-
(1990)
Science
, vol.87
, pp. 6649-6653
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
5
-
-
0025271543
-
Bcr-Abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice
-
Elefanty AG, Hariharan IK, Cory S. Bcr-Abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J 1990;9:1069-1078
-
(1990)
EMBO J
, vol.9
, pp. 1069-1078
-
-
Elefanty, A.G.1
Hariharan, I.K.2
Cory, S.3
-
6
-
-
0025187837
-
Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL
-
Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci USA 1990;87:6649-6653
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6649-6653
-
-
Kelliher, M.A.1
McLaughlin, J.2
Witte, O.N.3
Rosenberg, N.4
-
7
-
-
0032533257
-
Efficient and rapid induction of a chronic myelogenous leukemia-like disease in mice receiving p210bcr-abl-transformed bone marrow
-
Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like disease in mice receiving p210bcr-abl- transformed bone marrow. Blood 1998;92:3780-3792
-
(1998)
Blood
, vol.92
, pp. 3780-3792
-
-
Pear, W.S.1
Miller, J.P.2
Xu, L.3
-
8
-
-
0025209916
-
Acute leukaemia in bcr/abl transgenic mice
-
Heisterkamp N, Jenster G, ten Hoeve J. Acute leukaemia in bcr/abl transgenic mice. Nature 1990;344:251-253
-
(1990)
Nature
, vol.344
, pp. 251-253
-
-
Heisterkamp, N.1
Jenster, G.2
Ten Hoeve, J.3
-
9
-
-
0025209916
-
Acute leukaemia in bcr/abl transgenic mice
-
Heisterkamp N, Jenster G, ten Hoeve J. Acute leukaemia in bcr/abl transgenic mice. Nature 1990;344:251-253
-
(1990)
Nature
, vol.344
, pp. 251-253
-
-
Heisterkamp, N.1
Jenster, G.2
Ten Hoeve, J.3
-
10
-
-
0022544401
-
The chronic myelogenous leukemiaspecific p210 protein is the product of the bcr-abl hybrid gene
-
Ben-Neriah Y, Daley G Q, Mes-Masson A, et al. The chronic myelogenous leukemiaspecific p210 protein is the product of the bcr-abl hybrid gene Science 1986;233:212-214
-
(1986)
Science
, vol.233
, pp. 212-214
-
-
Ben-Neriah, Y.1
Daley, G.Q.2
Mes-Masson, A.3
-
11
-
-
3242808935
-
Natural history and staging of chronic myelogenous leukemia
-
DOI 10.1016/j.hoc.2004.03.011, PII S0889858804000164
-
Cortes J. Natural history and staging of chronic myelogenous leukemia. Hematol Oncol Clin North Am 2004;18:569-584 (Pubitemid 38969132)
-
(2004)
Hematology/Oncology Clinics of North America
, vol.18
, Issue.3
, pp. 569-584
-
-
Cortes, J.1
-
12
-
-
0029816460
-
The diversity of Bcr-Abl fusion proteins and their relationship to leukemia phenotype
-
Melo J.V. The diversity of Bcr-Abl fusion proteins and their relationship to leukemia phenotype. Blood 1996;88:2375-2384
-
(1996)
Blood
, vol.88
, pp. 2375-2384
-
-
Melo, J.V.1
-
13
-
-
33646017748
-
Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: Transplant activity, long-term data and current results
-
An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
-
Gratwohl A, Brand R, Apperley J, et al. Allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia in Europe 2006: transplant activity, long-term data and current results. An analysis by the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2006;91:513-521
-
(2006)
Haematologica
, vol.91
, pp. 513-521
-
-
Gratwohl, A.1
Brand, R.2
Apperley, J.3
-
14
-
-
0345696854
-
Interferon alpha-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia
-
Guilhot F, Chastang C, Michallet M, et al. Interferon alpha-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. N Engl J Med 1997;337:223-229
-
(1997)
N Engl J Med
, vol.337
, pp. 223-229
-
-
Guilhot, F.1
Chastang, C.2
Michallet, M.3
-
15
-
-
34247863611
-
Impact of imatinib therapy on the use of allogeneic haematopoietic progenitor cell transplantation for the treatment of chronic myeloid leukaemia
-
Giralt SA, Arora M, Goldman JM, et al. Impact of imatinib therapy on the use of allogeneic haematopoietic progenitor cell transplantation for the treatment of chronic myeloid leukaemia. Br J Haematol 2007;137:461-467
-
(2007)
Br J Haematol
, vol.137
, pp. 461-467
-
-
Giralt, S.A.1
Arora, M.2
Goldman, J.M.3
-
16
-
-
0036094117
-
Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
-
Cohen MH, Williams G, Johnson JR, et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 2002;8:935-942
-
(2002)
Clin Cancer Res
, vol.8
, pp. 935-942
-
-
Cohen, M.H.1
Williams, G.2
Johnson, J.R.3
-
17
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta D, et al. Efficacy and safety of a specific inhibitor of the Bcr-Abl tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-1037
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.3
-
18
-
-
0035810142
-
Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukaemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukaemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
19
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. New Engl J Med 2002;346:645-652
-
(2002)
New Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
20
-
-
38949178846
-
Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukaemia after failure of interferon-alpha treatment
-
Hochhaus A, Druker B, Sawyers C, et al. Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukaemia after failure of interferon-alpha treatment. Blood 2008;111:1039-1043
-
(2008)
Blood
, vol.111
, pp. 1039-1043
-
-
Hochhaus, A.1
Druker, B.2
Sawyers, C.3
-
21
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
DOI 10.1182/blood.V99.10.3530
-
Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myeloid leukaemia in myeloid blast crisis: results of a phase II study. Blood 2002;99:3530-3539 (Pubitemid 34534519)
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
Goldman, J.M.4
Miller, C.B.5
Ottmann, O.G.6
Schiffer, C.A.7
Talpaz, M.8
Guilhot, F.9
Deininger, M.W.N.10
Fischer, T.11
O'Brien, S.G.12
Stone, R.M.13
Gambacorti-Passerini, C.B.14
Russell, N.H.15
Reiffers, J.J.16
Shea, T.C.17
Chapuis, B.18
Coutre, S.19
Tura, S.20
Morra, E.21
Larson, R.A.22
Saven, A.23
Peschel, C.24
Gratwohl, A.25
Mandelli, F.26
Ben-Am, M.27
Gathmann, I.28
Capdeville, R.29
Paquette, R.L.30
Druker, B.J.31
more..
-
22
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
DOI 10.1182/blood.V99.6.1928
-
Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002;99:1928-1937 (Pubitemid 34525471)
-
(2002)
Blood
, vol.99
, Issue.6
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
Goldman, J.M.4
Gambacorti-Passerini, C.5
Guilhot, F.6
Schiffer, C.A.7
Fischer, T.8
Deininger, M.W.N.9
Lennard, A.L.10
Hochhaus, A.11
Ottmann, O.G.12
Gratwohl, A.13
Baccarani, M.14
Stone, R.15
Tura, S.16
Mahon, F.-X.17
Fernandes-Reese, S.18
Gathmann, I.19
Capdeville, R.20
Kantarjian, H.M.21
Sawyers, C.L.22
more..
-
23
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
24
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006;355:2408-2417
-
(2006)
N Engl J Med
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
26
-
-
33747154547
-
Evolving concepts in themanagement of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
-
Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in themanagement of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006;108:1809-1820
-
(2006)
Blood
, vol.108
, pp. 1809-1820
-
-
Baccarani, M.1
Saglio, G.2
Goldman, J.3
-
27
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
DOI 10.1182/blood-2006-09-047266
-
Hochhaus A, Kantarjian H, Baccarani M, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007;109:2303-2309 (Pubitemid 46425867)
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.M.2
Baccarani, M.3
Lipton, J.H.4
Apperley, J.F.5
Druker, B.J.6
Facon, T.7
Goldberg, S.L.8
Cervantes, F.9
Niederwieser, D.10
Silver, R.T.11
Stone, R.M.12
Hughes, T.P.13
Muller, M.C.14
Ezzeddine, R.15
Countouriotis, A.M.16
Shah, N.P.17
-
28
-
-
36348968931
-
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
-
Kantarjian HM, Giles F, Gattermann N, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007;110:3540-3546
-
(2007)
Blood
, vol.110
, pp. 3540-3546
-
-
Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
-
29
-
-
19944428353
-
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6- methylphenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004;47:6658-6661
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
-
30
-
-
54949154484
-
Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C)
-
abstract 7009
-
Mauro MJ, Baccarani M, Cervantes F, et al. Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C). J Clin Oncol 2008;26:abstract 7009
-
(2008)
J Clin Oncol
, vol.26
-
-
Mauro, M.J.1
Baccarani, M.2
Cervantes, F.3
-
31
-
-
65749098290
-
Dasatinib efficacy in patients with imatinib-resistant/-intolerant Philadelphia-chromosome-positive acute lymphoblastic leukemia: 24-month data from START-L
-
abstract 001
-
Porkka K, Martinelli G, Ottmann O, et al. Dasatinib efficacy in patients with imatinib-resistant/-intolerant Philadelphia-chromosome-positive acute lymphoblastic leukemia: 24-month data from START-L. Haematologica 2008;93s1:1 abstract 001
-
(2008)
Haematologica
, vol.93 S1
, pp. 1
-
-
Porkka, K.1
Martinelli, G.2
Ottmann, O.3
-
32
-
-
60049095629
-
Dasatinib efficacy in patients with imatinib-resistant/-intolerant chronic myeloid leukemia in accelerated phase 24-month data from START-A
-
abstract 0982
-
Rea D, Dombret H, Kim DW, et al. Dasatinib efficacy in patients with imatinib-resistant/-intolerant chronic myeloid leukemia in accelerated phase 24-month data from START-A. Haematologica 2008;93s1:391 abstract 0982
-
(2008)
Haematologica
, vol.93 S1
, pp. 391
-
-
Rea, D.1
Dombret, H.2
Kim, D.W.3
-
33
-
-
60049086655
-
Dasatinib efficacy in patients with imatinib-resistant/-intolerant chronic myeloid leukemia in blast phase: 24-month data from the START program
-
abstact 0880
-
Saglio G, Dombret H, Rea D, et al. Dasatinib efficacy in patients with imatinib-resistant/-intolerant chronic myeloid leukemia in blast phase: 24-month data from the START program. Haematologica 2008;93s1:349 abstact 0880
-
(2008)
Haematologica
, vol.93 S1
, pp. 349
-
-
Saglio, G.1
Dombret, H.2
Rea, D.3
-
34
-
-
38549144899
-
Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations
-
abstact 7023
-
Hochhaus A, Branford S, Radich J, et al. Efficacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations. J Clin Oncol 2007;25: abstact 7023
-
(2007)
J Clin Oncol
, vol.25
-
-
Hochhaus, A.1
Branford, S.2
Radich, J.3
-
35
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004;305:399-401
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
-
36
-
-
14744274624
-
Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
-
Burgess MR, Skaggs BJ, Shah NP, et al. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci USA 2005;102:3395-3400
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3395-3400
-
-
Burgess, M.R.1
Skaggs, B.J.2
Shah, N.P.3
-
37
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003;101:690-698
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
-
38
-
-
38549130207
-
Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia
-
Li S. Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia. Leuk Lymphoma 2008;49:19-26
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 19-26
-
-
Li, S.1
-
39
-
-
38349014380
-
Src family kinases: Regulation of their activities, levels and identification of new pathways
-
Ingley E. Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim Biophys Acta 2008;1784:56-65
-
(2008)
Biochim Biophys Acta
, vol.1784
, pp. 56-65
-
-
Ingley, E.1
-
40
-
-
0037328534
-
The interaction of the BCR-ABL tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains
-
Stanglmaier M, Warmuth M, Kleinlein I, et al. The interaction of the BCR-ABL tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains. Leukemia 2003;17:283-289
-
(2003)
Leukemia
, vol.17
, pp. 283-289
-
-
Stanglmaier, M.1
Warmuth, M.2
Kleinlein, I.3
-
41
-
-
0036847027
-
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukaemia cells
-
Klejman A, Schreiner SJ, Nieborowska-Skorska M, et al. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukaemia cells. EMBO J 2002;21:5766-5774
-
(2002)
EMBO J
, vol.21
, pp. 5766-5774
-
-
Klejman, A.1
Schreiner, S.J.2
Nieborowska-Skorska, M.3
-
42
-
-
0031455168
-
The Src family kinase Hck interacts with BCR-ABL by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr
-
Warmuth M, Bergmann M, Priess A, et al. The Src family kinase Hck interacts with BCR-ABL by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem 1997;272:33260-33270
-
(1997)
J Biol Chem
, vol.272
, pp. 33260-33270
-
-
Warmuth, M.1
Bergmann, M.2
Priess, A.3
-
43
-
-
36048934648
-
CD4 and CD8: Hogging all the Lck
-
Kappes DJ. CD4 and CD8: hogging all the Lck. Immunity 2007;5:691-693
-
(2007)
Immunity
, vol.5
, pp. 691-693
-
-
Kappes, D.J.1
-
44
-
-
2442465000
-
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1?induced B?lymphoblastic leukaemia but not chronic myeloid leukemia
-
Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1?induced B?lymphoblastic leukaemia but not chronic myeloid leukemia. Nature Genet 2004;36:453-461
-
(2004)
Nature Genet
, vol.36
, pp. 453-461
-
-
Hu, Y.1
Liu, Y.2
Pelletier, S.3
-
45
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M, Hamilton A, Elrick LJ, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006;107:4532-4539
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
46
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant BCR-ABL
-
Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant BCR-ABL. Cancer Cell 2005;7:29-141
-
(2005)
Cancer Cell
, vol.7
, pp. 29-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
47
-
-
33745086350
-
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
-
DOI 10.1056/NEJMoa055104
-
Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006;354:2542-2551 (Pubitemid 43882350)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2542-2551
-
-
Kantarjian, H.1
Giles, F.2
Wunderle, L.3
Bhalla, K.4
O'Brien, S.5
Wassmann, B.6
Tanaka, C.7
Manley, P.8
Rae, P.9
Mietlowski, W.10
Bochinski, K.11
Hochhaus, A.12
Griffin, J.D.13
Hoelzer, D.14
Albitar, M.15
Dugan, M.16
Cortes, J.17
Alland, L.18
Ottmann, O.G.19
-
48
-
-
43549116467
-
Nilotinib is highly active and safe in chronic phase chronic myelogenous leukemia (CML-CP) patients with imatinib-resistance or intolerance. ASH Annual Meeting Abstract Book
-
abstract 735
-
Kantarjian H, Hochhaus A, Cortes J, et al. Nilotinib is highly active and safe in chronic phase chronic myelogenous leukemia (CML-CP) patients with imatinib-resistance or intolerance. ASH Annual Meeting Abstract Book. Blood 2007;110:abstract 735
-
(2007)
Blood
, vol.110
-
-
Kantarjian, H.1
Hochhaus, A.2
Cortes, J.3
-
49
-
-
41349083969
-
Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia
-
le Coutre P, Ottmann OG, Giles F. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia. Blood 111:1834-1839
-
Blood
, vol.111
, pp. 1834-1839
-
-
Le Coutre, P.1
Ottmann, O.G.2
Giles, F.3
-
50
-
-
37349112422
-
Nilotinib monotherapy in patients with imatinib-resistant or -intolerant Ph+ chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL)
-
abstract 556
-
Ottmann O, Larson R, Kantarjian H, et al. Nilotinib monotherapy in patients with imatinib-resistant or -intolerant Ph+ chronic myelogenous leukemia (CML) in blast crisis (BC) or relapsed/refractory Ph+ acute lymphoblastic leukemia (ALL). Haematologica 2007;92: abstract 556
-
(2007)
Haematologica
, vol.92
-
-
Ottmann, O.1
Larson, R.2
Kantarjian, H.3
-
51
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib resistant Abl kinase domain mutants. Cancer Res 2005;65:4500-4505
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
52
-
-
65249133156
-
Molecular response according to type of preexisting BCR-ABL mutations after second line dasatinib therapyin chronic phase CML patients. ASH Annual Meeting Abstract Book
-
abstract 319
-
Mueller MC, Erben P, Ernst T, et al. Molecular response according to type of preexisting BCR-ABL mutations after second line dasatinib therapyin chronic phase CML patients. ASH Annual Meeting Abstract Book. Blood 2007;110: abstract 319
-
(2007)
Blood
, vol.110
-
-
Mueller, M.C.1
Erben, P.2
Ernst, T.3
-
53
-
-
0037439689
-
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice
-
Golas JM, Arndt K, Etienne C, et al. SKI-606, a 4-anilino-3- quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice. Cancer Res 2003;63:375-381
-
(2003)
Cancer Res
, vol.63
, pp. 375-381
-
-
Golas, J.M.1
Arndt, K.2
Etienne, C.3
-
54
-
-
28444479480
-
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
-
Kimura S, Naito H, Segawa H, et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood 2005;106:3948-3954
-
(2005)
Blood
, vol.106
, pp. 3948-3954
-
-
Kimura, S.1
Naito, H.2
Segawa, H.3
-
55
-
-
33845806858
-
In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib resistant BCR-ABL+ neoplastic cells
-
Puttini M, Coluccia AM, Boschelli F, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib resistant BCR-ABL+ neoplastic cells. Cancer Res 2006;66:11314-11322
-
(2006)
Cancer Res
, vol.66
, pp. 11314-11322
-
-
Puttini, M.1
Coluccia, A.M.2
Boschelli, F.3
-
56
-
-
34248994815
-
A phase 1/2 study of SKI-606, a dual Inhibitor of Src and Abl kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory or intolerant of imatinib. ASH Annual Meeting Abstract Book
-
abstract 168
-
Cortes J, Kantarjian HM, Baccarani M, et al. A phase 1/2 study of SKI-606, a dual Inhibitor of Src and Abl kinases, in adult patients with Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) or acute lymphocytic leukemia (ALL) relapsed, refractory or intolerant of imatinib. ASH Annual Meeting Abstract Book. Blood 2006;108: abstract 168
-
(2006)
Blood
, vol.108
-
-
Cortes, J.1
Kantarjian, H.M.2
Baccarani, M.3
-
57
-
-
33748094100
-
In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations
-
Naito H, Kimura S, Nakaya Y, et al. In vivo antiproliferative effect of NS-187, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor, on leukemic cells harbouring Abl kinase domain mutations. Leuk Res 2006;30:1443-1446
-
(2006)
Leuk Res
, vol.30
, pp. 1443-1446
-
-
Naito, H.1
Kimura, S.2
Nakaya, Y.3
-
58
-
-
33846018356
-
INNO?406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity
-
Yokota A, Kimura S, Masuda S, et al. INNO?406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity. Blood 2007;109:306-314
-
(2007)
Blood
, vol.109
, pp. 306-314
-
-
Yokota, A.1
Kimura, S.2
Masuda, S.3
-
59
-
-
33846240316
-
MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
-
Giles FJ, Cortes JE, Jones D, et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007;109:500-502
-
(2007)
Blood
, vol.109
, pp. 500-502
-
-
Giles, F.J.1
Cortes, J.E.2
Jones, D.3
-
61
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA 2005;102:11011-11016
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
-
62
-
-
34247520736
-
The most common dasatinib-resistant BCR- ABL kinase domain mutations in patients with chronic myeloid leukemia are sensitive to VX-680: Rationale for early combination kinase inhibitor therapy. ASH Annual Meeting Abstract Book
-
abstract 2175
-
Shah NP, Skaggs B, Branford S, et al. The most common dasatinib-resistant BCR- ABL kinase domain mutations in patients with chronic myeloid leukemia are sensitive to VX-680: rationale for early combination kinase inhibitor therapy. ASH Annual Meeting Abstract Book. Blood 2006;108:abstract 2175
-
(2006)
Blood
, vol.108
-
-
Shah, N.P.1
Skaggs, B.2
Branford, S.3
-
63
-
-
33644889108
-
Allosteric inhibitors of BCR-ABL dependent cell proliferation
-
Adrián FJ, Ding Q, Sim T, et al. Allosteric inhibitors of BCR-ABL dependent cell proliferation. Nature Chem Biol 2006;2:95-102
-
(2006)
Nature Chem Biol
, vol.2
, pp. 95-102
-
-
Adrián, F.J.1
Ding, Q.2
Sim, T.3
-
64
-
-
13844261144
-
A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
-
Gumireddy K, Baker SJ, Cosenza SC, et al. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci USA 2005;102:1992-1997
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1992-1997
-
-
Gumireddy, K.1
Baker, S.J.2
Cosenza, S.C.3
-
65
-
-
43549121470
-
Omacetaxine mepesuccinate-a semisynthetic formulation of the natural antitumoral alkaloid homoharringtonine, for chronic myelocytic leukemia and other myeloid malignancies
-
Quintás-Cardama A, Cortes J. Omacetaxine mepesuccinate-a semisynthetic formulation of the natural antitumoral alkaloid homoharringtonine, for chronic myelocytic leukemia and other myeloid malignancies. Drugs 2008;5:356-372
-
(2008)
Drugs
, vol.5
, pp. 356-372
-
-
Quintás-Cardama, A.1
Cortes, J.2
-
67
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996;56:100-104
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
68
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-566
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
69
-
-
50649118068
-
Expansion of BCR-ABL positive leukemic stem cells is dependent on hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR, et al. Expansion of BCR-ABL positive leukemic stem cells is dependent on hedgehog pathway activation. Cancer Cell 2008;14:238-249
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
-
70
-
-
31644438945
-
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the aurora kinase inhibitor VX-680
-
Young MA, Shah NP, Chao, et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the aurora kinase inhibitor VX-680. Cancer Res 2006;66:1007-1014
-
(2006)
Cancer Res
, vol.66
, pp. 1007-1014
-
-
Young, M.A.1
Chao, S.N.2
-
71
-
-
33846240316
-
MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
-
Giles FJ, Cortes JE, Jones D, et al. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood 2007;109:500-502
-
(2007)
Blood
, vol.109
, pp. 500-502
-
-
Giles, F.J.1
Cortes, J.E.2
Jones, D.3
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