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European Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2010, Pages 4601-4608

Synthesis and evaluation of fatty acyl ester derivatives of cytarabine as anti-leukemia agents

(3) Chhikara, Bhupender S a Mandal, Deendayal a Parang, Keykavous a

a UNIVERSITY OF RHODE ISLAND (United States)

Author keywords

Cellular uptake; Cytarabine; Fatty acids; Leukemia; Nucleoside; Prodrug

Indexed keywords

1 [2' O (12 THIOETHYLDODECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [2' O TETRADECANOYL BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [2',5' DI(O TETRADECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 2' O (12 THIOETHYLDODECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 2' O TETRADECANOYL BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 2',5' DI(O TETRADECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 2',5' DI(O TETRADECANOYL) N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 5' O (12 THIOETHYLDODECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 5' O (12 THIOETHYLDODECANOYL) N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 5' O TETRADECANOYL BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) 5' O TETRADECANOYL N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3' O (TERTBUTYLDIMETHYLSILYL) N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3',5' DI (O TERTBUTYLDIMETHYLSILYL) 2' O MYRISTOYL N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3',5' DI (O TERTBUTYLDIMETHYLSILYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3',5' DI(O TERTBUTYLDIMETHYLSILYL) 2' O (12 THIOETHYLDODECANOYL) N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [3',5' DI(O TERTBUTYLDIMETHYLSILYL) N (4,4' DIMETHOXYTRITYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 1 [5' O TETRADECANOYL BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; 5 [5' O (12 THIOETHYLDODECANOYL) BETA DEXTRO ARABINOFURANOSYL]CYTOSINE; ANTILEUKEMIC AGENT; CYTARABINE; CYTARABINE DERIVATIVE; HYDROXYL GROUP; LAURIC ACID; MYRISTIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; GROWTH INHIBITION; HUMAN; HUMAN CELL; SUBSTITUTION REACTION;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL PROLIFERATION; CYTARABINE; ESTERS; FATTY ACIDS; HUMANS; LEUKEMIA; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 77956188936 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.07.024 Document Type: Article

Times cited : (39)

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