Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2439-2446

  Mehellou, Youcef ^a   Valente, Rocco ^a   Mottram, Huw ^a   Walsby, Elisabeth ^b   Mills, Kenneth I ^b   Balzarini, Jan ^c   McGuigan, Christopher ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anticancer; Antiviral; Nucleosides; Nucleotides; Prodrugs; Protides

Indexed keywords

ARABINOURIDINE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBOXYPEPTIDASE C; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ESTERASE; HINT1 PROTEIN, HUMAN; NERVE PROTEIN; URACIL ARABINOSIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MOLECULAR MODEL; NONHUMAN; ANIMAL; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LIVER; LYMPHOCYTE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SWINE; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; TUMOR CELL LINE; VIRUS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ARABINOFURANOSYLURACIL; CATHEPSIN A; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; ESTERASES; HUMANS; INDICATORS AND REAGENTS; LIVER; LYMPHOCYTES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VIRUSES;

EID: 77950026170     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.059     Document Type: Article

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