Inhibitive effect of cremophor RH40 or tween 80-based self- microemulsiflying drug delivery system on cytochrome P450 3A enzymes in murine hepatocytes

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 30, Issue 5, 2010, Pages 562-568

  Rao, Zichao ^a   Si, Luqin ^a   Guan, Yanbin ^a   Pan, Hongping ^a   Qiu, Jun ^a   Li, Gao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cremophor RH40; cytochrome P450 3A; midazolam; self microemulsifying drug delivery systems; Tween 80

Indexed keywords

CREMOPHOR; CYTOCHROME P450 3A; DRUG VEHICLE; MACROGOL DERIVATIVE; MIDAZOLAM; POLYSORBATE; SURFACTANT;

ANIMAL; ARTICLE; BIOAVAILABILITY; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; EMULSION; ENZYMOLOGY; LIVER CELL; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 CYP3A; DRUG DELIVERY SYSTEMS; EMULSIONS; HEPATOCYTES; MALE; MIDAZOLAM; PHARMACEUTICAL VEHICLES; POLYETHYLENE GLYCOLS; POLYSORBATES; RATS; RATS, SPRAGUE-DAWLEY; SURFACE-ACTIVE AGENTS;

EID: 78649902848     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-010-0543-0     Document Type: Article

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