Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450

International Journal of Pharmaceutics

Volumn 211, Issue 1-2, 2000, Pages 89-92

  Mountfield, Richard J ^a   Senepin, Sandrine ^a   Schleimer, Michael ^a   Walter, Isabelle ^a   Bittner, Beate ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Cytochrome P450; Formulations; Inhibition; Microsomes

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA TOCOPHEROL; AMPHOPHILE; CREMOPHOR; CYTOCHROME P450; GLYCOCHOLIC ACID; INTESTINE ENZYME; MACROGOL 400; MIGLYOL; N,N DIMETHYLACETAMIDE; NEW DRUG; OLEIC ACID; PHOSPHATIDYLCHOLINE; POLYSORBATE 20; POLYSORBATE 80; PROPYLENE GLYCOL; SOYBEAN OIL; TAUROCHOLIC ACID; WATER;

ANIMAL TISSUE; ARTICLE; DOG; DRUG FORMULATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MICELLE; MONKEY; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIGESTIVE SYSTEM; DOGS; HUMANS; INHIBITORY CONCENTRATION 50; MACACA FASCICULARIS; MICELLES; MICROSOMES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OILS; SOLVENTS; SPECIES SPECIFICITY; SURFACE-ACTIVE AGENTS;

EID: 0034671884     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00586-X     Document Type: Article

References (7)

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5. Influence of ionic strength on the P450 monooxygenase reaction and role of cytochrome b5 in the process
6. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man