Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease

Molecular and Cellular Biology

Volumn 22, Issue 11, 2002, Pages 3633-3638

  Zumbansen, Markus ^a   Stoffel, Wilhelm ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 O ALKYLGLYCERO 3 PHOSPHORYLCHOLINE; CERAMIDE; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHOLIPASE; MAGNESIUM; PHOSPHORYLCHOLINE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATALYSIS; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EUKARYOTIC CELL; GENE TARGETING; LIPID HYDROLYSIS; LIPIDOSIS; LIPOLYSIS; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CLONING, MOLECULAR; FEMALE; GENE TARGETING; LIPID METABOLISM; LIPID METABOLISM, INBORN ERRORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NIEMANN-PICK DISEASES; PHENOTYPE; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMALIA; EUKARYOTA;

EID: 0036097252     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.11.3633-3638.2002     Document Type: Article

References (44)

1. A rapid method of total lipid extraction and purification
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. A simple, specific spray for the detection of phospholipids on thin layer chromatography
4. A neutral magnesium-dependent sphingomyelinase isoform associated with intracellular membranes and reversibly inhibited by reactive oxygen species
5. Magnesium-dependent sphingomyelinase
6. Structure and functional properties of diacylglycerols in membranes
7. Ceramide in apoptosis - Does it really matter?
8. Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
9. Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
10. Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding
11. Gangliosides: Structure, isolation, and analysis
12. Sphingomyelinases in cell regulation
13. Cloning and expression of rat neutral sphingomyelinase: Enzymological characterization and identification of essential histidine residues
14. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
15. A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum
16. Functional analysis of the glycosylation of murine acid sphingomyelinase
17. Molecular cloning of the acid sphingo-myelinase of the mouse and the organization and complete nucleotide sequence of the gene
18. Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation
19. Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
20. Isolation of cDNA clones encoding human acid sphingomyelinase: Occurrence of alternatively processed transcripts
21. Acid sphingomyelinase from human urine: Purification and characterization
22. Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0
23. Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin
24. Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis
25. Deconstructing golgi inheritance
26. Vesicle membrane fusion induced by the concerted activities of sphingomyelinase and phospholipase C
27. Interaction of cholesterol with various glycerophospholipids and sphingomyelin
28. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C
29. Identification of ISC1 (YER019w) as inositol phosphos-phingolipid phospholipase C in Saccharomyces cerevisiae
30. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
31. Structural organization and complete nucleotide sequence of the gene encoding human acid sphingomyelinase (SMPD1)
32. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
33. Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis
34. Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
35. Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase
36. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
37. Sphingolipid transport in eukaryotic cells
38. Ceramides in phospholipid membranes: Effects on bilayer stability and transition to nonlamellar phases
39. Germ line chimeras from female ES cells
40. On the complexities of ceramide changes in cells undergoing apoptosis: Lack of evidence for a second messenger function in apoptotic induction
41. Fas-induced apoptosis of T cells occurs independently of ceramide generation
42. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
43. Molecular structures of proteins involved in vesicle fusion
44. Sphingomyelinase treatment induces ATP-independent endocytosis