A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction

Journal of Experimental Medicine

Volumn 189, Issue 10, 1999, Pages 1581-1589

  Tonnetti, Laura ^a   Verí, Maria Concetta ^b   Bonvini, Ezio ^b   D'Adamio, Luciano ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Activation; Apoptosis; Ceramide; Neutral sphingomyelinase; Signaling; T cell receptor

Indexed keywords

CERAMIDE; COMPLEMENTARY RNA; FUMONISIN B1; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOMYELIN PHOSPHODIESTERASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN CELL; HYBRIDOMA; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBOXYLIC ACIDS; CERAMIDES; ENZYME ACTIVATION; FAS LIGAND PROTEIN; FUMONISINS; HUMANS; HYBRIDOMAS; INTERLEUKIN-2; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MYCOTOXINS; RECEPTORS, ANTIGEN, T-CELL; RNA, ANTISENSE; RNA, MESSENGER; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; SPLEEN; T-LYMPHOCYTES;

EID: 0033577806     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.10.1581     Document Type: Article

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