메뉴 건너뛰기




Volumn 20, Issue 6, 2010, Pages 431-438

T-cell function in chronic lymphocytic leukaemia

Author keywords

Antigen presentation; Chronic lymphocytic leukaemia; Lenalidomide; T cell function; Tumour antigens

Indexed keywords

ALEMTUZUMAB; CANCER VACCINE; CD3 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; DENDRITIC CELL VACCINE; FLUDARABINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; LENALIDOMIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RITUXIMAB; T LYMPHOCYTE RECEPTOR; THALIDOMIDE; TUMOR CELL VACCINE;

EID: 78649777544     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2010.09.006     Document Type: Review
Times cited : (44)

References (109)
  • 3
    • 0023143381 scopus 로고
    • The B cell is the initiating antigen-presenting cell in peripheral lymph nodes
    • Janeway C.A., Ron J., Katz M.E. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J Immunol 1987, 138:1051-1055.
    • (1987) J Immunol , vol.138 , pp. 1051-1055
    • Janeway, C.A.1    Ron, J.2    Katz, M.E.3
  • 4
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle R.J., Roy M., Shepherd D.M., Stamenkovic I., Ledbetter J.A., Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992, 89:6550-6554.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3    Stamenkovic, I.4    Ledbetter, J.A.5    Aruffo, A.6
  • 5
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim E.A., Kipps T.J. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993, 177:925-935.
    • (1993) J Exp Med , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 6
    • 0028365149 scopus 로고
    • T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity
    • Yellin M.J., Sinning J., Covey L.R., Sherman W., Lee J.J., Glickman-Nir E., et al. T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity. J Immunol 1994, 153:666-674.
    • (1994) J Immunol , vol.153 , pp. 666-674
    • Yellin, M.J.1    Sinning, J.2    Covey, L.R.3    Sherman, W.4    Lee, J.J.5    Glickman-Nir, E.6
  • 8
    • 0030989818 scopus 로고    scopus 로고
    • CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules
    • Van den Hove L.E., Van Gool S.W., Vandenberghe P., Bakkus M., Thielemans K., Boogaerts M.A., et al. CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules. Leukemia 1997, 11:572-580.
    • (1997) Leukemia , vol.11 , pp. 572-580
    • Van den Hove, L.E.1    Van Gool, S.W.2    Vandenberghe, P.3    Bakkus, M.4    Thielemans, K.5    Boogaerts, M.A.6
  • 9
    • 0030846220 scopus 로고    scopus 로고
    • Acquired CD40-ligand deficiency in chronic lymphocytic leukemia
    • Cantwell M., Hua T., Pappas J., Kipps T.J. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nat Med 1997, 3:984-989.
    • (1997) Nat Med , vol.3 , pp. 984-989
    • Cantwell, M.1    Hua, T.2    Pappas, J.3    Kipps, T.J.4
  • 10
    • 0032032524 scopus 로고    scopus 로고
    • Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
    • Kato K., Cantwell M.J., Sharma S., Kipps T.J. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998, 101:1133-1141.
    • (1998) J Clin Invest , vol.101 , pp. 1133-1141
    • Kato, K.1    Cantwell, M.J.2    Sharma, S.3    Kipps, T.J.4
  • 11
    • 0035831627 scopus 로고    scopus 로고
    • Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes
    • Takahashi S., Rousseau R.F., Yotnda P., Mei Z., Dotti G., Rill D., et al. Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes. Hum Gene Ther 2001, 12:659-670.
    • (2001) Hum Gene Ther , vol.12 , pp. 659-670
    • Takahashi, S.1    Rousseau, R.F.2    Yotnda, P.3    Mei, Z.4    Dotti, G.5    Rill, D.6
  • 12
    • 0033560068 scopus 로고    scopus 로고
    • CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells
    • Buhmann R., Nolte A., Westhaus D., Emmerich B., Hallek M. CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells. Blood 1999, 93:1992-2002.
    • (1999) Blood , vol.93 , pp. 1992-2002
    • Buhmann, R.1    Nolte, A.2    Westhaus, D.3    Emmerich, B.4    Hallek, M.5
  • 13
    • 0036660173 scopus 로고    scopus 로고
    • T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy
    • Krackhardt A.M., Harig S., Witzens M., Broderick R., Barrett P., Gribben J.G. T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy. Blood 2002, 100:167-173.
    • (2002) Blood , vol.100 , pp. 167-173
    • Krackhardt, A.M.1    Harig, S.2    Witzens, M.3    Broderick, R.4    Barrett, P.5    Gribben, J.G.6
  • 14
    • 0037105497 scopus 로고    scopus 로고
    • Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX
    • Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., et al. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. Blood 2002, 100:2123-2131.
    • (2002) Blood , vol.100 , pp. 2123-2131
    • Krackhardt, A.M.1    Witzens, M.2    Harig, S.3    Hodi, F.S.4    Zauls, A.J.5    Chessia, M.6
  • 15
    • 20144377093 scopus 로고    scopus 로고
    • Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes
    • Biagi E., Dotti G., Yvon E., Lee E., Pule M., Vigouroux S., et al. Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes. Blood 2005, 105:2436-2442.
    • (2005) Blood , vol.105 , pp. 2436-2442
    • Biagi, E.1    Dotti, G.2    Yvon, E.3    Lee, E.4    Pule, M.5    Vigouroux, S.6
  • 16
    • 8844226681 scopus 로고    scopus 로고
    • CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack
    • Kater A.P., Evers L.M., Remmerswaal E.B., Jaspers A., Oosterwijk M.F., van Lier R.A., et al. CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack. Br J Haematol 2004, 127:404-415.
    • (2004) Br J Haematol , vol.127 , pp. 404-415
    • Kater, A.P.1    Evers, L.M.2    Remmerswaal, E.B.3    Jaspers, A.4    Oosterwijk, M.F.5    van Lier, R.A.6
  • 17
    • 10244251606 scopus 로고    scopus 로고
    • Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells
    • Gricks C.S., Zahrieh D., Zauls A.J., Gorgun G., Drandi D., Mauerer K., et al. Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells. Blood 2004, 104:4002-4009.
    • (2004) Blood , vol.104 , pp. 4002-4009
    • Gricks, C.S.1    Zahrieh, D.2    Zauls, A.J.3    Gorgun, G.4    Drandi, D.5    Mauerer, K.6
  • 18
    • 32244442244 scopus 로고    scopus 로고
    • Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation
    • McWhirter J.R., Kretz-Rommel A., Saven A., Maruyama T., Potter K.N., Mockridge C.I., et al. Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. Proc Natl Acad Sci USA 2006, 103:1041-1046.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1041-1046
    • McWhirter, J.R.1    Kretz-Rommel, A.2    Saven, A.3    Maruyama, T.4    Potter, K.N.5    Mockridge, C.I.6
  • 19
    • 14044259353 scopus 로고    scopus 로고
    • Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R
    • Gorczynski R.M., Lee L., Boudakov I. Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R. Transplantation 2005, 79:1180-1183.
    • (2005) Transplantation , vol.79 , pp. 1180-1183
    • Gorczynski, R.M.1    Lee, L.2    Boudakov, I.3
  • 20
    • 58549108182 scopus 로고    scopus 로고
    • Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade
    • Pallasch C.P., Ulbrich S., Brinker R., Hallek M., Uger R.A., Wendtner C.M. Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. Leuk Res 2009, 33:460-464.
    • (2009) Leuk Res , vol.33 , pp. 460-464
    • Pallasch, C.P.1    Ulbrich, S.2    Brinker, R.3    Hallek, M.4    Uger, R.A.5    Wendtner, C.M.6
  • 21
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino D.F., Bond M.W., Mosmann T.R. Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989, 170:2081-2095.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 22
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • de Waal Malefyt R., Haanen J., Spits H., Roncarolo M.G., te Velde A., Figdor C., et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991, 174:915-924.
    • (1991) J Exp Med , vol.174 , pp. 915-924
    • de Waal Malefyt, R.1    Haanen, J.2    Spits, H.3    Roncarolo, M.G.4    te Velde, A.5    Figdor, C.6
  • 23
    • 0035160749 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome
    • Fayad L., Keating M.J., Reuben J.M., O'Brien S., Lee B.N., Lerner S., et al. Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. Blood 2001, 97:256-263.
    • (2001) Blood , vol.97 , pp. 256-263
    • Fayad, L.1    Keating, M.J.2    Reuben, J.M.3    O'Brien, S.4    Lee, B.N.5    Lerner, S.6
  • 24
    • 0030447760 scopus 로고    scopus 로고
    • Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors
    • Voorzanger N., Touitou R., Garcia E., Delecluse H.J., Rousset F., Joab I., et al. Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors. Cancer Res 1996, 56:5499-5505.
    • (1996) Cancer Res , vol.56 , pp. 5499-5505
    • Voorzanger, N.1    Touitou, R.2    Garcia, E.3    Delecluse, H.J.4    Rousset, F.5    Joab, I.6
  • 25
    • 0026784556 scopus 로고
    • Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10
    • Benjamin D., Knobloch T.J., Dayton M.A. Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992, 80:1289-1298.
    • (1992) Blood , vol.80 , pp. 1289-1298
    • Benjamin, D.1    Knobloch, T.J.2    Dayton, M.A.3
  • 26
    • 0027955125 scopus 로고
    • Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells
    • Fluckiger A.C., Durand I., Banchereau J. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells. J Exp Med 1994, 179:91-99.
    • (1994) J Exp Med , vol.179 , pp. 91-99
    • Fluckiger, A.C.1    Durand, I.2    Banchereau, J.3
  • 27
    • 0031677776 scopus 로고    scopus 로고
    • Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5+ B-cells
    • Tangye S.G., Weston K.M., Raison R.L. Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5+ B-cells. Leuk Lymphoma 1998, 31:121-130.
    • (1998) Leuk Lymphoma , vol.31 , pp. 121-130
    • Tangye, S.G.1    Weston, K.M.2    Raison, R.L.3
  • 28
    • 0029117028 scopus 로고
    • The role of interleukin-10 (IL-10) in chronic B-lymphocytic leukemia: IL-10 prevents leukemic cells from apoptotic cell death
    • Kitabayashi A., Hirokawa M., Miura A.B. The role of interleukin-10 (IL-10) in chronic B-lymphocytic leukemia: IL-10 prevents leukemic cells from apoptotic cell death. Int J Hematol 1995, 62:99-106.
    • (1995) Int J Hematol , vol.62 , pp. 99-106
    • Kitabayashi, A.1    Hirokawa, M.2    Miura, A.B.3
  • 29
    • 0029937459 scopus 로고    scopus 로고
    • Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia
    • Reittie J.E., Yong K.L., Panayiotidis P., Hoffbrand A.V. Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. Leuk Lymphoma 1996, 22:83-90.
    • (1996) Leuk Lymphoma , vol.22 , pp. 83-90
    • Reittie, J.E.1    Yong, K.L.2    Panayiotidis, P.3    Hoffbrand, A.V.4
  • 30
    • 0027528694 scopus 로고
    • Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta
    • Aderka D., Maor Y., Novick D., Engelmann H., Kahn Y., Levo Y., et al. Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta. Blood 1993, 81:2076-2084.
    • (1993) Blood , vol.81 , pp. 2076-2084
    • Aderka, D.1    Maor, Y.2    Novick, D.3    Engelmann, H.4    Kahn, Y.5    Levo, Y.6
  • 32
    • 0034878106 scopus 로고    scopus 로고
    • Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia
    • Mainou-Fowler T., Proctor S.J., Miller S., Dickinson A.M. Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma 2001, 42:689-698.
    • (2001) Leuk Lymphoma , vol.42 , pp. 689-698
    • Mainou-Fowler, T.1    Proctor, S.J.2    Miller, S.3    Dickinson, A.M.4
  • 33
    • 0031044585 scopus 로고    scopus 로고
    • Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells
    • Mu X., Kay N.E., Gosland M.P., Jennings C.D. Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells. Br J Haematol 1997, 96:733-735.
    • (1997) Br J Haematol , vol.96 , pp. 733-735
    • Mu, X.1    Kay, N.E.2    Gosland, M.P.3    Jennings, C.D.4
  • 34
    • 0035106335 scopus 로고    scopus 로고
    • Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis
    • Kay N.E., Han L., Bone N., Williams G. Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis. Br J Haematol 2001, 112:760-767.
    • (2001) Br J Haematol , vol.112 , pp. 760-767
    • Kay, N.E.1    Han, L.2    Bone, N.3    Williams, G.4
  • 35
    • 0027379859 scopus 로고
    • Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis P., Ganeshaguru K., Jabbar S.A., Hoffbrand A.V. Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro. Br J Haematol 1993, 85:439-445.
    • (1993) Br J Haematol , vol.85 , pp. 439-445
    • Panayiotidis, P.1    Ganeshaguru, K.2    Jabbar, S.A.3    Hoffbrand, A.V.4
  • 36
    • 0026754538 scopus 로고
    • Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
    • Dancescu M., Rubio-Trujillo M., Biron G., Bron D., Delespesse G., Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med 1992, 176:1319-1326.
    • (1992) J Exp Med , vol.176 , pp. 1319-1326
    • Dancescu, M.1    Rubio-Trujillo, M.2    Biron, G.3    Bron, D.4    Delespesse, G.5    Sarfati, M.6
  • 37
    • 0033025248 scopus 로고    scopus 로고
    • IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia
    • de Totero D., Reato G., Mauro F., Cignetti A., Ferrini S., Guarini A., et al. IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 104:589-599.
    • (1999) Br J Haematol , vol.104 , pp. 589-599
    • de Totero, D.1    Reato, G.2    Mauro, F.3    Cignetti, A.4    Ferrini, S.5    Guarini, A.6
  • 38
    • 0035257011 scopus 로고    scopus 로고
    • Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells
    • Cerutti A., Kim E.C., Shah S., Schattner E.J., Zan H., Schaffer A., et al. Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells. Nat Immunol 2001, 2:150-156.
    • (2001) Nat Immunol , vol.2 , pp. 150-156
    • Cerutti, A.1    Kim, E.C.2    Shah, S.3    Schattner, E.J.4    Zan, H.5    Schaffer, A.6
  • 39
    • 78649439306 scopus 로고    scopus 로고
    • T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies
    • [Epub ahead of print]
    • Lindqvist C.A., Christiansson L.H., Simonsson B., Enblad G., Olsson-Stromberg U., Loskog A.S. T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies. Immunology 2010, [Epub ahead of print].
    • (2010) Immunology
    • Lindqvist, C.A.1    Christiansson, L.H.2    Simonsson, B.3    Enblad, G.4    Olsson-Stromberg, U.5    Loskog, A.S.6
  • 41
    • 0019788524 scopus 로고
    • Unusual T-cell phenotype in advanced B-chronic lymphocytic leukaemia
    • Matutes E., Wechsler A., Gomez R., Cherchi M., Catovsky D. Unusual T-cell phenotype in advanced B-chronic lymphocytic leukaemia. Br J Haematol 1981, 49:635-642.
    • (1981) Br J Haematol , vol.49 , pp. 635-642
    • Matutes, E.1    Wechsler, A.2    Gomez, R.3    Cherchi, M.4    Catovsky, D.5
  • 42
    • 0019934873 scopus 로고
    • Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: an analysis by monoclonal antibodies
    • Platsoucas C.D., Galinski M., Kempin S., Reich L., Clarkson B., Good R.A. Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: an analysis by monoclonal antibodies. J Immunol 1982, 129:2305-2312.
    • (1982) J Immunol , vol.129 , pp. 2305-2312
    • Platsoucas, C.D.1    Galinski, M.2    Kempin, S.3    Reich, L.4    Clarkson, B.5    Good, R.A.6
  • 43
    • 0019949239 scopus 로고
    • Imbalance of T cell subpopulations in patients with chronic lymphocytic leukaemia of the B cell type
    • Herrmann F., Lochner A., Philippen H., Jauer B., Ruhl H. Imbalance of T cell subpopulations in patients with chronic lymphocytic leukaemia of the B cell type. Clin Exp Immunol 1982, 49:157-162.
    • (1982) Clin Exp Immunol , vol.49 , pp. 157-162
    • Herrmann, F.1    Lochner, A.2    Philippen, H.3    Jauer, B.4    Ruhl, H.5
  • 44
    • 0032101593 scopus 로고    scopus 로고
    • Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia
    • Tinhofer I., Marschitz I., Kos M., Henn T., Egle A., Villunger A., et al. Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia. Blood 1998, 91:4273-4281.
    • (1998) Blood , vol.91 , pp. 4273-4281
    • Tinhofer, I.1    Marschitz, I.2    Kos, M.3    Henn, T.4    Egle, A.5    Villunger, A.6
  • 45
    • 0021013632 scopus 로고
    • Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia
    • Pizzolo G., Chilosi M., Ambrosetti A., Semenzato G., Fiore-Donati L., Perona G. Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia. Blood 1983, 62:1289-1296.
    • (1983) Blood , vol.62 , pp. 1289-1296
    • Pizzolo, G.1    Chilosi, M.2    Ambrosetti, A.3    Semenzato, G.4    Fiore-Donati, L.5    Perona, G.6
  • 46
    • 0036099832 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    • Ghia P., Strola G., Granziero L., Geuna M., Guida G., Sallusto F., et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. Eur J Immunol 2002, 32:1403-1413.
    • (2002) Eur J Immunol , vol.32 , pp. 1403-1413
    • Ghia, P.1    Strola, G.2    Granziero, L.3    Geuna, M.4    Guida, G.5    Sallusto, F.6
  • 47
    • 0028125308 scopus 로고
    • T cell repertoire in patients with B chronic lymphocytic leukemia Evidence for multiple in vivo T cell clonal expansions
    • Farace F., Orlanducci F., Dietrich P.Y., Gaudin C., Angevin E., Courtier M.H., et al. T cell repertoire in patients with B chronic lymphocytic leukemia Evidence for multiple in vivo T cell clonal expansions. J Immunol 1994, 153:4281-4290.
    • (1994) J Immunol , vol.153 , pp. 4281-4290
    • Farace, F.1    Orlanducci, F.2    Dietrich, P.Y.3    Gaudin, C.4    Angevin, E.5    Courtier, M.H.6
  • 48
    • 0033178658 scopus 로고    scopus 로고
    • Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: major perturbations are preferentially seen within the CD4 T-cell subset
    • Rezvany M.R., Jeddi-Tehrani M., Osterborg A., Kimby E., Wigzell H., Mellstedt H. Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: major perturbations are preferentially seen within the CD4 T-cell subset. Blood 1999, 94:1063-1069.
    • (1999) Blood , vol.94 , pp. 1063-1069
    • Rezvany, M.R.1    Jeddi-Tehrani, M.2    Osterborg, A.3    Kimby, E.4    Wigzell, H.5    Mellstedt, H.6
  • 49
    • 0034659294 scopus 로고    scopus 로고
    • Expansions of clonal and oligoclonal T cells in B-cell chronic lymphocytic leukemia are primarily restricted to the CD3(+)CD8(+) T-cell population
    • Goolsby C.L., Kuchnio M., Finn W.G., Peterson L. Expansions of clonal and oligoclonal T cells in B-cell chronic lymphocytic leukemia are primarily restricted to the CD3(+)CD8(+) T-cell population. Cytometry 2000, 42:188-195.
    • (2000) Cytometry , vol.42 , pp. 188-195
    • Goolsby, C.L.1    Kuchnio, M.2    Finn, W.G.3    Peterson, L.4
  • 51
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 52
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M., Kochanek M., Darabi K., Popov A., Jensen M., Endl E., et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005, 106:2018-2025.
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3    Popov, A.4    Jensen, M.5    Endl, E.6
  • 53
    • 54549110000 scopus 로고    scopus 로고
    • Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia
    • Giannopoulos K., Schmitt M., Kowal M., Wlasiuk P., Bojarska-Junak A., Chen J., et al. Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia. Oncol Rep 2008, 20:677-682.
    • (2008) Oncol Rep , vol.20 , pp. 677-682
    • Giannopoulos, K.1    Schmitt, M.2    Kowal, M.3    Wlasiuk, P.4    Bojarska-Junak, A.5    Chen, J.6
  • 54
    • 68449093742 scopus 로고    scopus 로고
    • Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia
    • Jak M., Mous R., Remmerswaal E.B.M., Spijker R., Jaspers A., Yague A., et al. Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 2009, 50:788-801.
    • (2009) Leuk Lymphoma , vol.50 , pp. 788-801
    • Jak, M.1    Mous, R.2    Remmerswaal, E.B.M.3    Spijker, R.4    Jaspers, A.5    Yague, A.6
  • 56
    • 27144559654 scopus 로고    scopus 로고
    • Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia
    • Motta M., Rassenti L., Shelvin B.J., Lerner S., Kipps T.J., Keating M.J., et al. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Leukemia 2005, 19:1788-1793.
    • (2005) Leukemia , vol.19 , pp. 1788-1793
    • Motta, M.1    Rassenti, L.2    Shelvin, B.J.3    Lerner, S.4    Kipps, T.J.5    Keating, M.J.6
  • 57
    • 22144489127 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
    • Gorgun G., Holderried T.A., Zahrieh D., Neuberg D., Gribben J.G. Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest 2005, 115:1797-1805.
    • (2005) J Clin Invest , vol.115 , pp. 1797-1805
    • Gorgun, G.1    Holderried, T.A.2    Zahrieh, D.3    Neuberg, D.4    Gribben, J.G.5
  • 58
    • 33846626054 scopus 로고    scopus 로고
    • Regulation of T-cell activation by the cytoskeleton
    • Billadeau D.D., Nolz J.C., Gomez T.S. Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol 2007, 7:131-143.
    • (2007) Nat Rev Immunol , vol.7 , pp. 131-143
    • Billadeau, D.D.1    Nolz, J.C.2    Gomez, T.S.3
  • 59
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay A.G., Johnson A.J., Lee A.M., Gorgun G., Le Dieu R., Blum W., et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008, 118:2427-2437.
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3    Gorgun, G.4    Le Dieu, R.5    Blum, W.6
  • 60
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G., Ramsay A.G., Holderried T.A., Zahrieh D., Le Dieu R., Liu F., et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci USA 2009, 106:6250-6255.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3    Zahrieh, D.4    Le Dieu, R.5    Liu, F.6
  • 61
    • 85047692890 scopus 로고
    • T-cell functional abnormality in B-chronic lymphocytic leukaemia: evidence of a defect of the T-helper subset
    • Lauria F., Foa R., Mantovani V., Fierro M.T., Catovsky D., Tura S. T-cell functional abnormality in B-chronic lymphocytic leukaemia: evidence of a defect of the T-helper subset. Br J Haematol 1983, 54:277-283.
    • (1983) Br J Haematol , vol.54 , pp. 277-283
    • Lauria, F.1    Foa, R.2    Mantovani, V.3    Fierro, M.T.4    Catovsky, D.5    Tura, S.6
  • 62
    • 0018741577 scopus 로고
    • T cell helper defect in patients with chronic lymphocytic leukemia
    • Chiorazzi N., Fu S.M., Montazeri G., Kunkel H.G., Rai K., Gee T. T cell helper defect in patients with chronic lymphocytic leukemia. J Immunol 1979, 122:1087-1090.
    • (1979) J Immunol , vol.122 , pp. 1087-1090
    • Chiorazzi, N.1    Fu, S.M.2    Montazeri, G.3    Kunkel, H.G.4    Rai, K.5    Gee, T.6
  • 63
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson P.G., Schlossman R.L., Weller E., Hideshima T., Mitsiades C., Davies F., et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100:3063-3067.
    • (2002) Blood , vol.100 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3    Hideshima, T.4    Mitsiades, C.5    Davies, F.6
  • 65
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber D.M., Chen C., Niesvizky R., Wang M., Belch A., Stadtmauer E.A., et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007, 357:2133-2142.
    • (2007) N Engl J Med , vol.357 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3    Wang, M.4    Belch, A.5    Stadtmauer, E.A.6
  • 66
    • 33947243663 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study
    • Chanan-Khan A., Miller K.C., Musial L., Lawrence D., Padmanabhan S., Takeshita K., et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 2006, 24:5343-5349.
    • (2006) J Clin Oncol , vol.24 , pp. 5343-5349
    • Chanan-Khan, A.1    Miller, K.C.2    Musial, L.3    Lawrence, D.4    Padmanabhan, S.5    Takeshita, K.6
  • 67
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A., Lee B.N., Schlette E.J., O'Brien S.M., Gao H., Wen S., et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008, 111:5291-5297.
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1    Lee, B.N.2    Schlette, E.J.3    O'Brien, S.M.4    Gao, H.5    Wen, S.6
  • 68
    • 70349150560 scopus 로고    scopus 로고
    • Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
    • Aue G., Njuguna N., Tian X., Soto S., Hughes T., Vire B., et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica 2009, 94:1266-1273.
    • (2009) Haematologica , vol.94 , pp. 1266-1273
    • Aue, G.1    Njuguna, N.2    Tian, X.3    Soto, S.4    Hughes, T.5    Vire, B.6
  • 69
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
    • Andritsos L.A., Johnson A.J., Lozanski G., Blum W., Kefauver C., Awan F., et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008, 26:2519-2525.
    • (2008) J Clin Oncol , vol.26 , pp. 2519-2525
    • Andritsos, L.A.1    Johnson, A.J.2    Lozanski, G.3    Blum, W.4    Kefauver, C.5    Awan, F.6
  • 70
    • 41149168649 scopus 로고    scopus 로고
    • Lenalidomide for the treatment of B-cell malignancies
    • Chanan-Khan A.A., Cheson B.D. Lenalidomide for the treatment of B-cell malignancies. J Clin Oncol 2008, 26:1544-1552.
    • (2008) J Clin Oncol , vol.26 , pp. 1544-1552
    • Chanan-Khan, A.A.1    Cheson, B.D.2
  • 72
    • 77950966887 scopus 로고    scopus 로고
    • Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B Cells through a PI3-kinase dependent pathway
    • Lapalombella R., Andritsos L., Liu Q., May S.E., Browning R., Pham L.V., et al. Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B Cells through a PI3-kinase dependent pathway. Blood 2009, 115:2619-2629.
    • (2009) Blood , vol.115 , pp. 2619-2629
    • Lapalombella, R.1    Andritsos, L.2    Liu, Q.3    May, S.E.4    Browning, R.5    Pham, L.V.6
  • 73
    • 77954096721 scopus 로고    scopus 로고
    • Lenalidomide therapy is associated with normalization of lymphocyte populations and increase in immunoglobulin levels in elderly patients with chronic lymphocytic leukemia
    • 10.31
    • Badoux X., Reuben J., Lee B., Jorgensen J., Estrov Z., Yerrow K., et al. Lenalidomide therapy is associated with normalization of lymphocyte populations and increase in immunoglobulin levels in elderly patients with chronic lymphocytic leukemia. Haematologica 2009, 94. 10.31.
    • (2009) Haematologica , vol.94
    • Badoux, X.1    Reuben, J.2    Lee, B.3    Jorgensen, J.4    Estrov, Z.5    Yerrow, K.6
  • 74
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
    • Corral L.G., Haslett P.A., Muller G.W., Chen R., Wong L.M., Ocampo C.J., et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J Immunol 1999, 163:380-386.
    • (1999) J Immunol , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.2    Muller, G.W.3    Chen, R.4    Wong, L.M.5    Ocampo, C.J.6
  • 75
    • 67651111993 scopus 로고    scopus 로고
    • Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
    • Xu Y., Li J., Ferguson G.D., Mercurio F., Khambatta G., Morrison L., et al. Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood 2009, 114:338-345.
    • (2009) Blood , vol.114 , pp. 338-345
    • Xu, Y.1    Li, J.2    Ferguson, G.D.3    Mercurio, F.4    Khambatta, G.5    Morrison, L.6
  • 76
    • 79951917839 scopus 로고    scopus 로고
    • Lenalidomide alone and in combination with rituximab enhances NK cell immune synapse formation in chronic lymphocytic leukemia (CLL) cells in vitro through activation of Rho and Rac1 GTPases
    • Gaidarova S.L.J., Corral L.G., Glezer E., Schafer P.H., Xie W., Lopez-Girona A., et al. Lenalidomide alone and in combination with rituximab enhances NK cell immune synapse formation in chronic lymphocytic leukemia (CLL) cells in vitro through activation of Rho and Rac1 GTPases. Blood 2009, 114.
    • (2009) Blood , pp. 114
    • Gaidarova, S.L.J.1    Corral, L.G.2    Glezer, E.3    Schafer, P.H.4    Xie, W.5    Lopez-Girona, A.6
  • 77
    • 75649140955 scopus 로고    scopus 로고
    • How I treat CLL up front
    • Gribben J.G. How I treat CLL up front. Blood 2010, 115:187-197.
    • (2010) Blood , vol.115 , pp. 187-197
    • Gribben, J.G.1
  • 78
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai K.R., Peterson B.L., Appelbaum F.R., Kolitz J., Elias L., Shepherd L., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000, 343:1750-1757.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3    Kolitz, J.4    Elias, L.5    Shepherd, L.6
  • 79
    • 61849091076 scopus 로고    scopus 로고
    • Immunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression free survival (PFS) of previously untreated patients with advanced chronic lymphocytic leukemia (CLL)
    • abstract 325
    • Hallek M., Fingerle-Rowson G., Fink A.M. Immunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression free survival (PFS) of previously untreated patients with advanced chronic lymphocytic leukemia (CLL). Blood 2008, 112. abstract 325.
    • (2008) Blood , vol.112
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 80
    • 70350123882 scopus 로고    scopus 로고
    • Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
    • Giannopoulos K., Dmoszynska A., Kowal M., Wasik-Szczepanek E., Bojarska-Junak A., Rolinski J., et al. Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia. Leukemia 2009, 23:1771-1778.
    • (2009) Leukemia , vol.23 , pp. 1771-1778
    • Giannopoulos, K.1    Dmoszynska, A.2    Kowal, M.3    Wasik-Szczepanek, E.4    Bojarska-Junak, A.5    Rolinski, J.6
  • 81
    • 51349108336 scopus 로고    scopus 로고
    • Vaccine therapy and chronic lymphocytic leukaemia
    • Ramsay A.G., Gribben J.G. Vaccine therapy and chronic lymphocytic leukaemia. Best Pract Res Clin Haematol 2008, 21:421-436.
    • (2008) Best Pract Res Clin Haematol , vol.21 , pp. 421-436
    • Ramsay, A.G.1    Gribben, J.G.2
  • 82
    • 33646010349 scopus 로고    scopus 로고
    • Vaccine- and immune-based therapy in chronic lymphocytic leukemia
    • Le Dieu R., Gribben J. Vaccine- and immune-based therapy in chronic lymphocytic leukemia. Semin Oncol 2006, 33:220-229.
    • (2006) Semin Oncol , vol.33 , pp. 220-229
    • Le Dieu, R.1    Gribben, J.2
  • 83
    • 0037818503 scopus 로고    scopus 로고
    • Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells
    • Schmidt S.M., Schag K., Muller M.R., Weck M.M., Appel S., Kanz L., et al. Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. Blood 2003, 102:571-576.
    • (2003) Blood , vol.102 , pp. 571-576
    • Schmidt, S.M.1    Schag, K.2    Muller, M.R.3    Weck, M.M.4    Appel, S.5    Kanz, L.6
  • 84
    • 33750478484 scopus 로고    scopus 로고
    • Expression of RHAMM/CD168 and other tumor-associated antigens in patients with B-cell chronic lymphocytic leukemia
    • Giannopoulos K., Li L., Bojarska-Junak A., Rolinski J., Dmoszynska A., Hus I., et al. Expression of RHAMM/CD168 and other tumor-associated antigens in patients with B-cell chronic lymphocytic leukemia. Int J Oncol 2006, 29:95-103.
    • (2006) Int J Oncol , vol.29 , pp. 95-103
    • Giannopoulos, K.1    Li, L.2    Bojarska-Junak, A.3    Rolinski, J.4    Dmoszynska, A.5    Hus, I.6
  • 85
    • 30344432112 scopus 로고    scopus 로고
    • MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes
    • Mayr C., Bund D., Schlee M., Bamberger M., Kofler D.M., Hallek M., et al. MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes. Exp Hematol 2006, 34:44-53.
    • (2006) Exp Hematol , vol.34 , pp. 44-53
    • Mayr, C.1    Bund, D.2    Schlee, M.3    Bamberger, M.4    Kofler, D.M.5    Hallek, M.6
  • 87
    • 13544251390 scopus 로고    scopus 로고
    • Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes
    • Mayr C., Bund D., Schlee M., Moosmann A., Kofler D.M., Hallek M., et al. Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. Blood 2005, 105:1566-1573.
    • (2005) Blood , vol.105 , pp. 1566-1573
    • Mayr, C.1    Bund, D.2    Schlee, M.3    Moosmann, A.4    Kofler, D.M.5    Hallek, M.6
  • 88
    • 34249101912 scopus 로고    scopus 로고
    • CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes
    • Bund D., Mayr C., Kofler D.M., Hallek M., Wendtner C.M. CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes. Exp Hematol 2007, 35:920-930.
    • (2007) Exp Hematol , vol.35 , pp. 920-930
    • Bund, D.1    Mayr, C.2    Kofler, D.M.3    Hallek, M.4    Wendtner, C.M.5
  • 89
    • 42949121156 scopus 로고    scopus 로고
    • Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
    • Fukuda T., Chen L., Endo T., Tang L., Lu D., Castro J.E., et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci USA 2008, 105:3047-3052.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3047-3052
    • Fukuda, T.1    Chen, L.2    Endo, T.3    Tang, L.4    Lu, D.5    Castro, J.E.6
  • 90
    • 0016515376 scopus 로고
    • Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes
    • Janeway C.A., Sakato N., Eisen H.N. Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes. Proc Natl Acad Sci USA 1975, 72:2357-2360.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 2357-2360
    • Janeway, C.A.1    Sakato, N.2    Eisen, H.N.3
  • 91
    • 0034125194 scopus 로고    scopus 로고
    • Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies
    • Trojan A., Schultze J.L., Witzens M., Vonderheide R.H., Ladetto M., Donovan J.W., et al. Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies. Nat Med 2000, 6:667-672.
    • (2000) Nat Med , vol.6 , pp. 667-672
    • Trojan, A.1    Schultze, J.L.2    Witzens, M.3    Vonderheide, R.H.4    Ladetto, M.5    Donovan, J.W.6
  • 92
    • 0026793994 scopus 로고
    • Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors
    • Kwak L.W., Campbell M.J., Czerwinski D.K., Hart S., Miller R.A., Levy R. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med 1992, 327:1209-1215.
    • (1992) N Engl J Med , vol.327 , pp. 1209-1215
    • Kwak, L.W.1    Campbell, M.J.2    Czerwinski, D.K.3    Hart, S.4    Miller, R.A.5    Levy, R.6
  • 93
    • 0031007771 scopus 로고    scopus 로고
    • Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma-long-term results of a clinical trial
    • Hsu F.J., Caspar C.B., Czerwinski D., Kwak L.W., Liles T.M., Syrengelas A., et al. Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma-long-term results of a clinical trial. Blood 1997, 89:3129-3135.
    • (1997) Blood , vol.89 , pp. 3129-3135
    • Hsu, F.J.1    Caspar, C.B.2    Czerwinski, D.3    Kwak, L.W.4    Liles, T.M.5    Syrengelas, A.6
  • 94
    • 0035892122 scopus 로고    scopus 로고
    • Induction of cytotoxic T-cell responses against immunoglobulin V region-derived peptides modified at human leukocyte antigen-A2 binding residues
    • Harig S., Witzens M., Krackhardt A.M., Trojan A., Barrett P., Broderick R., et al. Induction of cytotoxic T-cell responses against immunoglobulin V region-derived peptides modified at human leukocyte antigen-A2 binding residues. Blood 2001, 98:2999-3005.
    • (2001) Blood , vol.98 , pp. 2999-3005
    • Harig, S.1    Witzens, M.2    Krackhardt, A.M.3    Trojan, A.4    Barrett, P.5    Broderick, R.6
  • 95
    • 26944462424 scopus 로고    scopus 로고
    • Allogeneic dendritic cells pulsed with tumor lysates or apoptotic bodies as immunotherapy for patients with early-stage B-cell chronic lymphocytic leukemia
    • Hus I., Rolinski J., Tabarkiewicz J., Wojas K., Bojarska-Junak A., Greiner J., et al. Allogeneic dendritic cells pulsed with tumor lysates or apoptotic bodies as immunotherapy for patients with early-stage B-cell chronic lymphocytic leukemia. Leukemia 2005, 19:1621-1627.
    • (2005) Leukemia , vol.19 , pp. 1621-1627
    • Hus, I.1    Rolinski, J.2    Tabarkiewicz, J.3    Wojas, K.4    Bojarska-Junak, A.5    Greiner, J.6
  • 96
    • 43749119376 scopus 로고    scopus 로고
    • Vaccination of B-CLL patients with autologous dendritic cells can change the frequency of leukemia antigen-specific CD8+ T cells as well as CD4+CD25+FoxP3+ regulatory T cells toward an antileukemia response
    • Hus I., Schmitt M., Tabarkiewicz J., Radej S., Wojas K., Bojarska-Junak A., et al. Vaccination of B-CLL patients with autologous dendritic cells can change the frequency of leukemia antigen-specific CD8+ T cells as well as CD4+CD25+FoxP3+ regulatory T cells toward an antileukemia response. Leukemia 2008, 22:1007-1017.
    • (2008) Leukemia , vol.22 , pp. 1007-1017
    • Hus, I.1    Schmitt, M.2    Tabarkiewicz, J.3    Radej, S.4    Wojas, K.5    Bojarska-Junak, A.6
  • 97
    • 21244467877 scopus 로고    scopus 로고
    • A phase I/II trial of oxidized autologous tumor vaccines during the " watch and wait" phase of chronic lymphocytic leukemia
    • Spaner D.E., Hammond C., Mena J., Foden C., Deabreu A. A phase I/II trial of oxidized autologous tumor vaccines during the " watch and wait" phase of chronic lymphocytic leukemia. Cancer Immunol Immunother 2005, 54:635-646.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 635-646
    • Spaner, D.E.1    Hammond, C.2    Mena, J.3    Foden, C.4    Deabreu, A.5
  • 98
    • 27744468475 scopus 로고    scopus 로고
    • Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules
    • Palena C., Foon K.A., Panicali D., Yafal A.G., Chinsangaram J., Hodge J.W., et al. Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules. Blood 2005, 106:3515-3523.
    • (2005) Blood , vol.106 , pp. 3515-3523
    • Palena, C.1    Foon, K.A.2    Panicali, D.3    Yafal, A.G.4    Chinsangaram, J.5    Hodge, J.W.6
  • 99
    • 0034925044 scopus 로고    scopus 로고
    • Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphoma
    • Takahashi S., Yotnda P., Rousseau R.F., Mei Z., Smith S., Rill D., et al. Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphoma. Cancer Gene Ther 2001, 8:378-387.
    • (2001) Cancer Gene Ther , vol.8 , pp. 378-387
    • Takahashi, S.1    Yotnda, P.2    Rousseau, R.F.3    Mei, Z.4    Smith, S.5    Rill, D.6
  • 100
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan R.A., Dudley M.E., Wunderlich J.R., Hughes M.S., Yang J.C., Sherry R.M., et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006, 314:126-129.
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3    Hughes, M.S.4    Yang, J.C.5    Sherry, R.M.6
  • 101
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically-engineered to recognize CD19
    • [Epub ahead of print]
    • Kochenderfer J.N., Wilson W.H., Janik J.E., Dudley M.E., Stetler-Stevenson M., Feldman S.A., et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically-engineered to recognize CD19. Blood 2010, [Epub ahead of print].
    • (2010) Blood
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3    Dudley, M.E.4    Stetler-Stevenson, M.5    Feldman, S.A.6
  • 102
    • 78649461928 scopus 로고    scopus 로고
    • The B-cell tumor associated antigen ROR1 can be targeted with T-cells modified to express a ROR1-specific chimeric antigen receptor
    • [Epub ahead of print]
    • Hudecek M., Schmitt T.M., Baskar S., Lupo-Stanghellini M.T., Nishida T., Yamamoto T.N., et al. The B-cell tumor associated antigen ROR1 can be targeted with T-cells modified to express a ROR1-specific chimeric antigen receptor. Blood 2010, [Epub ahead of print].
    • (2010) Blood
    • Hudecek, M.1    Schmitt, T.M.2    Baskar, S.3    Lupo-Stanghellini, M.T.4    Nishida, T.5    Yamamoto, T.N.6
  • 103
    • 76249116978 scopus 로고    scopus 로고
    • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice
    • James S.E., Orgun N.N., Tedder T.F., Shlomchik M.J., Jensen M.C., Lin Y., et al. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood 2009, 114:5454-5463.
    • (2009) Blood , vol.114 , pp. 5454-5463
    • James, S.E.1    Orgun, N.N.2    Tedder, T.F.3    Shlomchik, M.J.4    Jensen, M.C.5    Lin, Y.6
  • 104
    • 0042130360 scopus 로고    scopus 로고
    • Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group
    • Schetelig J., Thiede C., Bornhauser M., Schwerdtfeger R., Kiehl M., Beyer J., et al. Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. J Clin Oncol: Off J Am Soc Clin Oncol 2003, 21:2747-2753.
    • (2003) J Clin Oncol: Off J Am Soc Clin Oncol , vol.21 , pp. 2747-2753
    • Schetelig, J.1    Thiede, C.2    Bornhauser, M.3    Schwerdtfeger, R.4    Kiehl, M.5    Beyer, J.6
  • 105
    • 20844436596 scopus 로고    scopus 로고
    • Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis
    • [Leukemia Research Fund, UK]
    • Dreger P., Brand R., Milligan D., Corradini P., Finke J., Lambertenghi Deliliers G., et al. Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis. Leuk: Off J Leuk Soc Am 2005, 19:1029-1033. [Leukemia Research Fund, UK].
    • (2005) Leuk: Off J Leuk Soc Am , vol.19 , pp. 1029-1033
    • Dreger, P.1    Brand, R.2    Milligan, D.3    Corradini, P.4    Finke, J.5    Lambertenghi Deliliers, G.6
  • 106
    • 28844483804 scopus 로고    scopus 로고
    • Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
    • Gribben J.G., Zahrieh D., Stephans K., Bartlett-Pandite L., Alyea E.P., Fisher D.C., et al. Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood 2005, 106:4389-4396.
    • (2005) Blood , vol.106 , pp. 4389-4396
    • Gribben, J.G.1    Zahrieh, D.2    Stephans, K.3    Bartlett-Pandite, L.4    Alyea, E.P.5    Fisher, D.C.6
  • 107
    • 27744549869 scopus 로고    scopus 로고
    • Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-)
    • Caballero D., Garcia-Marco J.A., Martino R., Mateos V., Ribera J.M., Sarra J., et al. Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-). Clin Cancer Res: Off J Am Assoc Cancer Res 2005, 11:7757-7763.
    • (2005) Clin Cancer Res: Off J Am Assoc Cancer Res , vol.11 , pp. 7757-7763
    • Caballero, D.1    Garcia-Marco, J.A.2    Martino, R.3    Mateos, V.4    Ribera, J.M.5    Sarra, J.6
  • 108
    • 35548991084 scopus 로고    scopus 로고
    • Cellular immune therapy for chronic lymphocytic leukemia
    • Kater A.P., van Oers M.H., Kipps T.J. Cellular immune therapy for chronic lymphocytic leukemia. Blood 2007, 110:2811-2818.
    • (2007) Blood , vol.110 , pp. 2811-2818
    • Kater, A.P.1    van Oers, M.H.2    Kipps, T.J.3
  • 109
    • 33748694108 scopus 로고    scopus 로고
    • Autologous graft-versus-host disease-like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia
    • Zenz T., Ritgen M., Dreger P., Krober A., Barth T.F., Schlenk R., et al. Autologous graft-versus-host disease-like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia. Blood 2006, 108:2127-2130.
    • (2006) Blood , vol.108 , pp. 2127-2130
    • Zenz, T.1    Ritgen, M.2    Dreger, P.3    Krober, A.4    Barth, T.F.5    Schlenk, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.