Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia

Leukemia and Lymphoma

Volumn 42, Issue 4, 2001, Pages 689-698

  Mainou Fowler, T ^a   Proctor, S J ^a   Miller, S ^a   Dickinson, A M ^a  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

B and T lymphocytes; B cell chronic lymphocytic leukaemia; Interleukin 4

Indexed keywords

CALCIUM IONOPHORE; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; IONOMYCIN; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ;

ADULT; AGED; ARTICLE; AUTOCRINE EFFECT; B CELL LEUKEMIA; B LYMPHOCYTE; CELL FUNCTION; CELL ISOLATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CLINICAL OBSERVATION; CLINICAL STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; EVIDENCE BASED MEDICINE; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MALE; PARACRINE SIGNALING; PERIPHERAL LYMPHOCYTE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE;

EID: 0034878106     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190109099331     Document Type: Article

References (36)

1. Human T cell antigens defined by monoclonal antibodies: The 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin
2. The French Co-operative Group on CLL B-cell chronic lymphocytic leukaemia: Present status and future directions
3. Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro
4. Association between clonogenic cell growth and clinical risk group in B-cell chronic lymphocytic leukemia
5. Autocrine and paracrine growth loops in chronic lymphocytic leukaemia
6. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukaemia cells
7. Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4
8. Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukaemia
9. Interleukin-2 prevents programmed cell death in chronic lymphocytic leukemia cells
10. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
11. Production of IL4 by human T cells and regulation of differentiation of T-cell subsets by IL4
12. Immunoregulation by interleukin-4 in man
13. Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells
14. Regulation of IL-4 responsiveness in lymphoma B cells
15. In vitro activation of B-CLL cells
16. Interleukin-4 enhances homotypic adhesion of activated B-chronic lymphocytic leukemia (B-CLL) cells via a selective upregulation of CD54
17. Elevation of IgE-binding factors in serum of patients with B cell-derived chronic lymphocytic leukemia
18. Expression of CD23 antigen and its regulation by IL-4 in chronic lymphocytic leukemia
19. Chronic lymphocytic leukemia: Staging and prognostic factors
20. Effect of anti-apolipoprotein-1 on spontaneous apoptosis of B cells in chronic lymphocytic leukaemia: The role of bcl-2 and Interleukin 4
21. Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukaemia cells
22. Interleukin 4 induces synthesis of IgE and IgG4 in human B cells
23. Altered pattern of cytokine production by peripheral blood CD2+ cells from B chronic lymphocytic leukaemia patients
24. Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: Evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells
25. Chronic lymphocytic leukaemia B cells express restricted sets of mutated and unmutated antigen receptors
26. Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia
27. IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia
28. Role of accessory cells in cytokine production by T cells in chronic B-cell lymphocytic leukemia
29. Molecular investigation of the cytokines produced by normal and malignant B lymphocytes
30. Normal and aberrant expression of cytokines in neoplastic cells from chronic lymphocytic leukemias
31. Interleukin-4 and its receptor; modulating effects on immature and mature hematopoietic cells
32. Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway
33. Transcriptional and posttranscriptional regulation of the interleukin-4 and interleukin-3 genes in human T cells
34. Regulation of IL-4 receptors (IL-4R) in human CD5-positive B-cell lymphomas
35. Expression of IL-4 receptor on human a T and B lymphocytes
36. Regulation of Interleukin 4 receptors on human T cells