Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women [3]

Gastroenterology

Volumn 119, Issue 2, 2000, Pages 598-

  Malkhosyan, S R ^a   Yamamoto, H ^a   Piao, Z ^a   Perucho, M ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN MLH1; UNCLASSIFIED DRUG;

ADULT; CANCER INCIDENCE; COLON CARCINOMA; CONTROLLED STUDY; FEMALE; GENDER; GENE MUTATION; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; METHYLATION; PHENOTYPE; PRIORITY JOURNAL;

EID: 0033862311     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.16154     Document Type: Article

References (10)

1. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
2. Lessons from hereditary colorectal cancer
3. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
4. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
5. Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
6. Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLH1
7. Frameshift mutator mutations
8. Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features
9. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
10. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands