SCOPUS 정보 검색 플랫폼

Volumn 650, Issue 1, 2011, Pages 58-63

Pharmacological profile of AS1670542, a novel orally-active human thrombopoietin receptor agonist

(9) Abe, Masaki a Suzuki, Ken Ichi a Sakata, Chinatsu a Sugasawa, Keizo a Hirayama, Fukushi a Koga, Yuji a Kawasaki, Tomihisa a Naganuma, Shin a Itoh, Hiroyuki a

a ASTELLAS PHARMA INC (Japan)

Author keywords

AS1670542; Eltrombopag; Megakaryocyte; NOD SCID mice; Thrombopoietin; TPO receptor

Indexed keywords

AS 1670542; CD34 ANTIGEN; ELTROMBOPAG; HEMOSTATIC AGENT; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; THROMBOCYTE COUNT; TREATMENT OUTCOME; UMBILICAL CORD BLOOD;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD34; BENZOIC ACIDS; CELL LINE; CELL MEMBRANE; DOGS; FEMALE; HISTIDINE; HUMANS; HYDRAZINES; LIVER; MICE; MOLECULAR SEQUENCE DATA; PLATELET COUNT; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; RATS; RECEPTORS, THROMBOPOIETIN; SPECIES SPECIFICITY; STEM CELL TRANSPLANTATION; THIAZOLES; THIOPHENES;

EID: 78649740069 PISSN: 00142999 EISSN: None Source Type: Journal
DOI: 10.1016/j.ejphar.2010.09.072 Document Type: Article

Times cited : (16)

References (27)

1
- 52049096805
- Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor
- P.B. Alper, T.H. Marsilje, D. Mutnick, W. Lu, A. Chatterjee, M.J. Roberts, Y. He, D.S. Karanewsky, D. Chow, J. Lao, A. Gerken, T. Tuntland, B. Liu, J. Chang, P. Gordon, H.M. Seidel, and S.S. Tian Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor Bioorg. Med. Chem. Lett. 18 2008 5255 5258
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5255-5258
- Alper, P.B.¹ Marsilje, T.H.² Mutnick, D.³ Lu, W.⁴ Chatterjee, A.⁵ Roberts, M.J.⁶ He, Y.⁷ Karanewsky, D.S.⁸ Chow, D.⁹ Lao, J.¹⁰ Gerken, A.¹¹ Tuntland, T.¹² Liu, B.¹³ Chang, J.¹⁴ Gordon, P.¹⁵ Seidel, H.M.¹⁶ Tian, S.S.¹⁷

2
- 0036530040
- Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
- R.L. Basser, E. O'Flaherty, M. Green, M. Edmonds, J. Nichol, D.M. Menchaca, B. Cohen, and C.G. Begley Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor Blood 99 2002 2599 2602
- (2002) Blood , vol.99 , pp. 2599-2602
- Basser, R.L.¹ O'Flaherty, E.² Green, M.³ Edmonds, M.⁴ Nichol, J.⁵ Menchaca, D.M.⁶ Cohen, B.⁷ Begley, C.G.⁸

3
- 48249118558
- Safety of eltrombopag, an oral non-peptide platelet growth factor, in the treatment of thrombocytopenia: Results of four randomized, placebo-controlled studies
- J.B. Bussel, J. McHutchison, D. Provan, A. Jagiello-Gruzfeld, R. Rafi, and S. Goodison Safety of eltrombopag, an oral non-peptide platelet growth factor, in the treatment of thrombocytopenia: results of four randomized, placebo-controlled studies Blood 110 2007 1299
- (2007) Blood , vol.110 , pp. 1299
- Bussel, J.B.¹ McHutchison, J.² Provan, D.³ Jagiello-Gruzfeld, A.⁴ Rafi, R.⁵ Goodison, S.⁶

4
- 60249099882
- Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: A randomised, double-blind, placebo-controlled trial
- J.B. Bussel, D. Provan, T. Shamsi, G. Cheng, B. Psaila, L. Kovaleva, A. Salama, J.M. Jenkins, D. Roychowdhury, B. Mayer, N. Stone, and M. Arning Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial Lancet 373 2009 641 648
- (2009) Lancet , vol.373 , pp. 641-648
- Bussel, J.B.¹ Provan, D.² Shamsi, T.³ Cheng, G.⁴ Psaila, B.⁵ Kovaleva, L.⁶ Salama, A.⁷ Jenkins, J.M.⁸ Roychowdhury, D.⁹ Mayer, B.¹⁰ Stone, N.¹¹ Arning, M.¹²

5
- 0035950101
- Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
- K.J. Duffy, M.G. Darcy, E. Delorme, S.B. Dillon, D.F. Eppley, C. Erickson-Miller, L. Giampa, C.B. Hopson, Y. Huang, R.M. Keenan, P. Lamb, L. Leong, N. Liu, S.G. Miller, A.T. Price, J. Rosen, R. Shah, T.N. Shaw, H. Smith, K.C. Stark, S.S. Tian, C. Tyree, K.J. Wiggall, L. Zhang, and J.I. Luengo Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis J. Med. Chem. 44 2001 3730 3745
- (2001) J. Med. Chem. , vol.44 , pp. 3730-3745
- Duffy, K.J.¹ Darcy, M.G.² Delorme, E.³ Dillon, S.B.⁴ Eppley, D.F.⁵ Erickson-Miller, C.⁶ Giampa, L.⁷ Hopson, C.B.⁸ Huang, Y.⁹ Keenan, R.M.¹⁰ Lamb, P.¹¹ Leong, L.¹² Liu, N.¹³ Miller, S.G.¹⁴ Price, A.T.¹⁵ Rosen, J.¹⁶ Shah, R.¹⁷ Shaw, T.N.¹⁸ Smith, H.¹⁹ Stark, K.C.²⁰ more..

6
- 62549153611
- Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
- C.L. Erickson-Miller, E. Delorme, S.S. Tian, C.B. Hopson, A.J. Landis, E.I. Valoret, T.S. Sellers, J. Rosen, S.G. Miller, J.I. Luengo, K.J. Duffy, and J.M. Jenkins Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist Stem Cells (Dayton, Ohio) 27 2009 424 430
- (2009) Stem Cells (Dayton, Ohio) , vol.27 , pp. 424-430
- Erickson-Miller, C.L.¹ Delorme, E.² Tian, S.S.³ Hopson, C.B.⁴ Landis, A.J.⁵ Valoret, E.I.⁶ Sellers, T.S.⁷ Rosen, J.⁸ Miller, S.G.⁹ Luengo, J.I.¹⁰ Duffy, K.J.¹¹ Jenkins, J.M.¹²

7
- 52249095318
- AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis
- M. Fukushima-Shintani, K. Suzuki, Y. Iwatsuki, M. Abe, K. Sugasawa, F. Hirayama, and T. Kawasaki AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis Exp. Hematol. 36 2008 1337 1342
- (2008) Exp. Hematol. , vol.36 , pp. 1337-1342
- Fukushima-Shintani, M.¹ Suzuki, K.² Iwatsuki, Y.³ Abe, M.⁴ Sugasawa, K.⁵ Hirayama, F.⁶ Kawasaki, T.⁷

8
- 61349155417
- AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist
- M. Fukushima-Shintani, K. Suzuki, Y. Iwatsuki, M. Abe, K. Sugasawa, F. Hirayama, T. Kawasaki, and T. Nakahata AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist Eur. J. Haematol. 82 2009 247 254
- (2009) Eur. J. Haematol. , vol.82 , pp. 247-254
- Fukushima-Shintani, M.¹ Suzuki, K.² Iwatsuki, Y.³ Abe, M.⁴ Sugasawa, K.⁵ Hirayama, F.⁶ Kawasaki, T.⁷ Nakahata, T.⁸

9
- 34249719511
- Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
- J.M. Jenkins, D. Williams, Y. Deng, J. Uhl, V. Kitchen, D. Collins, and C.L. Erickson-Miller Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist Blood 109 2007 4739 4741
- (2007) Blood , vol.109 , pp. 4739-4741
- Jenkins, J.M.¹ Williams, D.² Deng, Y.³ Uhl, J.⁴ Kitchen, V.⁵ Collins, D.⁶ Erickson-Miller, C.L.⁷

10
- 0032505102
- Thrombopoietin
- K. Kaushansky Thrombopoietin N Engl J. Med. 339 1998 746 754
- (1998) N Engl J. Med. , vol.339 , pp. 746-754
- Kaushansky, K.¹

11
- 0037071389
- The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production
- K. Kaushansky, and J.G. Drachman The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production Oncogene 21 2002 3359 3367
- (2002) Oncogene , vol.21 , pp. 3359-3367
- Kaushansky, K.¹ Drachman, J.G.²

12
- 34347210686
- NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains
- M.J. Kim, S.H. Park, S.J. Opella, T.H. Marsilje, P.Y. Michellys, H.M. Seidel, and S.S. Tian NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains J. Biol. Chem. 282 2007 14253 14261
- (2007) J. Biol. Chem. , vol.282 , pp. 14253-14261
- Kim, M.J.¹ Park, S.H.² Opella, S.J.³ Marsilje, T.H.⁴ Michellys, P.Y.⁵ Seidel, H.M.⁶ Tian, S.S.⁷

13
- 0032577533
- A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl
- T. Kimura, H. Kaburaki, T. Tsujino, Y. Ikeda, H. Kato, and Y. Watanabe A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl FEBS Lett. 428 1998 250 254
- (1998) FEBS Lett. , vol.428 , pp. 250-254
- Kimura, T.¹ Kaburaki, H.² Tsujino, T.³ Ikeda, Y.⁴ Kato, H.⁵ Watanabe, Y.⁶

14
- 34249733156
- New thrombopoietic growth factors
- D.J. Kuter New thrombopoietic growth factors Blood 109 2007 4607 4616
- (2007) Blood , vol.109 , pp. 4607-4616
- Kuter, D.J.¹

15
- 0035760892
- Thrombocytopenia caused by the development of antibodies to thrombopoietin
- J. Li, C. Yang, Y. Xia, A. Bertino, J. Glaspy, M. Roberts, and D.J. Kuter Thrombocytopenia caused by the development of antibodies to thrombopoietin Blood 98 2001 3241 3248
- (2001) Blood , vol.98 , pp. 3241-3248
- Li, J.¹ Yang, C.² Xia, Y.³ Bertino, A.⁴ Glaspy, J.⁵ Roberts, M.⁶ Kuter, D.J.⁷

16
- 52049092313
- Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold
- T.H. Marsilje, P.B. Alper, W. Lu, D. Mutnick, P.Y. Michellys, Y. He, D.S. Karanewsky, D. Chow, A. Gerken, J. Lao, M.J. Kim, H.M. Seidel, and S.S. Tian Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold Bioorg. Med. Chem. Lett. 18 2008 5259 5262
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5259-5262
- Marsilje, T.H.¹ Alper, P.B.² Lu, W.³ Mutnick, D.⁴ Michellys, P.Y.⁵ He, Y.⁶ Karanewsky, D.S.⁷ Chow, D.⁸ Gerken, A.⁹ Lao, J.¹⁰ Kim, M.J.¹¹ Seidel, H.M.¹² Tian, S.S.¹³

17
- 36549047972
- Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
- J.G. McHutchison, G. Dusheiko, M.L. Shiffman, M. Rodriguez-Torres, S. Sigal, M. Bourliere, T. Berg, S.C. Gordon, F.M. Campbell, D. Theodore, N. Blackman, J. Jenkins, and N.H. Afdhal Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C N Engl J. Med. 357 2007 2227 2236
- (2007) N Engl J. Med. , vol.357 , pp. 2227-2236
- McHutchison, J.G.¹ Dusheiko, G.² Shiffman, M.L.³ Rodriguez-Torres, M.⁴ Sigal, S.⁵ Bourliere, M.⁶ Berg, T.⁷ Gordon, S.C.⁸ Campbell, F.M.⁹ Theodore, D.¹⁰ Blackman, N.¹¹ Jenkins, J.¹² Afdhal, N.H.¹³

18
- 33744456732
- A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
- T. Nakamura, Y. Miyakawa, A. Miyamura, A. Yamane, H. Suzuki, M. Ito, Y. Ohnishi, N. Ishiwata, Y. Ikeda, and N. Tsuruzoe A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis Blood 107 2006 4300 4307
- (2006) Blood , vol.107 , pp. 4300-4307
- Nakamura, T.¹ Miyakawa, Y.² Miyamura, A.³ Yamane, A.⁴ Suzuki, H.⁵ Ito, M.⁶ Ohnishi, Y.⁷ Ishiwata, N.⁸ Ikeda, Y.⁹ Tsuruzoe, N.¹⁰

19
- 54349089372
- The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
- W. Nogami, H. Yoshida, K. Koizumi, H. Yamada, K. Abe, A. Arimura, N. Yamane, K. Takahashi, A. Yamane, A. Oda, Y. Tanaka, H. Takemoto, Y. Ohnishi, Y. Ikeda, and Y. Miyakawa The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis Haematologica 93 2008 1495 1504
- (2008) Haematologica , vol.93 , pp. 1495-1504
- Nogami, W.¹ Yoshida, H.² Koizumi, K.³ Yamada, H.⁴ Abe, K.⁵ Arimura, A.⁶ Yamane, N.⁷ Takahashi, K.⁸ Yamane, A.⁹ Oda, A.¹⁰ Tanaka, Y.¹¹ Takemoto, H.¹² Ohnishi, Y.¹³ Ikeda, Y.¹⁴ Miyakawa, Y.¹⁵

20
- 13044262566
- Mimicry of erythropoietin by a nonpeptide molecule
- S.A. Qureshi, R.M. Kim, Z. Konteatis, D.E. Biazzo, H. Motamedi, R. Rodrigues, J.A. Boice, J.R. Calaycay, M.A. Bednarek, P. Griffin, Y.D. Gao, K. Chapman, and D.F. Mark Mimicry of erythropoietin by a nonpeptide molecule Proc. Natl Acad. Sci. USA 96 1999 12156 12161
- (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12156-12161
- Qureshi, S.A.¹ Kim, R.M.² Konteatis, Z.³ Biazzo, D.E.⁴ Motamedi, H.⁵ Rodrigues, R.⁶ Boice, J.A.⁷ Calaycay, J.R.⁸ Bednarek, M.A.⁹ Griffin, P.¹⁰ Gao, Y.D.¹¹ Chapman, K.¹² Mark, D.F.¹³

21
- 34548588275
- Pyrimidine benzamide-based thrombopoietin receptor agonists
- L.A. Reiter, C. Subramanyam, E.J. Mangual, C.S. Jones, M.I. Smeets, W.H. Brissette, S.P. McCurdy, P.D. Lira, R.G. Linde, Q. Li, F. Zhang, A.S. Antipas, L.C. Blumberg, J.L. Doty, J.P. Driscoll, M.J. Munchhof, S.L. Ripp, A. Shavnya, R.M. Shepard, D. Sperger, L.M. Thomasco, K.A. Trevena, L.A. Wolf-Gouveia, and L. Zhang Pyrimidine benzamide-based thrombopoietin receptor agonists Bioorg. Med. Chem. Lett. 17 2007 5447 5454
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5447-5454
- Reiter, L.A.¹ Subramanyam, C.² Mangual, E.J.³ Jones, C.S.⁴ Smeets, M.I.⁵ Brissette, W.H.⁶ McCurdy, S.P.⁷ Lira, P.D.⁸ Linde, R.G.⁹ Li, Q.¹⁰ Zhang, F.¹¹ Antipas, A.S.¹² Blumberg, L.C.¹³ Doty, J.L.¹⁴ Driscoll, J.P.¹⁵ Munchhof, M.J.¹⁶ Ripp, S.L.¹⁷ Shavnya, A.¹⁸ Shepard, R.M.¹⁹ Sperger, D.²⁰ more..

22
- 43049181695
- Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists
- L.A. Reiter, C.S. Jones, W.H. Brissette, S.P. McCurdy, Y.A. Abramov, J. Bordner, F.M. DiCapua, M.J. Munchhof, D.M. Rescek, I.J. Samardjiev, and J.M. Withka Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists Bioorg. Med. Chem. Lett. 18 2008 3000 3006
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 3000-3006
- Reiter, L.A.¹ Jones, C.S.² Brissette, W.H.³ McCurdy, S.P.⁴ Abramov, Y.A.⁵ Bordner, J.⁶ Dicapua, F.M.⁷ Munchhof, M.J.⁸ Rescek, D.M.⁹ Samardjiev, I.J.¹⁰ Withka, J.M.¹¹

23
- 33846074538
- Efficient assay for evaluating human thrombopoiesis using NOD/SCID mice transplanted with cord blood CD34+ cells
- K. Suzuki, H. Hiramatsu, M. Fukushima-Shintani, T. Heike, and T. Nakahata Efficient assay for evaluating human thrombopoiesis using NOD/SCID mice transplanted with cord blood CD34+ cells Eur. J. Haematol. 78 2007 123 130
- (2007) Eur. J. Haematol. , vol.78 , pp. 123-130
- Suzuki, K.¹ Hiramatsu, H.² Fukushima-Shintani, M.³ Heike, T.⁴ Nakahata, T.⁵

24
- 0034041388
- Hematopoietic repopulating ability of cord blood CD34(+) cells in NOD/Shi-scid mice
- T. Ueda, H. Yoshino, K. Kobayashi, M. Kawahata, Y. Ebihara, M. Ito, S. Asano, T. Nakahata, and K. Tsuji Hematopoietic repopulating ability of cord blood CD34(+) cells in NOD/Shi-scid mice Stem Cells (Dayton, Ohio) 18 2000 204 213
- (2000) Stem Cells (Dayton, Ohio) , vol.18 , pp. 204-213
- Ueda, T.¹ Yoshino, H.² Kobayashi, K.³ Kawahata, M.⁴ Ebihara, Y.⁵ Ito, M.⁶ Asano, S.⁷ Nakahata, T.⁸ Tsuji, K.⁹

25
- 0030966361
- Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer
- S. Vadhan-Raj, L.J. Murray, C. Bueso-Ramos, S. Patel, S.P. Reddy, W.K. Hoots, T. Johnston, N.E. Papadopolous, W.N. Hittelman, D.A. Johnston, T.A. Yang, V.E. Paton, R.L. Cohen, S.D. Hellmann, R.S. Benjamin, and H.E. Broxmeyer Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer Ann. Intern. Med. 126 1997 673 681
- (1997) Ann. Intern. Med. , vol.126 , pp. 673-681
- Vadhan-Raj, S.¹ Murray, L.J.² Bueso-Ramos, C.³ Patel, S.⁴ Reddy, S.P.⁵ Hoots, W.K.⁶ Johnston, T.⁷ Papadopolous, N.E.⁸ Hittelman, W.N.⁹ Johnston, D.A.¹⁰ Yang, T.A.¹¹ Paton, V.E.¹² Cohen, R.L.¹³ Hellmann, S.D.¹⁴ Benjamin, R.S.¹⁵ Broxmeyer, H.E.¹⁶

26
- 43549086159
- Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor
- N. Yamane, Y. Tanaka, N. Ohyabu, S. Yamane, K. Maekawa, J. Ishizaki, R. Suzuki, T. Itoh, and H. Takemoto Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor Eur. J. Pharmacol. 586 2008 44 51
- (2008) Eur. J. Pharmacol. , vol.586 , pp. 44-51
- Yamane, N.¹ Tanaka, Y.² Ohyabu, N.³ Yamane, S.⁴ Maekawa, K.⁵ Ishizaki, J.⁶ Suzuki, R.⁷ Itoh, T.⁸ Takemoto, H.⁹

27
- 78649742589
- AKR-501 activates the thrombopoietin receptor through interaction with the transmembrane domain
- J. Zhang, J. Alt, M. Yang, A. Baranwal, and T.B. Luby AKR-501 activates the thrombopoietin receptor through interaction with the transmembrane domain Blood 112 2008 5391
- (2008) Blood , vol.112 , pp. 5391
- Zhang, J.¹ Alt, J.² Yang, M.³ Baranwal, A.⁴ Luby, T.B.⁵

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