Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5259-5262

  Marsilje, Thomas H ^a   Alper, Phil B ^a   Lu, Wenshuo ^a   Mutnick, Daniel ^a   Michellys, Pierre Yves ^a   He, Yun ^a   Karanewsky, Donald S ^a   Chow, Donald ^a   Gerken, Andrea ^a   Lao, Jianmin ^a   Kim, Min Ju ^a   Seidel, H Martin ^a   Tian, Shin Shay ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Agonist; cMpl; Hematopoietic growth factor; Thrombopoietin; Tpo; TpoR

Indexed keywords

BENZENE DERIVATIVE; BENZO[A]CARBAZOLE DERIVATIVE; CARBAZOLE DERIVATIVE; ELTROMBOPAG; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; LIPOPHILICITY; MEGAKARYOCYTE;

BENZENE DERIVATIVES; CARBAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MEGAKARYOCYTES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECEPTORS, THROMBOPOIETIN; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPOIETIN;

EID: 52049092313     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.077     Document Type: Article

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