Identification of malignancy factors by analyzing cystic tumors of the pancreas

Pancreatology

Volumn 9, Issue 1-2, 2009, Pages 34-44

  Bauer, Andrea ^a,c   Kleeff, Jörg ^b   Bier, Melanie ^a   Wirtz, Martin ^b   Kayed, Hany ^b   Esposito, Irene ^b   Korc, Murray ^d   Hafner, Mathias ^c   Hoheisel, Jörg D ^a   Friess, Helmut ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Cystic lesions; Expression profiling; Fas activated serine threonine kinase; Pancreatic carcinoma; SiRNA silencing

Indexed keywords

FAS ACTIVATED SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PANCREAS CYSTIC CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; WESTERN BLOTTING;

EID: 57449113065     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000178873     Document Type: Article

References (34)

1. Volkan Adsay N: Cystic lesions of the pancreas. Mod Pathol 2007; 20(suppl 1):S71- S93.
2. Kloppel G, Kosmahl M: Cystic lesions and neoplasms of the pancreas. The features are becoming clearer. Pancreatology 2001; 1: 648-655.
3. Fernandez-del Castillo C, Warshaw AL: Cystic neoplasms of the pancreas. Pancreatology 2001; 1: 641-647.
4. Hamilton SR, Aaltonen LA (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon, IARC Press, 2000.
5. Strobel O, Z'Graggen K, Schmitz-Winnenthal FH, Friess H, Kappeler A, Zimmermann A, Uhl W, Büchler MW: Risk of malignancy in serous cystic neoplasms of the pancreas. Digestion 2003; 68: 24-33.
6. Brat DJ, Lillemoe KD, Yeo CJ, Warfield PB, Hruban RH: Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol 1998; 22: 163-169.
7. Brandt R, Grutzmann R, Bauer A, Jesnowski R, Ringel J, Lohr M, Pilarsky C, Hoheisel JD: DNA microarray analysis of pancreatic malignancies. Pancreatology 2004; 4: 587-597.
8. Friess H, Ding J, Kleeff J, Fenkell L, Rosinski JA, Guweidhi A, Reidhaar-Olson JF, Korc M, Hammer J, Büchler MW: Microarray-based identification of differentially expressed growth- and metastasis-associated genes in pancreatic cancer. Cell Mol Life Sci 2003; 60: 1180-1199.
9. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M: Minimum information about a microarray experiment (MIAME) - toward standards for microarray data. Nat Genet 2001; 29: 365-371.
10. Fellenberg K, Hauser NC, Brors B, Hoheisel JD, Vingron M: Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis. Bioinformatics 2002; 18: 423-433.
11. Beissbarth T, Fellenberg K, Brors B, Arribas- Prat R, Boer J, Hauser NC, Scheideler M, Hoheisel JD, Schutz G, Poustka A, Vingron M: Processing and quality control of DNA array hybridisation data. Bioinformatics 2000; 16: 1014-1022.
12. Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-5121.
13. Fellenberg K, Hauser NC, Brors B, Neutzner A, Hoheisel JD, Vingron M: Correspondence analysis applied to microarray data. Proc Natl Acad Sci USA 2001; 98: 10781-10786.
14. Esposito I, Kleeff J, Bischoff SC, Fischer L, Collecchi P, Iorio M, Bevilacqua G, Büchler MW, Friess H: The stem cell factor-c-kit system and mast cells in human pancreatic cancer. Lab Invest 2002; 82: 1481-1492.
15. Esposito I, Bauer A, Hoheisel JD, Kleeff J, Friess H, Bergmann F, Rieker RJ, Otto HF, Kloppel G, Penzel R: Microcystic tubulopapillary carcinoma of the pancreas: a new tumour entity? Virchows Arch 2004; 444: 447- 453.
16. Buchholz M, Kestler HA, Bauer A, Bock W, Rau B, Leder G, Kratzer W, Bommer M, Scarpa A, Schilling MK, Adler G, Hoheisel JD, Gress TM: Specialized DNA arrays for the differentiation of pancreatic tumours. Clin Cancer Res 2005; 11: 8048-8054.
17. Fellenberg K, Busold C, Witt O, Bauer A, Beckmann B, Hauser NC, Frohme M, Winter S, Dippon J, Hoheisel JD: Systematic interpretation of microarray data using experiment annotations. BMC Genomics 2006; 7: 319.
18. Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheisel JD, Friess H, Kleeff J: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. Cancer Biol Ther 2007; 6: 367-376.
19. Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A: Potential tumour suppressive pathway involving dusp6/mkp-3 in pancreatic cancer. Am J Pathol 2003; 162: 1807- 1815.
20. Luttges J, Zamboni G, Longnecker D, Kloppel G: The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. Am J Surg Pathol 2001; 25: 942-948.
21. Luttges J, Feyerabend B, Buchelt T, Pacena M, Kloppel G: The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 2002; 26: 466-471.
22. Sato N, Fukushima N, Maitra A, Iacobuzio- Donahue CA, van Heek NT, Cameron JL, Yeo CJ, Hruban RH, Goggins M: Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol 2004; 164: 903-914.
23. Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM: Cfos is required for malignant progression of skin tumours. Cell 1995; 82: 721-732.
24. Tian Q, Taupin J, Elledge S, Robertson M, Anderson P: Fas-activated serine/threonine kinase (fast) phosphorylates tia-1 during fasmediated apoptosis. J Exp Med 1995; 182: 865-874.
25. Li W, Simarro M, Kedersha N, Anderson P: Fast is a survival protein that senses mitochondrial stress and modulates tia-1-regulated changes in protein expression. Mol Cell Biol 2004; 24: 10718-10732.
26. Forch P, Valcarcel J: Molecular mechanisms of gene expression regulation by the apoptosis- promoting protein tia-1. Apoptosis 2001; 6: 463-468.
27. Holmstrom TH, Tran SE, Johnson VL, Ahn NG, Chow SC, Eriksson JE: Inhibition of mitogen- activated kinase signalling sensitizes hela cells to fas receptor-mediated apoptosis. Mol Cell Biol 1999; 19: 5991-6002.
28. Harvey SR, Hurd TC, Markus G, Martinick MI, Penetrante RM, Tan D, Venkataraman P, DeSouza N, Sait SN, Driscoll DL, Gibbs JF: Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer. Clin Cancer Res 2003; 9: 4935-4943.
29. Campani D, Esposito I, Boggi U, Cecchetti D, Menicagli M, De Negri F, Colizzi L, Del Chiaro M, Mosca F, Fornaciari G, Bevilacqua G: Bcl-2 expression in pancreas development and pancreatic cancer progression. J Pathol 2001; 194: 444-450.
30. Ueda S, Ogata S, Tsuda H, Kawarabayashi N, Kimura M, Sugiura Y, Tamai S, Matsubara O, Hatsuse K, Mochizuki H: The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumour aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 2004; 29:e1-e8.
31. Otte JM, Kiehne K, Schmitz F, Folsch UR, Herzig KH: C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells. Scand J Gastroenterol 2000; 35: 90-95.
32. Ozkan H, Kaya M, Cengiz A: Comparison of tumour marker CA 242 with CA 19-9 and carcinoembryonic antigen (CEA) in pancreatic cancer. Hepatogastroenterology 2003; 50: 1669-1674.
33. Gomez D, Rahman SH, Wong LF, Verbeke CS, Menon KV: Predictors of malignant potential of cystic lesions of the pancreas. Eur J Surg Oncol 2007; Epub ahead of print.
34. Demos TC, Posniak HV, Harmath C, Olson MC, Aranha G: Cystic lesions of the pancreas. AJR Am J Roentgenol 2002; 179: 1375- 1388.