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Volumn 10, Issue SUPPL. 3, 2010, Pages

Does the PI3K pathway play a role in basal breast cancer?

Author keywords

HER2; Targeted therapy; Triple negative disease

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (1H INDAZOL 4 YL) 6 (4 METHANESULFONYL 1 PIPERAZINYLMETHYL) 4 MORPHOLINOTHIENO[3,2 D]PYRIMIDINE; CAL 101; CARBOPLATIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; EVEROLIMUS; GSK 1059615; LETROZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MK 2206; NAVELBINE; NVP BGT 226; PACLITAXEL; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROGESTERONE RECEPTOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE INHIBITOR; TEMSIROLIMUS; TRASTUZUMAB; TRICIRIBINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 147; XL 765; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE;

EID: 78649717890     PISSN: 15268209     EISSN: None     Source Type: Journal    
DOI: 10.3816/CBC.2010.s.014     Document Type: Article
Times cited : (22)

References (67)
  • 1
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Clinical features and patterns of recurrence
    • Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 2007; 13:4429-34.
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 2
    • 55849132481 scopus 로고    scopus 로고
    • Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: High incidence of central nervous system metastases
    • Lin NU, Claus E, Sohl J, et al. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer 2008; 113:2638-45.
    • (2008) Cancer , vol.113 , pp. 2638-2645
    • Lin, N.U.1    Claus, E.2    Sohl, J.3
  • 3
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406:747-52.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 4
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 2003; 100:8418-23.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 5
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigman VJ, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007; 8:R76.
    • (2007) Genome Biol , vol.8
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3
  • 6
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10:5367-74
    • (2004) Clin Cancer Res , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 7
    • 36549004041 scopus 로고    scopus 로고
    • Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    • Kreike B, van Kouwenhove M, Horlings H, et al. Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res 2007; 9:R65.
    • (2007) Breast Cancer Res , vol.9
    • Kreike, B.1    Van Kouwenhove, M.2    Horlings, H.3
  • 8
    • 43949095489 scopus 로고    scopus 로고
    • How basal are triple-negative breast cancers?
    • Bertucci F, Finetti P, Cervera N, et al. How basal are triple-negative breast cancers? Int J Cancer 2008; 123:236-40.
    • (2008) Int J Cancer , vol.123 , pp. 236-240
    • Bertucci, F.1    Finetti, P.2    Cervera, N.3
  • 9
    • 33847136743 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Therapeutic options
    • Cleator S, Heller W, Coombes RC. Triple-negative breast cancer: therapeutic options. Lancet Oncol 2007; 8:235-44.
    • (2007) Lancet Oncol , vol.8 , pp. 235-244
    • Cleator, S.1    Heller, W.2    Coombes, R.C.3
  • 10
    • 4544315354 scopus 로고    scopus 로고
    • New targets for therapy in breast cancer: Mammalian target of rapamycin (mTOR) antagonists
    • Carraway H, Hidalgo M. New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists. Breast Cancer Res 2004; 6:219-24.
    • (2004) Breast Cancer Res , vol.6 , pp. 219-224
    • Carraway, H.1    Hidalgo, M.2
  • 11
    • 0033598161 scopus 로고    scopus 로고
    • Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling
    • Gillham H, Golding MC, Pepperkok R, et al. Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling. J Cell Biol 1999; 146:869-80.
    • (1999) J Cell Biol , vol.146 , pp. 869-880
    • Gillham, H.1    Golding, M.C.2    Pepperkok, R.3
  • 12
    • 77649268890 scopus 로고    scopus 로고
    • Inhibitors of the PI3K/Akt/mTOR pathway: New hope for breast cancer patients
    • Ghayad SE, Cohen PA. Inhibitors of the PI3K/Akt/mTOR pathway: new hope for breast cancer patients. Recent Pat Anticancer Drug Discov 2010; 5: 29-57.
    • Recent Pat Anticancer Drug Discov , vol.2010 , Issue.5 , pp. 29-57
    • Ghayad, S.E.1    Cohen, P.A.2
  • 13
    • 34249931118 scopus 로고    scopus 로고
    • Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
    • Geering B, Cutillas PR, Nock G, et al. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci USA 2007; 104:7809-14.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7809-7814
    • Geering, B.1    Cutillas, P.R.2    Nock, G.3
  • 14
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 15
    • 18644370396 scopus 로고    scopus 로고
    • Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phos-phorylation in breast cancer
    • Viglietto G, Motti ML, Bruni P, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phos-phorylation in breast cancer. Nat Med 2002; 8:1136-44.
    • (2002) Nat Med , vol.8 , pp. 1136-1144
    • Viglietto, G.1    Motti, M.L.2    Bruni, P.3
  • 16
    • 20044380158 scopus 로고    scopus 로고
    • Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: Regulation of p27kip1 expression and localization
    • Motti ML, Califano D, Troncone G, et al. Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol 2005; 166:737-49.
    • (2005) Am J Pathol , vol.166 , pp. 737-749
    • Motti, M.L.1    Califano, D.2    Troncone, G.3
  • 17
    • 33644795229 scopus 로고    scopus 로고
    • PI3K-Akt signaling is involved in the regulation of p21(WAF/CIP) expression and androgen-independent growth in prostate cancer cells
    • Lu S, Ren C, Liu Y, et al. PI3K-Akt signaling is involved in the regulation of p21(WAF/CIP) expression and androgen-independent growth in prostate cancer cells. Int J Oncol 2006; 28:245-51.
    • (2006) Int J Oncol , vol.28 , pp. 245-251
    • Lu, S.1    Ren, C.2    Liu, Y.3
  • 18
    • 6344256753 scopus 로고    scopus 로고
    • MTOR: A protein kinase switching between life and death
    • Asnaghi L, Bruno P, Priulla M, et al. mTOR: a protein kinase switching between life and death. Pharmacol Res 2004; 50:545-9.
    • (2004) Pharmacol Res , vol.50 , pp. 545-549
    • Asnaghi, L.1    Bruno, P.2    Priulla, M.3
  • 19
    • 33847397874 scopus 로고    scopus 로고
    • Insulin signaling to mTOR mediated by the Akt/PKB substrate PRAS40
    • Vander Haar E, Lee SI, Bandhakavi S, et al. Insulin signaling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 2007; 9:316-23.
    • (2007) Nat Cell Biol , vol.9 , pp. 316-323
    • Vander Haar, E.1    Lee, S.I.2    Bandhakavi, S.3
  • 20
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 2002; 4:648-57.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3
  • 21
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304:554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 22
    • 16644393213 scopus 로고    scopus 로고
    • The PIK3CA gene is mutated with high frequency in human breast cancers
    • Bachman KE, Argani P, Samuels Y, et al. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004; 3:772-5.
    • (2004) Cancer Biol Ther , vol.3 , pp. 772-775
    • Bachman, K.E.1    Argani, P.2    Samuels, Y.3
  • 23
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 2005; 102:802-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 24
    • 0032857217 scopus 로고    scopus 로고
    • Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
    • Perren A, Weng L P, Boag AH, et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999; 155:1253-60.
    • (1999) Am J Pathol , vol.155 , pp. 1253-1260
    • Perren, A.1    Weng, L.P.2    Boag, A.H.3
  • 25
    • 23844530876 scopus 로고    scopus 로고
    • Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast
    • Tsutsui S, Inoue H, Yasuda K, et al. Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast. Oncology 2005; 68:398-404.
    • (2005) Oncology , vol.68 , pp. 398-404
    • Tsutsui, S.1    Inoue, H.2    Yasuda, K.3
  • 26
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S, Scheulen ME, Johnston S, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005; 23:5314-22.
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 27
    • 73649109111 scopus 로고    scopus 로고
    • Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163
    • Ellard SL, Clemons M, Gelmon KA, et al. Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163. J Clin Oncol 2009; 27:4536-41.
    • (2009) J Clin Oncol , vol.27 , pp. 4536-4541
    • Ellard, S.L.1    Clemons, M.2    Gelmon, K.A.3
  • 28
    • 33748530840 scopus 로고    scopus 로고
    • Randomized 3-arm, phase 2 study of temsirolimus (CCI-779) in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer
    • abstract 564
    • Carpenter J T, Roche H, Campone M, et al. Randomized 3-arm, phase 2 study of temsirolimus (CCI-779) in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol 2005; 23(16 suppl):19s (abstract 564).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Carpenter, J.T.1    Roche, H.2    Campone, M.3
  • 29
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoad-juvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al. Phase II randomized study of neoad-juvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009; 27:2630-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3
  • 30
    • 79960599214 scopus 로고    scopus 로고
    • Phase I/II trial of everolimus (RAD001) and trastuzumab in patients with trastuzumab-resistant, HER2-overexpressing breast cancer
    • abstract 1014
    • Morrow P, Wulf GM, Booser DJ, et al. Phase I/II trial of everolimus (RAD001) and trastuzumab in patients with trastuzumab-resistant, HER2-overexpressing breast cancer. J Clin Oncol 2010; 28(15 suppl):117s (abstract 1014).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Morrow, P.1    Wulf, G.M.2    Booser, D.J.3
  • 31
    • 79952158066 scopus 로고    scopus 로고
    • Phase i clinical trial of everolimus (E) in combination with vinorelbine (V) and trastuzumab (H) in patients with HER2-positive (HER2+) metastatic breast cancer (MBC) with prior resistance to trastuzumab
    • October 8-10 San Francisco, CA. Abstract 253
    • Dieras VG, Gianni L, Jerusalem A, et al. Phase I clinical trial of everolimus (E) in combination with vinorelbine (V) and trastuzumab (H) in patients with HER2-positive (HER2+) metastatic breast cancer (MBC) with prior resistance to trastuzumab. Presented at: the 2009 American Society of Clinical Oncology Breast Cancer Symposium; October 8-10, 2009; San Francisco, CA. Abstract 253.
    • (2009) Presented At: The 2009 American Society of Clinical Oncology Breast Cancer Symposium
    • Dieras, V.G.1    Gianni, L.2    Jerusalem, A.3
  • 32
    • 77955879325 scopus 로고    scopus 로고
    • Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: A multi-center phase II clinical trial
    • abstract 1013
    • Dalenc F, Campone P, Hupperets R, et al. Everolimus in combination with weekly paclitaxel and trastuzumab in patients (pts) with HER2-overexpressing metastatic breast cancer (MBC) with prior resistance to trastuzumab and taxanes: a multi-center phase II clinical trial. J Clin Oncol 2010; 28(15 suppl):117s (abstract 1013).
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Dalenc, F.1    Campone, P.2    Hupperets, R.3
  • 33
    • 63749129788 scopus 로고    scopus 로고
    • PI3K and mTOR inhibitors: A new generation of targeted anticancer agents
    • Brachmann S, Fritsch C, Maira SM, et al. PI3K and mTOR inhibitors: a new generation of targeted anticancer agents. Curr Opin Cell Biol 2009; 21:194-8
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 194-198
    • Brachmann, S.1    Fritsch, C.2    Maira, S.M.3
  • 34
    • 52449106253 scopus 로고    scopus 로고
    • The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin- 1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d] pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class i PI3 kinase for the treatment of cancer
    • Folkes AJ, Ahmadi K, Alderton WK, et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl) -4-morpholin-4-yl-thieno[3,2-d] pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem 2008; 51:5522-32.
    • (2008) J Med Chem , Issue.51 , pp. 5522-5532
    • Folkes, A.J.1    Ahmadi, K.2    Alderton, W.K.3
  • 35
    • 77957201023 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-{delta} inhibitor CAL-101 demonstrates promising pre-clinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
    • Herman SE, Gordon AL, Wagner AJ, et al. The phosphatidylinositol 3-kinase-{delta} inhibitor CAL-101 demonstrates promising pre-clinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010; 116:2078-88.
    • Blood , vol.2010 , Issue.116 , pp. 2078-2088
    • Herman, S.E.1    Gordon, A.L.2    Wagner, A.J.3
  • 36
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mam-malian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mam-malian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008; 7:1851-63.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3
  • 37
    • 39149123820 scopus 로고    scopus 로고
    • A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
    • Garlich JR, De P, Dey N, et al. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 2008; 68:206-15.
    • (2008) Cancer Res , vol.68 , pp. 206-215
    • Garlich, J.R.1    De P Dey, N.2
  • 38
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V, Markman B, Scaltriti M, et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008; 68:8022-30.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3
  • 39
    • 3042743988 scopus 로고    scopus 로고
    • Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
    • Yang L, Dan HC, Sun M, et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 2004; 64:4394-9.
    • (2004) Cancer Res , vol.64 , pp. 4394-4399
    • Yang, L.1    Dan, H.C.2    Sun, M.3
  • 40
    • 0029656181 scopus 로고    scopus 로고
    • Phase I-II study: Triciribine (tricyclic nucleoside phosphate) for metastatic breast cancer
    • Hoffman K, Holmes FA, Fraschini G, et al. Phase I-II study: triciribine (tricyclic nucleoside phosphate) for metastatic breast cancer. Cancer Chemother Pharmacol 1996; 37:254-8.
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 254-258
    • Hoffman, K.1    Holmes, F.A.2    Fraschini, G.3
  • 41
    • 2542547908 scopus 로고    scopus 로고
    • Perifosine, a novel alkyl phos-pholipid, inhibits protein kinase B activation
    • Kondapaka SB, Singh SS, Dasmahapatra G P, et al. Perifosine, a novel alkyl phos-pholipid, inhibits protein kinase B activation. Mol Cancer Ther 2003; 2:1093-103.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1093-1103
    • Kondapaka, S.B.1    Singh, S.S.2    Dasmahapatra, G.P.3
  • 42
    • 37549010727 scopus 로고    scopus 로고
    • Pharmacodynamic markers of perifosine efficacy
    • Hennessy BT, Lu Y, Poradosu E, et al. Pharmacodynamic markers of perifosine efficacy. Clin Cancer Res 2007; 13:7421-31.
    • (2007) Clin Cancer Res , vol.13 , pp. 7421-7431
    • Hennessy, B.T.1    Lu, Y.2    Poradosu, E.3
  • 43
    • 43049107243 scopus 로고    scopus 로고
    • A Phase 2 study of perifosine in advanced or metastatic breast cancer
    • Leighl NB, Dent S, Clemons M, et al. A Phase 2 study of perifosine in advanced or metastatic breast cancer. Breast Cancer Res Treat 2008; 108:87-92.
    • (2008) Breast Cancer Res Treat , vol.108 , pp. 87-92
    • Leighl, N.B.1    Dent, S.2    Clemons, M.3
  • 44
    • 38949161181 scopus 로고    scopus 로고
    • Are triple-negative and basal-like breast cancer synonymous?
    • Rakha E, Ellis I, Reis-Filho J. Are triple-negative and basal-like breast cancer synonymous? Clin Cancer Res 2008; 14: 618.
    • (2008) Clin Cancer Res , vol.14 , pp. 618
    • Rakha, E.1    Ellis, I.2    Reis-Filho, J.3
  • 45
    • 65249104546 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Distinguishing between basal and non basal subtypes
    • Rakha EA, Elsheikh SE, Aleskandarany MA, et al. Triple-negative breast cancer: distinguishing between basal and non basal subtypes. Clin Cancer Res 2009; 15:2302-10.
    • (2009) Clin Cancer Res , vol.15 , pp. 2302-2310
    • Rakha, E.A.1    Elsheikh, S.E.2    Aleskandarany, M.A.3
  • 46
    • 65549098841 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer
    • Corkery B, Crown J, Clynes M, et al. Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. Ann Oncol 2009; 20:862-7.
    • (2009) Ann Oncol , vol.20 , pp. 862-867
    • Corkery, B.1    Crown, J.2    Clynes, M.3
  • 47
    • 62849093453 scopus 로고    scopus 로고
    • EGFR as paradoxical predictor of che-mosensitivity and outcome among triple-negative breast cancer
    • Nogi H, Kobayashi T, Suzuki M, et al. EGFR as paradoxical predictor of che-mosensitivity and outcome among triple-negative breast cancer. Oncol Rep 2009; 21:413-7.
    • (2009) Oncol Rep , vol.21 , pp. 413-417
    • Nogi, H.1    Kobayashi, T.2    Suzuki, M.3
  • 48
    • 0034640524 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
    • Wang X, McCullough KD, Franke T F, et al. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 2000; 275:14624-31.
    • (2000) J Biol Chem , vol.275 , pp. 14624-14631
    • Wang, X.1    McCullough, K.D.2    Franke, T.F.3
  • 49
    • 77953702943 scopus 로고    scopus 로고
    • ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells
    • Sarkar S, Mazumdar A, Dash R, et al. ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. Cancer Biol Ther 2010; 9:592-603.
    • Cancer Biol Ther , vol.2010 , Issue.9 , pp. 592-603
    • Sarkar, S.1    Mazumdar, A.2    Dash, R.3
  • 50
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515-27.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3
  • 51
    • 33745620000 scopus 로고    scopus 로고
    • Basal-like breast cancer tumor-derived cell lines are growth inhibited and radiosensitized by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
    • abstract 311
    • Sartor C, Zhou H, Perou C, et al. Basal-like breast cancer tumor-derived cell lines are growth inhibited and radiosensitized by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Breast Cancer Res Treat 2004; 88 (abstract 311).
    • (2004) Breast Cancer Res Treat , vol.88
    • Sartor, C.1    Zhou, H.2    Perou, C.3
  • 52
    • 35548972342 scopus 로고    scopus 로고
    • Increased phosphorylation of Akt in triple-negative breast cancers
    • Umemura S, Yoshida S, Ohta Y, et al. Increased phosphorylation of Akt in triple-negative breast cancers. Cancer Sci 2007; 98:1889-92.
    • (2007) Cancer Sci , vol.98 , pp. 1889-1892
    • Umemura, S.1    Yoshida, S.2    Ohta, Y.3
  • 53
    • 1042267229 scopus 로고    scopus 로고
    • Determinants of rapamycin sensitivity in breast cancer cells
    • Noh WC, Mondesire WH, Peng J, et al. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 2004; 10:1013-23.
    • (2004) Clin Cancer Res , vol.10 , pp. 1013-1023
    • Noh, W.C.1    Mondesire, W.H.2    Peng, J.3
  • 54
    • 63849329936 scopus 로고    scopus 로고
    • Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
    • Marty B, Maire V, Gravier E, et al. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells. Breast Cancer Res 2008; 10:R101.
    • (2008) Breast Cancer Res , vol.10
    • Marty, B.1    Maire, V.2    Gravier, E.3
  • 55
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008; 68:6084-91.
    • (2008) Cancer Res , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3
  • 56
    • 74049107249 scopus 로고    scopus 로고
    • PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality
    • Lopez-Knowles E, O'Toole SA, McNeil CM, et al. PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality. Int J Cancer 2010; 126:1121-31.
    • (2010) Int J Cancer , vol.126 , pp. 1121-1131
    • Lopez-Knowles, E.1    O'Toole, S.A.2    McNeil, C.M.3
  • 57
    • 37549020704 scopus 로고    scopus 로고
    • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
    • Saal LH, Gruvberger-Saal SK, Persson C, et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet 2008; 40:102-7.
    • (2008) Nat Genet , vol.40 , pp. 102-107
    • Saal, L.H.1    Gruvberger-Saal, S.K.2    Persson, C.3
  • 58
    • 61349152550 scopus 로고    scopus 로고
    • TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer
    • abstract 1009
    • Carey LA, Rugo HS, Marcom PK, et al. TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer. J Clin Oncol 2008; 26(15 suppl):43s (abstract 1009).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 59
    • 43549106185 scopus 로고    scopus 로고
    • Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer
    • December 10-14 San Antonio, TX. Abstract 308
    • O'Shaughnessy J, Weckstein D, Vukelja S, et al. Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer. Presented at: the 31st Annual San Antonio Breast Cancer Symposium; December 10-14, 2008; San Antonio, TX. Abstract 308.
    • (2008) Presented At: The 31st Annual San Antonio Breast Cancer Symposium
    • O'Shaughnessy, J.1    Weckstein, D.2    Vukelja, S.3
  • 60
    • 78649459901 scopus 로고    scopus 로고
    • Potential predictive markers of benefit from cetuximab in metastatic breast cancer: An analysis of two randomized phase 2 trials
    • abstract 2014
    • Carey L, O'Shaughnessy J, O'Shaughnessy K, et al. Potential predictive markers of benefit from cetuximab in metastatic breast cancer: an analysis of two randomized phase 2 trials. Cancer Res 2009; 69(24 suppl): (abstract 2014).
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL.
    • Carey, L.1    O'Shaughnessy, J.2    O'Shaughnessy, K.3
  • 61
    • 77954755623 scopus 로고    scopus 로고
    • Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models
    • O'Brien C, Wallin JJ, Sampath D, et al. Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. Clin Cancer Res 2010; 16:3523-5.
    • Clin Cancer Res , vol.2010 , Issue.16 , pp. 3523-3525
    • O'Brien, C.1    Wallin, J.J.2    Sampath, D.3
  • 62
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
    • Pantuck AJ, Zeng G, Belldegrun AS, et al. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 2003; 9:4641-52.
    • (2003) Clin Cancer Res , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3
  • 63
    • 33745242315 scopus 로고    scopus 로고
    • Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
    • Del Bufalo D, Ciuffreda L, Trisciuoglio D, et al. Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006; 66:5549-54.
    • (2006) Cancer Res , vol.66 , pp. 5549-5554
    • Del Bufalo, D.1    Ciuffreda, L.2    Trisciuoglio, D.3
  • 64
    • 10744223743 scopus 로고    scopus 로고
    • The prognostic implication of the basal-like (cyclin e high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer
    • Foulkes WD, Brunet JS, Stefansson IM, et al. The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular- proliferation+) phenotype of BRCA1-related breast cancer. Cancer Res 2004; 64:830-5.
    • (2004) Cancer Res , vol.64 , pp. 830-835
    • Foulkes, W.D.1    Brunet, J.S.2    Stefansson, I.M.3
  • 65
    • 58349091262 scopus 로고    scopus 로고
    • Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
    • Mirzoeva OK, Das D, Heiser LM, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 2009; 69:565-72.
    • (2009) Cancer Res , vol.69 , pp. 565-572
    • Mirzoeva, O.K.1    Das, D.2    Heiser, L.M.3
  • 66
    • 68049085887 scopus 로고    scopus 로고
    • In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    • Hoeflich K P, O'Brien C, Boyd Z, et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009; 15:4649-64.
    • (2009) Clin Cancer Res , vol.15 , pp. 4649-4664
    • Hoeflich, K.P.1    O'Brien, C.2    Boyd, Z.3
  • 67
    • 68349150810 scopus 로고    scopus 로고
    • Mammary development meets cancer genomics
    • Prat A, Perou CM. Mammary development meets cancer genomics. Nat Med 2009; 15:842-4.
    • (2009) Nat Med , vol.15 , pp. 842-844
    • Prat, A.1    Perou, C.M.2


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