Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer

Gastroenterology

Volumn 139, Issue 6, 2010, Pages 1984-1994

  Matsumoto, Yuko ^a   Marusawa, Hiroyuki ^a   Kinoshita, Kazuo ^b   Niwa, Yoko ^b   Sakai, Yoshiharu ^a   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Shiga Medical Center Research Institute   (Japan)

Author keywords

Activation Induced Cytidine Deaminase; Gastric Cancer; Genetic Alterations; Tumor Related Genes

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DOSAGE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENOME ANALYSIS; HELICOBACTER INFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; STOMACH; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH MUCOSA; TUMOR SUPPRESSOR GENE; UPREGULATION;

EID: 78649688865     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.07.010     Document Type: Article

References (45)

1. W.C. Hahn, and R.A. Weinberg Rules for making human tumor cells N Engl J Med 347 2002 1593 1603
2. C. Lengauer, K.W. Kinzler, and B. Vogelstein Genetic instabilities in human cancers Nature 396 1998 643 649
3. T. Honjo, K. Kinoshita, and M. Muramatsu Molecular mechanism of class switch recombination: linkage with somatic hypermutation Annu Rev Immunol 20 2002 165 196
4. H. Zhang, B. Yang, and R.J. Pomerantz The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA Nature 424 2003 94 98
5. J.E. Wedekind, G.S. Dance, and M.P. Sowden Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business Trends Genet 19 2003 207 216
6. K. Kinoshita, and T. Nonaka The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond Int J Hematol 83 2006 201 207
7. H. Marusawa Aberrant AID expression and human cancer development Int J Biochem Cell Biol 40 2008 1399 1402
8. T. Chiba, and H. Marusawa A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction J Mol Med 87 2009 1023 1027
9. Y.M. Endo, H. Kou, and T. Nakase Activation-induced cytidine deaminase links between inflammation to colitis-associated colorectal cancers Gastroenterology 135 2008 889 898 e881e883
10. J. Komori, H. Marusawa, and T. Machimoto Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma Hepatology 47 2008 888 896
11. Y. Endo, H. Marusawa, and K. Kinoshita Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling Oncogene 26 2007 5587 5595 (Pubitemid 47267836)
12. T. Kou, H. Marusawa, and K. Kinoshita Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis Int J Cancer 120 2007 469 476 (Pubitemid 44969015)
13. Y. Matsumoto, H. Marusawa, and K. Kinoshita Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium Nat Med 13 2007 470 476
14. A. Takai, T. Toyoshima, and M. Uemura A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations Oncogene 28 2009 469 478
15. I.M. Okazaki, H. Hiai, and N. Kakazu Constitutive expression of AID leads to tumorigenesis J Exp Med 197 2003 1173 1181
16. T. Morisawa, H. Marusawa, and Y. Ueda Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression Int J Cancer 123 2008 2735 2740
17. R. Casellas, A. Yamane, and A.L. Kovalchuk Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes Immunology 126 2009 316 328
18. Y. Dorsett, D.F. Robbiani, and M. Jankovic A role for AID in chromosome translocations between c-myc and the IgH variable region J Exp Med 204 2007 2225 2232
19. A.R. Ramiro, M. Jankovic, and T. Eisenreich AID is required for c-myc/IgH chromosome translocations in vivo Cell 118 2004 431 438
20. A.L. Kovalchuk, W. duBois, and E. Mushinski AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements J Exp Med 204 2007 2989 3001
21. D.F. Robbiani, A. Bothmer, and E. Callen AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations Cell 135 2008 1028 1038
22. A.R. Ramiro, M. Jankovic, and E. Callen Role of genomic instability and p53 in AID-induced c-myc-Igh translocations Nature 440 2006 105 109
23. M. Takizawa, H. Tolarova, and Z. Li AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development J Exp Med 205 2008 1949 1957
24. M. Muramatsu, K. Kinoshita, and S. Fagarasan Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 2000 553 563
25. Y. Matsumoto, T.G. Blanchard, and M.L. Drakes Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice Helicobacter 10 2005 407 415
26. Y. Matsumoto, H. Marusawa, and K. Kinoshita Detection of activation-induced cytidine deaminase in gastric epithelial cells infected with cag pathogenicity island-positive Helicobacter pylori Nature Protocols 2007 10.1038/nprot.2007.237
27. K. Uchida, K. Okazaki, and A. Debrecceni Analysis of cytokines in the early development of gastric secondary lymphoid follicles in Helicobacter pylori-infected BALB/c mice with neonatal thymectomy Infect Immun 69 2001 6749 6754
28. T. Doi, K. Kinoshita, and M. Ikegawa De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination Proc Natl Acad Sci U S A 100 2003 2634 2638
29. J. Gil, and G. Peters Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all Nat Rev Mol Cell Biol 7 2006 667 677
30. W.K. Leung, J. Yu, and E.K. Ng Concurrent hypermethylation of multiple tumor-related genes in gastric carcinoma and adjacent normal tissues Cancer 91 2001 2294 2301
31. K.F. To, W.K. Leung, and T.L. Lee Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer Int J Cancer 102 2002 623 628
32. T. Ushijima, T. Nakajima, and T. Maekita DNA methylation as a marker for the past and future J Gastroenterol 41 2006 401 407
33. G. Tamura Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer World J Gastroenterol 12 2006 192 198
34. S. Canning, and T.P. Dryja Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene Proc Natl Acad Sci U S A 86 1989 5044 5048
35. E.G. Boerma, R. Siebert, and P.M. Kluin Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of today's knowledge Leukemia 23 2009 225 234
36. G.W. Bornkamm Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more questions than answers Int J Cancer 124 2009 1745 1755
37. S.J. Korsmeyer Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes Annu Rev Immunol 10 1992 785 807
38. W.Y. Kim, and N.E. Sharpless The regulation of INK4/ARF in cancer and aging Cell 127 2006 265 275
39. S.W. Lowe, and C.J. Sherr Tumor suppression by Ink4a-Arf: progress and puzzles Curr Opin Genet Dev 13 2003 77 83
40. T. Kohno, and J. Yokota Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: deduction from structural analysis of breakpoints for deletions DNA Repair (Amst) 5 2006 1273 1281
41. S.J. Gallagher, R.F. Kefford, and H. Rizos The ARF tumour suppressor Int J Biochem Cell Biol 38 2006 1637 1641
42. N. Feldhahn, N. Henke, and K. Melchior Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells J Exp Med 204 2007 1157 1166
43. L. Klemm, C. Duy, and I. Iacobucci The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia Cancer Cell 16 2009 232 245
44. N. Michael, H.M. Shen, and S. Longerich The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription Immunity 19 2003 235 242
45. T. Ushijima Epigenetic field for cancerization J Biochem Mol Biol 40 2007 142 150