Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice

Helicobacter

Volumn 10, Issue 5, 2005, Pages 407-415

  Matsumoto, Yuko ^a   Blanchard, Thomas G ^a,c   Drakes, Maureen L ^a   Basu, Malini ^a   Redline, Raymond W ^a   Levine, Alan D ^a,b   Czinn, Steven J ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Gastritis; Il 10; Immunoregulation; Inflammation; Pathogenesis; T cell

Indexed keywords

BACTERIAL ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; CELL ACTIVITY; CONTROLLED STUDY; GASTRITIS; HELICOBACTER INFECTION; IMMUNE RESPONSE; IMMUNITY; IMMUNOREGULATION; INOCULATION; MICROBIAL ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN CELL; STOMACH MUCOSA; T LYMPHOCYTE; WILD TYPE;

ANIMALS; ANTIBODIES, BACTERIAL; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; SPLEEN;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 25444492869     PISSN: 10834389     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2005.00349.x     Document Type: Article

References (44)

1. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998;115:182-205.
2. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
3. Berg DJ, Davidson N, Kühn R, Müller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 1996;98:1010-20.
4. Sartor RB. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol Clin North Am 1995;24:475-507.
5. Crabbe PA, Nash DR, Bazin H, Eyssen H, Heremans JF. Immunohistochermcal observations on lymphoid tissues from conventional and germfree mice. Lab Invest 1970;22:448-57.
6. Rhee KJ, Sethupathi P, Driks A, Lanning DK, Knight KL. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol 2004;172:1118-24.
7. Stepankova R, Kovaru F, Kruml J. Lymphatic tissue of the intestinal tract of germfree and conventional rabbits. Folia Microbiol (Praha) 1980;25:491-5.
8. Talham GL, Jiang HQ, Bos NA, Cebra JJ. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect Immun 1999;67:1992-2000.
9. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI, Blaser MJ. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989;321:1562-6.
10. Warren JR. Gastric pathology associated with Helicobacter pylori. Gastroenterol Clin North Am 2000;29:705-51.
11. Ernst PB, Gold BD. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol 2000;54:615-40.
12. Lindholm C, Quiding-Jarbrink M, Lonroth H, Hamlet A, Svennerholm AM. Local cytokine response in Helicobacter pylori-infected subjects. Infect Immun 1998;66:5964-71.
13. Fan XJ, Chua A, Shahi CN, McDevitt J, Keeling PWN, Kelleher D. Gastric T lymphocyte responses to Helicobacter pylori colonisation. Gut 1994;35:1379-84.
14. Karttunen R, Andersson G, Poiikonen K, Kosunen TU, Karttunen T, Juutinen K, Niemela S. Helicobacter pylori induces lymphocyte activation in peripheral blood cultures. Clin Exp Immunol 1990;82:485-8.
15. Karttunen R. Blood lymphocyte proliferation, cytokine secretion and appearance of T cells with activation markers in cultures with Helicobacter pylori. Clin Exp Immunol 1991;83:396-400.
16. Karttunen R, Karttunen T, Ekre HP, MacDonald TT. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 1995;36:341-5.
17. Lundgren A, Suri-Payer E, Enarsson K, Svennerholm AM, Lundin BS. Helicobacter pylori-specific CD4+ CD25 high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect Immun 2003;71:1755-62.
18. Raghavan S, Fredriksson M, Svennerholm AM, Holmgren J, Suri-Payer E. Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin Exp Immunol 2003;132:393-400.
19. Chen W, Shu D, Chadwick VS. Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10. J Gastroenterol Hepatol 2001;16:377-83.
20. Berg DJ, Lynch NA, Lynch RG, Lauricella DM. Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10 (-/-) mice. Am J Pathol 1998;152:1377-86.
21. Ismail HF, Fick P, Zhang J, Lynch RG, Berg DJ. Depletion of neutrophils in IL-10 (-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol 2003;170:3782-9.
22. Park SM, Kim JH, Hong YH, Jung HR, Park J, Kim JG, Yoo BC. Expression of mucosal cytochemokine mRNAs in patients with Helicobacter pylori infection. Korean J Intern Med 2001;16:230-5.
23. Lindholm C, Quiding-Jarbrink M, Lonroth H, Svennerholm AM. Induction of chemokine and cytokine responses by Helicobacter pylori in human stomach explants. Scand J Gastroenterol 2001;36:1022-9.
24. Haeberle HA, Kubin M, Bamford KB, Garofalo R, Graham DY, El-Zaatari F, Karttunen R, Crowe SE, Reyes VE, Ernst PB. Differential stimulation of interleukin-12 and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa. Infect Immun 1997;65:4229-35.
25. Bodger K, Bromelow K, Wyatt JI, Heatley RV. Interleukin 10 in Helicobacter pylori associated gastritis: immunohistochemical localisation and in vitro effects on cytokine secretion. J Clin Pathol 2001;54:285-92.
26. Bodger K, Wyatt JI, Heatley RV. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut 1997;40:739-44.
27. Lee A, Hazell SL, O'Rourke J, Kouprach S. Isolation of a spiral-shaped bacterium from the cat stomach. Infect Immun 1988;56:2843-50.
28. Lee A, O'Rourke J, De Ungria MC, Robertson B, Daskalopoulos G, Dixon MF. A standardised mouse model of Helicobacter pylori infection. Introducing the Sydney strain. Gastroenterology 1997;112:1386-97.
29. Eisenberg JC, Czinn SJ, Garhart CA, et al. Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infect Immun 2003;71:1820-7.
30. Czinn SJ, Cai A, Nedrud JG. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine 1993;11:637-42.
31. Blanchard TG, Hsieh F, Yu CL, Redline RW. Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. J Infect Dis 2003;187:1609-15.
32. Rahn W, Redline RW, Blanchard TG. Molecular analysis of Helicobacter pylori-associated gastric inflammation in naive versus previously immunized mice. Vaccine 2004;23:807-18.
33. Ismail HF, Zhang J, Lynch RG, Wang Y, Berg DJ. Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. Infect Immun 2003;71:7140-8.
34. Ermak TH, Ding R, Ekstein B, Hill J, Myers GA, Lee CK, Pappo J, Kleanthous HK, Monath TP. Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria. Gastroenterology 1997;113:1118-28.
35. Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn SJ. Murine CD4 T-cell response to Helicobacter infection. TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 1997;113:1848-57.
36. Bamford KB, Fan X, Crowe SE, Leary JF, Gourley WK, Luthra GK, Brooks EG, Graham DY, Reyes VE, Ernst PB. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 1998;114:482-92.
37. Saldinger PF, Porta N, Launois P, Louis JA, Waanders GA, Bouzourene H, Michetti P, Blum AL, Corthesy-Theulaz IE. Immunization of B ALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection. Gastroenterology 1998;115:891-7.
38. Gottwein JM, Blanchard TG, Targoni OS, Eisenberg JC, Zagorski BM, Redline RW, Nedrud JG, Tary-Lehmann M, Lehmann PV, Czinn SJ. Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization. J Infect Dis 2001;184:308-14.
39. Garhart CA, Heinzel FP, Czinn SJ, Nedrud JG. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun 2003;71:910-21.
40. Garhart CA, Nedrud JG, Heinzel FP, Sigmund NE, Czinn SJ. Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun 2003;71:3628-33.
41. Akhiani AA, Pappo J, Kabok Z, Schon K, Gao W, Franzen L, Lycke N. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 2002;169:6977-84.
42. Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy AM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-9.
43. Hsieh CS, Macatonia SE, O'Garra A, Murphy AM. Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent. Int Immunol 1993;5:371-82.
44. Garhart CA, Redline RW, Nedrud JG, Czinn SJ. Clearance of Helicobacter pylori infection and resolution of postimmunization gastritis in a kinetic study of prophylactically immunized mice. Infect Immun 2002;70:3529-38.