Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line

Clinica Chimica Acta

Volumn 379, Issue 1-2, 2007, Pages 139-144

  Lin, Pei Ying ^a   Yang, Tsai Hsiu ^b   Lin, Hung Gi ^a   Hu, Miao Lin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

DNA damage; DNA hypomethylation; Homocysteine; Reactive oxygen species; S adenosylhomocysteine; Synergy

Indexed keywords

CATALASE; DEFEROXAMINE; DNA; HOMOCYSTEINE; S ADENOSYLHOMOCYSTEINE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CORRELATION ANALYSIS; DNA DAMAGE; DNA DETERMINATION; ENZYME INHIBITION; METHYLATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANIMALS; CELL LINE; DNA; DNA DAMAGE; DNA METHYLATION; DRUG SYNERGISM; FREE RADICAL SCAVENGERS; HOMOCYSTEINE; HYDROGEN PEROXIDE; MICE; MICROGLIA; REACTIVE OXYGEN SPECIES; S-ADENOSYLHOMOCYSTEINE; URACIL;

MURINAE;

EID: 33847678000     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2007.01.007     Document Type: Article

References (38)

1. Lee M.E., and Wang H. Homocysteine and hypomethylation: a novel link to vascular disease. Trends Cardiovasc Med 9 (1999) 49-54
2. Miller J.W. Homocysteine, folate deficiency, and Parkinson's disease. Nutr Rev 60 (2002) 410-413
3. Vollset S.E., Refsum H., Tverdal A., et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study. Am J Clin Nutr 74 (2001) 130-136
4. Fu W., Dudman N.P.B., Perry M.A., Young K., and Wang X.I. Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine. Biochem Biophys Res Commun 271 (2000) 47-53
5. James S.J., Melnyk S., Pogribny M., Pogribny I.P., and Caudill M.A. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132 (2002) 2361S-2366S
6. Kloor D., Delabar U., Mühlbauer B., Luippold G., and Osswald H. Tissue concentrations of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine. Biochem Pharmacol 63 (2002) 809-825
7. Hoffman D.R., Cornatzer W.E., and Duerre J.A. Relationship between tissue concentrations of S-adenosylmethionine, S-adenosylhomocysteine, and transmethylation reactions. Can J Biochem 57 (1979) 56-65
8. Finkelstein J.D., Kyle W.E., and Harris B.J. Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine. Arch Biochem Biophys 165 (1974) 774-779
9. De Cabo S.F., Hazen M.J., Molero M.L., and Fernández-piqueras J. S-adenosyl-l-homocysteine: a non-cytotoxic hypomethylating agent. Experientia 50 (1994) 658-659
10. Ueland P.M. Pharmacological and biochemical aspects of S-adenosyl-homocysteine hydrolase. Pharmacol Rev 34 (1982) 223-253
11. Barbés C., Sánchez J., Yebra M.J., Robert-Geró M., and Hardisson C. Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria. FEMS Microbiol Lett 69 (1990) 239-243
12. Yau E.D., and Coward J.L. Synthesis of complex 6′-alkynyl-6′-dethia nucleoside analogues of S-adenosylhomocysteine as potential inhibitors of methyltransferase. J Org Chem 55 (1990) 3147-3158
13. Kerins D.M., Koury M.J., Capdevila A., Rana S., and Wagner C. Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr 74 (2001) 723-729
14. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hinet R.J., and James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275 (2000) 29318-29323
15. James S.J., Pogribny I.P., Pogribna M., Miller B.J., Jernigan S., and Melnyk S. Mechanism of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr 133 (2003) 3740S-3747S
16. Perna A.F., Ingrosso D., De Santo N.G., Galletti P., and Zappia V. Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia. Kidney Int 47 (1998) 247-253
17. Eto K., Asada T., Arima K., Makifuchi T., and Kimura H. Brain hydrogen sulfite is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 293 (2002) 1485-1488
18. Kennedy B.P., Bottiglieri T., Hansen A., and Maslish E. Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferase and cognitive function. J Neural Transm 111 (2004) 547-567
19. Yang T.S., Yang N.C., and Hu M.L. S-adenosylhomocysteine enhances Hydrogen peroxide-induced DNA damage by inhibition of DNA repair. Nutr Cancer 47 (2003) 70-75
20. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low concentrations of DNA damage in individual cells. Exp Cell Res 175 (1998) 184-191
21. Yeh S.L., and Hu M.L. Induction of oxidative DNA damage in human foreskin fibroblast Hs68 cells by oxidized β-carotene and lycopene. Free Radic Res 35 (2001) 203-213
22. Hu M.L., Chuang C.H., Sio H.M., and Yeh S.L. Simple cryoprotection and cell dissociation techniques for application of the comet assay to fresh and frozen rat tissues. Free Radic Res 36 (2002) 203-209
23. Duthie S.J., and Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J 12 (1998) 491-1497
24. Xu C., and Zhang Z. Fluorescence determination of hydrogen peroxide using hemoglobin as a mimetic enzyme of peroxidase. Anal Sci 17 (2001) 1449-1451
25. Cooney C.A., Wise C.K., and Poirier L.A. An improved sample preparation method for the quantitative HPLC determination 5-methyldeoxycytidine in animal tissue DNA. J Liq Chromatogr Relat Technol 20 (1997) 1279-1293
26. Gupta R.C. Nonrandom binding of the carcinogen N-hydroxy-2-Acetylamino-fluorene to repetitive sequences of rat liver DNA in vivo. Proc Natl Acad Sci 81 (1984) 6943-6947
27. Finkelstein J.D., and Martin J.J. Homocysteine. Int J Biochem Cell Biol 32 (2000) 385-389
28. Kyle M.E., Nakae D., Sakaida I., Miccadei S., and Farber J.L. Endocytosis of superoxide dismutase is required in order to protect hepatocytes from the cytotoxicity of hydrogen peroxide. J Biol Chem 260 (1985) 1099-10104
29. Li L., Wattiaux-De Coninck S., and Wattiaux R. Endocytosis of superoxide dismutase by rat liver. Biochem Biophys Res Commun 184 (1992) 727-732
30. Halliwell B., and Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?. Br J Pharmacol 142 (2004) 231-255
31. Harrison J., Shi X., Wang L., Ma J.K., and Rojanasakul Y. Novel delivery of antioxidant enzyme catalase to alveolar macrophages by Fc receptor-mediated endocytosis. Pharm Res 11 (1994) 1110-1114
32. Olszewski A.J., and McCully K.S. Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radic Biol Med 14 (1992) 683-693
33. +2 fluxes. J Lab Clin Med 133 (1999) 362-369
34. Zhu B.T. On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis. Histol Histopathol 17 (2002) 1283-1291
35. Holiday R. Aspects of DNA repair and nucleotide pool imbalance. Basic Life Sci 31 (1985) 453-460
36. Choi S.W., and Mason J.B. Folate and carcinogenesis: an integrated scheme. J Nutr 130 (2000) 129-132
37. Barber J.R., and Clarke S. Inhibition of protein carboxyl methylation by S-adenosyl-l-homocysteine in intact erythrocytes. Physiological consequences. J Biol Chem 259 (1984) 7115-7122
38. Hultberg B., Andersson A., and Isaksson A. Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines. Toxicology 147 (2000) 69-75