Developing multidrug-resistant cells and exploring correlation between BCRP/ABCG2 over-expression and DNA methyltransferase

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 12, 2010, Pages 854-862

  Ji, Nana ^a   Yuan, Jianhui ^b   Liu, Jianjun ^b   Tian, Shengli ^a  

^a SHENZHEN UNIVERSITY   (China)

^b SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

ATP binding cassette sub family G member 2 (ABCG2); breast cancer resistance protein (BCRP); DNA methyltransferase; drug efflux transporter; multidrug resistance

Indexed keywords

ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; DNA METHYLTRANSFERASE; MYCOTOXIN; TUMOR PROTEIN;

ARTICLE; BREAST TUMOR; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; DNA MODIFICATION METHYLASES; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MYCOTOXINS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 78649647876     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq097     Document Type: Article

References (42)

1. Germann UA and Chambers TC. Molecular analysis of the multidrug transporter, P-glycoprotein. Cytotechnology 1998, 27: 31-60.
2. Deeley RG, Westlake C and Cole SP. Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006, 86: 849-899.
3. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK and Ross DD. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998, 95: 15665-15670.
4. Miyake K, Mickley L, Litman T, Zhan Z, Robey R, Cristensen B and Brangi M, et al. Molecular cloning of cDNAs which are highly overex-pressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. Cancer Res 1999, 59: 8-13.
5. Turner JG, Gump JL, Zhang C, Cook JM, Marchion D, Hazlehurst L and Munster P, et al. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood 2006, 108: 3881-3999.
6. Pollex E, Lubetsky A and Koren G. The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta. Placenta 2008, 29: 743-747.
7. Maliepaard M, Scheffer GL, Faneyte IF, van Gastelen MA, Pijnenborg AC, Schinkel AH and van De Vijver MJ, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001, 61: 3458-3464.
8. Huls M, Brown CD, Windass AS, Sayer R, van den Heuvel JJ, Heemskerk S and Russel FG, et al. The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int 2008, 73: 220-225.
9. Polgar O, Robey RW and Bates SE. ABCG2: structure, function and role in drug response. Expert Opin Drug Metab Toxicol 2008, 4: 1-15.
10. Doyle LA and Ross DD. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 2003, 22: 7340-7358.
11. Maliepaard M, van Gastelen MA, de Jong LA, Pluim D, van Waardenburg RC, Ruevekamp-Helmers MC and Floot BG, et al. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res 1999, 59: 4559-4563.
12. Volk EL, Farley KM, Wu Y, Li F, Robey RW and Schneider E. Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res 2002, 62: 5035-5040.
13. Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE and Sarkadi B, et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 2004, 279: 24218-24225.
14. Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD and Beck WT. Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res 2004, 64: 1247-1251.
15. Bailey-Dell KJ, Hassel B, Doyle LA and Ross DD. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim Biophys Acta 2001, 1520: 234-241.
16. Nakano H, Nakamura Y, Soda H, Kamikatahira M, Uchida K, Takasu M and Kitazaki T, et al. Methylation status of breast cancer resistance protein detected by methylation-specific polymerase chain reaction analysis is correlated inversely with its expression in drug-resistant lung cancer cells. Cancer 2008, 112: 1122-1130.
17. Yaqinuddin A, Qureshi SA, Qazi R and Abbas F. Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration. Cancer Cell Int 2008, 8: 13.
18. Yu Y, Zhang H, Tian F, Zhang W, Fang H and Song J. An integrated epi-genetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines. PLoS ONE 2008, 3: e2672.
19. Girault I, Tozlu S, Lidereau R and Bièche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 2003, 9: 4415-4422.
20. Jin F, Dowdy SC, Xiong Y, Eberhardt NL, Podratz KC and Jiang SW. Up-regulation of DNA methyltransferase 3B expression in endometrial cancers. Gynecol Oncol 2005, 96: 531-538.
21. Rahman MM, Qian ZR, Lu Wang E, Yoshimoto K, Nakasono M, Sultana R and Yoshida T. DNA methyltransferases 1, 3a, and 3b overex-pression and clinical significance in gastroenteropancreatic neuroendocrine tumors. Hum Pathol 2010, 41: 1069-1078.
22. Qiu YY, Mirkin BL and Dwivedi RS. Inhibition of DNA methyltransfer-ase reverses cisplatin induced drug resistance in murine neuroblastoma cells. Cancer Detect Prev 2005, 29: 456-463.
23. Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Chavez-Blanco A, Revilla-Vazquez A, Benitez-Bribiesca L and Duenas-González A. Global DNA hypermethylation-associated cancer chemotherapy resistance and its reversion with the demethylating agent hydralazine. J Transl Med 2006, 4: 32.
24. Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25: 402-408.
25. Minderman H, Suvannasankha A, O'Loughlin KL, Scheffer GL, Scheper RJ, Robey RW and Baer MR. Flow cytometric analysis of breast cancer resistance protein expression and function. Cytometry 2002, 48: 59-65.
26. Garć?a-Escarp M, Mart́?nez-Muñoz V, Sales-Pardo I, Barquinero J, Domingo JC, Marin P and Petriz J. Flow cytometry-based approach to ABCG2 function suggests that the transporter differentially handles the influx and efflux of drugs. Cytometry A 2004, 62: 129-138.
27. Vethanayagam RR, Wang H, Gupta A, Zhang Y, Lewis F, Unadkat JD and Mao Q. Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N. Drug Metab Dispos 2005, 33: 697-705.
28. Evseenko DA, Murthi P, Paxton JW, Reid G, Emerald BS, Mohankumar KM and Lobie PE, et al. The ABC transporter BCRP/ABCG2 is a placen-tal survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB J 2007, 21: 3592-3605.
29. Volk EL, Rohde K, Rhee M, McGuire JJ, Doyle LA, Ross DD and Schneider E. Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux. Cancer Res 2000, 60: 3514-3521.
30. Yamagata T, Morishita M, Kusuhara H, Takayama K, Benameur H and Sugiyama Y. Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients. Int J Pharm 2009, 370: 216-219.
31. Paturi DK, Kwatra D, Ananthula HK, Pal D and Mitra AK. Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3). Int J Pharm 2010, 384: 32-38.
32. Arbach H, Viglasky V, Lefeu F, Guinebretière JM, Ramirez V, Bride N and Boualaga N, et al. Epstein-Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J Virol 2006, 80: 845-853.
33. Duan Z, Choy E, Jimeno JM, Cuevas Cdel M, Mankin HJ and Hornicek FJ. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol 2009, 63: 1121-1129.
34. Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K and Bendayan R. Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharm Res 2007, 24: 1262-1274.
35. Katayama R, Koike S, Sato S, Sugimoto Y, Tsuruo T and Fujita N. Do fequidar fumarate sensitizes cancer stem-like side population cells to che-motherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci 2009, 100: 2060-2068.
36. Matsson P, Pedersen JM, Norinder U, Bergström CA and Artursson P. Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs. Pharm Res 2009, 26: 1816-1831.
37. Ifergan I and Assaraf YG. Molecular mechanisms of adaptation to folate deficiency. Vitam Horm 2008, 79: 99-143.
38. Baker EK and El-Osta A. Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing. Methods Mol Biol 2010, 596: 183-198.
39. To KK, Polgar O, Huff LM, Morisaki K and Bates SE. Histone modifications at the ABCG2 promoter following treatment with histone deacety-lase inhibitor mirror those in multidrug-resistant cells. Mol Cancer Res 2008, 6: 151-164.
40. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN and Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998, 393: 386-389.
41. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S and van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 2003, 370: 737-749.
42. Scotto KW. Transcriptional regulation of ABC drug transporters. Oncogene 2003, 22: 7496-7511.