Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients

International Journal of Pharmaceutics

Volumn 370, Issue 1-2, 2009, Pages 216-219

  Yamagata, Tetsuo ^a   Morishita, Mariko ^a   Kusuhara, Hiroyuki ^b   Takayama, Kozo ^a   Benameur, Hassan ^c   Sugiyama, Yuichi ^b  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c PFIZER INC   (United States)

Author keywords

BCRP; Competitive or noncompetitive; Excipients; Inhibition; Reversible

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; MITOXANTRONE; POLOXAMER; POLYSORBATE 20;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG UPTAKE; ENZYME SUBSTRATE; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; DOGS; DRUG RESISTANCE, NEOPLASM; EXCIPIENTS; MITOXANTRONE; NEOPLASM PROTEINS; POLOXALENE; POLYSORBATES; TRANSFECTION;

EID: 61349159869     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.12.005     Document Type: Article

References (4)

1. Pan G., and Elmquist W.F. Mitoxantrone permeability in MDCKII cells is influenced by active influx transport. Mol. Pharm. 4 (2007) 475-483
2. van Hervaarden A.E., and Schinkel A.H. The function of breast cancer resistance protein (BCRP/ABCG2) in epithelial barriers, in stem cells and in milk secretion of drugs and xenotoxins. Trends Pharmacol. Sci. 27 (2006) 10-16
3. Yamagata T., Kusuhara H., Morishita M., Takayama K., Benameur H., and Sugiyama Y. Effect of excipients on breast cancer resistance protein substrate uptake activity. J. Controlled Release 124 (2007) 1-5
4. Yamagata T., Kusuhara H., Morishita M., Takayama K., Benameur H., and Sugiyama Y. Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients. Drug Metab. Dispos. 35 (2007) 1142-1148