Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high-fat-fed mice

Phytotherapy Research

Volumn 24, Issue 12, 2010, Pages 1769-1780

  Shih, Chun Ching ^a   Lin, Cheng Hsiu ^b   Wu, Jin Bin ^c  

^a CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b FENG YUAN HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

body fat; Eriobotrya japonica; hyperglycemia; leptin

Indexed keywords

ADIPOCYTOKINE; COROSOLIC ACID; ERIOBOTRYA JAPONICA EXTRACT; LEPTIN; MASLINIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; ROSIGLITAZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; EPIDIDYMIS FAT; FOOD INTAKE; GENE EXPRESSION; HISTOLOGY; HYPERGLYCEMIA; HYPERLEPTINEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID DIET; LOQUAT; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAL GLUCOSE TOLERANCE TEST; WEIGHT CHANGE; WESTERN BLOTTING; WHITE ADIPOSE TISSUE;

ADIPOKINES; ADIPOSE TISSUE; ADMINISTRATION, ORAL; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ERIOBOTRYA; FATTY ACIDS, NONESTERIFIED; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; HYPERLIPIDEMIAS; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; PPAR GAMMA; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; WEIGHT GAIN;

ERIOBOTRYA JAPONICA; MUS;

EID: 78649637009     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3143     Document Type: Article

References (62)

1. A Group of Editors for Chinese Materia Medica. 1996. Chinese Materia Medica. Science and Technology Press: Shanghai, 777.
2. Boden G., 1997. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10.
3. Bourgeois F, Alexiu A, Lemonnier D., 1983. Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice. Br J Nutr 49: 17-26.
4. Brown MS, Goldstein JL., 1999. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96: 11041-11048.
5. Cabrero A, Alegret M, Scanchez RM, Adzet T, Laguna JC, Vazquez M., 2001. Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50: 1883-1890.
6. Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA., 1994. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135: 798-800.
7. Chen J, Li WL, Wu JL, Ren BR, Zhang HQ., 2008. Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.). Phytomedicine 15: 98-102.
8. Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O., 2002. WY 14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem 277: 24484-24489.
9. Crute BE, Seefeld K, Gamble J, Kemo BE, Witters LA., 1998. Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J Biol Chem 273: 35347-35354.
10. Ding CK, Chachin K, Ueda Y, Imahori Y, Wang CY., 2001. Metabolism of phenolic compounds during loquat fruit development. J Agric Food Chem 49: 2883-2888.
11. Eckel RH., 1989. Lipoprotein lipase: A multifunctional enzyme relevant to common metabolic disease. N Engl J Med 320: 1060-1068.
12. Ersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W., 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103: 1489-1498.
13. Folch J, Lees M, Sloan-Stanley GH., 1957. A sample method for isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
14. Foretz M, Carling D, Guichard C, Ferre P, Foufelle F., 1998. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem 273: 14767-14771.
15. Godoy HT, Amaya DB., 1995. Carotenoid composition and vitamin A value of Brazilian loquat (Eriobotrya japonica Lindl.). Arch Latinoam Nutr 45: 336-339.
16. Ho HA, Lin WC, Kitanaka S, Chang CT, Wu JB., 2008. Analysis of bioactive triterpenes in Eriobotrya japonica Lindl. by high-performance liquid chromatography. J Food Drug Anal 16: 41-45.
17. Horton JD, Bashmakov Y, Shimomura I, Shimano H., 1998. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95: 5987-5992.
18. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM., 1996. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274: 1377-1379.
19. Ide T, Ashakumary L, Takahashi Y, Kushiro M, Fukuda N, Sugano M., 2000. Sesamin, a sesamine lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta 1534: 1-13.
20. Ito H, Kobayashi E, Takamatsu Y, et al,. 2000. Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines. Chem Pharm Bull 48: 687-693.
21. Ju JH, Zhou L, Lin G, Liu D, Wang LW, Yang JS., 2003. Studies on constituents of triterpene acids from Eriobotrya japonica and their anti-inflammatory and antitussive effects. J Chin Pharmacol 38: 752-757.
22. TM) from Lagerstroemia speciosa leaves in Type II diabetics, a dose-dependence study. J Ethnopharmacol 87: 115-117.
23. Kim H, Haluzik M, Asghar Z, Yau D, Joseph JW, Fernandez AM., 2003. Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes 52: 1770-1778.
24. Kissebah AH., 1997. Central obesity: measurement and metabolic effects. Diabetes Rev 5: 8-20.
25. Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K., 1999. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell Biol 4: 597-609.
26. Laemmli UK., 1970. Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
27. Lee CH, Olson P, Evans RM., 2003. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptor. Endocrinology 144: 2201-2207.
28. Liang ZZ, Aquino R, De Feo V, De Simone F, Pizza C., 1990. Polyhydroxylated triterpenes from Eriobotrya japonica. Planta Med 56: 330-332.
29. Louati S, Simmonds MSJ, Grayer RJ, Kite GC, Damak M., 2003. Flavonoids from Eriobotrya japonica (Rosaceae) growing in Tunisia. Biochem System Ecol 31: 99-101.
30. McGarry JD, Brown NF., 1997. The mitochondrial carnitine palmitoyl-transferase system from concept to molecular analysis. Eur J Biochem 244: 1-14.
31. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D., 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein. Nature 415: 339-343.
32. Muoio DM, Seefeld K, Witters LA, Coleman RA., 1999. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyl-transferase is a novel target. Biochem J 338: 783-791.
33. Murase T, Mizuno T, Omachi T, et al,. 2001. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice. J Lipid Res 42: 372-378.
34. Noreen W, Wadood A, Hidayat HK, Wahid SA., 1988. Effect of Eriobotrya japonica on blood glucose levels of normal and alloxan-diabetic rabbits. Planta Med 54: 196-199.
35. Nozato N, Matsumoto K, Uemitsu N., 1994. Triterpene from the leaves of Eriobotrya japonica. Nat Med 48: 336.
36. Olefsky JM, Kolterman OG, Scarlet JA., 1982. Insulin action and resistance in obesity and non-insulin dependent type II diabetes mellitus. Am J Physiol 243: E15-E30.
37. Park HJ, Yoon SH, Han LS, et al,. 2005. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol 11: 5156-5161.
38. Rangwala SM, Lazar MA., 2004. Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 25: 331-336.
39. Raser KJ, Posner A, Wang KK., 1995. Casein zymography: A method to study mu-calpain, m-calpain, and their inhibitory agents. Arch Biochem Biophys 319: 211-216.
40. Reddy JK, Hashimoto T., 2001. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Ann Rev Nutr 21: 193-230.
41. Rossi AS, Lombardo Y, Lacorte JM, et al,. 2005. Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. Am J Physiol Regul Integr Comp Physiol 289: R486-R494.
42. Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W., 1995. Induction of the acyl-coenzyme synthase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 270: 19269-19276.
43. Shen QW, Jones CS, Kalchayanand N, Zhu MJ, Du M., 2005. Effect of dietary alpha-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mice. J Anim Sci 83: 2611-2617.
44. Shimizu M, Fukumura H, Tsuji H, Tanaami S, Hayashi T, Morita N., 1986. Anti-inflammatory constituents of topically applied crude drugs I: constituents and anti-inflammatory effect of Eriobotrya japonica Lindl. Chem Pharm Bull 34: 2614-2617.
45. Shimizu M, Uemits N, Shirota M, Matsumoto K, Tezuka Y., 1996. A new triterpene ester from Eriobotrya japonica. Chem Pharm Bull 44: 2181-2182.
46. Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL., 2000. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6: 77-86.
47. Sood V, Colleran K, Burge MR., 2000. Thiazolidinediones: a comparative review of approved uses. Diabetes Technol Ther 2: 429-449.
48. Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC., 1998. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98: 2088-2093.
49. Stein SC, Woods A, Jones NA, Davison MD, Carling D., 2000. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 345: 437-443.
50. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN., 1988. Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37: 1163-1167.
51. Tommasi ND, Shimone FD, Pizza C., 1992. Constituents of Eriobotrya japonica: a study of their antiviral properties. J Nat Prod 55: 1067-1073.
52. Unger RH, Orci L., 2001. Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord 24 (Suppl 4): S28-S32.
53. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS., 2000. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141: 3388-3396.
54. Veiseth E, Shackelford SD, Wheeler TL, Koohmaraie M., 2001. Effect of postmortem storage on mu-calpain and m-calpain in ovine skeletal muscle. J Anim Sci 79: 1502-1508.
55. Verges B., 2004. Clinical interest of PPARs ligands: particular benefit in type 2 diabetes and metabolic syndrome. Diabetes Metab 30: 7-12.
56. Wakil S., 1989. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28: 4523-4530.
57. Wen X, Sun H, Liu J, et al,. 2005. Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorg Med Chem Lett 15: 4944-4948.
58. Wen X, Xia J, Cheng K, et al,. 2007. Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Bioorg Med Chem Lett 17: 5777-5782.
59. Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ., 2003. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52: 1355-1363.
60. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S., 2002. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-1295.
61. Zhou G, Myers R, Li Y, et al,. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174.
62. Zhuang YF., 2002. Determination of amygdalin content in Eriobotrya japonica leaves by high performance liquid chromatography (HPLC). Strait Pharm J 14: 64-65.