Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation

Comparative Hepatology

Volumn 9, Issue , 2010, Pages

  Limaye, Pallavi B ^a   Bowen, William C ^a   Orr, Anne ^a   Apte, Udayan M ^a,b   Michalopoulos, George K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' METHYLENEDIANILINE; CYTOKERATIN 19; DIPEPTIDYL DIPEPTIDASE IV; DIPEPTIDYL PEPTIDASE; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 6; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE DUCT; BILE DUCT INJURY; BILE DUCT LIGATION; BILIARY REGENERATION; CELL POPULATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL TRANSDIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; DRUG EXPOSURE; EMBRYO DEVELOPMENT; EPITHELIUM CELL; HEPATOBILIARY SYSTEM; LIVER CELL; MALE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TISSUE REGENERATION;

EID: 78649607563     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-9-9     Document Type: Article

References (33)

1. Michalopoulos GK, Bowen WC, Mule K, Stolz DB. Histological organization in hepatocyte organoid cultures. Am J Pathol 2001, 159:1877-1887. 1867077, 11696448.
2. Michalopoulos GK, Bowen WC, Mulè K, Lopez-Talavera JC, Mars W. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 2002, 36:278-283. 10.1053/jhep.2002.34858, 1769334, 12143035.
3. Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005, 41:535-544. 10.1002/hep.20600, 1821079, 15726663.
4. Limaye PB, Bowen WC, Orr AV, Luo J, Tseng GC, Michalopoulos GK. Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology 2008, 47:1702-1713. 10.1002/hep.22221, 2615562, 18398918.
5. Nishikawa Y, Doi Y, Watanabe H, Tokairin T, Omori Y, Su M, Yoshioka T, Enomoto K. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol 2005, 166:1077-1088. 1602375, 15793288.
6. Watanabe H, Hata M, Terada N, Ueda H, Yamada N, Yamanegi K, Ohyama H, Kakihana M, Okamura H, Nakasho K. Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen. Pathology 2008, 40:272-276. 10.1080/00313020801911546, 18428047.
7. Desmet V, Roskams T, Van Eyken P. Ductular reaction in the liver. Pathol Res Pract 1995, 191:513-524.
8. Chen YK, Zhao XX, Li JG, Lang S, Wang YM. Ductular proliferation in liver tissues with severe chronic hepatitis B: an immunohistochemical study. World J Gastroenterology 2006, 12:1443-1446.
9. Limaye PB, Alarcón G, Walls AL, Nalesnik MA, Michalopoulos GK, Demetris AJ, Ochoa ER. Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Lab Invest 2008, 88:865-872. 10.1038/labinvest.2008.56, 2631390, 18574450.
10. Kanz MF, Gunasena GH, Kaphalia L, Hammond DK, Syed YA. A minimally toxic dose of methylene dianiline injures biliary epithelial cells in rats. Toxicol Appl Pharmacol 1998, 150:414-426. 10.1006/taap.1998.8382, 9653073.
11. Kanz MF, Wang A, Campbell GA. Infusion of bile from methylene dianiline-treated rats into the common bile duct injures biliary epithelial cells of recipient rats. Toxicol Lett 1995, 78:165-171. 10.1016/0378-4274(95)03251-F, 7618181.
12. Duncan SA. Transcriptional regulation of liver development. Dev Dyn 2000, 219:131-142. 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1051>3.3.CO;2-E, 11002334.
13. Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008, 322:1490-1494. 10.1126/science.1161431, 2641009, 19056973.
14. Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach JP, Babinet C, Yaniv M. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 1996, 84:575-585. 10.1016/S0092-8674(00)81033-8, 8598044.
15. Li J, Ning G, Duncan SA. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev 2000, 14:464-474. 316377, 10691738.
16. Hayhurst GP, Strick-Marchand H, Mulet C, Richard AF, Morosan S, Kremsdorf D, Weiss MC. Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells. J Hepatol 2008, 49:384-395. 10.1016/j.jhep.2008.04.024, 2625285, 18617288.
17. Coffinier C, Gresh L, Fiette L, Tronche F, Schütz G, Babinet C, Pontoglio M, Yaniv M, Barra J. Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta. Development 2002, 129:1829-1838.
18. Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development 2002, 129:1819-1828.
19. Clotman F, Lemaigre FP. Control of hepatic differentiation by activin/TGFbeta signaling. Cell Cycle 2006, 5:168-171. 10.4161/cc.5.2.2341, 16357531.
20. Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev 2005, 19:1849-1854. 10.1101/gad.340305, 1186184, 16103213.
21. Laconi E, Oren R, Mukhopadhyay DK, Hurston E, Laconi S, Pani P, Dabeva MD, Shafritz DA. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998, 153:319-329. 1852941, 9665494.
22. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997, 276:60-66. 10.1126/science.276.5309.60, 9082986.
23. Michalopoulos GK. Liver regeneration. J Cell Physiol 2007, 213:286-300. 10.1002/jcp.21172, 2701258, 17559071.
24. del Castillo G, Alvarez-Barrientos A, Carmona-Cuenca I, Fernández M, Sánchez A, Fabregat I. Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF-beta. J Cell Physiol 2008, 215:846-855. 10.1002/jcp.21370, 18286537.
25. Bisgaard HC, Nagy P, Santoni-Rugiu E, Thorgeirsson SS. Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens. Hepatology 1996, 1:62-70.
26. Zhou H, Rogler LE, Teperman L, Morgan G, Rogler CE. Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver. Hepatology 2007, 45:716-724. 10.1002/hep.21557, 17326146.
27. Petersen BE, Zajac VF, Michalopoulos GK. Bile ductular damage induced by methylene dianiline inhibits oval cell activation. Am J Pathol 1997, 151:905-909. 1858051, 9327722.
28. Best DH, Coleman WB. Bile duct destruction by 4,4'-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Hepatology 2007, 46:1611-1619. 10.1002/hep.21876, 17705295.
29. Paku S, Nagy P, Kopper L, Thorgeirsson SS. 2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies. Hepatology 2004, 39:1353-1361. 10.1002/hep.20178, 15122764.
30. Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J 1996, 10:267-282.
31. Darlington GJ. Molecular mechanisms of liver development and differentiation. Curr Opin Cell Biol 1999, 11:678-682. 10.1016/S0955-0674(99)00035-6, 10600708.
32. Jacquemin P, Lannoy VJ, Rousseau GG, Lemaigre FP. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. J Biol Chem 1999, 274:2665-2671. 10.1074/jbc.274.5.2665, 9915796.
33. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 2007, 132:1434-1446. 10.1053/j.gastro.2007.01.033, 17408630.