Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen

Pathology

Volumn 40, Issue 3, 2008, Pages 272-276

  Watanabe, Hirofumi ^a   Hata, Masaki ^a   Terada, Nobuyuki ^a   Ueda, Haruyasu ^a   Yamada, Naoko ^a   Yamanegi, Koji ^a   Ohyama, Hideki ^a   Kakihana, Michiko ^a   Okamura, Haruki ^a   Nakasho, Keiji ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Biliary cell; Dipeptidyl peptidase IV; Hepatocyte; Rat; Spleen; Transdifferentiation; Transplantation

Indexed keywords

CYTOKERATIN 19; CYTOKERATIN 7; DIPEPTIDYL PEPTIDASE IV; RETRORSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL DIFFERENTIATION; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME INHIBITION; HEPATOCYTE TRANSPLANTATION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER RESECTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPLEEN; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 42449101658     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020801911546     Document Type: Article

References (22)

1. Fogli L, Cappellari L, Gorini P, et al. The origin of bile ductular-like structures after transplantation of regenerating hepatocytes into the spleen of syngeneic rats. Ital J Surg Sci 1987; 17: 147-51.
2. Hillan KJ, Burt AD, George WD, et al. Intrasplenic hepatocyte transplantation in rats with experimental liver injury: Morphological and morphometric studies. J Pathol 1989; 159: 67-73.
3. Jiang B, Kasai S, Sawa M, et al. Beneficial effect of hepatic stimulatory substances on the survival of intrasplenically transplantation hepatocytes. Cell Transplant 1993; 2: 325-9.
4. Sakata H, Jiang B, Kusano M, et al. Proliferation and morphogenesis of biliary epithelial cells in syngeneic hepatocytes transplantation into the spleen under FK 506. Int Hepatol Commun 1994; 2: 67-9.
5. Alison MR, Golding MH, Sarraf CE. Pluripotential liver stem cells: Facultative stem cells located in the biliary tree. Cell Prolif 1996; 29: 373-402.
6. Thorgeirsson SS. Hepatic stem cells in liver regeneration. FASEB J 1996; 10: 1249-56.
7. Shafritz DA, Dabeva MD. Liver stem cells and model systems for liver repopulation. J Hepatol 2002; 36: 552-64.
8. Fukuda K, Sugihara A, Nakasho K, et al. The origin of biliary ductular cells that appear in the spleen after transplantation of hepatocytes. Cell Transplant 2004; 13: 27-33.
9. Ise H, Nikaido T, Negishi N, et al. Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression. Am J Pathol 2004; 165: 501-10.
10. Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol 1969; 43: 506-20.
11. Laconi E, Oren R, Mukhopadhyay DK, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998; 153: 319-29.
12. Michalopoulos GK, Bowen WC, Mulè K, et al. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 2002; 36: 278-83.
13. Michalopoulos GK, Barua L, Bowen WC. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005; 41: 535-44.
14. Van Eyken P, Sciot R, Van Damme B, et al. Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient. Virchow Arch A 1987; 412: 63-72.
15. Lenzi R, Liu MH, Tarsetti F, et al. Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells. Lab Invest 1992; 66: 390-402.
16. Paku S, Dezs}o K, Kopper L, et al. Immunohistochemical analysis of cytokeratin 7 expression in resting and proliferating biliary structures of rat liver. Hepatology 2005; 42: 863-70.
17. Mitaka T, Kojima T, Mizuguchi T, et al. Growth and maturation of small hepatocytes isolated from adult rat liver. Biochem Biophys Res Commun 1995; 214: 310-7.
18. Tateno C, Yoshizato K. Growth and differentiation in culture of clonogenic hepatocytes that express both phenotypes of hepatocytes and biliary epithelial cells. Am J Pathol 1996; 149: 1593-605.
19. Katayama S, Tateno C, Asahara T, et al. Size-depedent in vivo growth potential of adult rat hepatocytes. Am J Pathol 2001; 158: 97-105.
20. Nishikawa Y, Doi Y, Watanabe H, et al. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol 2005; 166: 1077-88.
21. Desmet V, Roskams T, Van Eyken P. Ductular reaction in the liver. Pathol Res Pract 1995; 191: 513-24.
22. Alvaro D, Gigliozzi A, Attili AF. Regulation and deregulation of cholangiocyte proliferation. J Hepatol 2000; 33: 333-40.