A minimally toxic dose of methylene dianiline injuries biliary epithelial cells in rats

Toxicology and Applied Pharmacology

Volumn 150, Issue 2, 1998, Pages 414-426

  Kanz, Mary F ^a   Gunasena, G Harshani ^a   Kaphalia, Lata ^a   Hammond, Dianne K ^a   Syed, Yasmeen A ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' METHYLENEDIANILINE; BILE SALT; BILIRUBIN; CYTOCHROME P450; GLUCOSE; GLUTATHIONE; PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; HEPATOBILIARY SYSTEM; HISTOCHEMISTRY; LIVER NECROSIS; LIVER TOXICITY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; ULTRASTRUCTURE;

ANIMALIA;

EID: 0032103387     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8382     Document Type: Article

References (46)

1. Ahmed A. E., Grissom M., el-Azhary R., Haque A., Boor P. J., Costanzi J. Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital. Cancer Chemother. Pharmacol. 19:1987;103-108.
2. Aitio A. A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal. Biochem. 85:1978;488-491.
3. Angermuller S., Fahimi H. D. Selective cytochemical localization of peroxidase, cytochrome oxidase and catalase in rat liver with 3,3′-diaminobenzidine. Histochemistry. 71:1981;33-44.
4. Bailie M. B., Hewett J. A., Schultze A. E., Roth R. A. Methylene dianiline hepatotoxicity is not leukocyte-dependent. Toxicol. Appl. Pharmacol. 124:1994;25-30.
5. Bailie M. B., Mullaney T. P., Roth R. A. Characterization of acute 4,4′-methylene dianiline hepatotoxicity in the rat. Environ. Health Perspect. 101:1993;130-133.
6. Ballatori N., Truong A. T. Relation between biliary glutathione excretion and bile acid-independent bile flow. Am. J. Physiol. 256:1989;G22-G30.
7. Ballatori N., Truong A. T. Cholestasis, altered junctional permeability and inverse changes in sinusoidal and biliary glutathione release by vasopressin and epinephrine. Mol. Pharmacol. 38:1990;64-71.
8. Bastien P. G. Occupational hepatitis caused by methylenedianiline. Med. J. Aust. 141:1984;533-535.
9. Berruet R., Vinard E., Calle A., Tighzert H. L., Chabert B., Magloire H., Eloy R. Mechanical properties and biocompatibility of two polyepoxy matrices: DGEBA-DDM and DGEBA-IPD. Biomaterials. 8:1987;162-171.
10. Birch-Machin M., Jackson S., Kler R. S., Turnbull D. M. Study of skeletal muscle mitochondrial dysfunction. Mitochondrial Dysfunction. 1993;Academic Press, San Diego. p. 51-69.
11. Connolly A. K., Price S. C., Connelly J. C., Hinton R. H. Early changes in bile duct lining cells and hepatocytes in rats treated with α-naphthylisothiocyanate. Toxicol. Appl. Pharmacol. 93:1988;208-219.
12. Cullen J. M., Ruebner B. H. A histopathologic classification of chemical-induced injury of the liver. Meeks R. G., Harrison S. D., Bull R. J. Hepatotoxicology. 1991;67-92 CRC Press, Boca Raton.
13. Dignamn J. D., Strobel H. W. NADPH-Cytochrome P-450 reductase from rat liver: Purification by affinity chromatography and characterization. Biochemistry. 6:1977;1116-1123.
14. Eyer P. Detoxication ofN. Xenobiotica. 18:1988;1327-1333.
15. Guzelian P., Boyer J. L. Glucose reabsorption from bile: Evidence for a biliohepatic circulation. J. Clin. Invest. 53:1974;526-535.
16. Handler J. A., Kossor D. C., Goldstein R. S. Assessment of hepatobiliary function in vivo and ex vivo in the rat. J. Pharmacol. Toxicol. Methods. 31:1994;11-19.
17. IARC. (International Agency for Research on Cancer), 1986, 39, Chemicals used in plastics and elastomers, Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, 347, 365, IARC, Lyon, France.
18. Imai Y., Ito A., Sato R. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Biochem. 60:1966;417-428.
19. Kajbaf M., Sepai O., Lamb J. H. Identification of metabolites of 4,4′-diaminodiphenylmethane (methylene dianiline) using liquid chromatographic and mass spectrometric techniques. J. Chromatogr. 583:1992;63-76.
20. Kan K. S., Coleman R. 1-Naphthylisothiocyanate-induced permeability of hepatic tight junctions to proteins. Biochem. J. 238:1986;323-328.
21. Kanz M. F., Gunasena G. H., Moslen M. T. Modulation of methylene dianiline toxicity by hyperthyroidism and phenobarbital pretreatment. Toxicologist. 12:1992b;415.
22. Kanz M. F., Kaphalia L., Kaphalia B. S., Romagnoli E., Ansari G. A. S. Methylene dianiline: Acute toxicity and effects on biliary function. Toxicol. Appl. Pharmacol. 117:1992a;88-97.
23. Kanz M. F., Wang A., Campbell G. A. Infusion of bile from methylene dianiline-treated rats into the common bile duct injures biliary epithelial cells of recipient rats. Toxicol. Lett. 78:1995;165-171.
24. Kanz M. F., Reynolds E. S. Early effects of 1,1-dichloroethylene on canalicular and plasma membranes: Ultrastructure and stereology. Exp. Mol. Pathol. 44:1986;93-110.
25. Kopelman H., Scheuer P. J., Williams R. The liver lesion of the Epping jaundice. Quart. J. Med. 35:1966;553-564.
26. Koss F. W., Mayer D., Haindl H. Bile acids. Methods Enzymol. Anal. 4:1974;1886-1888.
27. Krell, H. Trummer, E. Fromm, H. 1988, Paracellular transport of inorganic phosphate into bile in intrahepatic cholestasis, Cellular Calcium and Phosphate Transport in Health and Disease, F. BronnerM. Peterlik, 293, 298, A. R. Liss, New York.
28. Kretschmer N. W., Boor P. J., el Azhary R. A., Ahmed A. E., Reynolds E. S. Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. III. Ultrastructural characterization of bile duct injury. Cancer Chemother. Pharmacol. 19:1987;109-117.
29. Kugler P., Wrobel K. H. Studies on the optimalisation and standardization of the light microscopical succinate dehydrogenase histochemistry. Histochemistry. 57:1978;47-60.
30. Lai J. C. K., Clark J. B. Preparation and properties of mitochondria derived from synaptosomes. Biochem. J. 154:1976;423-432.
31. Lazaridis K. N., Pham L., Vroman B., de Groen P. C., LaRusso N. F. Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. Am. J. Physiol. 272:1997;G1168-G1174.
32. Lira M., Schteingart C. D., Steinbach J. H., Lambert K., McRoberts J. A., Hoffman A. F. Sugar absorption by the biliary ductular epithelium of the rat: Evidence for two transport systems. Gastroenterology. 102:1992;563-571.
33. Lowe P. J., Kan K. S., Barnwell S. G., Sharma R. K., Coleman R. Transcytosis and paracellular movements of horseradish peroxidase across liver parenchymal tissue from blood to bile. Effects of alpha-naphthylisothiocyanate and colchicine. Biochem. J. 229:1985;529-537.
34. Mazzu A. L., Smith C. P. Determination of extractable methylenedianiline in thermoplastic polyurethane by HPLC. J. Biomed. Mater. Res. 18:1984;961-968.
35. McGill D. B., Motto J. D. An industrial outbreak of toxic hepatitis due to methylenedianiline. N. Engl. J. Med. 291:1974;278-282.
36. Moore W. M. Methylenedianiline. Mark H. F., Othmer D. F., Overberger C. G., Seaborg G. T. Kirk-Othmer Encyclopedia of Chemical Technology. 1978;338-348 John Wiley and Sons, New York.
37. Moslen M. T., Kanz M. F., Ferguson A. E. A stable colorimetric assay to measure toxin elevation of inorganic phosphate in bile. Anal. Biochem. 168:1988;405-410.
38. +. Biochem. J. 151:1975;131-140.
39. Nathanson M. H., Boyer J. L. Mechanisms and regulation of bile secretion. Hepatology. 14:1991;551-566.
40. Neghab M., Stacey N. H. Alpha-naphthylisothiocyanate-induced elevation of serum bile acids: Lack of causative effect on bile acid transport. Chem.-Biol. Interact. 99:1996;179-192.
41. Remmer H., Greim H., Schenkman J. B., Estabrook R. W. Methods for the elevation of hepatic microsomal mixed function oxidase levels and cytochrome P-450. Methods Enzymol. 10:1967;703-708.
42. Schaffner F., Scharnbeck H. H., Hutterer F., Denk H., Greim H. A., Popper H. Mechanism of cholestasis. VII. α-Naphthylisothiocyanate-induced jaundice. Lab. Invest. 28:1973;321-331.
43. Shintani H., Nakamura A. Analysis of a carcinogen, 4,4′-methylenedianiline, from thermosetting polyurethane during sterilization. J. Anal. Toxicol. 13:1989;354-357.
44. Smith P. K., Krohn R. I., Hermanson G. T., Mallia A. K., Gartner F. H., Provenzano M. D., Fujumoto E. K., Goeke N. M., Olson B. J., Klenk D. C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:1985;76-85.
45. Sottocasa G. L., Kuylenstierna B., Ernster L., Bergstrand A. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J. Cell Biol. 32:1967;415-438.
46. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem. 27:1969;502-515.