Telomere healing following DNA polymerase arrest-induced breakages is likely the main mechanism generating chromosome 4p terminal deletions

Human Mutation

Volumn 31, Issue 12, 2010, Pages 1343-1351

  Hannes, Femke ^a   Houdt, Jeroen Van ^a   Quarrell, Oliver W ^b   Poot, Martin ^c   Hochstenbach, Ron ^c   Fryns, Jean Pierre ^a   Vermeesch, Joris R ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Chromosome 4p; DNA polymerase arrest sites; Telomerase; Telomere healing; Terminal deletions; Wolf Hirschhorn syndrome

Indexed keywords

DNA POLYMERASE; SINGLE STRANDED DNA;

ARTICLE; CHROMOSOME 4P; CHROMOSOME BREAKAGE; CHROMOSOME DELETION 4; CLINICAL ARTICLE; COPY NUMBER VARIATION; DNA SEQUENCE; HUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; TELOMERE; WOLF HIRSCHHORN SYNDROME;

BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 4; COMPUTATIONAL BIOLOGY; DNA-DIRECTED DNA POLYMERASE; HUMANS; MOLECULAR SEQUENCE DATA; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; TELOMERE;

EID: 78649603334     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.21368     Document Type: Article

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