Chromosome healing: Spontaneous and programmed de novo telomere formation by telomerase

BioEssays

Volumn 18, Issue 4, 1996, Pages 301-308

  Melek, Meni ^a   Shippen, Dorothy E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TELOMERASE;

ANIMAL; BIOLOGICAL MODEL; CHROMOSOME; DNA DAMAGE; DNA REPAIR; EUPLOTES; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; REVIEW; TELOMERE;

ANIMALS; BASE SEQUENCE; CHROMOSOMES; DNA; DNA DAMAGE; DNA REPAIR; EUPLOTES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; TELOMERASE; TELOMERE;

EID: 0030131123     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.950180408     Document Type: Article

References (73)

1. Muller, H. J. (1938). The remaking of chromosomes. Collect. Net. 13, 181-195.
2. McClintock, B. (1941). The stability of broken ends of chromosomes of Zea mays. Genet. 26, 234-282.
3. Sandell, L. L. and Zakian, V. A. (1993). Loss of a yeast telomere: arrest, recovery and chromosome loss. Cell 75, 729-739.
4. Watson, J. D. (1972). Origin of concatameric T4 DMA. Nature New Biol. 239, 197-201.
5. Harley, C. B., Homayoun, V., Counter, C. M. and Allsopp, R. C. (1992) The telomere hypothesis of cellular aging. Exp. Gerontol. 27, 375-382.
6. Harley, C. B. (1995). Telomeres and aging. In Telomeres (ed. E. H. Blackburn and C. W. Greider), pp. 247-263. Cold Spring Harbor Press.
7. Biessmann, H. and Mason, J. M. (1992). Genetics and molecular biology of telomeres. Adv. Genet. 30, 185-249.
8. Greider, C. W. (1995). Telomerase biochemistry and regulation. In Telomeres (ed. E. H. Blackburn and C. W. Greider), pp. 35-68. Cold Spring Harbor Press.
9. Henderson, E. (1995). Telomere DNA structure. In Telomeres (ed. E. H. Blackburn and C.W. Greider), pp. 11-34. Cold Spring Harbor Laboratory Press.
10. Moyzis, R. K. et al. (1988). A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl Acad. Sci. USA 85, 6622-6626.
11. Zhong, Z., Shiue, L., Kaplan, S. and de Lange, T. (1992). A mammalian factor that binds telomeric TTAGGG repeats in vitro. Mot. Cell. Biol. 12, 4834-4843.
12. Autexier, C. and Greider, C. W. (1994). Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev. 8, 563-575.
13. Autexier, C. and Greider, C. W. (1995). Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes Dev. 9, 2227-2239.
14. Gilley, D., Lee, M. S. and Blackburn, E. H. (1995). Altering specific telomerase RNA template residues affects active site function. Genes Dev. 9, 2214-2226
15. Feng, J. et al. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
16. Yu, G., Bradley, J. D., Attardi, L. D. and Blackburn, E. H. (1990). In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344, 126-132.
17. Singer, M. S. and Gottschling, D. E. (1994). TLC1, template RNA component of Saccharomyces cerevisiae telomerase. Science 266, 404-409.
18. McEachern, M. J. and Blackburn, E. H. (1995). Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376, 403-409.
19. Greider, C. W. and Blackburn, E. H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413.
20. Zahler, A. M. and Prescott, O. M. (1988). Telomere terminal transferase activity in the hypotrichous ciliate Oxytricha nova and a model for replication of the ends of linear DNA molecules. Nucl. Acids Res. 16, 6953-6972.
21. Shippen-Lentz, D. and Blackburn, E. H. (1989). Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers. Mol. Cell Biol. 9, 2762-2764.
22. Morin, G. B. (1989). The human telomere terminal transferase enzyme is ribonucleopratein that synthesizes TTAGGG repeats. Cell 59, 521-529.
23. Collins, K., Kobayashi, R. and Greider, C. W. (1995). Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81, 677-686.
24. Harrington, L., Hull, C., Crittenden, J. and Greider, C. W. (1995). Gel shift and UV cross-linking analysis of Tetrahymena telomerase. J. Biol. Chem. 270, 8893-8901.
25. Cohn, M. and Blackburn, E. H. (1995). Telomerase in yeast. Science 269, 396-400.
26. Lin, J.-J. and Zakian, V. A. (1995). An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81, 1127-1135.
27. Mantell, L. L. and Greider, C. W. (1994). Telomerase activity in germline and embryonic cells of Xenopus. EMBO J. 13, 3211-3217.
28. Kim, N. W. et al. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2014.
29. Harrington, L. and Greider, C. (1991). Telomerase primer specificity and chromosome healing. Nature 353, 451-453.
30. Morin, G. (1991). Recognition of a chromosome truncation site associated with alpha-thalassemia by human telomerase. Nature 353, 454-456.
31. Lee, M. and Blackburn, E. H. (1993). Sequence-specific DNA primer effects on telomerase polymerization activity. Mol. Cell Biol. 13, 6586-6599.
32. Collins, K. and Greider, C.W. (1993). Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev. 7, 1364-1376.
33. Lee, D. N., Feng, G. and Landick, R. (1994). GreA-induced transcript cleavage is accompanied by reverse translocation to a different transcription complex conformation. J. Biol. Chem. 35, 22295-22303.
34. Rudd, M. D., Izban, M. G. and Luse, O. S. (1994). The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes. Proc. Natl Acad. Sci. USA 91, 8057-8061.
35. Chamberlin, M. J. (1994). New models for the mechanism of transcription elongation and its regulation. Harvey Lect. 88, 1-21.
36. Counter, C. M. et al. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
37. Counter, C. M., Gupta, J., Harley, C. B., Leber, B. and Bacchetti, S. (1995) Telomerase activity in normal leukocytes and in hematologie malignancies. Blood 85, 2315-2320.
38. Broccoli, D., Young, J. W. and de Lange, T. (1995). Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl Acad. Sci. USA 92, 9082-9086.
39. de Lange, T. (1995). Telomere dynamics and genome instability in human cancer. In Telomeres (ed. E. H. Blackburn and C. W. Greider), pp. 265-293. Cold Spring Harbor Press.
40. Yu, G. and Blackburn, E. H. (1991). Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell 67, 823-832.
41. Greider, C. W. and Blackburn, E. H. (1987). The telomere terminal transferase of Tetrahymena is a ribonucleopratein enzyme with two kinds of primer specificity. Cell 51, 887-898.
42. Greider, C. W. and Blackburn, E. H. (1989). A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat syntheses. Nature 337, 331-337.
43. Shampay, J., Szostak, J. W. and Blackburn, E. H. (1984). DNA sequences of telomeres maintained in yeast. Nature 310, 154-157.
44. Prescott, D. M. (1994). The DNA of ciliated protozoa. Microbiol. Rev. 58, 233-267.
45. Baird, S. E. and Klobutcher, L. A. (1989). Characterization of chromosome fragmentation in two protozoans and identification of a candidate fragmentation sequence in Euplotes crassus. Genes Dev. 3, 585-597.
46. Yao, M.-C., Yao, C.-H. and Monks, B. (1990). The controlling sequence for site-specific chromosome breakage in Tetrahymena. Cell 63, 763-772.
47. Klobutcher, L. A., Swanton, M. T., Donini, O. and Prescott, D. M. (1981). All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′terminus. Proc. Natl Acad. Sci. USA 78, 3015-3019.
48. Melek, M., Davis, B. T. and Shippen, D. E. (1994). Oligonucleotides complementary to the Oxytricha nova telomerase RNA delineate the templating domain and uncover a novel mode of primer utilization. Mol. Cell. Biol. 14, 7827-7838.
49. Avilion, A. A., Harrington, L. A. and Greider, C. W. (1992) Tetrahymena telomerase RNA levels increase during macronuclear development. Dev. Genet. 13, 80-86
50. Price, C. M., Adams, A. K. and Varmeesch, J. R. (1994). Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Buplotes. J. Euk. Microbiol. 41, 267-275.
51. Gilley, D., Preer, J. R., Aufderheide, K. J. and Polisky, B. (1988) Autonomously replication and addition of telomerelike sequences to DNA microinjected into Paramecium tetraurelia macronuclei. Mol. Cell Biol. 8, 4765-4772.
52. Pimpinelli, S. and Goday, C. (1989). Unusual kinetochores and chromosome diminution in Parascaris. Trends Genet. 5, 310-315.
53. Muller, R., Wichy, C., Spicher, A. and Tobler, H. (1991). New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in Ascaris lumbricoides. Cell 67, 815-822.
54. Werner, J. E., Kota, R. S. and Gill, B. S. (1992). Distribution of telomeric repeats and their role in the healing of broken chromosome ends in wheat. Genome 35, 844-848.
55. Tsuchiya, T. (1991). Chromosome mapping by means of aneuploid analysis in barley. In Chromosome Engineering in Plants: Genetics, Breeding, Evolution, Part A (ed. P. K. Gupta and T. Tsuchiya), pp. 361-384. New York, Elsevier Science Publishing Co.
56. 4sl lines. Genome 35, 975-980.
57. Schert, A. et al. (1992). Gene inactivation of Pf11-1 of Plasmodium falciparum by chromosome breakage and healing: identification of a gametocyte-specific protein with a potential role in gametogenesis. EMBO J. 11, 2293-2301.
58. Pologe, L. G. and Ravetch, J. V. (1988). Large deletions result from breakage and healing of P. falciparum chromosomes. Cell 55, 869-874.
59. Mattei, D. and Schert, A. (1994). Subtelomeric chromosome instability in Plasmodium falciparum: short telomeric-like sequence motifs found frequently at healed chromosome breakpoints. Mut. Res. 324, 115-120.
60. Gusella, J. F. et al. (1985). Deletion of Huntington's disease-linked G8(D4S10) locus in Wolf-Hirschhom syndrome. Nature 318, 75-85.
61. Ledbetter, D. H. et al. (1989). Molecular dissection of a contiguous gene syndrome: frequent submicroscopic deletions, evolutionarily conserved sequences and a hypomethylated 'island' in the Miller-Dieker chromosome region. Proc. Natl Acad. Sci. USA 86, 5136-5140.
62. Wilkie, A. O. M., Lamb, J., Harris, P. C., Finney, R. D. and Higgs, D. R. (1990). A truncated human chromosome 16 associated with α-thalassemia is stabilized by addition of telomeric repeat (TTAGGG)n. Nature 346, 868-871.
63. Flint, J. ef al. (1994). Healing of broken chromosomes by the addition of telomeric repeats. Am. J. Hum. Genet. 55, 505-512.
64. Lee, M. S., Gallagher, R. C., Bradley, J. and Blackburn, E. H. (1993). In vivo and in vitro studies of telomeres and telomerase. Cold Spring Harbor Symp. Quant. Biol. 58, 707-718.
65. White, C. I. and Haber, J. E. (1990). Intermediates of recombination during mating type switching in Saccharomyces cerevisiae. EMBO J. 9, 663-673.
66. Kramer, K. M. and Haber, J. E. (1993). New telomeres in yeast are initiated with a highly selected subset of TG1-3 repeats. Genes Dev. 7, 2345-2356.
67. Hanish, J. P., Yanowitz, J. L. and de Lange, T. (1994). Stringent sequence requirements for the formation of human telomeres. Proc. Natl Acad. Sci. USA 91, 8861-8865.
68. Farr, C., Fantes, J., Goodfellow, P. and Cooke, H. (1991). Functional reintroduction of human telomeres into mammalian cells. Proc. Natl Acad. Sci. USA 88, 7006-7010.
69. Surosky, R. T. and Tye, B. K. (1985). Construction of telocentric chromosomes in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA 82, 2106-2110.
70. Murray, A. W., Claus, T. E. and Szostak, J. W. (1988). Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 4642-4650.
71. Barnett, M. A. et al. (1993). Telomere directed fragmentation of mammalian chromosomes. Nucl. Acids Res. 21, 27-36.
72. Murnane, J. P. and Yu, L.-C. . (1993). Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol. Cell. Biol. 13, 977-983.
73. Schert, A. and Mattei, D. (1992). Cloning and characterization of chromosome breakpoints of Plasmodium falciparum: breakage and new telomere formation occurs frequently and randomly in subtelomeric genes. Nucl. Acids Res. 20, 1491-1496.