The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells

Journal of Molecular Biology

Volumn 289, Issue 5, 1999, Pages 1231-1238

  Arnaudeau, Catherine ^a   Helleday, Thomas ^a   Jenssen, Dag ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Exchange mechanism; Homologous recombination; Hypoxanthine guanine phosphoribosyltransferase; Mammalian cells; RAD51

Indexed keywords

DNA BINDING PROTEIN; PROTEIN P53; RECA PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CHROMATID EXCHANGE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; GENETIC RECOMBINATION; HAMSTER; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; TRIXIS;

EID: 0033603537     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2856     Document Type: Article

References (47)

1. Akaboshi E., Inoue Y., Ryo H. Cloning of the cDNA and genomic DNA that corresponding to the recA -like gene of Drosophila melanogaster. Jpn. J. Genet. 69:1994;663-670.
2. Baumann P., West S. C. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem. Sci. 23:1998;247-251.
3. Baumann P., Benson F. E., West S. C. Human RAD51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell. 87:1996;757-766.
4. Benson F. E., Baumann P., West S. C. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair. Nature. 391:1998;401-404.
5. Bezzubova O., Shinohara A., Mueller R. G., Ogawa H., Buerstedde J. M. A chicken Rad51 homologue is expressed at high levels in lymphoid and reproductive organs. Nucl. Acids Res. 21:1993;1577-1580.
6. Bishop D. K., Ear U., Bhattacharyya A., Calderone C., Beckett M., Weichselbaum R. R., Shinohara A. XRCC3 is required for assembly of RAD51 complexes in vivo. J. Biol. Chem. 273:1998;21482-21488.
7. Buchhop S., Gibson M. K., Wang X. W., Wagner P., Sturzbecher H. W., Harris C. C. Interaction of p53 with the human RAD51 protein. Nucl. Acids Res. 25:1997;3868-3874.
8. Chaung W., Mi L. J., Boorstein R. J. The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair. Nucl. Acids Res. 25:1997;992-994.
9. Cheng R. Z., Shammas M. A., Li J., Shmookler Reis R. J. Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells. Exp. Cell Res. 234:1997;300-312.
10. Crook T., Marston N. J., Sara E. A., Vousden K. H. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell. 79:1994;817-827.
11. Dare E., Zhang L. H., Jenssen D. Characterization of mutants involving partial exon duplications in the hprt gene of Chinese hamster V79 cells. Somat. Cell Mol. Genet. 22:1996;201-210.
12. Doutriaux M. P., Couteau F., Bergounioux C., White C. Isolation and characterisation of the RAD51 and DMC1 homologues from Arabidopsis thaliana. Mol. Gen. Genet. 257:1998;283-291.
13. Golub E. I., Kovalenko O. V., Gupta R. C., Ward D. C., Radding C. M. Interaction of human recombination proteins RAD51 and RAD54. Nucl. Acids Res. 25:1997;4106-4110.
14. Golub E. I., Gupta R. C., Haaf T., Wold M. S., Radding C. M. Interaction of human RAD51 recombination protein with single-stranded DNA binding protein, RPA. Nucl. Acids Res. 26:1998;5388-5393.
15. Gupta R. C., Folta-Stogniew E., Raddig C. M. Human RAD51 protein can form homologous joints in the absence of net strand exchange. J. Biol. Chem. 274:1999;1248-1256.
16. Hays S. L., Firmenich A. A., Berg P. Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl Acad. Sci. USA. 92:1995;6925-6929.
17. Helleday T., Arnaudeau C., Jenssen D. A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination. J. Mol. Biol. 279:1998;687-694.
18. Jiang H., Xie Y., Houston P., Stemke-Hale K., Mortensen U. H., Rothstein R., Kodadek T. Direct association between the yeast Rad51 and Rad54 recombination proteins. J. Biol. Chem. 271:1996;33181-33186.
19. Johnson R. D., Symington L. S. Functional differences and interactions among the putative RecA homologues Rad51, Rad55, and Rad57. Mol. Cell Biol. 15:1995;4843-4850.
20. Kinzler K. W., Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature. 386:1997;761-763.
21. Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
22. Li J., Ayyadevera R., Shmookler Reis R. J. Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human dipolid fibroblasts. Mutat. Res. 385:1997;173-193.
23. Lim D. S., Hasty P. A mutation in mouse RAD51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell Biol. 16:1996;7133-7143.
24. Liu N., Lamerdin J. E., Tebbs R. S., Schild D., Tucker J. D., Shen M. R., Brookman K. W., Siciliano M. J., Walter C. A., Fan W., Narayana L. S., Zhou Z. Q., Adamson A. W., Sorensen K. J., Chen D. J., Jones N. J., Thompson L. H. XRCC2 and XRCC3, new human RAD51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol. Cell. 1:1998;783-793.
25. Maeshima K., Morimatsu L., Shinohara A., Horii T. RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis. Gene. 160:1995;195-200.
26. Marmorstein L. Y., Ouchi T., Aaronson S. A. The BRCA2 gene product functionally interacts with p53 and RAD51. Proc. Natl Acad. Sci. USA. 95:1998;13869-13874.
27. Morita T., Yoshimura Y., Yamamoto A., Murata K., Mori M., Yamamoto H., Matsushiro A. A mouse homologue of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes. Proc. Natl Acad. Sci. USA. 90:1993;6577-6580.
28. Ogawa T., Yu X., Shinohara A., Egelman E. H. Similarity of the yeast Rad51 filament to the bacterial RecA filament. Science. 259:1993;1896-1899.
29. Osman F., Subramani S. Double-strand break-induced recombination in eukaryotes. Prog. Nucl. Acid Res. Mol. Biol. 58:1998;263-299.
30. Phillips J. W., Morgan W. F. Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome. Mol. Cell Biol. 14:1994;5794-5803.
31. Reddy G., Golub E. I., Radding C. M. Human RAD52 protein promotes single-strand DNA annealing followed by branch migration. Mutat. Res. 377:1997;53-59.
32. Sargent R. G., Brenneman M. A., Wilson J. H. Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination. Mol. Cell Biol. 17:1997;267-277.
33. Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T., Livingston D. M. Association of BRCA1 with RAD51 in mitotic and meiotic cells. Cell. 88:1997;265-275.
34. Sharan S. K., Morimatsu M., Albrecht U., Lim D. S., Regel E., Dinh C., Sands A., Eichele G., Hasty P., Bradley A. Embryonic lethality and radiation hypersensitivity mediated by RAD51 in mice lacking BRCA2. Nature. 386:1997;804-810.
35. Shinohara A., Ogawa H., Ogawa T. Rad51 protein involved in repair and recombination in S. cerevisiae is a recA-like protein. Cell. 69:1992;457-470.
36. Shinohara A., Ogawa H., Matsuda Y., Ushio N., Ikeo K., Ogawa T. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Nature Genet. 4:1993;239-243.
37. Sonoda E., Sasaki M. S., Buerstedde J. M., Bezzubova O., Shinohara A., Ogawa H., Takata M., Yamaguchi-Iwai Y., Takeda S. RAD51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J. 17:1998;598-608.
38. Sturzbecher H. W., Donzelmann B., Henning W., Knippschild U., Buchhop S. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J. 15:1996;1992-2002.
39. Sugawara N., Ivanov E. L., Fishman-Lobell J., Ray B. L., Wu X., Haber J. E. DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature. 373:1995;84-86.
40. Sung P. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast Rad51 protein. Science. 265:1994;1241-1243.
41. Tsuzuki T., Fujii Y., Sakumi K., Tominaga Y., Nakao K., Sekiguchi M., Matsushiro A., Yoshimura Y., Morita T. Targeted disruption of the RAD51 gene leads to lethality in embryonic mice. Proc. Natl Acad. Sci. USA. 93:1996;6236-6240.
42. Van Dyck E., Hajibagheri N. M. A., Stasiak A., West S. C. Visualization of human RAD52 protein and its complexes with hRAD51 and DNA. J. Mol. Biol. 284:1998;1027-1038.
43. Vispe S., Cazaux C., Lesca C., Defais M. Overexpression of RAD51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucl. Acids Res. 26:1998;2859-2864.
44. Vrieling H., Niericker M. J., Simons J. W., van Zeeland A. A. Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the hprt locus in mouse lymphoma cells. Mutat. Res. 198:1988;99-106.
45. Xia S. J., Shammas M. A., Shmookler Reis R. J. Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase. Mol. Cell Biol. 17:1997;7151-7158.
46. Yoshimura Y., Morita T., Yamamoto A., Matsushiro A. Cloning and sequence of the human recA -like gene cDNA. Nucl. Acids Res. 21:1993;1665.
47. Zhang L. H., Jenssen D. Reversion of the hprt mutant clone SP5 by intrachromosomal recombination. Carcinogenesis. 13:1992;609-615.