Iron physiology and metabolism;Fisiologia e metabolismo do ferro

Revista Brasileira de Hematologia e Hemoterapia

Volumn 32, Issue SUPPL. 2, 2010, Pages 8-17

  Grotto, Helena Z W ^a  

^a UNIVERSIDADE DE PERNAMBUCO   (Brazil)

Author keywords

Hepcidin; Iron deficiency anemia; Iron homeostasis; Iron metabolism; Iron overload

Indexed keywords

EID: 78649542889     PISSN: 15168484     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1516-84842010005000050     Document Type: Review

References (45)

1. Dunn LL, Rahmanto YS, Richardson DR. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007; 17(2):93-100.
2. Wijayanti N, Katz N, Immenschuh S. Biology of heme in health and disease. Curr Med Chem. 2004;11(8):981-6.
3. Fairbanks VG, Beutler E. Iron metabolism. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, editors. Williams- Hematology. 6th ed. New York: Mcgraw-Hill; 2001.p. 295-304.
4. Gattermann N. From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes. Leuk Res. 1999; 24(2):141-51.
5. Hoffbrand AV, Pettit FE, Moss PAH. Essential Haematology. 5th ed. Oxford (UK): Blackwell Publishing; c2006. Chapter 3, Hypochromic anaemias and iron overload; p. 28-43
6. Chung J, Wessling-Resnick. Molecular mechanisms and regulation of iron transport. Crit Rev Clin Lab Sci. 2003;40(2):151-82.
7. Andrews NC. A genetic view of iron homeostasis. Semin Hematol. 2002;39(4):227-34.
8. Oiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006;127(5):917-28.
9. Krishnamurthy P, Xie T, Schuetz JD. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther. 2007; 114(3):345-58.
10. Anderson J, Frazer DM, McLaren GD. Iron absorption and metabolism. Curr Opin Gastroenterol. 2009; 25:129-35.
11. Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis. 2004;32(1):131-8.
12. Oates PS. The role of hepcidin and ferroportin in iron absorption. Histol Histopathol. 2007;22(7):791-804.
13. Lutz HU, Fasler S, Stammler P, Bussolino F, Arese P. Naturally occurring anti-band 3 antibodies and complement in phagocytosis of oxidatively-stressed and in clearance of senescent red cells. Blood Cells. 1988;14(1):175-203.
14. Bratosin D, Estaquier J, Petit F, Amoult D, Quatannens B, Tissier JP, et al. Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ. 2001;8(12):1143-56.
15. Knutson M, Wessling-Resnick. Iron metabolism in the reticuloendothelial system. Cri Rev Biochem Mol Biol 2003;38(1):61-88.
16. De Domenico I, McVey Ward D, Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol. 2008;9(1):72-81.
17. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol. 1998;35(1):35-54.
18. Worwood M. Serum transferrin receptor assays and their application. Ann Clin Biochem. 2002;39(Pt 3):221-30.
19. Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37(11):1264-9.
20. Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ. Zip 14 (Sic39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci USA. 2006; 103:13612-7.
21. Beguin Y. The soluble transferrin receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Hematologica. 1992;77(1):1-10.
22. Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990;75(9): 1870-6.
23. Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem. 1999; 274(30):20826-32.
24. Roetto A, Daraio F, Alberti F, Porporato P, Cali A, De Gobbi M, et al. Hemochromatosis due to mutations in transferrin receptor 2. Blood Cells Mol Dis. 2002;29 (3):465-70.
25. Camaschella C, Silvestri L. New and old players in the hepcidin pathway. Haematologica. 2008;93(10):1441-4.
26. Cooper JM, Schapira AH. Friedreich's ataxia: coenzyme Q(10) and vitamin E therapy. Mitochondrions. 2007;7:S127-135.
27. Alcindor T, Bridges KR. Sideroblastic anaemias. Brit J Haematol. 2002;116(4):733-43.
28. Nairz M, Weiss G. Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis. Wien Klin Wochenschr. 2006;118(15-16): 442-62.
29. Levi S, Rovida E. The role of iron in mitochondrial function. Biochim Biophys Acta. 2009;1790(7):629-36.
30. Donovan A, Roy CN, Andrews NC. The ins and outs of iron homeostasis. Physiology. 2006;21:115-23.
31. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001; 276(11):7806-10.
32. Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480(2-3):147-50.
33. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA. 2002; 99(7):4596-601.
34. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290(2):G199-203.
35. Ganz T. Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005;18(2):171-82
36. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone Hepcidin. J Clin Invest. 2004;113(4):1271-76.
37. Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005;105(4):1797-802.
38. Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crowford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet. 2003;361(9358):669-73.
39. Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, et al. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet. 2004;36(5):481-5.
40. De Domenico I, Ward DM. Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest. 2007;117(7):1755-8.
41. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006:108(9):3204-9.
42. Verga Falzacappa MV, Vujic Sapsic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, Blood. 2007: 109(1):353-8.
43. Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science 2008;320(5879):1088-92.
44. Finberg KE. Iron homeostasis: casting new roles. Blood. 2008; 112(6):2181.
45. Knutson MD. Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2. Nutr Rev. 2009;67(5):284-8.