Reversal of a Mutator Activity by a Nearby Fidelity-Neutral Substitution in the RB69 DNA Polymerase Binding Pocket

Journal of Molecular Biology

Volumn 404, Issue 5, 2010, Pages 778-793

  Trzemecka, Anna ^a   Jacewicz, Agata ^a   Carver, Geraldine T ^b   Drake, John W ^b   Bebenek, Anna ^a  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Exo; Pol

Indexed keywords

ALANINE; BACTERIOPHAGE DNA; DNA POLYMERASE; DNA POLYMERASE RB 69; EXONUCLEASE; GLYCINE; MUTANT PROTEIN; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BACTERIOPHAGE; BACTERIOPHAGE RB 69; BASE MISPAIRING; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA BINDING; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; FRAMESHIFT MUTATION; IN VITRO STUDY; IN VIVO STUDY; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

EID: 78649529327     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.09.058     Document Type: Article

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