Synthesis and characterization of selective dopamine D2 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 3, 2006, Pages 815-825

  Vangveravong, Suwanna ^a   McElveen, Elizabeth ^b   Taylor, Michelle ^b   Xu, Jinbin ^a   Tu, Zhude ^a   Luedtke, Robert R ^b   Mach, Robert H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

D2 like dopamine receptors; Dopamine receptor antagonists; Indoles; Sigma receptors

Indexed keywords

1 [(1H INDOL 3 YL)METHYL] 4 (4 BROMOPHENYL)PIPERIDIN 4 OL OXALATE; 1 [(1H INDOL 3 YL)METHYL] 4 (4 CHLOROPHENYL)PIPERIDIN 4 OL OXALATE; 1 [(1H INDOL 3 YL)METHYL] 4 [4 (METHYLTHIO)PHENYL]PIPERIDIN 4 OL OXALATE; 1 [(5 METHOXY 1H INDOL 3 YL)METHYL] 4 [4 (METHYLTHIO)PHENYL]PIPERIDIN 4 OL OXALATE; 1 [1 (1H INDOL 3 YL)METHYL] 4 PHENYLPIPERIDINE OXALATE; 1 [1 [(1H INDOL 3 YL)METHYL]PIPERIDIN 4 YL] 1 H BENZO[D]IMIDAZOL 2(3H) ONE OXALATE; 3 METHYLSPIPERONE; 4 (4 BROMOPHENYL) 1 [(4 METHOXY 1H INDOL 3 YL)METHYL]PIPERIDIN 4 OL OXALATE; 4 (4 BROMOPHENYL) 1 [(5 METHOXY 1H INDOL 3 YL)METHYL]PIPERIDIN 4 OL OXALATE; 4 (4 CHLOROPHENYL) 1 [(4 METHOXY 1H INDOL 3 YL)METHYL]PIPERIDIN 4 OL OXALATE; 4 (4 CHLOROPHENYL) 1 [(5 METHOXY 1H INDOL 3 YL)METHYL]PIPERIDIN 4 OL OXALATE; 8 [(1H INDOL 3 YL)METHYL] 3 METHYL 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE OXALATE; 8 [(4 METHOXY 1H INDOL 3 YL)METHYL] 3 METHYL 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE OXALATE; 8 [(5 METHOXY 1H INDOL 3 YL)METHYL] 3 METHYL 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE OXALATE; ADENYLATE CYCLASE; BENPERIDOL; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; FORSKOLIN; FUNCTIONAL GROUP; HALOPERIDOL; INDOLE DERIVATIVE; QUINPIROLE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GENETIC TRANSFECTION; GUINEA PIG; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADENYLATE CYCLASE; ANIMALS; BRAIN; CELL LINE; DOPAMINE ANTAGONISTS; GUINEA PIGS; HUMANS; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, SIGMA; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA; CAVIA PORCELLUS;

EID: 28844438985     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.008     Document Type: Article

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