Sleep and metabolism: Role of hypothalamic neuronal circuitry

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 24, Issue 5, 2010, Pages 817-828

  Rolls, Asya ^a   Borg, Jana Schaich ^a   De Lecea, Luis ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

dopamine; ghrelin; hypocretin; hypothalamus; leptin; metabolism; NPY; POMC; sleep; stress; VTA

Indexed keywords

CORTICOTROPIN; NEUROPEPTIDE Y;

AGING; BRAIN REGION; ENVIRONMENTAL FACTOR; FOOD INTAKE; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOREACTIVITY; LOCOMOTION; METABOLISM; NARCOLEPSY; NONHUMAN; OBESITY; REM SLEEP; REVIEW; REWARD; SLEEP; SLEEP APNEA SYNDROME; SLEEP DISORDER; STRESS;

ANIMALS; AROUSAL; FEEDING BEHAVIOR; HUMANS; HYPOTHALAMUS; METABOLIC NETWORKS AND PATHWAYS; METABOLISM; MODELS, BIOLOGICAL; NERVE NET; REWARD; SLEEP; STRESS, PHYSIOLOGICAL;

EID: 78649508984     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2010.08.002     Document Type: Review

References (104)

1. C.B. Saper Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms Progress in Brain Research 153 2006 243 252
2. M.N. Alam, S. Kumar, and N. Suntsova GABAergic regulation of the perifornical-lateral hypothalamic neurons during non-rapid eye movement sleep in rats Neuroscience 167 3 2010 920 928
3. C.B. Saper, T.E. Scammell, and J. Lu Hypothalamic regulation of sleep and circadian rhythms Nature 437 7063 2005 1257 1263 (Pubitemid 41568665)
4. R. Szymusiak, and D. McGinty Hypothalamic regulation of sleep and arousal Annals of the New York Academy of Sciences 1129 2008 275 286
5. C. Peyron, D.K. tighe, and A.N. van den pol Neurons containing hypocretin (orexin) project to multiple neuronal systems The Journal of Neuroscience 18 23 1998 9996 10015
6. D.L. Rosin, M.C. weston, and C.P. Sevigny Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2 The Journal of Comparative Neurology 465 4 2003 593 603
7. A. Adamantidis, and L. de Lecea Sleep and metabolism: shared circuits, new connections Trends in Endocrinology and Metabolism 19 10 2008 362 370
8. T. Sakurai The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness Nature Reviews. Neuroscience 8 3 2007 171 181
9. A. Adamantidis, and L. de Lecea Physiological arousal: a role for hypothalamic systems Cellular and Molecular Life Sciences 65 10 2008 1475 1488
10. J.G. Sutcliffe, and L. de Lecea Novel neurotransmitters for sleep and energy homeostasis Results and Problems in Cell Differentiation 26 1999 239 255
11. A.R. Adamantidis, F. Zhang, and A.M. Aravanis Neural substrates of awakening probed with optogenetic control of hypocretin neurons Nature 450 7168 2007 420 424
12. M.E. Carter, A. Adamantidis, and H. Ohtsu Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions The Journal of Neuroscience 29 35 2009 10939 10949
13. G. Aston-Jones, and F.E. Bloom Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle The Journal of Neuroscience 1 8 1981 876 886 (Pubitemid 11025876)
14. A. Dahlstrom, and K. Fuxe Localization of monoamines in the lower brain stem Experientia 20 7 1964 398 399
15. J. Lu, T.C. Jhou, and C.B. Saper Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter The Journal of Neuroscience 26 1 2006 193 202
16. C.B. Saper Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections The Journal of Comparative Neurology 237 1 1985 21 46
17. B.K. Anand, and J.R. Brobeck Localization of a "feeding center" in the hypothalamus of the rat Proceedings of the Society for Experimental Biology and Medicine 77 2 1951 323 324
18. A. Abizaid, and T.L. Horvath Brain circuits regulating energy homeostasis Regulatory Peptides 149 1-3 2008 3 10
19. K. Spiegel, E. Tasali, and R. Leproult Effects of poor and short sleep on glucose metabolism and obesity risk Nature Reviews. Endocrinology 5 5 2009 253 261
20. K.L. Knutson, and E. Van Cauter Associations between sleep loss and increased risk of obesity and diabetes Annals of the New York Academy of Sciences 1129 2008 287 304
21. X. Chen, M.A. Beydoun, and Y. Wang Is sleep duration associated with childhood obesity? A systematic review and meta-analysis Obesity (Silver Spring) 16 2 2008 265 274 (Pubitemid 351271904)
22. Y.D. Van Der Werf, E. Altena, and M.M. Schoonheim Sleep benefits subsequent hippocampal functioning Nature Neuroscience 12 2 2009 122 123
23. M.L. Unruh, M.H. Sanders, and S. Redline Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health Study Journal of the American Society of Nephrology 17 12 2006 3503 3509
24. S.W. Kok, S. Overeem, and T.L. Visscher Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity Obesity Research 11 9 2003 1147 1154
25. N. Dahmen, P. Tonn, and L. Messroghli Basal metabolic rate in narcoleptic patients Sleep 32 7 2009 962 964
26. F. Poli, G. Plazzi, and G. Di Dalmazi Body mass index-independent metabolic alterations in narcolepsy with cataplexy Sleep 32 11 2009 1491 1497
27. H.A. Fortuyn, S. Swinkels, and J. Buitelaar High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study Sleep 31 3 2008 335 341
28. Y. Dauvilliers, I. Arnulf, and E. Mignot Narcolepsy with cataplexy Lancet 369 9560 2007 499 511
29. S. Nishino The hypocretin/orexin system in health and disease Biological Psychiatry 54 2 2003 87 95
30. T. Sakurai, A. Amemiya, and M. Ishii Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 4 1998 573 585
31. A. Yamanaka, C.T. Beuckmann, and J.T. Willie Hypothalamic orexin neurons regulate arousal according to energy balance in mice Neuron 38 5 2003 701 713
32. S. Zhang, J.M. Zeitzer, and T. Sakurai Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy The Journal of Physiology 581 Pt 2 2007 649 663
33. S. Muroya, H. Funahashi, and A. Yamanaka Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus The European Journal of Neuroscience 19 6 2004 1524 1534
34. X. Ma, L. Zubcevic, and J.C. Bruning Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin The Journal of Neuroscience 27 7 2007 1529 1533
35. P.J. Martins, M.S. Marques, and S. Tufik Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation. American journal of physiology Endocrinology and metabolism 298 3 2010 E726 E734
36. C. Cirelli, U. Faraguna, and G. Tononi Changes in brain gene expression after long-term sleep deprivation Journal of Neurochemistry 98 5 2006 1632 1645
37. V.V. Vyazovskiy, C. Cirelli, and G. Tononi Cortical metabolic rates as measured by 2-deoxyglucose-uptake are increased after waking and decreased after sleep in mice Brain Research Bulletin 75 5 2008 591 597
38. C.A. Crispim, I. Zalcman, and M. Dattilo The influence of sleep and sleep loss upon food intake and metabolism Nutrition Research Reviews 20 2 2007 195 212
39. P.M. Fuller, J. Lu, and C.B. Saper Differential rescue of light- and food-entrainable circadian rhythms Science 320 5879 2008 1074 1077
40. M. Mieda, S.C. Williams, and J.A. Richardson The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker Proceedings of the National Academy of Sciences of the United States of America 103 32 2006 12150 12155
41. C. Broberger Brain regulation of food intake and appetite: molecules and networks Journal of Internal Medicine 258 4 2005 301 327
42. L.Y. Fu, C. Acuna-Goycolea, and A.N. van den Pol Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system The Journal of Neuroscience 24 40 2004 8741 8751
43. C. Acuna-Goycolea, N. Tamamaki, and Y. Yanagawa Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus The Journal of Neuroscience 25 32 2005 7406 7419
44. A.P. Silva, A.P. Carvalho, and C.M. Carvalho Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus Neuropharmacology 44 2 2003 282 292
45. T.L. Horvath, S. Diano, and A.N. van den Pol Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations The Journal of Neuroscience 19 3 1999 1072 1087
46. Y. Yamamoto, Y. Ueta, and Y. Date Down regulation of the prepro-orexin gene expression in genetically obese mice Brain Research. Molecular Brain Research 65 1 1999 14 22
47. H. Kawauchi Functions of melanin-concentrating hormone in fish Journal of Experimental Zoology. Part A, Comparative Experimental Biology 305 9 2006 751 760
48. P. Pissios, R.L. Bradley, and E. Maratos-Flier Expanding the scales: the multiple roles of MCH in regulating energy balance and other biological functions Endocrine Reviews 27 6 2006 606 620
49. Y. Shi Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions Peptides 25 10 2004 1605 1611
50. L.L. Rokosz, and D.W. Hobbs Biological examination of melanin concentrating hormone receptor 1: multi-tasking from the hypothalamus Drug News & Perspectives 19 5 2006 273 286
51. J.R. Espiritu Aging-related sleep changes Clinics in Geriatric Medicine 24 1 2008 1 14 v
52. N. Sawai Developmental and aging change of orexin-A and -B immunoreactive neurons in the male rat hypothalamus Neuroscience Letters 468 1 2010 51 55
53. S.E. Brownell, and B. Brownell Age- and gender-specific changes of hypocretin immunopositive neurons in C57Bl/6 mice Neuroscience Letters 472 1 2010 29 32
54. J.L. Downs, M.R. Dunn, and E. Borok Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque Neurobiology of Aging 28 8 2007 1286 1295
55. J.H. Zhang, S. Sampogna, and F.R. Morales Age-related changes of hypocretin in basal forebrain of guinea pig Peptides 26 12 2005 2590 2596
56. H. Tsuneki, S. Murata, and Y. Anzawa Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice Diabetologia 51 4 2008 657 667
57. C.M. Kotz, M.A. Mullett, and C. Wang Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 289 2 2005 R359 R366
58. S. Akimoto-Takano, C. Sakurai, and S. Kanai Differences in the appetite-stimulating effect of orexin, neuropeptide Y and ghrelin among young, adult and old rats Neuroendocrinology 82 5-6 2005 256 263
59. Z. Kmiec Central regulation of food intake in ageing J Physiol Pharmacol 57 Suppl. 6 2006 7 16
60. J.Y. Jeon MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance Diabetes 55 2 2006 428 434
61. B.S. McEwen, and P.J. Gianaros Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease Annals of the New York Academy of Sciences 1186 2010 190 222
62. R. Pasquali The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome Annals of the New York Academy of Sciences 1083 2006 111 128 (Pubitemid 44955469)
63. S.L. Teegarden, and T.L. Bale Effects of stress on dietary preference and intake are dependent on access and stress sensitivity Physiology & Behavior 93 4-5 2008 713 723
64. T.D. Brewerton Eating disorders, trauma, and comorbidity: focus on PTSD Eating Disorders 15 4 2007 285 304
65. L.A. Papale, M.L. Andersen, and I.B. Antunes Sleep pattern in rats under different stress modalities Brain Research 1060 1-2 2005 47 54
66. L.D. Sanford, L. Yang, and L.L. Wellman Mouse strain differences in the effects of corticotropin releasing hormone (CRH) on sleep and wakefulness Brain Research 1190 2008 94 104
67. G. Vazquez-Palacios, and J. Velazquez-Moctezuma Effect of electric foot shocks, immobilization, and corticosterone administration on the sleep-wake pattern in the rat Physiology & Behavior 71 1-2 2000 23 28
68. V. Baubet, M. Fevre-Montange, and N. Gay Effects of an acute immobilization stress upon proopiomelanocortin (POMC) mRNA levels in the mediobasal hypothalamus: a quantitative in situ hybridization study Brain Research. Molecular Brain Research 26 1-2 1994 163 168
69. A. Lopez-Calderon, C. Ariznavarreta, and C.L. Chen Influence of chronic restraint stress on pro-opiomelanocortin mRNA and beta-endorphin in the rat hypothalamus Journal of Molecular Endocrinology 7 3 1991 197 204
70. F.P. Pralong, R. Corder, and R.C. Gaillard The effects of chronic glucocorticoid excess, adrenalectomy and stress on neuropeptide Y in individual rat hypothalamic nuclei Neuropeptides 25 4 1993 223 231
71. M.A. Dutton, E.W. Lee, and Z. Zukowska NPY and extreme stress: lessons learned from posttraumatic stress disorder EXS 95 2006 213 222
72. F. Gomez, H. Houshyar, and M.F. Dallman Marked regulatory shifts in gonadal, adrenal, and metabolic system responses to repeated restraint stress occur within a 3-week period in pubertal male rats Endocrinology 143 8 2002 2852 2862
73. R. Winsky-Sommerer, A. Yamanaka, and S. Diano Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response The Journal of Neuroscience 24 50 2004 11439 11448
74. J.J. Tebbe, S. Mronga, and M.K. Schafer Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptors American Journal of Physiology. Gastrointestinal and Liver Physiology 285 6 2003 G1075 G1083
75. M. Kuru, Y. Ueta, and R. Serino Centrally administered orexin/hypocretin activates HPA axis in rats Neuroreport 11 9 2000 1977 1980
76. T. Ida, K. Nakahara, and T. Murakami Possible involvement of orexin in the stress reaction in rats Biochemical and Biophysical Research Communications 270 1 2000 318 323
77. L.K. Malendowicz, C. Tortorella, and G.G. Nussdorfer Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade The Journal of Steroid Biochemistry and Molecular Biology 70 4-6 1999 185 188
78. W.K. Samson, B. Gosnell, and J.K. Chang Cardiovascular regulatory actions of the hypocretins in brain Brain Research 831 1-2 1999 248 253
79. L. Lu, J.D. Shepard, and F.S. Hall Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review Neuroscience and Biobehavioral Reviews 27 5 2003 457 491
80. F. Sakamoto, S. Yamada, and Y. Ueta Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons Regulatory Peptides 118 3 2004 183 191
81. R. Leproult, G. Copinschi, and O. Buxton Sleep loss results in an elevation of cortisol levels the next evening Sleep 20 10 1997 865 870
82. A. Sgoifo, B. Buwalda, and M. Roos Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats Psychoneuroendocrinology 31 2 2006 197 208
83. P. Meerlo, M. Koehl, and K. van der Borght Sleep restriction alters the hypothalamic-pituitary-adrenal response to stress Journal of Neuroendocrinology 14 5 2002 397 402
84. A.E. Kelley Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning Neuroscience and Biobehavioral Reviews 27 8 2004 765 776
85. S. Sakurai, T. Nishijima, and S. Takakashi Low plasma orexin-A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apnea-hypopnea syndrome Chest 127 3 2005 731 737
86. N. Tsujino, and T. Sakurai Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system Pharmacological Reviews 61 2 2009 162 176
87. T.M. Korotkova, O.A. Sergeeva, and K.S. Eriksson Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins The Journal of Neuroscience 23 1 2003 7 11
88. J.W. Muschamp, J.W. Dominguez, and S.M. Sato A role for hypocretin (orexin) in male sexual behavior The Journal of Neuroscience 27 11 2007 2837 2845
89. S.L. Borgland, S.A. Taha, and F. Sarti Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine Neuron 49 4 2006 589 601
90. M. Narita, Y. Nagumo, and S. Hashimoto Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine The Journal of Neuroscience 26 2 2006 398 405
91. C.W. Berridge, and R.A. Espana Hypocretins: waking, arousal, or action? Neuron 46 5 2005 696 698
92. M. Narita Implication of protein kinase C in the orexin-induced elevation of extracellular dopamine levels and its rewarding effect The European Journal of Neuroscience 25 5 2007 1537 1545
93. N.M. Vittoz, B. Schmeichel, and C.W. Berridge Hypocretin/orexin preferentially activates caudomedial ventral tegmental area dopamine neurons The European Journal of Neuroscience 28 8 2008 1629 1640
94. G. Di Chiara Nucleus accumbens shell and core dopamine: differential role in behavior and addiction Behavioural Brain Research 137 1-2 2002 75 114
95. A.K. Anderson, and E.A. Phelps Lesions of the human amygdala impair enhanced perception of emotionally salient events Nature 411 6835 2001 305 309
96. S. Nakamura, T. Tsumori, and S. Yokota Amygdaloid axons innervate melanin-concentrating hormone- and orexin-containing neurons in the mouse lateral hypothalamus Brain Research 1278 2009 66 74
97. J.M. Siegel Hypocretin (orexin): role in normal behavior and neuropathology Annual Review of Psychology 55 2004 125 148
98. S. Schwartz, A. Ponz, and R. Poryazova Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy Brain 131 Pt 2 2008 514 522
99. T.S. Gray, and J.E. Morley Neuropeptide Y: anatomical distribution and possible function in mammalian nervous system Life Science 38 5 1986 389 401
100. A.M. Naleid, M.K. Grace, and M.K. Cummings Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens Peptides 26 11 2005 2274 2279
101. A. Abizaid, Z.W. Liu, and Z.B. Andrews Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite The Journal of Clinical Investigation 116 12 2006 3229 3239
102. J.D. Hommel, R. Trinko, and R.M. Sears Leptin receptor signaling in midbrain dopamine neurons regulates feeding Neuron 51 6 2006 801 810
103. S. Fulton, P. Pissios, and R.P. Manchon Leptin regulation of the mesoaccumbens dopamine pathway Neuron 51 6 2006 811 822
104. C.S. Maldonado-Irizarry, C.J. Swanson, and A.E. Kelley Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus The Journal of Neuroscience 15 10 1995 6779 6788