The Na+-/glucose cotransporters: From genes to therapy

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 11, 2010, Pages 1019-1026

  Sabino Silva, R ^a   Mori, R C ^a   David Silva, A ^a   Okamoto, M M ^a   Freitas, H S ^a   MacHado, U F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Diabetes; HNF 1; SGLT1; SGLT2; SLC5A1; SLC5A2

Indexed keywords

3 (5 BENZOFURANYL) 1 [2 HYDROXY 6 [6 O (METHOXYCARBONYL) BETA DEXTRO GLUCOPYRANOSYL] 4 METHYLPHENYL] 1 PROPANONE; DAPAGLIFLOZIN; PROTEIN KINASE; SERGLIFLOZIN ETABONATE; SODIUM CHANNEL AFFECTING AGENT; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CARBOHYDRATE METABOLISM; DIABETES MELLITUS; DIETARY INTAKE; GENE EXPRESSION; GENE MUTATION; GENETIC DISORDER; GLUCOSE GALACTOSE MALABSORPTION; GLUCOSE TRANSPORT; HUMAN; MALABSORPTION; NONHUMAN; ORAL REHYDRATION THERAPY; RENAL DIABETES; REVIEW; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 78649464508     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500115     Document Type: Review

References (60)

1. Bell GI, Kayano T, Buse JB, Burant CF, Takeda J, Lin D, et al. Molecular biology of mammalian glucose transporters. Diabetes Care 1990; 13: 198-208.
2. Hediger MA, Rhoads DB. Molecular physiology of sodiumglucose cotransporters. Physiol Rev 1994; 74: 993-1026.
3. Crane RK, Miller D, Bihler I. The restrictions on possible mechanism of intestinal active transport of sugars. Proceedings of the Membrane Transport and Metabolism Symposium. Prague, August 22-27, 1960. Czech Academy of Sciences; 1960. p 439-449.
4. +-glucose cotransporters: SLC5. Physiology 2004; 19: 370-376.
5. Turk E, Wright EM. Membrane topology motifs in the SGLT cotransporter family. J Membr Biol 1997; 159: 1-20.
6. +/glucose- cotransporter 1 (SGLT1). J Cell Biochem 2003; 90: 339-346.
7. +-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. J Membr Biol 2009; 228: 63-69.
8. +-dependent glucose cotransporters: comparison of SGLT1 and SGLT3. J Membr Biol 2000; 176: 111-117.
9. Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 2003; 89: 3-9.
10. +-glucose cotransporter SGLT1 from humans and rabbit. J Physiol 2001; 531: 631-644.
11. +/gk-+bnKLHg- cotransport. Biophys J 2004; 86: 125-133.
12. Loo DD, Wright EM, Zeuthen T. Water pumps. J Physiol 2002; 542: 53-60.
13. +/glucose- cotransporters. J Biol Chem 1993; 268: 1509-1512.
14. +/glucose- cotransporter and not an amino acid transporter. A reinterpretation. J Biol Chem 1994; 269: 22488-22491.
15. Zhao FQ, Keating AF. Functional properties and genomics of glucose transporters. Curr Genomics 2007; 8: 113-128.
16. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM, Hediger MA. Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. Am J Physiol 1992; 263: F459-F465.
17. +-to-sugar stoichiometry of SGLT3. Am J Physiol Renal Physiol 2001; 280: F278-F282.
18. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, et al. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 2003; 100: 11753-11758.
19. +/glucose- cotransporter expression by protein kinases in Xenopus laevis oocytes. J Biol Chem 1996; 271: 14740-14746.
20. Ishikawa Y, Eguchi T, Ishida H. Mechanism of beta-adrenergic agonist-induced transmural transport of glucose in rat small intestine. Regulation of phosphorylation of SGLT1 controls the function. Biochim Biophys Acta 1997; 1357: 306-318.
21. Balakrishnan A, Stearns AT, Rhoads DB, Ashley SW, Tavakkolizadeh A. Defining the transcriptional regulation of the intestinal sodium-glucose cotransporter using RNAinterference mediated gene silencing. Surgery 2008; 144: 168-173.
22. Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science 1987; 238: 688-692.
23. +/glucose- cotransporter 1 mRNA levels is transcriptionally regulated. J Biol Chem 1998; 273: 9510-9516.
24. Hayashi Y, Wang W, Ninomiya T, Nagano H, Ohta K, Itoh H. Liver enriched transcription factors and differentiation of hepatocellular carcinoma. Mol Pathol 1999; 52: 19-24.
25. +-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1. Am J Physiol Gastrointest Liver Physiol 2000; 278: G591-G603.
26. +/glucose- cotransporter SGLT1 gene. Role of HNF-1 in glucose activation of promoter function. Eur J Biochem 2001; 268: 5460-5470.
27. Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F. Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha. J Biol Chem 2006; 281: 31268-31278.
28. Wan C, Tempel W, Liu ZJ, Wang BC, Rose RB. Structure of the conserved transcriptional repressor enhancer of rudimentary homolog. Biochemistry 2005; 44: 5017-5023.
29. Carriere V, Lacasa M, Rousset M. Activity of hepatocyte nuclear factor 1alpha and hepatocyte nuclear factor 1beta isoforms is differently affected by the inhibition of protein phosphatases 1/2A. Biochem J 2001; 354: 301-308.
30. Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach JP, et al. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 1996; 84: 575-585.
31. Friedlander G, Runembert I, Vrtovsnik F, Terzi F. Renal tubular cells cultured from genetically modified animals. Exp Nephrol 1999; 7: 407-412.
32. Pontoglio M, Prie D, Cheret C, Doyen A, Leroy C, Froguel P, et al. HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep 2000; 1: 359-365.
33. +-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1a expression and activity. Endocrinology 2008; 149: 717-724.
34. Solberg DH, Diamond JM. Comparison of different dietary sugars as inducers of intestinal sugar transporters. Am J Physiol 1987; 252: G574-G584.
35. Dyer J, Daly K, Salmon KS, Arora DK, Kokrashvili Z, Margolskee RF, et al. Intestinal glucose sensing and regulation of intestinal glucose absorption. Biochem Soc Trans 2007; 35: 1191-1194.
36. Lescale-Matys L, Dyer J, Scott D, Freeman TC, Wright EM, Shirazi-Beechey SP. Regulation of the ovine intestinal Na+/ glucose cotransporter (SGLT1) is dissociated from mRNA abundance. Biochem J 1993; 291 (Part 2): 435-440.
37. Machado UF, Okamoto MM, Zampieri RA, Souza KP, Nunes MT, Quintão ECR. Dietary sodium modulates body weight without changing food intake and intestinal glucose absorption. Diabetes Metab 2003; 29: 4s132.
38. Vestri S, Okamoto MM, de Freitas HS, Aparecida Dos Santos R, Nunes MT, Morimatsu M, et al. Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat. J Membr Biol 2001; 182: 105-112.
39. Haspel HC, Mynarcik DC, Ortiz PA, Honkanen RA, Rosenfeld MG. Glucose deprivation induces the selective accumulation of hexose transporter protein GLUT-1 in the plasma membrane of normal rat kidney cells. Mol Endocrinol 1991; 5: 61-72.
40. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 2007; 104: 15075-15080.
41. Dyer J, Wood IS, Palejwala A, Ellis A, Shirazi-Beechey SP. Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol 2002; 282: G241-G248.
42. Freitas HS, D'Agord SB, da Silva RS, Okamoto MM, Oliveira- Souza M, Machado UF. Insulin but not phlorizin treatment induces a transient increase in GLUT2 gene expression in the kidney of diabetic rats. Nephron Physiol 2007; 105: 42-51.
43. Kamran M, Peterson RG, Dominguez JH. Overexpression of GLUT2 gene in renal proximal tubules of diabetic Zucker rats. J Am Soc Nephrol 1997; 8: 943-948.
44. Freitas HS, Schaan BD, David-Silva A, Sabino-Silva R, Okamoto MM, Alves-Wagner AB, et al. SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta. Mol Cell Endocrinol 2009; 305: 63-70.
45. Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992; 20: 1-17.
46. D'Agord SB, Lacchini S, Bertoluci MC, Irigoyen MC, Machado UF, Schmid H. Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats: implications for the development of nephropathy complicating diabetes. Horm Metab Res 2001; 33: 664-669.
47. Murrah VA. Diabetes mellitus and associated oral manifestations: a review. J Oral Pathol 1985; 14: 271-281.
48. Conner S, Iranpour B, Mills J. Alteration in parotid salivary flow in diabetes mellitus. Oral Surg Oral Med Oral Pathol 1970; 30: 55-59.
49. Campbell MJ. Glucose in the saliva of the non-diabetic and the diabetic patient. Arch Oral Biol 1965; 10: 197-205.
50. Melin K, Meeuwisse GW. Glucose-galactose malabsorption. A genetic study. Acta Paediatr Scand 1969; 188 (Suppl): 19.
51. Turk E, Zabel B, Mundlos S, Dyer J, Wright EM. Glucose/ galactose malabsorption caused by a defect in the Na+/ glucose cotransporter. Nature 1991; 350: 354-356.
52. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, et al. Molecular analysis of the SGLT2 gene in patients with renal glucosuria. J Am Soc Nephrol 2003; 14: 2873-2882.
53. Elsas LJ, Rosenberg LE. Familial renal glycosuria: a genetic reappraisal of hexose transport by kidney and intestine. J Clin Invest 1969; 48: 1845-1854.
54. Hirschhorn N, Greenough WB III. Progress in oral rehydration therapy. Sci Am 1991; 264: 50-56.
55. Oku A, Ueta K, Arakawa K, Kano-Ishihara T, Matsumoto T, Adachi T, et al. Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats. Jpn J Pharmacol 2000; 84: 351-354.
56. Arakawa K, Ishihara T, Oku A, Nawano M, Ueta K, Kitamura K, et al. Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na+-glucose cotransporter inhibitor T-1095. Br J Pharmacol 2001; 132: 578-586.
57. Han S, Hagan DL, Taylor JR, Xin L, Meng W, Biller SA, et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 2008; 57: 1723-1729.
58. Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem 2008; 51: 1145-1149.
59. Jabbour SA, Goldstein BJ. Sodium glucose cotransporter 2 inhibitors: blocking renal tubular reabsorption of glucose to improve glycaemic control in patients with diabetes. Int J Clin Pract 2008; 62: 1279-1284.
60. Idris I, Donnelly R. Sodium-glucose cotransporter-2 inhibitors: an emerging new class of oral antidiabetic drug. Diabetes Obes Metab 2009; 11: 79-88.