Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats

Japanese Journal of Pharmacology

Volumn 84, Issue 3, 2000, Pages 351-354

  Oku, A ^a   Ueta, K ^a   Arakawa, K ^a   Kano Ishihara, T ^a   Matsumoto, T ^a   Adachi, T ^a   Yasuda, K ^a   Tsuda, K ^a   Ikezawa, K ^a   Saito, A ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Diabetes mellitus; Na+ glucose cotransporter; Streptozotocin

Indexed keywords

3 (5 BENZOFURANYL) 1 [2 HYDROXY 6 [6 O (METHOXYCARBONYL) BETA DEXTRO GLUCOPYRANOSYL] 4 METHYLPHENYL] 1 PROPANONE; 3 (BENZO[B]FURAN 5 YL) 2',6' DIHYDROXY 4' METHYLPROPIOPHENONE 2' O (6 O METHOXYCARBONYL) BETA DEXTRO GLUCOPYRANOSIDE; GLUCOPYRANOSIDE; GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; SODIUM; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG INHIBITION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY; MALE; NONHUMAN; RAT; SOLEUS MUSCLE;

EID: 0034532108     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.84.351     Document Type: Article

References (15)

1. Glucose toxicity
2. Renal handling of D-glucose and other sugers
3. Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: Evidence for reversal following phlorizin treatment
4. Diabetes control and complications
5. Glucose transport: Pivotal step in insulin action
6. The contribution of hyperglycaemia and hypoinsulinaemia to the insulin resistance of streptozotocin-diabetic rats
7. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
8. +-glucose cotransporter (SGLT) inhibitors as antidiabetic agents. 4. Synthesis and pharmacological properties of 4'-dehydroxyphlorizin derivatives substituted on the B ring
9. +-glucose cotransporters, may provide a novel approach to treating diabetes
10. Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver
11. Hyperglycemia contributes insulin resistance in hepatic and adipose tissue but not skeletal muscle of ZDF rats
12. +-glucose cotransporter, in neonatally streptozotocin-treated rats
13. +-glucose transporter inhibitor, improves hyperglycemia in streptozotocin induced diabetic rats
14. Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle
15. Activation of glucose transport in diabetic muscle: Responses to contraction and insulin