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Volumn 8, Issue 1, 2010, Pages

How incretin-based therapies address the spectrum of physiologic disturbance in type 2 diabetes

Author keywords

HbA1c; Hypoglycemia; Incretin; Type 2 diabetes; Weight

Indexed keywords


EID: 78649338565     PISSN: 10924078     EISSN: 10924078     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (103)
  • 4
    • 0032983666 scopus 로고    scopus 로고
    • The UK Prospective Diabetes Study Group: Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49)
    • Turner R, Cull C, Frighi V, et al: The UK Prospective Diabetes Study Group: Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA; 1999; 281: 2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.1    Cull, C.2    Frighi, V.3
  • 5
    • 33750722123 scopus 로고    scopus 로고
    • Insulin treatment and the problem of weight gain in type 2 diabetes
    • Carver C: Insulin treatment and the problem of weight gain in type 2 diabetes. Diabetes Educ; 2006; 32: 910-917.
    • (2006) Diabetes Educ , vol.32 , pp. 910-917
    • Carver, C.1
  • 6
    • 0036736185 scopus 로고    scopus 로고
    • When oral agents fail: practical barriers to starting insulin
    • Korytkowski M: When oral agents fail: practical barriers to starting insulin. Int J Obes Relat Metab Disord; 2002; 26(Suppl. 3): S18-S24.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.SUPPL. 3
    • Korytkowski, M.1
  • 7
    • 43049134178 scopus 로고    scopus 로고
    • Emerging concepts in the medical and surgical treatment of obesity
    • Aylwin S, Al-Zaman Y: Emerging concepts in the medical and surgical treatment of obesity. Front Horm Res; 2008; 36: 229-259.
    • (2008) Front Horm Res , vol.36 , pp. 229-259
    • Aylwin, S.1    Al-Zaman, Y.2
  • 8
    • 34249864128 scopus 로고    scopus 로고
    • The Look, AHEAD., Research Group: Reduction in weight and cardiovascular disease risk factors in individuals with type 2, diabetes., Diabetes Care
    • The Look AHEAD Research Group: Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care; 2007; 30(6): 1374-1383.
    • (2007) , vol.30 , Issue.6 , pp. 1374-1383
  • 9
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck M, Homberger E, Siegel EG, et al: Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab; 1986; 63: 492-498.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.1    Homberger, E.2    Siegel, E.G.3
  • 11
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans:tudies with the antagonist exendin 9-39
    • Edwards C, Todd J, Mahmoudi M, et al: Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans:tudies with the antagonist exendin 9-39. Diabetes; 1999; 48: 86-93.
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.1    Todd, J.2    Mahmoudi, M.3
  • 12
    • 0029028687 scopus 로고
    • Effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets
    • Fehmann H, Hering B, Wolf M, et al: Effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets. Pancreas; 1995; 11: 196-200.
    • (1995) Pancreas , vol.11 , pp. 196-200
    • Fehmann, H.1    Hering, B.2    Wolf, M.3
  • 14
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum and non-antraltomach
    • Orskov C, Holst J, Nielsen O: Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum and non-antraltomach. Endocrinology; 1988; 123(4): 2009-2013.
    • (1988) Endocrinology , vol.123 , Issue.4 , pp. 2009-2013
    • Orskov, C.1    Holst, J.2    Nielsen, O.3
  • 15
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ: Glucagon-like peptide 1 promotes satiety anduppresses energy intake in humans. J Clin Invest; 1998; 101: 515-520.
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 16
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose response, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA: Gastric emptying, glucose response, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab; 1996; 81(1): 327-332.
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.1 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 17
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck M, Niedereichholz U, Ettler R, et al: Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol; 1997; 273(5 part 1): E981-988.
    • (1997) Am J Physiol , vol.273 , Issue.5 PART 1
    • Nauck, M.1    Niedereichholz, U.2    Ettler, R.3
  • 18
    • 0034032317 scopus 로고    scopus 로고
    • Insulinitropic glucagon-like peptide 1 agoniststimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas Diabetes
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM: Insulinitropic glucagon-like peptide 1 agoniststimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas Diabetes; 2000; 49(5): 741-748
    • (2000) , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 19
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, Egan JM: Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes; 1999; 49(12): 2358-2366.
    • (1999) Diabetes , vol.49 , Issue.12 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 21
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon C, et al: Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes; 2001; 50(3): 609-613.
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.3
  • 22
    • 39749143348 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulinecretion during hyperglycaemia in patients with Type 2 diabetes mellitus
    • Vilsbøll T, Brock B, Perrild H, et al: Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulinecretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabet Med; 2008; 25(2): 152-156.
    • (2008) Diabet Med , vol.25 , Issue.2 , pp. 152-156
    • Vilsbøll, T.1    Brock, B.2    Perrild, H.3
  • 23
    • 16244385334 scopus 로고    scopus 로고
    • Exenatide: a novel treatment for type 2 diabetes
    • Ahren B. Exenatide: a novel treatment for type 2 diabetes. Therapy. 2005;2(2):207-222.
    • (2005) Therapy , vol.2 , Issue.2 , pp. 207-222
    • Ahren, B.1
  • 24
    • 15444367142 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus
    • Kolterman O, Kim D, Shen L, et al: Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus. Am Health Syst Pharm; 2005; 62: 173-181.
    • (2005) Am Health Syst Pharm , vol.62 , pp. 173-181
    • Kolterman, O.1    Kim, D.2    Shen, L.3
  • 25
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo R, Ratner R, Han J, et al: Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care; 2005; 28: 1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.1    Ratner, R.2    Han, J.3
  • 26
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks inulfonylurea-treated patients with type 2 diabetes
    • Buse J, Henry R, Jan J, et al: Effects of exenatide (exendin-4) on glycemic control over 30 weeks inulfonylurea-treated patients with type 2 diabetes. Diabetes Care; 2004; 27: 2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.1    Henry, R.2    Jan, J.3
  • 27
    • 17144371646 scopus 로고    scopus 로고
    • effects of exenatide (Exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and aulfonylurea
    • Kendall D, Riddle M, Rosenstock J, et al: effects of exenatide (Exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and aulfonylurea. Diabetes Care; 2005; 28(5): 1083-1091.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.1    Riddle, M.2    Rosenstock, J.3
  • 28
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione inuboptimally controlled type 2 diabetes
    • Zinman B, Hoogwerf B, Duran Garcia S, et al. The effect of adding exenatide to a thiazolidinedione inuboptimally controlled type 2 diabetes. Ann Intern Med; 2007; 146: 477-485.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.2    Duran Garcia, S.3
  • 29
    • 33748471110 scopus 로고    scopus 로고
    • Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus
    • Ratner R, Maggs D, Nielsen L, et al: Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab; 2006; 8: 419-428.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 419-428
    • Ratner, R.1    Maggs, D.2    Nielsen, L.3
  • 30
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein E, Han J, et al: Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab; 2006; 8: 436-447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.2    Han, J.3
  • 31
    • 78649340740 scopus 로고    scopus 로고
    • Change in HbA1c, fastingerum glucose, weight, lipids, and vitaligns by baseline BMI in 2 clinical trials of exenatide vs. insulin comparators
    • Rome, Italy. Presentation 875. Diabetologia
    • Trautmann M, Johns D, Burger J, et al: Change in HbA1c, fastingerum glucose, weight, lipids, and vitaligns by baseline BMI in 2 clinical trials of exenatide vs. insulin comparators. 44th Annual Meeting of the European Association for the Study of Diabetes, September 7-11, 2008. Rome, Italy. Presentation 875. Diabetologia; 2008; 51 (Suppl. 1): XXXXX
    • (2008) 44th Annual Meeting of the European Association for the Study of Diabetes, September 7-11, 2008 , vol.51 , Issue.SUPPL. 1
    • Trautmann, M.1    Johns, D.2    Burger, J.3
  • 32
    • 33947156808 scopus 로고    scopus 로고
    • Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
    • Buse J, Klonoff D, Nielsen L, et al: Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin Ther; 2007; 29: 139-153.
    • (2007) Clin Ther , vol.29 , pp. 139-153
    • Buse, J.1    Klonoff, D.2    Nielsen, L.3
  • 33
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff D, Buse J, Nielsen L, et al: Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin; 2008; 24(1): 275-286.
    • (2008) Curr Med Res Opin , vol.24 , Issue.1 , pp. 275-286
    • Klonoff, D.1    Buse, J.2    Nielsen, L.3
  • 34
  • 36
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who wereuboptimally controlled withulfonylurea and metformin: a non-inferioritytudy
    • Nauck M, Duran S, Kim D, et al: A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who wereuboptimally controlled withulfonylurea and metformin: a non-inferioritytudy. Diabetologia; 2007; 50(2): 259-267.
    • (2007) Diabetologia , vol.50 , Issue.2 , pp. 259-267
    • Nauck, M.1    Duran, S.2    Kim, D.3
  • 37
    • 78649385010 scopus 로고    scopus 로고
    • Exenatide and biphasic insulin aspart differentially affect postprandial glucose excursions in patients with type 2 diabetes
    • Malone J, Brodows R, Qu Y, et al: Exenatide and biphasic insulin aspart differentially affect postprandial glucose excursions in patients with type 2 diabetes. Diabetologia; 2008; 51(Suppl. 1): S349.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Malone, J.1    Brodows, R.2    Qu, Y.3
  • 38
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients withuboptimally controlled type 2 diabetes: a randomized trial
    • Heine R, Van Gaal L, Johns D, et al: Exenatide versus insulin glargine in patients withuboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med; 2005; 143: 559-569.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.1    Van Gaal, L.2    Johns, D.3
  • 39
    • 34249979209 scopus 로고    scopus 로고
    • Exenatide blocks JAK1-STAT1 in pancreatic beta cells
    • Couto F, Minn A, Pise-Masison C, et al: Exenatide blocks JAK1-STAT1 in pancreatic beta cells. Metabolism; 2007; 56(7): 915-918.
    • (2007) Metabolism , vol.56 , Issue.7 , pp. 915-918
    • Couto, F.1    Minn, A.2    Pise-Masison, C.3
  • 40
    • 33745196669 scopus 로고    scopus 로고
    • Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein
    • Chen J, Couto F, Minn A, Shalev A: Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochem Biophys Res Commun; 2006; 346(3): 1067-1074.
    • (2006) Biochem Biophys Res Commun , vol.346 , Issue.3 , pp. 1067-1074
    • Chen, J.1    Couto, F.2    Minn, A.3    Shalev, A.4
  • 42
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight inubjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, et al: Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight inubjects with type 2 diabetes. Diabetes Care; 2007; 30: 1487-1493.
    • (2007) Diabetes Care , vol.30 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3
  • 43
    • 56249125081 scopus 로고    scopus 로고
    • Exenatide once weekly results inignificantly greater improvements in glycemic control compared to exenatide twice daily in patients with type 2 diabetes
    • Drucker D, Buse J, Taylor K, et al: Exenatide once weekly results inignificantly greater improvements in glycemic control compared to exenatide twice daily in patients with type 2 diabetes. Diabetes; 2008; 57(Suppl. 1): A33.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Drucker, D.1    Buse, J.2    Taylor, K.3
  • 44
    • 78649337330 scopus 로고    scopus 로고
    • Improved diabetes treatmentatisfaction and weight-related quality of life with both exenatide once weekly and twice daily
    • Kim T, Boye K, Wintle M, et al: Improved diabetes treatmentatisfaction and weight-related quality of life with both exenatide once weekly and twice daily. Diabetes; 2008; 57(Suppl. 1): A147.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Kim, T.1    Boye, K.2    Wintle, M.3
  • 45
    • 78649344474 scopus 로고    scopus 로고
    • Higher diabetes treatmentatisfaction associated with improved glucose control for both exenatide once weekly and twice daily
    • Best J, Rubin R, Zhuang D, et al: Higher diabetes treatmentatisfaction associated with improved glucose control for both exenatide once weekly and twice daily. Diabetes; 2008; 57(Suppl. 1): A520.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Best, J.1    Rubin, R.2    Zhuang, D.3
  • 46
    • 0036676385 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics,afety, and tolerability of aingle-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy maleubjects
    • Elbrond B, Jakobsen G, Larsen S, et al: Pharmacokinetics, pharmacodynamics,afety, and tolerability of aingle-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy maleubjects. Diabetes Care; 2002; 25: 1398-1404.
    • (2002) Diabetes Care , vol.25 , pp. 1398-1404
    • Elbrond, B.1    Jakobsen, G.2    Larsen, S.3
  • 47
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al: Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet; 2009; 373(9662): 473-481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 48
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes mellitus (LEAD-2 Met)
    • Nauck MA, Frid A, Hermansen K, et al: Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes mellitus (LEAD-2 Met). Diabetes Care; 2009; 32; 84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.A.1    Frid, A.2    Hermansen, K.3
  • 49
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to aulphonylurea over 26 produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo inubjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M, et al: Liraglutide, a once-daily human GLP-1 analogue, added to aulphonylurea over 26 produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo inubjects with type 2 diabetes (LEAD-1 SU). Diabetic Med; 2009; 26: 268-278.
    • (2009) Diabetic Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3
  • 50
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse J, et al: Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care; 2009; 32: 1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.3
  • 51
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU)
    • Russell-Jones D, Vaag A, Schmitz O, et al: Liraglutide vs insulin glargine and placebo in combination with metformin and sulphonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU). Diabetologia; 2009; 52: 4026-4055.
    • (2009) Diabetologia , vol.52 , pp. 4026-4055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 52
    • 67649302782 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, substantially reduces HbA1c in subjects with type 2 diabetes, irrespective of HbA1c at baseline
    • Vaag A. Nauck M, Brandle M, et al: Liraglutide, a human GLP-1 analogue, substantially reduces HbA1c in subjects with type 2 diabetes, irrespective of HbA1c at baseline. Diabetologia; 2008; 51(Suppl 1): S68.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL 1
    • Vaag, A.1    Nauck, M.2    Brandle, M.3
  • 53
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study
    • Garber AJ, Schweizer A, Baron MA, Rochotte E, Dejager S: Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab; 2007; 9(2): 166-174.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3    Rochotte, E.4    Dejager, S.5
  • 54
    • 67649666737 scopus 로고    scopus 로고
    • For the LEAD 6tudy group: Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse J, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett J, Zychma M, Blonde L for the LEAD 6tudy group: Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet; 2009; 374(9683): 39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.6    Zychma, M.7    Blonde, L.8
  • 55
    • 67049122423 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, reduced bodyweight inubjects with type 2 diabetes, irrespective of body mass index at baseline
    • Schmitz O, Russell-Jones D, Shaw J, et al. Liraglutide, a human GLP-1 analogue, reduced bodyweight inubjects with type 2 diabetes, irrespective of body mass index at baseline. Diabetologia; 2008; 51(Suppl 1): S354.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL 1
    • Schmitz, O.1    Russell-Jones, D.2    Shaw, J.3
  • 56
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human GLP 1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes mellitus
    • Vilsbøll T, Zdravkovic M, Le-Thi T, et al: Liraglutide, a long-acting human GLP 1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes mellitus. Diabetes Care; 2007; 30: 1608-1610.
    • (2007) Diabetes Care , vol.30 , pp. 1608-1610
    • Vilsbøll, T.1    Zdravkovic, M.2    Le-Thi, T.3
  • 57
    • 70349107886 scopus 로고    scopus 로고
    • Liraglutide, a human GLP-1 analogue, significantly improves beta cell function in subjects with type 2 diabetes
    • Matthews D, Marre M, Le Thi TD, et al: Liraglutide, a human GLP-1 analogue, significantly improves beta cell function in subjects with type 2 diabetes. Diabetologia; 2009; 51(Suppl. 1): S356.
    • (2009) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Matthews, D.1    Marre, M.2    Le Thi, T.D.3
  • 58
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and α- and β-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • Degn K, Juhl C, Sturis J, et al: One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and α- and β-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes; 2004; 53: 1187-1194.
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.1    Juhl, C.2    Sturis, J.3
  • 59
    • 74049087761 scopus 로고    scopus 로고
    • Liraglutide induces beta cell proliferation and protects from interleukin-1-beta induced beta cell apoptosis in human islets
    • Prazak R, Rütti S, Ellingsgaard H, et al: Liraglutide induces beta cell proliferation and protects from interleukin-1-beta induced beta cell apoptosis in human islets. Diabetologia; 2008; 51(Suppl. 1): S212.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL 1
    • Prazak, R.1    Rütti, S.2    Ellingsgaard, H.3
  • 60
    • 34547660561 scopus 로고    scopus 로고
    • Williams-Herman DE; Sitagliptin 036 Study Group: Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE; Sitagliptin 036 Study Group: Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care; 2007; 30(8): 1979-1987.
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3    Johnson, J.4
  • 62
    • 58149245325 scopus 로고    scopus 로고
    • Initial combination therapy with saxagliptin and metformin improves glycaemic control compared with either monotherapy alone in drug-naïve patients with type 2 diabetes
    • Chen R., Pfutzner A., Jadzinsky M., Paz-Pacheco E., Xu Z., Allen E. Initial combination therapy with saxagliptin and metformin improves glycaemic control compared with either monotherapy alone in drug-naïve patients with type 2 diabetes. Diabetologia; 2008; 51(Suppl.1): S38.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Chen, R.1    Pfutzner, A.2    Jadzinsky, M.3    Paz-Pacheco, E.4    Xu, Z.5    Allen, E.6
  • 63
    • 33845489598 scopus 로고    scopus 로고
    • Sitagliptin Study 023 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H: Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia; 2006; 49(11): 2564-2571.
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 64
    • 33845472504 scopus 로고    scopus 로고
    • Sitagliptin Study 021 Group Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes M, Lunceford J, et al: Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care; 2006; 29: 2632-2637.
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.2    Lunceford, J.3
  • 65
    • 33846817233 scopus 로고    scopus 로고
    • Sitagliptin Study 024 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial
    • Nauck MA, Meininger G, Sheng D, et al: Sitagliptin Study 024 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab; 2007; 9: 194-205.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3
  • 66
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes Systematic review and meta-analysis
    • Amori R, Lau J, Pittas A: Efficacy and safety of incretin therapy in type 2 diabetes. Systematic review and meta-analysis. JAMA; 2007; 298(2): 194-206.
    • (2007) JAMA , vol.298 , Issue.2 , pp. 194-206
    • Amori, R.1    Lau, J.2    Pittas, A.3
  • 67
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S: Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract; 2007; 76(1): 132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , Issue.1 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 68
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A: Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care; 2007; 30(2): 217-223.
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 69
    • 33845476757 scopus 로고    scopus 로고
    • Sitagliptin Study 020 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, et al: Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care; 2006; 29: 2638-2643.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 70
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ: Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care; 2007; 30(4): 890-895.
    • (2007) Diabetes Care , vol.30 , Issue.4 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 71
    • 34547863123 scopus 로고    scopus 로고
    • Sitagliptin Study 035 Group: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P; Sitagliptin Study 035 Group: Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab; 2007; 9(5): 733-745.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3    Fanurik, D.4    Khatami, H.5    Stein, P.6
  • 72
    • 33751557143 scopus 로고    scopus 로고
    • Sitagliptin Study 019 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg R, Andrynk PJ, et al: Sitagliptin Study 019 Group Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther; 2006; 28: 1556-1568.
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andrynk, P.J.3
  • 73
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Baron MA, Camisasca RP, Cressier F, Couturier A, Dejager S: Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab; 2007; 9(2): 175-185.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 175-185
    • Rosenstock, J.1    Baron, M.A.2    Camisasca, R.P.3    Cressier, F.4    Couturier, A.5    Dejager, S.6
  • 74
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies withingle oral doses
    • Herman G, Stevens C, van Dyck K, et al: Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies withingle oral doses. Clin Pharmacol Ther; 2005; 78: 675-688.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 675-688
    • Herman, G.1    Stevens, C.2    van Dyck, K.3
  • 75
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman G, Bergman A, Stevens C, et al: Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab; 2006; 91: 4612-4619.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4612-4619
    • Herman, G.1    Bergman, A.2    Stevens, C.3
  • 76
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia inubjects with impaired glucose tolerance
    • Rosenstock J, Foley J, Rendell M, et al: Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia inubjects with impaired glucose tolerance. Diabetes Care; 2008; 31(1): 30-35.
    • (2008) Diabetes Care , vol.31 , Issue.1 , pp. 30-35
    • Rosenstock, J.1    Foley, J.2    Rendell, M.3
  • 79
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley RE, Jauffret-Kamel S, Galbreath E, Holmes D: Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res; 2006; 38: 423-428.
    • (2006) Horm Metab Res , vol.38 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3    Holmes, D.4
  • 80
    • 33748316958 scopus 로고    scopus 로고
    • Sustained reduction in HbA1c during one-year treatment with vildagliptin in patients with type 2 diabetes (T2DM)
    • Dejager S, Lebeaut A, Couturier A, Schweizer A: Sustained reduction in HbA1c during one-year treatment with vildagliptin in patients with type 2 diabetes (T2DM). Diabetes; 2006; 55(Suppl 1): A29.
    • (2006) Diabetes , vol.55 , Issue.SUPPL 1
    • Dejager, S.1    Lebeaut, A.2    Couturier, A.3    Schweizer, A.4
  • 81
    • 33748293273 scopus 로고    scopus 로고
    • Vildagliptin is as effective as rosiglitazone in lowering HbA1c but without weight gain in drug-naive patients with type 2 diabetes (T2DM)
    • Rosenstock J, Baron MA, Schweizer A, Mills D, Dejager S: Vildagliptin is as effective as rosiglitazone in lowering HbA1c but without weight gain in drug-naive patients with type 2 diabetes (T2DM). Diabetes; 2006; 55(Suppl 1): A133.
    • (2006) Diabetes , vol.55 , Issue.SUPPL 1
    • Rosenstock, J.1    Baron, M.A.2    Schweizer, A.3    Mills, D.4    Dejager, S.5
  • 82
    • 33748303262 scopus 로고    scopus 로고
    • Vildagliptin added to metformin improves glycemic control and may mitigate metformin-induced GI side effects in patients with type 2 diabetes (T2DM)
    • Garber A, Camisasca RP, Ehrsam E, Collober-Maugeais C, Rochotte E, Lebeaut A: Vildagliptin added to metformin improves glycemic control and may mitigate metformin-induced GI side effects in patients with type 2 diabetes (T2DM). Diabetes; 2006; 55(Suppl 1): A29.
    • (2006) Diabetes , vol.55 , Issue.SUPPL 1
    • Garber, A.1    Camisasca, R.P.2    Ehrsam, E.3    Collober-Maugeais, C.4    Rochotte, E.5    Lebeaut, A.6
  • 83
    • 33845982268 scopus 로고    scopus 로고
    • Sitagliptin monotherapy improved glycemic control in the fasting and postprandialtates and beta-cell function adter 24 weeks in patients with type 2 diabetes (T2DM)
    • Aschner P, Kipnes M, Lunceford J, Mickel C, Davies M, Williams-Herman D: Sitagliptin monotherapy improved glycemic control in the fasting and postprandialtates and beta-cell function adter 24 weeks in patients with type 2 diabetes (T2DM). Diabetes; 2006; 55(Suppl 1): A462.
    • (2006) Diabetes , vol.55 , Issue.SUPPL 1
    • Aschner, P.1    Kipnes, M.2    Lunceford, J.3    Mickel, C.4    Davies, M.5    Williams-Herman, D.6
  • 84
    • 33845971592 scopus 로고    scopus 로고
    • Sitagliptin added to ongoing metformin therapy enhanced glycemic control and beta-cell function in patients with type 2 diabetes
    • Karasik A, Charbonell B, Liu J, Wu M, Meehan A, Meininger G: Sitagliptin added to ongoing metformin therapy enhanced glycemic control and beta-cell function in patients with type 2 diabetes. Diabetes; 2006; 55(Suppl 1): A119-120.
    • (2006) Diabetes , vol.55 , Issue.SUPPL 1
    • Karasik, A.1    Charbonell, B.2    Liu, J.3    Wu, M.4    Meehan, A.5    Meininger, G.6
  • 85
    • 33846009864 scopus 로고    scopus 로고
    • Addition of sitagliptin to pioglitazone improved glycemic control with neutral weight effect over 24 weeks in inadequately controlled type 2 diabetes (T2DM)
    • Rosenstock J, Brazg R, Andryuk PJ, McCrary Sisk C, Lu K, Stein P: Addition of sitagliptin to pioglitazone improved glycemic control with neutral weight effect over 24 weeks in inadequately controlled type 2 diabetes (T2DM). Diabetes; 2006; 55(Suppl): A132-133.
    • (2006) Diabetes , vol.55 , Issue.SUPPL
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3    McCrary Sisk, C.4    Lu, K.5    Stein, P.6
  • 86
    • 58149275114 scopus 로고    scopus 로고
    • Once-daily saxagliptin monotherapy improves glycemic control in drug-naïve patients with type 2 diabetes
    • Rosenstock J., Aguilar-Salinas C., Klein E., List J., Blauwet M. B., Chen R: (2008a). Once-daily saxagliptin monotherapy improves glycemic control in drug-naïve patients with type 2 diabetes. Diabetes; 2008; 57(Suppl 1): A154
    • (2008) Diabetes , vol.57 , Issue.SUPPL 1
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    List, J.4    Blauwet, M.B.5    Chen, R.6
  • 87
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naïve patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF: Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naïve patients with type 2 diabetes. Diabetes Obes Metab; 2008; 10(5): 376-386.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.5 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 88
    • 38149057538 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan D, Buse J, Davidson M et al: Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care; 2008; 31: 1-11.
    • (2008) Diabetes Care , vol.31 , pp. 1-11
    • Nathan, D.1    Buse, J.2    Davidson, M.3
  • 89
    • 77649091668 scopus 로고    scopus 로고
    • Diabetes Mellitus Clinical Practice Guidelines Task Force: American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Management of Diabetes Mellitus 2007
    • AACE May/June
    • AACE Diabetes Mellitus Clinical Practice Guidelines Task Force: American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Management of Diabetes Mellitus 2007. Endocrine Pract; 2007; 13(Suppl 1): May/June.
    • (2007) Endocrine Pract , vol.13 , Issue.SUPPL 1
  • 92
    • 33748637338 scopus 로고    scopus 로고
    • Effect of exenatide on the pharmacokinetics and pharmacodynamics of warfarin in healthy Asian men
    • Soon D, Kothare PA, Linnebjerg H, Park S, Yuen E, Mace KF, Wise SD: Effect of exenatide on the pharmacokinetics and pharmacodynamics of warfarin in healthy Asian men. J Clin Pharmacol; 2006; 46(10): 1179-1187.
    • (2006) J Clin Pharmacol , vol.46 , Issue.10 , pp. 1179-1187
    • Soon, D.1    Kothare, P.A.2    Linnebjerg, H.3    Park, S.4    Yuen, E.5    Mace, K.F.6    Wise, S.D.7
  • 94
    • 67649651682 scopus 로고    scopus 로고
    • Metabolism and excretion of the once-daily human GLP-1 analogue liraglutide in healthy subject and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase
    • Bjørnsdottir I, Olsen A, Larsen U, Helleberg H, Vanggaard J, Oosterhuis B, Van Lier J, Zdravkovic M, Malm-Erjefält M: Metabolism and excretion of the once-daily human GLP-1 analogue liraglutide in healthy subject and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Diabetologia; 2008; 51(Suppl. 1): S356.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Bjørnsdottir, I.1    Olsen, A.2    Larsen, U.3    Helleberg, H.4    Vanggaard, J.5    Oosterhuis, B.6    Van Lier, J.7    Zdravkovic, M.8    Malm-Erjefält, M.9
  • 95
    • 69949110258 scopus 로고    scopus 로고
    • Influence of hepatic impairment on pharmacokinetics of the long-acting human glp-1 analogue liraglutide
    • Flint A, Nazzal K, Jagielski P, et al: Influence of hepatic impairment on pharmacokinetics of the long-acting human glp-1 analogue liraglutide. Diabetes; 2007; 56(Suppl 1): A145.
    • (2007) Diabetes , vol.56 , Issue.SUPPL 1
    • Flint, A.1    Nazzal, K.2    Jagielski, P.3
  • 96
    • 68849095619 scopus 로고    scopus 로고
    • The effect of liraglutide on the absorption pharmacokinetics of concomitant oral drugs with different solubility and permeability properties in healthy subjects
    • Zdravkovic M, Ekblom M, Brondsted L, Vouis J, Lenneras H, Malm-Erjefalt M: The effect of liraglutide on the absorption pharmacokinetics of concomitant oral drugs with different solubility and permeability properties in healthy subjects. Diabetologia; 2008; 51(Suppl. 1): S355.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Zdravkovic, M.1    Ekblom, M.2    Brondsted, L.3    Vouis, J.4    Lenneras, H.5    Malm-Erjefalt, M.6
  • 97
    • 84882255983 scopus 로고    scopus 로고
    • (Accessed 30 Jan, 2009)
    • Januvia prescribing information. http://www.merck.com/product/usa/pi_circulars/j/januvia/januvia_pi.pdf (Accessed 30 Jan, 2009).
    • Januvia prescribing information
  • 98
    • 41049103817 scopus 로고    scopus 로고
    • Sitagliptin: a novel agent for the management of type 2 diabetes mellitus
    • Pham DQ, Nogid A, Plakogiannis R. Sitagliptin: a novel agent for the management of type 2 diabetes mellitus. Am J Health Syst Pharm. 2008;65(6):521-531.
    • (2008) Am J Health Syst Pharm , vol.65 , Issue.6 , pp. 521-531
    • Pham, D.Q.1    Nogid, A.2    Plakogiannis, R.3
  • 100
    • 72049113937 scopus 로고    scopus 로고
    • Retrieved September 17th 2009 at
    • Onglyza prescribing information. Retrieved September 17th 2009 at:http://packageinserts.bms.com/pi/pi_onglyza.pdf.
    • Onglyza prescribing information
  • 101
    • 72049113937 scopus 로고    scopus 로고
    • Retrieved September 17th 2009 at
    • Onglyza prescribing information. Retrieved September 17th 2009 at:http://packageinserts.bms.com/pi/pi_onglyza.pdf
    • Onglyza prescribing information
  • 102
    • 78649337597 scopus 로고    scopus 로고
    • The effects of age and gender on the single-dose pharamcokinetics and saefty of saxagliptin in healthy subjects. 68th Scientific Session of the American Diabetes Association, San Francisco
    • Boulton D., Goyal A., Li L., Kornhauser D. M., Frevert U. (2008). The effects of age and gender on the single-dose pharamcokinetics and saefty of saxagliptin in healthy subjects. 68th Scientific Session of the American Diabetes Association, San Francisco, CA. Abstract 551-P.
    • (2008) CA. Abstract , pp. 551-560
    • Boulton, D.1    Goyal, A.2    Li, L.3    Kornhauser, D.M.4    Frevert, U.5
  • 103
    • 59449088692 scopus 로고    scopus 로고
    • Patient reported outcomes in subjects with type 2 diabetes treated with monotherapy regimens of once-daily human GLP-1 analogue liraglutide, or glimepiride
    • Rome, Italy. (Presentation 894). Diabetologia
    • Bode B, Hale P, Hammer M, et al: Patient reported outcomes in subjects with type 2 diabetes treated with monotherapy regimens of once-daily human GLP-1 analogue liraglutide, or glimepiride. 44th Annual Meeting of the European Association for the Study of Diabetes, September 7-11, 2008. Rome, Italy. (Presentation 894). Diabetologia; 2008; 52(Suppl 1): S357.
    • (2008) 44th Annual Meeting of the European Association for the Study of Diabetes, September 7-11, 2008 , vol.52 , Issue.SUPPL 1
    • Bode, B.1    Hale, P.2    Hammer, M.3


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