메뉴 건너뛰기




Volumn 65, Issue 6, 2008, Pages 521-531

Sitagliptin: A novel agent for the management of type 2 diabetes mellitus

Author keywords

Antidiabetic agents; Combined therapy; Diabetes mellitus; Dosage; Drug interactions; Mechanism of action; Metformin; Pharmacokinetics; Sitagliptin; Thiazolidinediones; Toxicity

Indexed keywords

CYCLOSPORIN; DIGOXIN; GLIPIZIDE; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; PIOGLITAZONE; PLACEBO; SITAGLIPTIN; 2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2,4-THIAZOLIDINEDIONE; ANTIDIABETIC AGENT; PYRAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 41049103817     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp070248     Document Type: Review
Times cited : (19)

References (42)
  • 1
    • 33846007241 scopus 로고    scopus 로고
    • Position statement: Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Position statement: diagnosis and classification of diabetes mellitus. Diabetes Care. 2007; 30:S42-7.
    • (2007) Diabetes Care , vol.30
  • 2
    • 33746588255 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
    • Nathan DM, Buse JB, Davidson MB et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care. 2006; 29:1963-72.
    • (2006) Diabetes Care , vol.29 , pp. 1963-1972
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 3
    • 33846614141 scopus 로고    scopus 로고
    • The physiology of incretin hormones and the basis for DPP-4 inhibitors
    • McKennon SA, Campbell RK. The physiology of incretin hormones and the basis for DPP-4 inhibitors. Diabetes Educ. 2007; 33:55-66.
    • (2007) Diabetes Educ , vol.33 , pp. 55-66
    • McKennon, S.A.1    Campbell, R.K.2
  • 4
    • 33845526656 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 secretion by the L-cell. The view from within
    • Lim GE, Brubaker PL. Glucagon-like peptide 1 secretion by the L-cell. The view from within. Diabetes. 2006; 55:S70-7.
    • (2006) Diabetes , vol.55
    • Lim, G.E.1    Brubaker, P.L.2
  • 5
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006; 3:153-65.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 6
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
    • Li Y, Hansotia T, Yusta B et al. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem. 2003; 278:471-8.
    • (2003) J Biol Chem , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3
  • 7
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • Farilla L, Bulotta A, Hirshberg B et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. 2003; 144:5149-58.
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 8
    • 0035434115 scopus 로고    scopus 로고
    • Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor
    • Burcelin R, Da Costa A, Drucker D et al. Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes. 2001; 50:1720-8.
    • (2001) Diabetes , vol.50 , pp. 1720-1728
    • Burcelin, R.1    Da Costa, A.2    Drucker, D.3
  • 9
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab. 2001; 86:3717-23.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 10
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T, Agerso H, Krarup T et al. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab. 2003; 88:220-4.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3
  • 11
    • 0033739493 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with type 2 diabetes mellitus
    • Mannucci E, Ognibene A, Cremasco F et al. Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with type 2 diabetes mellitus. Diabet Med. 2000; 17:713-9.
    • (2000) Diabet Med , vol.17 , pp. 713-719
    • Mannucci, E.1    Ognibene, A.2    Cremasco, F.3
  • 12
    • 0035462466 scopus 로고    scopus 로고
    • Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
    • Rask E, Olsson T, Söderberg S et al. Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men. Diabetes Care. 2001; 24:1640-5.
    • (2001) Diabetes Care , vol.24 , pp. 1640-1645
    • Rask, E.1    Olsson, T.2    Söderberg, S.3
  • 13
    • 3042832070 scopus 로고    scopus 로고
    • Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance
    • Theodorakis MJ, Carlson O, Muller DC et al. Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Diabetes Care. 2004; 27:1692-8.
    • (2004) Diabetes Care , vol.27 , pp. 1692-1698
    • Theodorakis, M.J.1    Carlson, O.2    Muller, D.C.3
  • 14
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept. 1999; 85:9-24.
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 15
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab. 1995; 80:952-7.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 16
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase-IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman GA, Stevens C, Van Dyck K et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase-IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005; 78:675-88.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    Van Dyck, K.3
  • 17
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo controlled study in healthy male volunteers
    • Bergman AJ, Stevens C, Zhou YY et al. Pharmacokinetics and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo controlled study in healthy male volunteers. Clin Ther. 2006; 28:55-72.
    • (2006) Clin Ther , vol.28 , pp. 55-72
    • Bergman, A.J.1    Stevens, C.2    Zhou, Y.Y.3
  • 18
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagin-like peptide 1 (7-36 amide) in type 2 (non insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C et al. Normalization of fasting hyperglycaemia by exogenous glucagin-like peptide 1 (7-36 amide) in type 2 (non insulin-dependent) diabetic patients. Diabetologia. 1993; 36:741-4.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 19
    • 4544232468 scopus 로고    scopus 로고
    • Inhibitors of dipeptidyl peptidase IV: A novel approach for the prevention and treatment of type 2 diabetes?
    • Deacon CF, Ahren B, Holst JJ. Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of type 2 diabetes? Expert Opin Investig Drugs. 2004; 13:1091-102.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1091-1102
    • Deacon, C.F.1    Ahren, B.2    Holst, J.J.3
  • 20
    • 14044264798 scopus 로고    scopus 로고
    • Glucagon like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus
    • Holst JJ, Deacon CF. Glucagon like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus. Curr Opin Pharmacol. 2004; 4:589-96.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 589-596
    • Holst, J.J.1    Deacon, C.F.2
  • 21
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman GA, Bergman A, Stevens C et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006; 91:4612-9.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 23
    • 34247236764 scopus 로고    scopus 로고
    • Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4Cl, and multidrug resistance p-glycoprotein
    • Chu XY, Bleasby K, Yabut J et al. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4Cl, and multidrug resistance p-glycoprotein. J Pharmacol Exp Ther. 2007; 321:673-83.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 673-683
    • Chu, X.Y.1    Bleasby, K.2    Yabut, J.3
  • 24
    • 34548820996 scopus 로고    scopus 로고
    • Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
    • Bergman A, Ebel D, Liu F et al. Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers. Biopharm Drug Dispos. 2007; 28:315-22.
    • (2007) Biopharm Drug Dispos , vol.28 , pp. 315-322
    • Bergman, A.1    Ebel, D.2    Liu, F.3
  • 25
    • 33745909432 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
    • Herman GA, Bergman A, Liu F et al. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol. 2006; 46:876-86.
    • (2006) J Clin Pharmacol , vol.46 , pp. 876-886
    • Herman, G.A.1    Bergman, A.2    Liu, F.3
  • 26
    • 34447120048 scopus 로고    scopus 로고
    • Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor
    • Bergman AJ, Cote J, Yi B. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care. 2007; 30:1862-4.
    • (2007) Diabetes Care , vol.30 , pp. 1862-1864
    • Bergman, A.J.1    Cote, J.2    Yi, B.3
  • 27
    • 33749818720 scopus 로고    scopus 로고
    • Lack of clinically significant effect of moderate hepatic insufficiency on the pharmacokinetics of MK-0431 (sitagliptin), a dipeptidyl-peptidase-IV (DPP-IV) inhibitor
    • Abstract
    • Stevens C, Bergman AJ, Liu Q et al. Lack of clinically significant effect of moderate hepatic insufficiency on the pharmacokinetics of MK-0431 (sitagliptin), a dipeptidyl-peptidase-IV (DPP-IV) inhibitor. Clin Pharmacol Ther. 2006; 79:49. Abstract.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 49
    • Stevens, C.1    Bergman, A.J.2    Liu, Q.3
  • 28
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006; 29:2632-7.
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 29
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the depeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M et al. Efficacy and tolerability of the depeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007; 61:171-80.
    • (2007) Int J Clin Pract , vol.61 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3
  • 30
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I, Hanefeld M, Xu L et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006; 49:2564-71.
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 31
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R, Xu L, Dalla Man C et al. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007; 9:186-93.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla Man, C.3
  • 32
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006; 29:2638-43.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 33
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, noninferiority trial
    • Nauck MA, Meininger G, Sheng D et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, noninferiority trial. Diabetes Obes Metab. 2007; 9:194-205.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3
  • 34
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J, Brazg R, Andryuk PJ et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006; 28:1556-68.
    • (2006) Clin Ther , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3
  • 35
    • 41149154292 scopus 로고    scopus 로고
    • Januvia (sitagliptin) package insert. Whitehouse Station, NJ: Merck and Co, 2007
    • Januvia (sitagliptin) package insert. Whitehouse Station, NJ: Merck and Co.; 2007.
  • 36
    • 33750517754 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
    • Herman GA, Bergman A, Yi B et al. Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes. Curr Med Res Opin. 2006; 22:1939-47.
    • (2006) Curr Med Res Opin , vol.22 , pp. 1939-1947
    • Herman, G.A.1    Bergman, A.2    Yi, B.3
  • 37
    • 33846404842 scopus 로고    scopus 로고
    • Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects
    • Mistry GC, Bergman AJ, Liu WL et al. Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects. J Clin Pharmacol. 2007; 47:159-64.
    • (2007) J Clin Pharmacol , vol.47 , pp. 159-164
    • Mistry, G.C.1    Bergman, A.J.2    Liu, W.L.3
  • 38
    • 33846463003 scopus 로고    scopus 로고
    • Effect of a single cyclosporine dose on single-dose pharmacokinetics of sitagliptin (MK-0431), a dipeptidyl peptidase-4 inhibitor, in healthy male subjects
    • Krishna R, Bergman A, Larson P et al. Effect of a single cyclosporine dose on single-dose pharmacokinetics of sitagliptin (MK-0431), a dipeptidyl peptidase-4 inhibitor, in healthy male subjects. J Clin Pharmacol. 2007; 47:165-74.
    • (2007) J Clin Pharmacol , vol.47 , pp. 165-174
    • Krishna, R.1    Bergman, A.2    Larson, P.3
  • 39
    • 33847735372 scopus 로고    scopus 로고
    • The effect of MK-0431 on the pharmacokinetics of digoxin after concomitant administration for 10 days in healthy subjects
    • Abstract
    • Miller JL, Migoya E, Talaty JE. The effect of MK-0431 on the pharmacokinetics of digoxin after concomitant administration for 10 days in healthy subjects. Clin Pharmacol Ther. 2006; 79:24. Abstract.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 24
    • Miller, J.L.1    Migoya, E.2    Talaty, J.E.3
  • 40
    • 33749993064 scopus 로고    scopus 로고
    • Multiple dose administration of MK-0431 (sitagliptin), an inhibitor of dipeptidyl peptidase-IV, does not meaningfully alter the plasma pharmacokinetics or pharmacodynamics of single doses of warfarin
    • Abstract
    • Wright D, Maes A, Yi B et al. Multiple dose administration of MK-0431 (sitagliptin), an inhibitor of dipeptidyl peptidase-IV, does not meaningfully alter the plasma pharmacokinetics or pharmacodynamics of single doses of warfarin. Clin Pharmacol Ther. 2006; 79:76. Abstract.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 76
    • Wright, D.1    Maes, A.2    Yi, B.3
  • 41
    • 33749847428 scopus 로고    scopus 로고
    • Sitagliptin (MK-0431), a selective dipeptidyl peptidase-IV (DPP-IV) inhibitor, does not affect the pharmacokinetics of simvastatin in humans
    • Abstract
    • Bergman AJ, Cote J, Maes A et al. Sitagliptin (MK-0431), a selective dipeptidyl peptidase-IV (DPP-IV) inhibitor, does not affect the pharmacokinetics of simvastatin in humans. Clin Pharmacol Ther. 2006; 79:48. Abstract.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 48
    • Bergman, A.J.1    Cote, J.2    Maes, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.