Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5781-5791

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Cara, Carlota Lopez ^a   Hamel, Ernest ^b   Basso, Giuseppe ^c   Bortolozzi, Roberta ^c   Viola, Giampietro ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Apoptosis; Benzo b thiophene; Microtubules

Indexed keywords

(3,4,5 TRIMETHOXYPHENYL) [3 (PHENYLAMINO)BENZO[B]THIOPHEN 2 YL]METHANONE; 2 (3',4',5' TRIMETHOXYBENZOYL) 3 (4' ETHOXYPHENYL)BENZO[B]THIOPHENE; [3 (4 CHLOROPHENYLAMINO)BENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [3 (4 ETHOXYPHENYLAMINO) 6 METHYLBENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [3 (4 ETHOXYPHENYLAMINO)BENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [3 (4 METHOXYPHENYLAMINO)BENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [3 (4 TOLYLAMINO) 6 METHYLBENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; [3 (4 TOLYLAMINO)BENZO[B]THIOPHEN 2 YL] (3,4,5 TRIMETHOXYPHENYL)METHANONE; ANTINEOPLASTIC AGENT; BENZOTHIOPHENE DERIVATIVE; CASPASE 3; CYCLIN B1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; DRUG SYNTHESIS; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROTUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; CASPASE 3; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; JURKAT CELLS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TUBULIN;

EID: 78649333056     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.038     Document Type: Article

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